CN110638976A

CN110638976A - Foot ointment for treating diabetic foot and preparation method thereof

Info

Publication number: CN110638976A
Application number: CN201911040095.9A
Authority: CN
Inventors: 陈启显
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-10-29
Filing date: 2019-10-29
Publication date: 2020-01-03
Anticipated expiration: 2039-10-29
Also published as: CN110638976B

Abstract

The invention discloses a foot ointment for treating diabetic foot and a preparation method thereof, belonging to the technical field of treatment of diabetic complications, wherein the foot ointment is prepared from the following components in parts by mass: 40-60 parts of pearl, 8-16 parts of pseudo-ginseng, 7-12 parts of coptis chinensis, 8-15 parts of scorpion, 7-13 parts of centipede, 9-14 parts of angelica sinensis, 8-14 parts of raw radix aconiti, 10-15 parts of scutellaria baicalensis, 8-13 parts of golden cypress, 28-34 parts of gypsum, 13-18 parts of radix scrophulariae, 27-31 parts of castor bean, 13-18 parts of euphorbia kansui, 45-60 parts of vaseline, 29-34 parts of black bean distillate oil, 28-31 parts of tree oil, 13-16 parts of borneol, 3-6 parts of glycerol, 27-33 parts of a pseudolarix extract, 4-8 parts of a licorice extract, 8-12 parts of zedoary oil and 40-50 parts of yellow lead, improves the skin immune barrier, diminishes inflammation and heals the ulcer surface, gradually reduces the sore mouth, disappears and finally heals.

Description

Foot ointment for treating diabetic foot and preparation method thereof

Technical Field

The invention belongs to the technical field of treatment of diabetic complications, and particularly relates to foot ointment for treating diabetic feet and a preparation method thereof.

Background

At present, no plaster specially used for treating the diabetic foot appears in the medical field of China, the diabetic foot is one of the most common chronic complications of diabetes, the diabetic foot is finally caused by two diseases of diabetic peripheral neuropathy and diabetic peripheral vasculopathy, so the drug treatment of the diabetic foot is also based on the two diseases, but the diabetic foot patient often accompanies gangrene due to the fact that foot ulcer is not healed for a long time, and the amputation patient does not count the education of the diabetic foot patient.

Of course, hypoglycemic therapy is certainly the most basic therapy, and both oral hypoglycemic drugs, combined insulin therapy and simple insulin therapy are the most basic therapy for diabetic foot; secondly, the medicines aiming at the neuropathy and the vasculopathy can relieve and delay the occurrence and the development of diabetic feet, the medicines aiming at the neuropathy comprise the most common nerve-nourishing mecobalamin, vitamin b12, aldose reductase inhibitors, epalrestat, nerve growth factors, lipoic acid antioxidant stress medicines and the like, and the medicines for improving circulation and improving vascular functions comprise antiplatelets, aspirin, almatypine, clopidogrel and medicines for improving circulation, such as danhong, salvia miltiorrhiza, ligusticum chuanxiong hort, alprostadil and the like. The medicine for treating the neuropathy and the medicine for improving circulation and blood vessel functions are combined together for use, which is helpful for delaying the diabetic foot, but has no good treatment effect on ulcer wound healing of the diabetic foot.

The diabetic foot is clinically treated at present: common operations include debridement, skin grafting, flap surgery, amputation and interventional therapy; non-surgical: hyperbaric oxygen, wound negative pressure therapy, and the like. These treatments are complex, require hospital hospitalization and are costly and lengthy.

Disclosure of Invention

In order to solve the problems in the prior art, the invention provides a foot ointment for treating diabetic feet.

The technical scheme adopted by the invention is as follows: a foot ointment for treating diabetic feet is prepared from the following components in parts by mass: 40-60 parts of pearl powder, 8-16 parts of pseudo-ginseng, 7-12 parts of coptis chinensis, 8-15 parts of scorpion, 7-13 parts of centipede, 9-14 parts of angelica sinensis, 8-14 parts of raw radix aconiti, 10-15 parts of scutellaria baicalensis, 8-13 parts of golden cypress, 28-34 parts of gypsum, 13-18 parts of radix scrophulariae, 27-31 parts of castor oil, 13-18 parts of euphorbia kansui, 45-60 parts of vaseline, 29-34 parts of black soybean distillate oil, 28-31 parts of tree oil, 13-16 parts of borneol, 3-6 parts of glycerol, 27-33 parts of a pseudolarix extract, 4-8 parts of a licorice extract, 8-12 parts of zedoary oil and 40-50 parts of yellow lead.

The working principle or the beneficial effects of the invention are as follows: pearl does not have the function of astringing and promoting granulation, and pseudo-ginseng has the effects of promoting blood circulation, removing blood stasis and dredging collaterals; the coptis, the scutellaria, the phellodendron, the gypsum and the radix scrophulariae are used as ministerial drugs, and the effects of clearing away heat and toxic materials, cooling blood and nourishing yin are achieved together; the scorpion, the centipede, the angelica and the unprocessed radix aconiti are adjuvant drugs and jointly achieve the effects of dredging collaterals, relieving pain, promoting blood circulation and removing blood stasis; ricinus communis and euphorbia kansui are guiding drugs and have the effects of reducing swelling by purgation and promoting ulcer healing.

Not only can recover the functions of skin mucosa and phagocyte, improve the skin immune barrier and effectively resist the attack of pathogens, but also can quickly diminish inflammation and quickly heal the ulcer surface, the sore opening is gradually reduced, the ulcer surface disappears and is finally healed.

Further limited, the composition is prepared from the following components in parts by mass: 50 parts of pearl powder, 10 parts of pseudo-ginseng, 10 parts of coptis chinensis, 10 parts of scorpion, 10 parts of centipede, 10 parts of angelica sinensis, 10 parts of raw radix aconiti, 10 parts of scutellaria baicalensis, 10 parts of golden cypress, 30 parts of gypsum, 15 parts of radix scrophulariae, 30 parts of castor bean, 15 parts of kansui root, 50 parts of vaseline, 30 parts of black bean distillate oil, 30 parts of eucalyptus oil, 15 parts of borneol, 5 parts of glycerol, 5 parts of a pseudolarix extract, 5 parts of a liquorice extract, 10 parts of zedoary oil and 42 parts of yellow lead.

Further limiting, the pearl powder, the pseudo-ginseng, the coptis root, the scorpion, the centipede, the Chinese angelica, the raw radix aconiti, the baical skullcap root, the amur corktree bark, the gypsum, the figwort root, the castor bean and the kansui root are prepared into cream oil; vaseline, distilled oil of semen Sojae Atricolor, tree oil and Plumbum Preparatium powder.

The invention also provides a preparation method of the foot ointment for treating diabetic foot, which comprises the following steps:

preparing cream oil:

adding Margarita, Notoginseng radix, Coptidis rhizoma, Scorpio, Scolopendra, radix Angelicae sinensis, radix Aconiti, Scutellariae radix, cortex Phellodendri, Gypsum Fibrosum, radix scrophulariae, Ricinus communis and radix kansui into edible oil, heating, stopping heating when Notoginseng radix, Coptidis rhizoma, Scorpio, Scolopendra, radix Angelicae sinensis, radix Aconiti, Scutellariae radix, cortex Phellodendri, Gypsum Fibrosum, radix scrophulariae, Ricinus communis and radix kansui become yellow, brown or withered black, and filtering to obtain cream oil; the mass of the edible oil is 8-10 times of the total mass of the traditional Chinese medicinal materials;

the preparation method of the pellet ointment comprises the following steps:

parching pill: pulverizing Plumbum Preparatium into powder, parching, stopping parching when the Plumbum Preparatium powder is in loose state, to obtain processed Plumbum Preparatium powder;

oil refining: heating the edible oil, adding vaseline, black soya bean distillate oil and eucalyptus oil into the edible oil when gas formed by volatilization in the edible oil rises in a peripheral spiral shape, stirring uniformly, and stopping heating to obtain mixed oil, wherein the mass ratio of the edible oil to the yellow lead powder is as follows: 16: 7;

the following components: mixing the powder and the mixed oil to obtain paste;

fire toxin removal:

uniformly mixing the cream oil and the pellet paste to prepare a paste dough, and soaking the paste dough in deionized water for 3-10 days;

heating to melt the paste mass after removing fire toxin, adding Borneolum Syntheticum, glycerol, cortex pseudolaricis extract, Glycyrrhrizae radix extract and zedoary turmeric oil, stirring, and cooling to obtain foot cream.

The working principle or the beneficial effects of the invention are as follows: the yellow lead is crushed into powder and fried, and then the yellow lead powder is mixed with hot edible oil to obtain the lead plaster, the edible oil in the lead plaster can moisten the skin and is not easy to volatilize, so that the efficacy of detoxification and inflammation diminishing can be kept for a long time, and the yellow lead has the efficacy of eliminating phlegm and relieving fever, weighing down phlegm and removing accumulation, drawing out toxin and removing stasis, and promoting granulation. The foot ointment has high concentration of each medicine, so that the ointment can be pasted on an affected part to ensure that the medicine concentration of the affected part is high, and the ointment can directly act on the affected part, thereby improving the treatment efficiency; the medicine in the foot ointment permeates into skin along with edible oil to stimulate nerve endings, promotes local blood circulation by reflecting and expanding blood vessels, improves the nutrition of peripheral tissues and achieves the functions of detumescence and antiphlogosis; part of the medicine permeates into subcutaneous tissues to play a local role in antisepsis, anti-inflammation and relieving pain; and part of the medicines enter the systemic circulation through blood or lymph vessels, and can generate the systemic medicinal effect to achieve the radical treatment of diseases.

Further limited, the edible oil is sesame oil or rapeseed oil.

Further limiting, the specific steps of the pellet are as follows:

heating the mixed oil, slowly adding Plumbum Preparatium powder, stirring and heating, stopping heating when the mixture is cooled and stick to hand but not greasy, and stirring to cool to obtain Plumbum Preparatium paste.

Further limiting, the specific steps of the pellet are as follows: directly adding the prepared yellow lead powder into the mixed oil without heating, and uniformly stirring to obtain the lead paste.

Further limiting, in the soaking step in the fire toxin removing process, water is changed for 1-2 times every day. In the oil refining process, the fire is fierce first and then small.

Detailed Description

Example 1

An instrument therefor

1 heater with controllable fire, 2 measuring cylinders, 1 scale, a plurality of glass rods, 1 filter screen, a plurality of beakers with different specifications and 1 crusher;

second, preparation of foot ointment for treating diabetic foot

A preparation method of foot ointment for treating diabetic feet comprises the following steps:

weighing 40g of pearl powder, 8g of pseudo-ginseng, 7g of coptis chinensis, 8g of scorpion, 7g of centipede, 9g of angelica, 8g of unprocessed radix aconite, 10g of scutellaria baicalensis, 8g of golden cypress, 28g of gypsum, 13g of radix scrophulariae, 27g of castor bean, 13g of euphorbia kansui, 45g of vaseline, 29g of black bean distillate oil, 28g of eucalyptus oil, 13g of borneol, 3g of glycerol, 27g of pseudolarix extract, 4g of liquorice extract, 8g of zedoary oil, 40g of yellow lead, 1448g of sesame oil and 91.4g of rapeseed oil;

preparing cream oil:

adding sesame oil into a beaker, placing the beaker on a fire-potential-controllable heater for heating, simultaneously adding pearl powder, pseudo-ginseng, coptis chinensis, scorpion, centipede, Chinese angelica, unprocessed radix aconite, scutellaria baicalensis, golden cypress, gypsum, radix scrophulariae, castor bean and kansui root, heating with small fire and continuously stirring by using a glass rod, stopping heating when the pseudo-ginseng, the coptis chinensis, the scorpion, the centipede, the Chinese angelica, the unprocessed radix aconite, the scutellaria baicalensis, the golden cypress, the gypsum, the radix scrophulariae, the castor bean and the kansui root become yellow, scorched or withered and black, and filtering by using a filter screen to obtain cream oil;

the preparation method of the pellet ointment comprises the following steps:

parching pill: pulverizing Plumbum Preparatium into powder by pulverizer, parching, and stopping parching when water and gas in the Plumbum Preparatium powder are completely dispersed and the Plumbum Preparatium powder is in loose state to obtain processed Plumbum Preparatium powder;

oil refining: heating oleum Rapae with strong fire, changing into small fire when gas formed by volatilization in edible oil rises in a circumferential shape, adding vaseline, semen Sojae Atricolor distillate oil and tree oil into oleum Rapae, stirring, and stopping heating to obtain mixed oil;

the following components: mixing the prepared yellow lead powder and the mixed oil uniformly to obtain a lead paste, which comprises the following specific steps: heating the mixed oil, slowly adding Plumbum Preparatium powder, stirring and heating, stopping heating when the mixture is cooled and sticks to but not greasy to hand, and stirring to cool to obtain Plumbum Preparatium paste;

wherein the specific operation of the mixture when the mixture is cooled and sticks to the hands but does not feel greasy is as follows: dropping the mixture on cold water by a glass rod quickly until the mixture is slightly beaded and does not disperse, wiping the water on the surface of the bead by the bead, and performing dry hand and trial kneading to stick the hand and ensure that the hand is not greasy when the hand leaves;

fire toxin removal:

uniformly mixing the cream oil and the pellet paste to prepare a paste dough, soaking the paste dough in deionized water for 3-10 days, and replacing water for 1-2 times every day;

heating and melting the paste mass after removing fire toxin, adding borneol, glycerin, pseudolarix extract, licorice extract and zedoary turmeric oil, stirring uniformly, and cooling to obtain the foot cream, wherein the specific cooling mode is as follows: the plaster is coated on paper cloth, the thickness of the plaster is 2-3 cm, and the plaster can be obtained after people feel cool naturally.

Application of ointment for treating feet and three diseases

The foot cream coated on the paper cloth and the paper cloth are put on a kettle, an alcohol lamp or a candle with low fire for heating, baking and melting, and the foot cream and the paper cloth can be spread and pasted after the temperature is proper.

Points of attention

1. Before application, the affected part is cleaned with warm water, or the affected part is sterilized with alcohol, and then applied after the skin is dried. The skin is not able to be applied when sweat or moisture is present, which can result in poor application. If the plaster is not tightly adhered in cold weather, the plaster can be applied again after being adhered.

2. The plaster is changed on time to prevent the skin from being stimulated by lead compounds in the plaster, the drug effect of one plaster can be maintained for 1-2 days generally, if the plaster is fried to be black, the drug effect is longer, and the plaster can be continuously pasted for 3 days and then taken off, so that the plaster is not suitable to be changed frequently or too seldom.

3. After the plaster is applied, allergy is caused, local itching is severe or blister and ulceration are caused, when the plaster is taken down, alcohol is used for disinfecting or gentian violet lotion is applied, and the plaster is applied after no itching and wound healing. Or applying preventive measures such as spreading Mentholum on plaster before application. And the patient is forbidden in severe cases.

4. The plaster can not be baked on a coal stove for application, because carcinogenic substances and harmful gases generated during the combustion of the coal stove can be absorbed by plaster substrate and water and permeate into human body through skin, thus being harmful to health.

5. The pregnant women should use it with cautions for all the cases where the plaster contains components of musk and Ruyu, etc. for promoting blood circulation and removing blood stasis. Especially, the pregnant women's waist, abdomen (especially the lower abdomen qi sea, Guanyuan acupoint), navel and the lower limb Sanyinjiao acupoint can not be applied to prevent the occurrence of accidents such as abortion.

6. When the ointment is torn off, the action is gentle, and the skin is prevented from being torn. The foot ointment adhered to the skin is wiped with gauze dipped with gasoline and then disinfected with alcohol.

Example 2

Different from the example 1, the following steps are carried out: mixing the prepared yellow lead powder and the mixed oil uniformly to obtain a lead paste, which comprises the following specific steps: directly adding the prepared yellow lead powder into the mixed oil without heating, and uniformly stirring to obtain the lead paste.

Example 3

Different from example 1, the different amounts of the components are specifically as follows: weighing 50g of pearl powder, 10g of pseudo-ginseng, 10g of coptis chinensis, 10g of scorpion, 10g of centipede, 10g of Chinese angelica, 10g of unprocessed radix aconite, 10g of scutellaria baicalensis, 10g of golden cypress, 30g of gypsum, 15g of radix scrophulariae, 30g of castor bean, 15g of kansui root, 50g of vaseline, 30g of black bean distillate oil, 30g of eucalyptus oil, 15g of borneol, 5g of glycerol, 27g of pseudolarix extract, 5g of liquorice extract, 10g of zedoary oil, 42g of yellow lead, 2200g of sesame oil and 96g of rapeseed oil.

Example 4

Different from example 1, the different amounts of the components are specifically as follows: weighing 60g of pearl powder, 16g of pseudo-ginseng, 12g of coptis chinensis, 15g of scorpion, 13g of centipede, 14g of Chinese angelica, 14g of unprocessed radix aconite, 15g of scutellaria baicalensis, 13g of golden cypress, 34g of gypsum, 18g of radix scrophulariae, 31g of castor bean, 18g of kansui root, 60g of vaseline, 34g of black bean distillate oil, 31g of eucalyptus oil, 16g of borneol, 6g of glycerol, 33g of pseudolarix extract, 8g of liquorice extract, 12g of zedoary oil, 50g of yellow lead, 2457g of sesame oil and 114.3g of rapeseed oil.

Clinical cases

Case 1

According to the traditional Chinese medicine, XX is old, the patient is 54 years old, the patient suffers from diabetes for 2 years, left heel swelling and pain can be caused in 2018 in 1 month, after 2 weeks, the pain of the left heel is aggravated, red swelling gradually spreads to the periphery, the patient is hospitalized in an outpatient clinic of a local hospital, debridement, oral antibiotics, blood sugar reduction, nutritional nerves and the like are given, the effect is not obvious, the left heel abscess is broken, and a large amount of white pyogenic secretions flow out are accompanied; checking blood sugar 16.8mmol/L, considering type II diabetes and diabetic foot, measuring body temperature 36 deg.C, pulse 80 times/min, breathing 17 times/min, blood pressure 132/80 mmHg; the left foot is swollen, the skin of the instep is blackened, local tenderness is caused, a flask-shaped fistula is visible at the bottom of the left heel, the diameter of an outer opening is 4cm, the depth is 10cm, a large amount of secretion flows out, the foot cream is malodorous, the foot cream prepared by the method is pasted on the affected part, and after one-month treatment, the effect is remarkable, and the wound is completely healed.

Case 2

Liu XX, age 64, diabetes mellitus 10 years old, without obvious causes of right heel swelling and pain, after 2 weeks because of right heel pain aggravation, red swelling gradually spread to the periphery, 14.8mmol/L glucose, regular urine: denier is 3, body temperature is 38 ℃, pulse is 90 times/min, respiration is 22 times/min, and blood pressure is 172/98 mmHg; swelling right foot, gangrene area of right foot inner ankle ulcer of 4cm × 5cm, skin blackening, local tenderness, large secretion outflow, light malodor, and diagnosis of type II diabetes and diabetes, diabetic nephropathy; the foot ointment has remarkable treatment effect after more than 40 days, and the diabetic foot is completely healed.

The invention is not limited to the above alternative embodiments, and any other various forms of products can be obtained by anyone in the light of the present invention, but any changes in shape or structure thereof, which fall within the scope of the present invention as defined in the claims, fall within the scope of the present invention.

Claims

1. The foot ointment for treating diabetic feet is characterized by being prepared from the following components in parts by mass: 40-60 parts of pearl powder, 8-16 parts of pseudo-ginseng, 7-12 parts of coptis chinensis, 8-15 parts of scorpion, 7-13 parts of centipede, 9-14 parts of angelica sinensis, 8-14 parts of raw radix aconiti, 10-15 parts of scutellaria baicalensis, 8-13 parts of golden cypress, 28-34 parts of gypsum, 13-18 parts of radix scrophulariae, 27-31 parts of castor oil, 13-18 parts of euphorbia kansui, 45-60 parts of vaseline, 29-34 parts of black soybean distillate oil, 28-31 parts of tree oil, 13-16 parts of borneol, 3-6 parts of glycerol, 27-33 parts of a pseudolarix extract, 4-8 parts of a licorice extract, 8-12 parts of zedoary oil and 40-50 parts of yellow lead.

2. The foot cream for treating diabetic feet according to claim 1, which is prepared from the following components in parts by mass: 50 parts of pearl powder, 10 parts of pseudo-ginseng, 10 parts of coptis chinensis, 10 parts of scorpion, 10 parts of centipede, 10 parts of angelica sinensis, 10 parts of raw radix aconiti, 10 parts of scutellaria baicalensis, 10 parts of golden cypress, 30 parts of gypsum, 15 parts of radix scrophulariae, 30 parts of castor bean, 15 parts of kansui root, 50 parts of vaseline, 30 parts of black bean distillate oil, 30 parts of eucalyptus oil, 15 parts of borneol, 5 parts of glycerol, 5 parts of a pseudolarix extract, 5 parts of a liquorice extract, 10 parts of zedoary oil and 42 parts of yellow lead.

3. The foot ointment for treating diabetic foot according to claim 1, wherein the pearl powder, the pseudo-ginseng, the coptis root, the scorpion, the centipede, the angelica, the raw monkshood, the scutellaria baicalensis, the phellodendron amurense, the gypsum, the radix scrophulariae, the castor bean and the kansui root are prepared into ointment; vaseline, distilled oil of semen Sojae Atricolor, tree oil and Plumbum Preparatium powder.

4. The method of preparing a foot cream for the treatment of diabetic foot according to any of claims 1 to 3, comprising the steps of:

preparing cream oil:

the preparation method of the pellet ointment comprises the following steps:

the following components: mixing the powder and the mixed oil to obtain paste;

fire toxin removal:

5. The method according to claim 4, wherein the edible oil is sesame oil or rapeseed oil.

6. The preparation method according to claim 4, wherein the steps of adding lead are as follows:

7. The preparation method according to claim 4, wherein the steps of adding lead are as follows: directly adding the prepared yellow lead powder into the mixed oil without heating, and uniformly stirring to obtain the lead paste.

8. The preparation method according to claim 4, wherein the water is changed 1-2 times per day in the soaking step in the fire toxin removing process.

9. The method according to claim 4, wherein the refining process is carried out by a high fire and then a low fire.