CN110638907A - 一种具有补气养血功能的口服液及其制备方法 - Google Patents
一种具有补气养血功能的口服液及其制备方法 Download PDFInfo
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Abstract
本发明涉及保健食品技术领域，具体涉及一种具有补气养血功能的口服液及其制备方法。该口服液包括重量份的如下原料：阿胶10~50份、枸杞子8~30份、酸枣5~20份、葡萄干2~16份、胡萝卜4~15份、核桃2~8份、红糖3~6份、黄豆2~6份、蜂蜜2~5份、9000~12000mL纯化水。制备方法为原料处理、处理液混合、灌装、灭菌及产品检验。本发明补气养血口服液中主要原料为常用的优质补气养血食材及中药：阿胶、枸杞子、酸枣、葡萄干、胡萝卜、核桃、红糖及黄豆起到了全面改善血气不足的作用；考虑口感的问题，在产品中加入蜂蜜调节口味，是口感更佳；本发明补气养血口服液的制备方法简单，操作方便；节省成本和劳动力；工艺设备安全卫生。
Description
技术领域
本发明涉及保健食品技术领域，具体涉及一种具有补气养血功能的口服液及其制备方法。
背景技术
血气不足，即中医学中的气虚和血虚。气血不足的结果会导致脏腑功能的减退，引起早衰的病变。气血是人之根本，气血的充足、经络的通畅是身体健康的最基本条件。所谓“气”，是指使人体器官发挥机能的动力，在生理上具有保持活力、温暖人体、防御外邪等功能。“气”就像是人体的“汽油”，推动行，使体表保持正常，防御各种病毒入侵。中医所说的“血”则有两层含义，其一是指西医讲的流动在脉管中的“血液”，具有营养和滋润全身的生理功能；其二是指与“气”同在的运行载体，中医有句话叫“气为血之帅，血为气之母”，气推动血的运行，血濡养气的充盛。 如果把人体比作生长植物的话，气就是阳光，血就是雨露，二者共同作用于人体，使其茁壮成长。这一点，不仅对整个人体如此，对每一个脏腑也是如此。气和血可以在人体的一些细节中发现出来，只要分辨出这些小细节，就能认清各个脏腑气血的运行状态，有助于预知疾病、保持健康。
现在社会人们面对来自各方压力与日俱增，由于“血气不足”伴随的症状主要表现为：（1）气虚：面色恍白，气短懒言，头晕，目眩，小腹空坠、畏寒肢冷、自汗、头晕耳鸣、精神萎靡、疲倦无力、心悸气短、发育迟缓。气虚即表明脏腑功能衰退，抗病能力差。（2）气滞：表现为胸闷，小腹涨痛连及两肋，痛无定处等。（3）血虚：面色无华萎黄、皮肤干燥不润、毛发枯萎、指甲干裂色淡、视物昏花、手足麻木、疲乏无力、失眠多梦、健忘心悸、精神恍惚。（4）血淤：小腹疼痛，按之更痛，皮肤干燥，口干又不想喝水等，都属于血气不足的症状。（5）头晕耳鸣：大脑的功能需依赖气血的充养，且精血、精气之间可以互生互化。若气血不足，不能上充头目，或致肾精亏虚，导致头晕耳鸣。（6）脸色暗淡发黄：皮肤白里透着粉红，有光泽、弹性、无皱纹、无斑代表气血充足。反之，皮肤粗糙，没光泽，发暗、发黄、发白、发青、发红、长斑都代表身体状况不佳、气血不足。（7）眼白混浊：俗话说“人老珠黄”，其实指的就是眼白的颜色变得混浊、发黄，有血丝，这就表明气血不足了。眼睛随时都能睁得大大的，说明气血充足；反之，眼袋很大、眼睛干涩、眼皮沉重，都代表气血不足。（8）头发干枯分叉：头发黝黑、浓密、柔顺代表气血充足，头发干枯、掉发、头发发黄、发白、开叉都是气血不足的表现。（9）手心偏热或冰凉：手的温度是人体气血的直接表现。气血充足的人手应该一年四季都是温暖干燥的，如果手心偏热或者出汗或者手冰冷，则都是气血不足。（9）牙齿不好：牙齿与肾的关系最为密切，如成人牙齿稀疏、牙齿松动、齿根外露等问题，多为肾气亏乏。牙龈萎缩也是气血不足的表现，当你发现牙齿的缝隙变大了，越来越容易塞牙，就要留意身体的状况。（10）月经量少：女性的月经和气血关系十分密切，如果女性月经量突然减少，甚至停经，那么很可能就是气血不足所致。（11）睡眠质量差：而入睡困难，易惊易醒、夜尿多，呼吸深重或打呼噜的人都是血亏。
目前，气血不足的结果会导致脏腑功能的减退，引起早衰，严重的甚至危机生命。所以伴随着社会的进步和人们生活水平的提高，越来越多的人开始关注日常保健。因此，以补气养血为主要功能的保健品市场潜力巨大，现在市面上的产品大多数是纯中药制成的补气养血类保健品，形势也较为单一。
发明内容
基于上述问题，本发明目的提供一种具有补气养血功能的口服液及其制备方法。
一种具有补气养血功能的口服液，该口服液包括重量份的如下原料：阿胶10~50份、枸杞子8~30份、酸枣5~20份、葡萄干2~16份、胡萝卜4~15份、核桃2~8份、红糖3~6份、黄豆2~6份、蜂蜜2~5份、9000~12000mL纯化水。
优化的，该口服液包括重量份的如下原料：阿胶38份、枸杞子8份、酸枣18份、葡萄干10份、胡萝卜9份、核桃6份、红糖4份、黄豆4份、蜂蜜3份、10000mL纯化水。
上述一种具有补气养血功能的口服液的制备方法：具体包括如下步骤：
步骤一：将酸枣、葡萄干、枸杞子、胡萝卜用水淋清洗干净，置于夹层锅中，十倍水量煎煮1.5小时，趁热过200目筛，滤液放置于配制罐中备用；
步骤二：将阿胶用高速粉碎机粉碎，将阿胶粉末加入纯化水洋化，200目筛过滤，得到阿胶液备用；
步骤三：将黄豆、核桃阴干后用粉碎机粉碎后，过100目筛备用，置于配置罐中，加热煮沸40分钟，搅拌使溶解，趁热过200目筛，滤液备用；
步骤四：将上述三个步骤的滤液与红糖和蜂蜜按比例混合均匀，纯化水定容至足量；
步骤五：将步骤四的混合液冷藏静置48小时后，通过板框过滤机过滤得到滤液；
步骤六：将步骤五的滤液放置于洁净不锈钢贮液罐内，用灌装机灌装于符合卫生要求的棕色玻璃瓶中，调整装量规格为10mL/支；
步骤七：罐装过后在115℃条件下灭菌25分钟，然后包装后进行成品检验。
进一步的，所述步骤二至六均在十万级洁净空间进行。
相比于现有的技术，本发明具有如下有益效果：
本发明补气养血口服液中主要原料为常用的优质补气养血食材及中药：阿胶、枸杞子、酸枣、葡萄干、胡萝卜、核桃、红糖及黄豆起到了全面改善血气不足的作用。考虑口感的问题，在产品中加入蜂蜜调节口味，是口感更佳。本发明补气养血口服液的制备方法简单，操作方便；节省成本和劳动力；工艺设备安全卫生。
具体实施方式
下面将结合实施例对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
实施例1
一种具有补气养血功能的口服液，该口服液包括重量份的如下原料：阿胶500g、枸杞子300g、酸枣50g、葡萄干20g、胡萝卜40g、核桃20g、红糖30g、黄豆20g、蜂蜜20g、9000mL纯化水。
上述一种具有补气养血功能的口服液的制备方法：具体包括如下步骤：
步骤一：将市售酸枣、葡萄干、枸杞子、胡萝卜用水淋清洗干净，置于夹层锅中，十倍水量煎煮1.5小时，趁热过200目筛，滤液放置于配制罐中备用；
步骤二：将阿胶用高速粉碎机粉碎，将阿胶粉末加入纯化水洋化，200目筛过滤，得到阿胶液备用；
步骤三：将黄豆、核桃阴干后用粉碎机粉碎后，过100目筛备用，置于配置罐中，加热煮沸40分钟，搅拌使溶解，趁热过200目筛，滤液备用；
步骤四：将上述三个步骤的滤液与红糖和蜂蜜按比例混合均匀，9000mL纯化水定容至足量；
步骤五：将步骤四的混合液冷藏静置48小时后，通过板框过滤机过滤得到滤液；
步骤六：将步骤五的滤液放置于洁净不锈钢贮液罐内，用灌装机灌装于符合卫生要求的棕色玻璃瓶中，调整装量规格为10mL/支；
步骤七：罐装过后在115℃条件下灭菌25分钟，然后包装后进行成品检验。其中，上述步骤二至六均在十万级洁净空间进行。
实施例2
一种具有补气养血功能的口服液，该口服液包括重量份的如下原料：阿胶380g、枸杞子80g、酸枣180g、葡萄干100g、胡萝卜90g、核桃60g、红糖40g、黄豆40g、蜂蜜30g、10000mL纯化水。
上述一种具有补气养血功能的口服液的制备方法：具体包括如下步骤：
步骤一：将市售酸枣、葡萄干、枸杞子、胡萝卜用水淋清洗干净，置于夹层锅中，十倍水量煎煮1.5小时，趁热过200目筛，滤液放置于配制罐中备用；
步骤二：将阿胶用高速粉碎机粉碎，将阿胶粉末加入纯化水洋化，200目筛过滤，得到阿胶液备用；
步骤三：将黄豆、核桃阴干后用粉碎机粉碎后，过100目筛备用，置于配置罐中，加热煮沸40分钟，搅拌使溶解，趁热过200目筛，滤液备用；
步骤四：将上述三个步骤的滤液与红糖和蜂蜜按比例混合均匀，10000mL纯化水定容至足量；
步骤五：将步骤四的混合液冷藏静置48小时后，通过板框过滤机过滤得到滤液；
步骤六：将步骤五的滤液放置于洁净不锈钢贮液罐内，用灌装机灌装于符合卫生要求的棕色玻璃瓶中，调整装量规格为10mL/支；
步骤七：罐装过后在115℃条件下灭菌25分钟，然后包装后进行成品检验。其中，上述步骤二至六均在十万级洁净空间进行。
实施例3
一种具有补气养血功能的口服液，该口服液包括重量份的如下原料：阿胶100g、枸杞子140g、酸枣200g、葡萄干160g、胡萝卜150g、核桃80g、红糖60g、黄豆60g、蜂蜜50g、纯化水12000mL。
上述一种具有补气养血功能的口服液的制备方法：具体包括如下步骤：
步骤一：将市售酸枣、葡萄干、枸杞子、胡萝卜用水淋清洗干净，置于夹层锅中，十倍水量煎煮1.5小时，趁热过200目筛，滤液放置于配制罐中备用；
步骤二：将阿胶用高速粉碎机粉碎，将阿胶粉末加入纯化水洋化，200目筛过滤，得到阿胶液备用；
步骤三：将黄豆、核桃阴干后用粉碎机粉碎后，过100目筛备用，置于配置罐中，加热煮沸40分钟，搅拌使溶解，趁热过200目筛，滤液备用；
步骤四：将上述三个步骤的滤液与红糖和蜂蜜按比例混合均匀，12000mL纯化水定容至足量；
步骤五：将步骤四的混合液冷藏静置48小时后，通过板框过滤机过滤得到滤液；
步骤六：将步骤五的滤液放置于洁净不锈钢贮液罐内，用灌装机灌装于符合卫生要求的棕色玻璃瓶中，调整装量规格为10mL/支；
步骤七：罐装过后在115℃条件下灭菌25分钟，然后包装后进行成品检验。其中，上述步骤二至六均在十万级洁净空间进行。
实施例4
毒理实验：
1、试验目的：本发明补气养血口服液是否有毒。
实验材料：（1）样品：补气养血口服液，人体口服液推荐量为每日20mL，成人体重按60kg计算，折合剂量0.333mL/kg/天，取5倍浓缩液进行实验。
2、实验动物：清洁级昆明种小鼠、SD大鼠及饲料。
3、实验环境条件：温度22~24℃，湿度52~58%。
4、实验方法：
通过小鼠急性毒理实验（取补气养血口服液5倍浓缩液给小鼠按20mL/kg.bw的灌胃体积给小鼠一次性经口灌胃）、Ames试验（试验设五个剂量，分别为5000μg/皿、1000μg/皿、200μg/皿、40μg/皿、8μg/皿，同时设自发回变、溶剂对照和阳性突变剂对照）、小鼠骨髓嗜多染红细胞核试验（以0.04g/kg.bw剂量的环磷酰胺为阳性对照，蒸馏水为阴性对照，试验组3个剂量分别为5倍浓缩液10.0g/kg.bw、5.0g/kg.bw、2.5g/kg.bw，取补气养血口服液5倍浓缩液25.0g、12.5g、6.25g加蒸馏水至50mL，给小鼠按0.2mL/10g.bw、体积间隔24小时灌胃2次）、小鼠精子畸形试验（以0.04g/kg.bw剂量的环磷酰胺为阳性对照，蒸馏水为阴性对照，试验组3个剂量分别为5倍浓缩液10.0g/kg.bw、5.0g/kg.bw、2.5g/kg.bw取补气养血口服液5倍浓缩液25.0g、12.5g、6.25g加蒸馏水至50mL，配成相应剂量的受试液给小鼠灌胃）、30天喂养试验（取补气养血口服液5倍浓缩液66.7mL、100.0mL、133.3mL，加蒸馏水定容至200mL，对照组给与等体积蒸馏水，每日灌胃一次，连续30天）来进行毒理学试验评定。
6、试验结果：
（1）急性经口毒性试验：对雌、雄昆明种小鼠的最大耐受剂量大于26.2g/kg.bw（20mL/kg.bw，相当于人体推荐量的300倍），属于无毒级。
（2）遗传毒性试验：Ames试验、小鼠骨髓嗜多染红细胞微核试验及小鼠精子畸形试验结果均为阴性。
（3）30天喂养试验：以补气养血口服液5倍浓缩液3.33mL/kg.bw、5.00mL/kg.bw、6.67mL/kg.bw剂量，加蒸馏水定容至200mL（折合成原液的剂量分别为16.67mL/kg.bw、25.00mL/kg.bw、33.33mL/kg.bw，分别相当于人体推荐计量的50、75、100倍）给大鼠经口灌胃30天，实验期间，各组动物生长发育良好，样品个剂量对大鼠体重、体重增长、平均进食量及食物利用率无显著影响。实验末，各剂量组血液学指标（血红蛋白、红细胞总数、红细胞压积、血小板总数、白细胞总数及分类）、血生化指标（血清谷丙转氨酶、谷草转氨酶、总蛋白、白蛋白、胆固醇、甘油三酯、尿素氮、肌酐、血糖）、脏体比值（肝、体、脾/体、肾/体比值及雄鼠的睾丸/体重比值）与相应对照组比较，无显著性差异。大体解剖和组织病理检查未见与样品有关的异常改变。在本实验条件下，在33.33mL/kg.bw~6.67mL/kg.bw剂量范围内，未见补气养血口服液5倍浓缩液30天喂养大鼠有明显毒副作用。
尽管已经示出和描述了本发明的实施例，对于本领域的普通技术人员而言，可以理解在不脱离本发明的原理和精神的情况下可以对这些实施例进行多种变化、修改、替换和变型，本发明的范围由所附权利要求及其等同物限定。
Claims (4)
1.一种具有补气养血功能的口服液，其特征在于，该口服液包括重量份的如下原料：阿胶10~50份、枸杞子8~30份、酸枣5~20份、葡萄干2~16份、胡萝卜4~15份、核桃2~8份、红糖3~6份、黄豆2~6份、蜂蜜2~5份、9000~12000mL纯化水。
2.根据权利要求1所述的一种具有补气养血功能的口服液，其特征在于，该口服液包括重量份的如下原料：阿胶38份、枸杞子8份、酸枣18份、葡萄干10份、胡萝卜9份、核桃6份、红糖4份、黄豆4份、蜂蜜3份，10000mL纯化水。
3.权利要求1所述一种具有补气养血功能的口服液的制备方法，其特征在于，具体包括如下步骤：
步骤一：将酸枣、葡萄干、枸杞子、胡萝卜用水淋清洗干净，置于夹层锅中，十倍水量煎煮1.5小时，趁热过200目筛，滤液放置于配制罐中备用；
步骤二：将阿胶用高速粉碎机粉碎，将阿胶粉末加入纯化水洋化，200目筛过滤，得到阿胶液备用；
步骤三：将黄豆、核桃阴干后用粉碎机粉碎后，过100目筛备用，置于配置罐中，加热煮沸40分钟，搅拌使溶解，趁热过200目筛，滤液备用；
步骤四：将上述三个步骤的滤液与红糖和蜂蜜按比例混合均匀，纯化水定容至足量；
步骤五：将步骤四的混合液冷藏静置48小时后，通过板框过滤机过滤得到滤液；
步骤六：将步骤五的滤液放置于洁净不锈钢贮液罐内，用灌装机灌装于符合卫生要求的棕色玻璃瓶中，调整装量规格为10mL/支；
步骤七：罐装过后在115℃条件下灭菌25分钟，然后包装后进行成品检验。
4.根据权利要求3所述的一种具有补气养血功能的口服液的制备方法，其特征在于，所述步骤二至六均在十万级洁净空间进行。
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