CN110679720A - 一种止咳糖及其制备方法 - Google Patents
一种止咳糖及其制备方法 Download PDFInfo
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- 206010011224 Cough Diseases 0.000 title claims abstract description 57
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- 241001644294 Fritillaria pallidiflora Species 0.000 claims abstract description 35
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 28
- 229930003270 Vitamin B Natural products 0.000 claims abstract description 18
- 235000019156 vitamin B Nutrition 0.000 claims abstract description 18
- 239000011720 vitamin B Substances 0.000 claims abstract description 18
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000011575 calcium Substances 0.000 claims abstract description 16
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 16
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- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims description 5
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 5
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- 238000010438 heat treatment Methods 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 239000008213 purified water Substances 0.000 claims description 3
- 229940124584 antitussives Drugs 0.000 claims description 2
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 claims 3
- 239000006188 syrup Substances 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 abstract description 8
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- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 3
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Classifications
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- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
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- A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
- A23G3/368—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing vitamins, antibiotics
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Abstract
本发明涉及一种止咳糖,包括由以下重量份的原料制成:每10g止咳糖含伊贝母提取物0.8~5.0g、钙200~500mg、维生素D 0.005~0.01mg、维生素C 20~60mg、维生素B6 1~2mg、维生素B12 0.001~0.002mg。本发明将伊贝母提取物与上述几种维生素协同使用,能够促进伊贝母的止咳药效,增强免疫力,促进呼吸系统的健康。本发明所述止咳糖,在具有上述功效的同时,又不需要加入其他的中药成分进行联用,有利于儿童安全、方便使用。
Description
技术领域
本发明属于保健食品制备技术领域,特别涉及一种止咳糖及其制备方法。
背景技术
咳嗽是最常见的呼吸系统疾病之一,且多伴随并发症。近年来,大气污染日趋严重,导致咳嗽的患病率逐年增高,其中剧烈而频繁的咳嗽会严重影响到我们正常的生活、睡眠和工作。因此,咳嗽已经成为影响人们生活和健康的重要疾病之一。临床上用于治疗咳嗽的药物主要为冲剂或中药煎剂,不便于携带或日常服用,且味苦不便于儿童服用。
伊贝母(Bulbus fritillariae Pallidiflorae)为百合科植物新疆贝母或伊犁贝母的干燥鳞茎,主要分布于新疆伊犁河流域,伊贝母为药用贝母之一,是一种与川贝、浙贝齐名的贵重中药材。其味苦、甘;性微寒,归肺经,具有清热润肺、化痰止咳功效。伊贝母常与其他中药成分一起,制备用于止咳的中药制剂。但对于儿童用药而言,存在不方便和适用的缺陷。
发明内容
基于此,本发明的目的之一是提供一种止咳糖,其适用于儿童的止咳和增强免疫力。
实现上述目的的技术方案如下。
一种止咳糖,其包括由以下原料制成:每10g止咳糖含伊贝母提取物0.8~5.0g、钙200~500mg、维生素D 0.005~0.01mg、维生素C 20~60mg、维生素B6 1~2mg、维生素B120.001~0.002mg。
在其中一些实施例中,每10g止咳糖含伊贝母提取物1.5~3.0g、钙300~400mg、维生素D 0.005~0.01mg、维生素C 30~50mg、维生素B6 1.2~1.8mg、维生素B12 0.001~0.002mg。
在其中一些实施例中,还包括有薄荷脑0.1~0.2g、果胶0.5~1.5g、蜂蜜5~6g,变形淀粉0.2~0.4g。
在其中一些实施例中,所述糖为棒棒糖。
在其中一些实施例中,它是由以下重量份的原料制成:每10g止咳糖含伊贝母提取物2.2~2.8g、钙330~360mg、维生素D 0.008~0.012mg、维生素C 38~42mg、维生素B6 1.6~2mg、维生素B12 0.0015~0.002mg、薄荷脑0.12~0.18g、果胶1~1.3g、蜂蜜5~6g,变形淀粉0.2~0.4g。
在其中一些实施例中,伊贝母提取物的制备方法如下:取伊贝母细粉适量,加入2-4倍的纯净水,煎煮1-3小时,过滤后继续加热浓缩成稠浸膏,备用。
本发明的另一目的是提供上述的止咳糖的制备方法。
所述止咳糖的制备方法,包括以下步骤:
在伊贝母提取物中加入钙、维生素D、维生素C、维生素B6、维生素B12,搅拌混匀,得伊贝母提取物混合物;加入糖果赋形剂,制备成型。
在其中一些实施例中,所述糖为棒棒糖,所述加入糖果赋形剂,制备成型为:将所述变形淀粉用少量水溶解,将所述薄荷脑、所述蜂蜜、果胶、按比例混合后,在温度为35-55℃左右下融化混合得到糖基,加入伊贝母提取物混合物,搅拌混匀,得糖液;
冷却后将糖液倒入棒棒糖模具中,插入可食用纸棒,冷却成型,制得止咳棒棒糖。
本发明将伊贝母提取物,与维生素D、维生素C、维生素B6、维生素B12选择合适的量结合在一起,制备成糖果类,可供儿童治疗咳嗽的食疗用。发明人发现,伊贝母提取物与上述几种维生素能具有协同促进止咳的效果,能够促进伊贝母的止咳药效,增强免疫力,促进呼吸系统的健康;同时,适当地添加钙和维生素D,能够坚固儿童牙齿,增强口腔健康和促进儿童生长发育。本发明所述止咳糖,在具有上述功效的同时,又不需要加入其他的中药成分进行联用,对儿童安全、方便地使用,具有很好的效果。
具体实施方式
除非另有定义,本发明所使用的所有的技术和科学术语与属于本发明的技术领域的技术人员通常理解的含义相同。本发明的说明书中所使用的术语只是为了描述具体的实施例的目的,不用于限制本发明。本发明所使用的术语“和/或”包括一个或多个相关的所列项目的任意的和所有的组合。
本发明以下实施例中所涉及的伊贝母提取物的制备方法如下:取伊贝母细粉适量,加入3倍的纯净水,煎煮2小时,过滤后继续加热浓缩成稠浸膏,室温下相对密度为1.4左右,备用。
实施例1
本实施例提供一种止咳棒棒糖,它是由以下重量份的原料制成:每10g止咳糖含伊贝母提取物2.6g、钙350mg、维生素D 0.01mg、维生素C 40mg、维生素B6 2mg、维生素B120.002mg、薄荷脑0.15g、果胶1.2g、蜂蜜5.5g,变形淀粉约0.3g。制备方法如下:在伊贝母提取物中加入钙、维生素D、维生素C、维生素B6、维生素B12,搅拌混匀,得伊贝母提取物混合物;
将变形淀粉用少量水溶解,将所述薄荷脑、所述蜂蜜、果胶、按一定的比例混合后,在温度为45℃左右下融化混合得到糖基,加入伊贝母提取物混合物,搅拌混匀,得糖液;
冷却后将糖液倒入棒棒糖模具中,插入可食用纸棒,冷却成型,制得止咳棒棒糖,用已杀菌的包装纸包装,迅速封口。
实施例2
本实施例提供一种止咳棒棒糖,它是由以下重量份的原料制成:每10g止咳糖含伊贝母提取物2g、钙400mg、维生素D 0.01mg、维生素C 30mg、维生素B6 1.2mg、维生素B120.002mg、薄荷脑0.18g、果胶1.25g、蜂蜜6g,变形淀粉约0.25g。
制备方法如实施例1。
实施例3
本实施例提供一种止咳棒棒糖,它是由以下重量份的原料制成:每10g止咳糖含伊贝母提取物2.6g、钙350mg、薄荷脑0.15g、果胶1.2g、蜂蜜5.8g,变形淀粉约0.3g。
制备方法如下:在伊贝母提取物中加入钙、搅拌混匀,得伊贝母提取物混合物;
将变形淀粉用少量水溶解,将所述薄荷脑、所述蜂蜜、果胶、按一定的比例混合后,在温度为45℃左右的融化混合得到糖基,加入伊贝母提取物混合物,混匀,得糖液;
冷却后将糖液倒入棒棒糖模具中,插入可食用纸棒,冷却成型,制得止咳棒棒糖,用已杀菌的包装纸包装,迅速封口。
实施例四:氨水引咳实验
1、动物给药及引咳
取昆明种小鼠50只,随机分为空白组、伊贝母提取物组、混合维生素组和实施例1中所述伊贝母提取物混合物(伊贝母提取物+混合维生素)组,实施例3中所述伊贝母提取物混合物组(伊贝母提取物+钙),每组10只,标记。其中维生素组给予的药物为混合物,包括维生素D、维生素C、维生素B6、维生素B12,比例为0.01:40:2:0.002。实验前禁食8小时,分别按下表1剂量灌胃给药,每天1次,连续3天,于末次给药后1小时开始实验,将小鼠置于引咳仪中,往雾化杯中加入25%浓氨水1ml,雾化15s(雾化速率0.15ml/min),计数3min内的咳嗽数。
2、结果
各组的咳嗽次数和镇咳率见表1,用SPSS 19.0软件进行统计分析,实验数据以x±s表示,组间比较用t检验。P<0.05为差异有统计学意义。
表1氨水引咳实验剂量和结果
*与空白组比较p<0.05;**与空白组比较p<0.01;#与伊贝母提取物组比较p<0.05;##与伊贝母提取物组比较p<0.01。
从上述结果中可以看出,伊贝母提取物组,咳嗽次数相对于空白组有显著差异,说明伊贝母提取物有良好的镇咳作用,镇咳率为21.9%;混合维生素组没有镇咳作用。混合维生素与伊贝母提取物混合(实施例1)后,小鼠的咳嗽次数显著减少,镇咳率显著提高,与空白组比较,差异更显著,实施例1伊贝母提取物混合物组与伊贝母提取物组比较,也有统计学的差异,说明维生素能够促进伊贝母提取物的止咳药效,该混合物表现出了更强的药效。但是实施例3伊贝母提取物混合物组与伊贝母提取物组比较,效果并没有得到明显提升。
以上所述实施例仅表达了本发明的几种实施方式,其描述较为具体和详细,但并不能因此而理解为对发明专利范围的限制。应当指出的是,对于本领域的普通技术人员来说,在不脱离本发明构思的前提下,还可以做出若干变形和改进,这些都属于本发明的保护范围。因此,本发明专利的保护范围应以所附权利要求为准。
Claims (8)
1.一种止咳糖,其特征在于,包括由以下原料制成:每10g止咳糖含伊贝母提取物0.8~5.0g、钙200~500mg、维生素D 0.005~0.01mg、维生素C 20~60mg、维生素B6 1~2mg、维生素B12 0.001~0.002mg。
2.根据权利要求1所述的止咳糖,其特征在于,每10g止咳糖含伊贝母提取物1.5~3.0g、钙300~400mg、维生素D 0.005~0.01mg、维生素C 30~50mg、维生素B6 1.2~1.8mg、维生素B12 0.001~0.002mg。
3.根据权利要求1或2所述的止咳糖,其特征在于,还包括有薄荷脑0.1~0.2g、果胶0.5~1.5g、蜂蜜5~6g,变形淀粉0.2~0.4g。
4.根据权利要求1所述的止咳糖,其特征在于,是由包括以下原料制成:每10g止咳糖含伊贝母提取物2.2~2.8g、钙330~360mg、维生素D 0.008~0.012mg、维生素C 38~42mg、维生素B6 1.6~2mg、维生素B12 0.0015~0.002mg、薄荷脑0.12~0.18g、果胶1~1.3g、蜂蜜5~6g,变形淀粉0.2~0.4g。
5.根据权利要求1所述的止咳糖,其特征在于,所述糖为棒棒糖。
6.根据权利要求1所述的止咳糖,其特征在于,所述伊贝母提取物的制备方法如下:取伊贝母细粉适量,加入2-4倍的纯净水,煎煮1-3小时,过滤后继续加热浓缩成稠浸膏,备用。
7.权利要求1-6任一项所述的止咳糖的制备方法,其特征在于,包括以下步骤:
在伊贝母提取物中加入钙、维生素D、维生素C、维生素B6、维生素B12,
搅拌混匀,得伊贝母提取物混合物;加入糖果赋形剂,制备成型。
8.根据权利要求7所述的制备方法,其特征在于,所述糖为棒棒糖,所述加入糖果赋形剂,制备成型为:将所述变形淀粉用少量水溶解,将所述薄荷脑、所述蜂蜜、果胶、按比例混合后,在温度为35-55℃左右下融化混合得到糖基,加入伊贝母提取物混合物,搅拌混匀,得糖液;
冷却后将糖液倒入棒棒糖模具中,插入可食用纸棒,冷却成型,制得止咳棒棒糖。
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