CN110678452A - 亚精胺及其衍生物的应用 - Google Patents

亚精胺及其衍生物的应用 Download PDF

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CN110678452A
CN110678452A CN201880031224.5A CN201880031224A CN110678452A CN 110678452 A CN110678452 A CN 110678452A CN 201880031224 A CN201880031224 A CN 201880031224A CN 110678452 A CN110678452 A CN 110678452A
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cancer
acid
tumor
high expression
pharmaceutically acceptable
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CN110678452B (zh
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朱威
潘武广
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GENEHEAL BIOTECHNOLOGY Co Ltd
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GENEHEAL BIOTECHNOLOGY Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/132—Amines having two or more amino groups, e.g. spermidine, putrescine

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明公开了亚精胺及其衍生物的应用。发明人基于现有的蛋白结构数据、小分子结构数据，使用软件计算分析，筛选得到可以有效干扰PAICS活性的化合物，使用后可以减少SAICAR的合成，达到治疗或改善肿瘤的目的。通过联合用药，有望获得更佳的治疗或改善肿瘤的效果。

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PCT国内申请，说明书已公开。

Claims (20)

  1. PCT国内申请，权利要求书已公开。
CN201880031224.5A 2017-04-20 2018-03-12 亚精胺及其衍生物的应用 Active CN110678452B (zh)

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CN201710262440 2017-04-20
CN2017102624408 2017-04-20
PCT/CN2018/078723 WO2018192323A1 (zh) 2017-04-20 2018-03-12 亚精胺及其衍生物的应用

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CN110678452A true CN110678452A (zh) 2020-01-10
CN110678452B CN110678452B (zh) 2023-02-28

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US (1) US11517541B2 (zh)
EP (1) EP3613731A4 (zh)
CN (1) CN110678452B (zh)
AU (1) AU2018253689B2 (zh)
CA (1) CA3064486C (zh)
WO (1) WO2018192323A1 (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113603721A (zh) * 2021-06-21 2021-11-05 重庆文理学院 一种合成saicar的方法
CN116425639A (zh) * 2022-11-04 2023-07-14 汤臣倍健股份有限公司 一种含亚精胺的植物提取物的制备方法

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WO2018059216A1 (zh) 2016-09-29 2018-04-05 广州君赫生物科技有限公司 降低saicar合成酶活性的化合物及应用
CA3064486C (en) 2017-04-20 2023-08-01 Geneheal Biotechnology Co., Ltd. Applications of spermidine and its derivatives
WO2020147471A1 (zh) * 2019-01-17 2020-07-23 广州君赫生物科技有限公司 天冬氨酸的新应用
CN118055769A (zh) * 2021-08-11 2024-05-17 剑桥企业有限公司 多胺在脑肿瘤治疗中的应用

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113603721A (zh) * 2021-06-21 2021-11-05 重庆文理学院 一种合成saicar的方法
CN113603721B (zh) * 2021-06-21 2023-12-01 重庆文理学院 一种合成saicar的方法
CN116425639A (zh) * 2022-11-04 2023-07-14 汤臣倍健股份有限公司 一种含亚精胺的植物提取物的制备方法
CN116425639B (zh) * 2022-11-04 2024-01-30 汤臣倍健股份有限公司 一种含亚精胺的植物提取物的制备方法

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US20200330403A1 (en) 2020-10-22
CN110678452B (zh) 2023-02-28
AU2018253689A1 (en) 2019-12-05
US11517541B2 (en) 2022-12-06
EP3613731A1 (en) 2020-02-26
AU2018253689B2 (en) 2020-07-23
WO2018192323A1 (zh) 2018-10-25
CA3064486C (en) 2023-08-01
CA3064486A1 (en) 2018-10-25
EP3613731A4 (en) 2021-01-13

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