CN110679597B - Medicament composition for preventing and treating macadimia nut gray mold - Google Patents
Medicament composition for preventing and treating macadimia nut gray mold Download PDFInfo
- Publication number
- CN110679597B CN110679597B CN201911126578.0A CN201911126578A CN110679597B CN 110679597 B CN110679597 B CN 110679597B CN 201911126578 A CN201911126578 A CN 201911126578A CN 110679597 B CN110679597 B CN 110679597B
- Authority
- CN
- China
- Prior art keywords
- fluxapyroxad
- gray mold
- preventing
- treating
- macadimia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims description 17
- 239000000203 mixture Substances 0.000 title claims description 16
- JHIPUJPTQJYEQK-ZLHHXESBSA-N orysastrobin Chemical compound CNC(=O)C(=N\OC)\C1=CC=CC=C1CO\N=C(/C)\C(=N\OC)\C(\C)=N\OC JHIPUJPTQJYEQK-ZLHHXESBSA-N 0.000 claims abstract description 10
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 claims abstract description 8
- ZMYFCFLJBGAQRS-IRXDYDNUSA-N (2R,3S)-epoxiconazole Chemical compound C1=CC(F)=CC=C1[C@@]1(CN2N=CN=C2)[C@H](C=2C(=CC=CC=2)Cl)O1 ZMYFCFLJBGAQRS-IRXDYDNUSA-N 0.000 claims abstract description 5
- 239000005767 Epoxiconazole Substances 0.000 claims abstract description 5
- 239000005788 Fluxapyroxad Substances 0.000 claims description 58
- SXSGXWCSHSVPGB-UHFFFAOYSA-N fluxapyroxad Chemical compound FC(F)C1=NN(C)C=C1C(=O)NC1=CC=CC=C1C1=CC(F)=C(F)C(F)=C1 SXSGXWCSHSVPGB-UHFFFAOYSA-N 0.000 claims description 55
- 239000005804 Mandipropamid Substances 0.000 abstract description 21
- KWLVWJPJKJMCSH-UHFFFAOYSA-N 2-(4-chlorophenyl)-N-{2-[3-methoxy-4-(prop-2-yn-1-yloxy)phenyl]ethyl}-2-(prop-2-yn-1-yloxy)acetamide Chemical compound C1=C(OCC#C)C(OC)=CC(CCNC(=O)C(OCC#C)C=2C=CC(Cl)=CC=2)=C1 KWLVWJPJKJMCSH-UHFFFAOYSA-N 0.000 abstract description 20
- URXNNPCNKVAQRA-XMHGGMMESA-N pyraoxystrobin Chemical compound CO\C=C(\C(=O)OC)C1=CC=CC=C1COC1=CC(C=2C=CC(Cl)=CC=2)=NN1C URXNNPCNKVAQRA-XMHGGMMESA-N 0.000 abstract description 20
- 239000000575 pesticide Substances 0.000 abstract description 13
- 238000011282 treatment Methods 0.000 abstract description 10
- 230000002265 prevention Effects 0.000 abstract description 5
- 230000002195 synergetic effect Effects 0.000 abstract description 5
- 239000000447 pesticide residue Substances 0.000 abstract description 4
- 239000008194 pharmaceutical composition Substances 0.000 abstract description 4
- 239000004480 active ingredient Substances 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 3
- 230000007246 mechanism Effects 0.000 abstract description 3
- 244000052616 bacterial pathogen Species 0.000 description 14
- 235000018330 Macadamia integrifolia Nutrition 0.000 description 7
- 240000000912 Macadamia tetraphylla Species 0.000 description 7
- 235000003800 Macadamia tetraphylla Nutrition 0.000 description 7
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 206010059866 Drug resistance Diseases 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 125000002252 acyl group Chemical group 0.000 description 4
- 244000053095 fungal pathogen Species 0.000 description 4
- 230000001018 virulence Effects 0.000 description 4
- 238000013329 compounding Methods 0.000 description 3
- 230000009036 growth inhibition Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 241000238631 Hexapoda Species 0.000 description 2
- 239000005605 Pyraflufen-ethyl Substances 0.000 description 2
- 102000019259 Succinate Dehydrogenase Human genes 0.000 description 2
- 108010012901 Succinate Dehydrogenase Proteins 0.000 description 2
- 241000607479 Yersinia pestis Species 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- APTZNLHMIGJTEW-UHFFFAOYSA-N pyraflufen-ethyl Chemical group C1=C(Cl)C(OCC(=O)OCC)=CC(C=2C(=C(OC(F)F)N(C)N=2)Cl)=C1F APTZNLHMIGJTEW-UHFFFAOYSA-N 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 229940124186 Dehydrogenase inhibitor Drugs 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000208467 Macadamia Species 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 241000918585 Pythium aphanidermatum Species 0.000 description 1
- 241000221662 Sclerotinia Species 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 235000011869 dried fruits Nutrition 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000037149 energy metabolism Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000009916 joint effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000006540 mitochondrial respiration Effects 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000000611 regression analysis Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000004102 tricarboxylic acid cycle Effects 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to the technical field of pesticides, and particularly relates to a pharmaceutical composition for preventing and treating macadimia nut gray mold. The effective components of the pharmaceutical composition for preventing and treating macadimia nut gray mold are compounded by epoxiconazole hydroxylamine and orysastrobin, pyraoxystrobin or mandipropamid. The pharmaceutical composition for preventing and treating the gray mold of the macadimia nuts, disclosed by the invention, is composed of active ingredients with different action mechanisms, has an obvious synergistic effect, has a good effect of preventing and treating the gray mold of the macadimia nuts, and can reduce the pesticide application dose and the pesticide application frequency, reduce the prevention and treatment cost, reduce the pressure of pesticides on the environment and reduce pesticide residues.
Description
Technical Field
The invention belongs to the technical field of research and development of new pesticides, and particularly relates to a medicament composition for preventing and treating macadimia nut gray mold.
Background
Macadamia nut, also known as macadamia nut, is a macadamia plant originally produced in Australia, not only has higher economic value, but also has good nutritional value and medicinal value, and is vegetatively reputed as the king of dried fruit. The macadimia nuts have more diseases and insect pests, more than 30 diseases and more than 300 insect pests, and the more serious diseases include damping off, root rot, flower blight, anthracnose, ulceration and gray mold. Wherein the gray mold damages the top parts of newly-extracted young leaves and inflorescences of the macadamia nut tree body, fine-spot water-immersed spots appear after the newly-extracted leaves are damaged, the whole diseased leaves become black along with the development of the disease course, and a layer of gray green powder is grown on the surfaces of the newly-extracted leaves and branches to cause the newly-extracted leaves and the branches to die; after the inflorescence is damaged, the top of the inflorescence cannot grow normally and is dried up, and the healthy growth and yield of the macadimia nuts are seriously influenced. At present, the pesticide preparation for preventing and treating the gray mold of the macadimia nuts is less, the macadimia nut gray mold has serious resistance to common pesticides, and the application dose and the application frequency of the pesticides are generally increased to achieve better prevention and treatment effects when fruit growers prevent and treat the diseases, so that the prevention and treatment cost is increased, and the pesticide residue of the macadimia nuts can be increased.
The fluxapyroxad is a latest generation succinate dehydrogenase inhibitor bactericide discovered and developed by the Prov. Chengdu, and is marketed in 2017, and the fluxapyroxad inhibits the respiration of pathogenic fungi by inhibiting succinate dehydrogenase in a tricarboxylic acid cycle during the mitochondrial respiration of the pathogenic fungi, so that the energy metabolism is blocked, the growth of the pathogenic fungi is inhibited, and the pathogenic fungi die. Has the advantages of high efficiency, broad spectrum, low toxicity and the like, and can prevent and treat various diseases including gray mold, brown spot, leaf spot, sclerotinia rot and gibberellic disease. Like other bactericides, the fluxapyroxad has a single action site, and pathogenic bacteria are easy to generate drug resistance if a large amount of single dosage is applied for a long time. The fluxapyroxad is compounded with other medicaments with different action mechanisms and no cross resistance, and has important significance for protecting the medicaments and delaying the drug resistance of pathogenic bacteria.
The information disclosed in this background section is only for enhancement of understanding of the general background of the invention and should not be taken as an acknowledgement or any form of suggestion that this information forms the prior art already known to a person skilled in the art.
Disclosure of Invention
The invention aims to provide a medicament composition for preventing and treating macadimia nut gray mold, so as to overcome the defects that the cost for preventing and treating the macadimia nut gray mold is high, pesticide residues of macadimia nuts are high due to large-dose application of pesticides, and pathogenic bacteria are easy to generate drug resistance due to long-term large-dose single-dose application of epoxiconazole hydroxylamine.
In order to achieve the purpose, the invention provides a medicament composition for preventing and treating macadimia nut gray mold, which is prepared by compounding the active ingredients of fluxapyroxad with orysastrobin, pyraoxystrobin or mandipropamid.
Preferably, the mass ratio of the fluxapyroxad to the orysastrobin is 1-40: 40-1.
Preferably, the mass ratio of the fluxapyroxad to the pyraoxystrobin is 1-15: 60-1.
Preferably, the mass ratio of the fluxapyroxad to the mandipropamid is 1-25: 100-1.
Compared with the prior art, the invention has the following beneficial effects:
(1) the pharmaceutical composition for preventing and treating the gray mold of the macadimia nuts consists of the active ingredients with different action mechanisms, can effectively slow down the drug resistance of the gray mold of the macadimia nuts, and reduces the drug resistance risk caused by the single use of the epoxiconazole hydroxylamine.
The pesticide composition for preventing and treating the gray mold of the macadimia nuts has obvious synergy when binary compounding is carried out, has good prevention and treatment effect on the gray mold of the macadimia nuts, can reduce the pesticide application dose and the pesticide application frequency, reduces the prevention and treatment cost, lightens the pressure of pesticides on the environment, and reduces pesticide residues.
Detailed Description
The following detailed description of specific embodiments of the invention is provided, but it should be understood that the scope of the invention is not limited to the specific embodiments.
Examples: indoor bioactivity test after compounding of epoxiconazole acyl hydroxylamine
Reagent to be tested: 99.0 percent of fluxapyroxad technical, 98 percent of orysastrobin technical, 96 percent of pyraoxystrobin technical and 93 percent of mandipropamid technical, wherein the technical materials are all sold in the market.
Test germs: pathogenic bacteria of gray mold of macadamia nut
The test method comprises the following steps:
1. dissolving the raw materials in ethanol, diluting with 0.1% Tween-80, respectively preparing single mother liquor, setting multiple groups of ratios, and setting 5-6 gradient mass concentrations of each single agent and each group of mixture according to equal ratio method;
2. firstly, quantitatively adding a pre-melted PDA culture medium into a sterile conical flask under the aseptic condition, quantitatively sucking liquid medicines from low concentration to high concentration in sequence, respectively adding into the conical flasks, and fully shaking. Then, the mixture was poured into 4 dishes 9cm in diameter in equal amounts to prepare drug-containing plates, and blank controls containing only ethanol and 0.1% Tween-80 were added to the plates, and 3 treatments were repeated for each treatment.
3. Under the aseptic condition, punching the edges of bacterial colonies of the gray mold pathogenic bacteria of the macadimia nuts by using a sterilization puncher with the diameter of 5mm to prepare bacterial cakes with the diameter of 5 mm; inoculating the fungus cake in the center of the medicated plate with the hypha facing upwards, covering with a dish, and culturing at 25 deg.C in an incubator.
4. When the diameter of the blank control colony is more than 2/3 of the diameter of the culture dish, measuring the diameter of the colony by a caliper, vertically measuring the diameter of each colony by a cross method once, taking the average value, calculating the hypha growth inhibition rate of each treatment, carrying out regression analysis on the logarithm value of the medicament concentration and the hypha growth inhibition rate value by DPS software, calculating the EC50 of each treatment medicament, and calculating the cotoxicity coefficient (CTC value) of the mixture according to the Sun Yunpei method.
Hypha growth inhibition ratio (%) = [ (blank control colony diameter-5) - (medicament treatment colony diameter-5) ]/[ (blank control colony diameter-5) ] × 100;
measured virulence index (ATI) = (standard agent EC 50/test agent EC 50) × 100;
theoretical virulence index (TTI) = a agent virulence index x percent of a in the mixture + B agent virulence index x percent of B in the mixture;
co-toxicity coefficient (CTC) = [ measured toxicity index (ATI)/theoretical toxicity index of the mixture (TTI) ] × 100.
Criteria are divided according to joint action:
the co-toxicity coefficient (CTC) is more than or equal to 120 and shows a synergistic effect; the co-toxicity coefficient (CTC) is less than or equal to 80, and the antagonism is shown; 80< co-toxicity coefficient (CTC) <120 showed additive effect.
The results of the experiments are shown in tables 1-3.
TABLE 1 indoor bioactivity determination of the complex formulation of fluxapyroxad and orysastrobin on the pathogenic bacteria of gray mold of macadamia nut
| Name and proportion of the medicament | EC50（mg/L） | ATI | TTI | CTC |
| Fluxapyroxad acyl hydroxylamine | 0.52 | 100 | -- | -- |
| Oxidofenamid | 3.29 | 15.81 | -- | -- |
| Fluxapyroxad 1: oxidofenamid 40 | 1.93 | 26.94 | 17.86 | 150.87 |
| Fluxapyroxad 1: orysastrobin 30 | 1.38 | 37.68 | 18.52 | 203.45 |
| Fluxapyroxad 1: oxidofenamid 20 | 1.02 | 50.98 | 19.81 | 257.29 |
| Fluxapyroxad 1: oxidofenamid 15 | 0.77 | 67.53 | 21.07 | 320.55 |
| Fluxapyroxad 1: oxidofenamid 10 | 0.54 | 96.30 | 23.46 | 410.48 |
| Fluxapyroxad 1: oxidofenamid 5 | 0.63 | 82.54 | 29.84 | 276.63 |
| Fluxapyroxad 1: oxidofenamid 1 | 0.56 | 92.86 | 57.90 | 160.37 |
| Fluxapyroxad 5: oxidofenamid 1 | 0.41 | 126.83 | 85.97 | 147.53 |
| Fluxapyroxad 10: oxidofenamid 1 | 0.24 | 216.67 | 92.35 | 234.62 |
| Fluxapyroxad 15: oxidofenamid 1 | 0.15 | 346.67 | 94.74 | 365.92 |
| Fluxapyroxad 20: oxidofenamid 1 | 0.23 | 226.09 | 95.99 | 235.53 |
| Fluxapyroxad 30: oxidofenamid 1 | 0.31 | 167.74 | 97.28 | 172.42 |
| Fluxapyroxad 40: oxidofenamid 1 | 0.40 | 130.00 | 97.95 | 132.73 |
As shown in Table 1, after the fluxapyroxad and the orysastrobin are compounded, the mass ratio of the fluxapyroxad to the orysastrobin is 1-40: the co-toxicity coefficient to the pathogenic bacteria of the gray mold of the macadimia nuts is more than 120 within the range of 40-1, and particularly, the mass ratio of the two is 1: when the dosage is 10, the co-toxicity coefficient reaches 410.48, and the synergistic effect is most obvious.
TABLE 2 indoor bioactivity assay of complex formulation of fluxapyroxad and pyraoxystrobin on pathogenic bacteria of gray mold of macadamia nut
| Name and proportion of the medicament | EC50（mg/L） | ATI | TTI | CTC |
| Fluxapyroxad acyl hydroxylamine | 0.52 | 100 | -- | -- |
| Pyraoxystrobin | 5.23 | 9.94 | -- | -- |
| Fluxapyroxad 1: pyraoxystrobin 60 | 2.11 | 26.64 | 11.42 | 215.82 |
| Fluxapyroxad 1: pyraoxystrobin 50 | 1.78 | 29.21 | 11.71 | 249.51 |
| Fluxapyroxad 1: pyraoxystrobin 40 | 1.52 | 34.21 | 12.14 | 281.82 |
| Fluxapyroxad 1: pyraoxystrobin 30 | 0.92 | 56.52 | 12.85 | 439.94 |
| Fluxapyroxad 1: pyraoxystrobin 20 | 1.07 | 48.60 | 14.23 | 314.49 |
| Fluxapyroxad 1: pyraoxystrobin 10 | 0.83 | 62.65 | 18.13 | 345.57 |
| Fluxapyroxad 1: pyraoxystrobin 1 | 0.52 | 100.00 | 54.97 | 181.91 |
| Fluxapyroxad 3: pyraoxystrobin 1 | 0.34 | 152.94 | 77.49 | 197.33 |
| Fluxapyroxad 5: pyraoxystrobin 1 | 0.24 | 216.67 | 84.99 | 254.93 |
| Fluxapyroxad 7: pyraoxystrobin 1 | 0.35 | 148.57 | 88.754 | 167.42 |
| Fluxapyroxad 9: pyraoxystrobin 1 | 0.43 | 120.93 | 90.99 | 132.90 |
| Fluxapyroxad 12: pyraoxystrobin 1 | 0.27 | 192.59 | 93.07 | 206.93 |
| Fluxapyroxad 15: pyraoxystrobin 1 | 0.19 | 273.68 | 94.37 | 290.01 |
As shown in Table 2, after the fluxapyroxad and the pyraoxystrobin are compounded, the mass ratio of the fluxapyroxad to the pyraoxystrobin is 1-15: the co-toxicity coefficient to the pathogenic bacteria of the gray mold of the macadimia nuts is more than 120 within the range of 60-1, and particularly, the mass ratio of the pathogenic bacteria to the gray mold of the macadimia nuts is 1: at 30 hours, the co-toxicity coefficient reaches 439.94, and the synergistic effect is most obvious.
TABLE 3 indoor bioactivity assay of complex pairs of Oxyfluorazole and mandipropamid on the pathogenic bacteria of gray mold of macadamia nut
| Name and proportion of the medicament | EC50（mg/L） | ATI | TTI | CTC |
| Fluxapyroxad acyl hydroxylamine | 0.52 | 100 | -- | -- |
| Mandipropamid | 32.57 | 1.60 | -- | -- |
| Fluxapyroxad 1: mandipropamid 100 | 13.24 | 3.93 | 2.57 | 152.77 |
| Fluxapyroxad 1: mandipropamid 90 | 8.85 | 5.88 | 2.68 | 219.41 |
| Fluxapyroxad 1: mandipropamid 70 | 6.36 | 8.18 | 2.98 | 274.13 |
| Fluxapyroxad 1: mandipropamid 50 | 3.47 | 14.99 | 3.53 | 425.00 |
| Fluxapyroxad 1: mandipropamid 30 | 5.19 | 10.02 | 4.77 | 210.01 |
| Fluxapyroxad 1: mandipropamid 10 | 2.71 | 19.19 | 10.54 | 182.01 |
| Fluxapyroxad 1: mandipropamid 1 | 0.75 | 69.33 | 50.80 | 136.49 |
| Pyraflufen-ethyl 4: mandipropamid 1 | 0.28 | 185.71 | 80.32 | 231.22 |
| Fluxapyroxad 8: mandipropamid 1 | 0.37 | 140.54 | 89.07 | 157.79 |
| Fluxapyroxad 12: mandipropamid 1 | 0.31 | 167.74 | 92.43 | 181.48 |
| Pyraflufen-ethyl 16: mandipropamid 1 | 0.26 | 200.00 | 94.21 | 212.29 |
| Fluxapyroxad 20: mandipropamid 1 | 0.20 | 26.00 | 95.31 | 272.78 |
| Fluxapyroxad 25: mandipropamid 1 | 0.17 | 305.88 | 96.22 | 317.91 |
As shown in Table 3, after the fluxapyroxad and the mandipropamid are compounded, the mass ratio of the fluxapyroxad to the mandipropamid is 1-25: the cotoxicity coefficient to the pathogenic bacteria of the gray mold of the macadimia nuts is more than 120 within the range of 100-1, and particularly, the mass ratio of the pathogenic bacteria to the gray mold of the macadimia nuts is 1: at 50, the co-toxicity coefficient reaches 425.00, and the synergistic effect is most obvious.
The foregoing descriptions of specific exemplary embodiments of the present invention have been presented for purposes of illustration and description. It is not intended to limit the invention to the precise form disclosed, and obviously many modifications and variations are possible in light of the above teaching. The exemplary embodiments were chosen and described in order to explain certain principles of the invention and its practical application to enable one skilled in the art to make and use various exemplary embodiments of the invention and various alternatives and modifications as are suited to the particular use contemplated. It is intended that the scope of the invention be defined by the claims and their equivalents.
Claims (1)
1. The medicament composition for preventing and treating the gray mold of the macadimia nuts is characterized in that the effective components of the medicament composition are compounded by epoxiconazole hydroxylamine and orysastrobin; the mass ratio of the fluxapyroxad to the orysastrobin is 1-40: 40-1.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111011922.9A CN113661998B (en) | 2019-11-18 | 2019-11-18 | Energy metabolism repressor for resisting gray mold |
| CN201911126578.0A CN110679597B (en) | 2019-11-18 | 2019-11-18 | Medicament composition for preventing and treating macadimia nut gray mold |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911126578.0A CN110679597B (en) | 2019-11-18 | 2019-11-18 | Medicament composition for preventing and treating macadimia nut gray mold |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111011922.9A Division CN113661998B (en) | 2019-11-18 | 2019-11-18 | Energy metabolism repressor for resisting gray mold |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110679597A CN110679597A (en) | 2020-01-14 |
| CN110679597B true CN110679597B (en) | 2021-08-06 |
Family
ID=69117426
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911126578.0A Active CN110679597B (en) | 2019-11-18 | 2019-11-18 | Medicament composition for preventing and treating macadimia nut gray mold |
| CN202111011922.9A Active CN113661998B (en) | 2019-11-18 | 2019-11-18 | Energy metabolism repressor for resisting gray mold |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111011922.9A Active CN113661998B (en) | 2019-11-18 | 2019-11-18 | Energy metabolism repressor for resisting gray mold |
Country Status (1)
| Country | Link |
|---|---|
| CN (2) | CN110679597B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114349569B (en) * | 2021-01-26 | 2022-10-18 | 广西启迪农林发展有限公司 | Ecological conditioning type fertilizer special for eucalyptus and preparation method thereof |
| CN114794130B (en) * | 2021-06-21 | 2023-09-26 | 广西壮族自治区亚热带作物研究所（广西亚热带农产品加工研究所） | Agent for preventing and treating anthracnose of macadimia nut |
| CN115868396B (en) * | 2022-12-16 | 2024-05-24 | 广西南亚热带农业科学研究所 | Ecological seedling raising substrate for macadimia nuts |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008049575A3 (en) * | 2006-10-26 | 2009-05-07 | Syngenta Participations Ag | A method for controlling soybean rust |
| CN102239137B (en) * | 2008-12-05 | 2013-11-27 | 先正达参股股份有限公司 | Novel pyrazole-4-N-alkoxycarboxamides as microbiocides |
| CN104486949A (en) * | 2012-07-26 | 2015-04-01 | 先正达参股股份有限公司 | Fungicidal compositions |
| CN107006480A (en) * | 2017-04-20 | 2017-08-04 | 陕西上格之路生物科学有限公司 | A kind of bactericidal composition of fluorine-containing azoles bacterium acyl azanol |
| CN107494568A (en) * | 2017-08-14 | 2017-12-22 | 河北省农林科学院植物保护研究所 | Prevent and treat compound synergistic bactericidal composition and its application of tomato and pear tree Major Diseases |
| CN109430279A (en) * | 2013-10-03 | 2019-03-08 | 先正达参股股份有限公司 | Fungicidal composition |
| CN109566640A (en) * | 2017-09-29 | 2019-04-05 | 江苏龙灯化学有限公司 | A kind of bactericidal composition |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR083112A1 (en) * | 2010-10-01 | 2013-01-30 | Syngenta Participations Ag | METHOD FOR CONTROLLING PHYTOPATHOGEN DISEASES AND COMPOSITIONS USEFUL FUNGICIDES FOR SUCH CONTROL |
| CN109418272A (en) * | 2017-09-01 | 2019-03-05 | 江苏莱科化学有限公司 | A kind of bactericidal composition |
-
2019
- 2019-11-18 CN CN201911126578.0A patent/CN110679597B/en active Active
- 2019-11-18 CN CN202111011922.9A patent/CN113661998B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008049575A3 (en) * | 2006-10-26 | 2009-05-07 | Syngenta Participations Ag | A method for controlling soybean rust |
| CN102239137B (en) * | 2008-12-05 | 2013-11-27 | 先正达参股股份有限公司 | Novel pyrazole-4-N-alkoxycarboxamides as microbiocides |
| CN104486949A (en) * | 2012-07-26 | 2015-04-01 | 先正达参股股份有限公司 | Fungicidal compositions |
| CN109430279A (en) * | 2013-10-03 | 2019-03-08 | 先正达参股股份有限公司 | Fungicidal composition |
| CN107006480A (en) * | 2017-04-20 | 2017-08-04 | 陕西上格之路生物科学有限公司 | A kind of bactericidal composition of fluorine-containing azoles bacterium acyl azanol |
| CN107494568A (en) * | 2017-08-14 | 2017-12-22 | 河北省农林科学院植物保护研究所 | Prevent and treat compound synergistic bactericidal composition and its application of tomato and pear tree Major Diseases |
| CN109566640A (en) * | 2017-09-29 | 2019-04-05 | 江苏龙灯化学有限公司 | A kind of bactericidal composition |
Non-Patent Citations (1)
| Title |
|---|
| 新近登记或上市的13个杀菌剂农药品种详解;柏亚罗等;《农药市场信息》;20180311(第06期);第30-33页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN110679597A (en) | 2020-01-14 |
| CN113661998A (en) | 2021-11-19 |
| CN113661998B (en) | 2022-11-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110679597B (en) | Medicament composition for preventing and treating macadimia nut gray mold | |
| CN113396924B (en) | Bactericidal composition for preventing and treating macadamia nut anthracnose | |
| CN111345297B (en) | Pesticide composition for preventing and treating pineapple black rot | |
| CN110386844A (en) | A kind of fulvic acid microbial bacterial agent and preparation method thereof | |
| CN113100251A (en) | Agricultural composition containing lecithin | |
| CN113615693A (en) | Anti-anthracnose respiratory inhibitor | |
| CN114651825A (en) | Macadimia nut stem canker inhibitor based on molecular disease resistance approach | |
| CN112674103A (en) | Antibacterial composition, pesticide bactericide and method for preventing and treating diseases of crops | |
| CN109090117B (en) | Compound bactericide containing phenazine-1-formamide and ethylicin and application thereof | |
| CN112438259A (en) | Bactericide composition for preventing and treating white disease of foxtail millet | |
| CN114190394B (en) | Fruit black spot resistant activator for macadimia nut breeding | |
| CN115918665B (en) | Wheat seed dressing agent for preventing and treating wheat stem-based rot | |
| CN113994972B (en) | Composition for treating gummosis of nectarines | |
| CN115968880B (en) | Sterilization composition for preventing and treating wheat powdery mildew | |
| CN113349202B (en) | Biological pesticide for preventing and treating macadamia nut leaf blight | |
| CN114946869B (en) | Macadimia nut recession disease control agent for disease resistance breeding | |
| CN113207898B (en) | Bactericide composition for preventing and treating wheat scab | |
| CN108990992B (en) | Sterilization composition containing pyraoxystrobin and mancozeb | |
| CN116784345A (en) | Composition for improving nitrogen absorption of wheat plants | |
| CN116686839A (en) | Sterilization composition and application thereof | |
| CN117044723A (en) | Synergistic composition for preventing and treating mango anthracnose | |
| CN116267957A (en) | Biopesticide for preventing and treating pineapple heart rot | |
| CN117099781A (en) | Synergistic composition containing aloe-emodin | |
| CN117099780A (en) | Bactericidal composition containing aloe-emodin | |
| CN115053900A (en) | Bactericide for preventing and treating avocado canker |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20200114 Assignee: GUANGXI NANNING HEINIBA AGRICULTURAL TECHNOLOGY CO.,LTD. Assignor: GUANGXI SUBTROPICAL CROPS Research Institute (GUANGXI SUBTROPICAL AGRICULTURAL PRODUCTS PROCESSING RESEARCH INSTITUTE) Contract record no.: X2023980046045 Denomination of invention: A pharmaceutical composition for preventing and controlling gray mold disease of macadamia nuts Granted publication date: 20210806 License type: Common License Record date: 20231108 |
|
| EE01 | Entry into force of recordation of patent licensing contract |