CN110596385A - 用于评估结肠肿瘤的存在或风险的方法 - Google Patents

用于评估结肠肿瘤的存在或风险的方法 Download PDF

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CN110596385A
CN110596385A CN201910577840.7A CN201910577840A CN110596385A CN 110596385 A CN110596385 A CN 110596385A CN 201910577840 A CN201910577840 A CN 201910577840A CN 110596385 A CN110596385 A CN 110596385A
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glu
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proteins
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约翰·布卢姆
瑞恩·本茨
莉萨·克罗纳
罗斯林·狄龙
阿尔洛·兰德尔
杰弗里·琼斯
希瑟·斯科尔
汤姆·斯托克菲希
布鲁斯·威尔考克斯
丹尼尔·鲁德尔曼
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Dysendex Co
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57535Immunoassay; Biospecific binding assay; Materials therefor for cancer of the large intestine, e.g. colon, rectum or anus
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20Supervised data analysis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/60Complex ways of combining multiple protein biomarkers for diagnosis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/70Mechanisms involved in disease identification
    • G01N2800/7023(Hyper)proliferation
    • G01N2800/7028Cancer
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

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  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Data Mining & Analysis (AREA)
  • Genetics & Genomics (AREA)
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CN201910577840.7A 2012-11-30 2013-12-02 用于评估结肠肿瘤的存在或风险的方法 Pending CN110596385A (zh)

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US201261732024P 2012-11-30 2012-11-30
US61/732,024 2012-11-30
US201361772979P 2013-03-05 2013-03-05
US61/772,979 2013-03-05
CN201380071930.XA CN104969071B (zh) 2012-11-30 2013-12-02 用于评估结肠肿瘤的存在或风险的方法

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EP (1) EP2926138A4 (show.php)
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KR (1) KR20150090240A (show.php)
CN (2) CN104969071B (show.php)
AU (1) AU2013351947A1 (show.php)
BR (1) BR112015012616A2 (show.php)
CA (1) CA2893158A1 (show.php)
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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110951707A (zh) * 2019-12-31 2020-04-03 南京医科大学 丙酮酸激酶m2突变体及其在心血管疾病中的应用
CN112194719A (zh) * 2020-09-01 2021-01-08 中日友好医院(中日友好临床医学研究所) Crt抗原和mage-a1抗原的制备及其应用
CN113447658A (zh) * 2021-07-01 2021-09-28 浙江大学医学院附属儿童医院 一种检测抗过氧化物还原酶-1-IgG抗体的试剂盒
CN113956327A (zh) * 2021-10-11 2022-01-21 中山大学肿瘤防治中心 靶向人apc蛋白的多肽及其在制备药物中的应用
CN114668836A (zh) * 2022-05-27 2022-06-28 暨南大学 Pdia6在制备治疗脊髓损伤和修复的药物中的应用
CN114958794A (zh) * 2022-06-14 2022-08-30 南京工业大学 一种苯乙醇胺-N-甲基转移酶hPNMT54及其克隆表达与应用
CN115616230A (zh) * 2020-03-18 2023-01-17 龙海市第一医院 用于肝癌早期诊断的检测岩藻糖基化载脂蛋白h的elisa试剂盒
CN118496322A (zh) * 2024-05-09 2024-08-16 昆明医科大学 一种靶向降解β-catenin的多肽型抑制剂及其应用

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9141756B1 (en) 2010-07-20 2015-09-22 University Of Southern California Multi-scale complex systems transdisciplinary analysis of response to therapy
CA2863819C (en) 2012-02-09 2021-11-23 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections and methods of use thereof
CA2943827A1 (en) * 2014-03-28 2015-10-01 Applied Proteomics, Inc. Protein biomarker profiles for detecting colorectal tumors
KR20190080973A (ko) * 2014-07-11 2019-07-08 익스프레션 패톨로지, 인크. GTPase KRas 단백질(KRas)에 대한 SRM/MRM 검정
CN111624346A (zh) 2014-08-14 2020-09-04 米密德诊断学有限公司 用于预测及/或决定预后的套组
CA2963785A1 (en) * 2014-09-05 2016-03-10 Nantomics, Llc Systems and methods for determination of provenance
CA2968650A1 (en) 2014-12-11 2016-06-16 Memed Diagnostics Ltd. Marker combinations for diagnosing infections and methods of use thereof
US11513123B2 (en) * 2014-12-11 2022-11-29 Wisconsin Alumni Research Foundation Methods for detection and treatment of colorectal cancer
CN105807062A (zh) * 2014-12-28 2016-07-27 复旦大学 人结肠癌蛋白Spondin-2在制备结肠癌诊断制剂中的应用
CN105385752A (zh) * 2015-03-23 2016-03-09 复旦大学 一种人结肠癌蛋白质标志物Spondin-2的检测方法及其检测试剂盒
EP3281016A1 (en) * 2015-04-10 2018-02-14 Applied Proteomics Inc. Protein biomarker panels for detecting colorectal cancer and advanced adenoma
CN107847464A (zh) * 2015-07-01 2018-03-27 杜克大学 诊断和治疗急性呼吸系统感染的方法
EP3371605B1 (en) * 2015-11-05 2021-06-23 Vanderbilt University Protein quantitation in multicellular tissue specimens
US11466331B2 (en) 2016-03-03 2022-10-11 Memed Diagnostics Ltd. RNA determinants for distinguishing between bacterial and viral infections
US20190130994A1 (en) * 2016-04-11 2019-05-02 Discerndx, Inc. Mass Spectrometric Data Analysis Workflow
JP6754116B2 (ja) * 2016-04-26 2020-09-09 学校法人近畿大学 大腸癌マーカー
CN107345236A (zh) * 2016-05-04 2017-11-14 北京美泽福临科技发展有限公司 一种amy2b信使rna的特异性扩增引物和肝癌辅助诊断试剂盒
CA3025004A1 (en) * 2016-06-10 2017-12-14 Wisconsin Alumni Research Foundation Methods for detection, staging, and surveillance of colorectal adenomas and carcinomas
WO2018011796A1 (en) 2016-07-10 2018-01-18 Memed Diagnostics Ltd. Early diagnosis of infections
CA3027341A1 (en) 2016-07-10 2018-01-18 Memed Diagnostics Ltd. Protein signatures for distinguishing between bacterial and viral infections
CN106202984B (zh) * 2016-08-26 2018-09-04 赵毅 一种基于多层复杂网络对肿瘤miRNA标志物的筛选方法
EP3519833B1 (en) 2016-09-29 2024-08-14 MeMed Diagnostics Ltd. Methods of prognosis and treatment
EP3519834A4 (en) * 2016-09-29 2020-06-17 MeMed Diagnostics Ltd. RISK ASSESSMENT AND DISEASE CLASSIFICATION METHODS
US20180100858A1 (en) * 2016-10-07 2018-04-12 Applied Proteomics, Inc. Protein biomarker panels for detecting colorectal cancer and advanced adenoma
US11423331B2 (en) 2017-01-19 2022-08-23 Shimadzu Corporation Analytical data analysis method and analytical data analyzer
US11204355B2 (en) 2017-02-20 2021-12-21 Vanderbilt University Immune checkpoint molecular fitness profiling by mass spectrometry
CN106919801B (zh) * 2017-03-08 2023-07-18 杭州大伽信息科技有限公司 一种免疫组织化学染色辅助分析系统及使用方法
CN106908608B (zh) * 2017-04-17 2018-10-02 首都医科大学附属北京胸科医院 辅助诊断重症继发性肺结核的蛋白标志物
US20180330059A1 (en) 2017-05-09 2018-11-15 James Stewart Bates Patient treatment systems and methods
US10455457B2 (en) 2017-05-24 2019-10-22 Qualcomm Incorporated NR-SS unified operation mode in coordinated and uncoordinated bands
US11164679B2 (en) 2017-06-20 2021-11-02 Advinow, Inc. Systems and methods for intelligent patient interface exam station
WO2019004430A1 (ja) * 2017-06-30 2019-01-03 国立研究開発法人医薬基盤・健康・栄養研究所 大腸がんを検出するためのバイオマーカー
EP3652663A4 (en) * 2017-07-14 2021-04-21 Cofactor Genomics, Inc. NEXT GENERATION IMMUNONCOLOGICAL APPLICATIONS BY SEQUENCING
CN109406785A (zh) * 2017-08-18 2019-03-01 山东泽济生物科技有限公司 肿瘤血液标志物及其应用
US20200386759A1 (en) * 2017-12-05 2020-12-10 Discerndx, Inc. Robust panels of colorectal cancer biomarkers
AU2018395255B2 (en) * 2017-12-29 2025-02-20 Abbott Laboratories Novel biomarkers and methods for diagnosing and evaluating traumatic brain injury
EP3743534B1 (en) * 2018-01-22 2022-03-23 Liquid Biopsy Research LLC Methods for colon cancer detection and treatment monitoring
US11348688B2 (en) 2018-03-06 2022-05-31 Advinow, Inc. Systems and methods for audio medical instrument patient measurements
US11681953B2 (en) 2018-04-13 2023-06-20 Freenome Holdings, Inc. Machine learning implementation for multi-analyte assay development and testing
EP3818376A1 (en) * 2018-07-05 2021-05-12 EDP Biotech Corporation Kits and methods for detecting markers
CN112888793A (zh) 2018-08-08 2021-06-01 里珍纳龙药品有限公司 使用lc-ms/ms对蛋白质生物标志物进行定量
EP3623813A1 (en) * 2018-09-17 2020-03-18 Institut d'Investigació Sanitària Pere Virgili Methods for the prognosis of hiv-infected subjects
AU2019432635B2 (en) * 2019-03-06 2025-10-09 Diadem S.R.L. P53 peptides as markers in the diagnosis and prognosis of Alzheimer's disease
US12499537B2 (en) * 2019-11-13 2025-12-16 University Of South Florida Systems and methods of deep learning for colorectal polyp screening
WO2022006628A1 (en) * 2020-07-08 2022-01-13 Southern Adelaide Local Health Network Inc. Computer-implemented method and system for identifying measurable features for use in a predictive model
CN112034182A (zh) * 2020-09-01 2020-12-04 复旦大学附属中山医院 一种结肠癌转移预测方法和系统
CN112266961B (zh) * 2020-10-29 2023-05-12 中山大学附属第六医院 Tsg-6基因在预测结直肠癌转移及预后方面的应用
CN112710856B (zh) * 2020-12-16 2022-12-02 江西省肿瘤医院(江西省癌症中心) 检测血清igf1蛋白的制剂在制备结直肠癌疗效监测试剂中的应用
WO2023183481A1 (en) * 2022-03-23 2023-09-28 Serum Detect, Inc. Biomarker signatures indicative of early stages of cancer
CN114445406B (zh) * 2022-04-07 2022-08-09 武汉大学 肠镜图像分析方法、装置和医学图像处理设备
TWI796228B (zh) 2022-05-25 2023-03-11 臺中榮民總醫院 急性腎損傷預測系統及其方法
CN116593431B (zh) * 2023-04-09 2025-11-07 湖南科技大学三亚研究院 一种基于亲和传感器法的米酵菌酸毒素便携式检测装置及检测方法
WO2024232926A1 (en) * 2023-05-08 2024-11-14 Venn Biosciences Corporation Diagnosis of colorectal cancer using targeted quantification of peptides
WO2025058445A1 (ko) * 2023-09-15 2025-03-20 연세대학교 산학협력단 대장암에 대한 정보 제공 방법
CN118067993B (zh) * 2024-04-17 2024-07-05 弗雷米德生物医药技术(天津)有限公司 一种用于肠息肉检测的联检试剂盒及其制备方法、检测方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101014859A (zh) * 2004-08-13 2007-08-08 因迪维姆德有限公司 运甲状腺素蛋白作为结肠直肠腺瘤和/或癌的生物标志的用途;检测方法和测试系统
CN101283280A (zh) * 2005-08-18 2008-10-08 Zadec私人有限公司 用于诊断结直肠癌的蛋白质标记和所述标记作为所述癌症类型治疗的药物靶点的用途
CN101896818A (zh) * 2007-12-10 2010-11-24 霍夫曼-拉罗奇有限公司 作为癌症的标记物的Seprase

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444879A (en) * 1981-01-29 1984-04-24 Science Research Center, Inc. Immunoassay with article having support film and immunological counterpart of analyte
US4517289A (en) * 1982-08-18 1985-05-14 Brigham And Women's Hospital Monoclonal antibodies for human tissue cross-matching
AU727445B2 (en) * 1995-08-18 2000-12-14 Donald W Landry Detection of organic compounds through regulation of antibody-catalyzed reactions
US5800347A (en) * 1995-11-03 1998-09-01 The General Hospital Corporation ROC method for early detection of disease
NO954667D0 (no) * 1995-11-17 1995-11-17 Dagfinn Oegreid Fremgangsmåte til deteksjon av Ki-ras mutasjoner
CA2372667A1 (en) * 1999-01-10 2000-11-23 Steven Laken Methods of detecting colorectal disease by conduction an assay to detect a mutation in a bat-26 locus
US20010041365A1 (en) * 2000-01-10 2001-11-15 Michael Laposata Methods for monitoring alcohol consumption
US20040018973A1 (en) * 2002-01-25 2004-01-29 University Of Pittsburgh Nuclear matrix protein alterations associated with colon cancer and colon metastasis to the liver, and uses thereof
US20050153382A1 (en) * 2002-06-06 2005-07-14 Chengdu Kuachang Science And Technology Co., Ltd. Biochip kit comprising biochip based on antigen-antibody reactions, and its usage
EP1723428A2 (en) * 2004-02-19 2006-11-22 Yale University Corporation Identification of cancer protein biomarkers using proteomic techniques
US20060105419A1 (en) * 2004-08-16 2006-05-18 Biosite, Inc. Use of a glutathione peroxidase 1 as a marker in cardiovascular conditions
WO2006094149A2 (en) * 2005-03-01 2006-09-08 Exact Sciences Corporation Methods and compositions for detecting adenoma
US7662580B2 (en) * 2005-11-10 2010-02-16 Aurelium Biopharma Inc. Tissue diagnostics for breast cancer
US9726670B2 (en) * 2007-07-19 2017-08-08 Biomerieux Method for the assay of liver fatty acid binding protein, ACE and CA 19-9 for the in vitro diagnosis of colorectal cancer
US8426140B2 (en) * 2007-09-28 2013-04-23 Royal College Of Surgeons In Ireland Method of assessing colorectal cancer status in an individual
JP5591711B2 (ja) * 2007-12-10 2014-09-17 エフ.ホフマン−ラ ロシュ アーゲー 結腸直腸癌のためのマーカーパネル
CN102027128A (zh) * 2008-02-11 2011-04-20 哈达斯特医学服务与开发有限公司 作为癌症标志物的结肠癌相关的转录物1(ccat-1)
JPWO2009107170A1 (ja) * 2008-02-29 2011-06-30 学校法人日本大学 抗crp抗体及びその利用
US20110245087A1 (en) * 2008-03-18 2011-10-06 Gunter Weiss Method for optimizing and validating an assay for determining the presence or absence of a medical condition
US20110065605A1 (en) * 2008-05-14 2011-03-17 Eth Zurich Method for biomarker and drug-target discovery for prostate cancer diagnosis and treatment as well as biomarker assays determined therewith
EP2300829B1 (en) * 2008-05-23 2014-07-23 Pronota NV New biomarker for diagnosis, prediction and/or prognosis of sepsis and uses thereof
WO2011047358A1 (en) * 2009-10-15 2011-04-21 Crescendo Bioscience Biomarkers and methods for measuring and monitoring inflammatory disease activity
US10119959B2 (en) * 2010-06-25 2018-11-06 The Board Of Trustees Of The Leland Stanford Junior University Method of assaying an individual for immune impairment
EP2668503B1 (en) * 2011-01-28 2015-06-24 F.Hoffmann-La Roche Ag Combinatorial biomarkers for clinical applications in lung cancer patient management
JP2014507160A (ja) * 2011-02-22 2014-03-27 カリス ライフ サイエンシズ ルクセンブルク ホールディングス エス.アー.エール.エル. 循環バイオマーカー
WO2013028554A2 (en) * 2011-08-19 2013-02-28 Myriad Genetics, Inc. Gene signatures for lung cancer prognosis and therapy selection

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101014859A (zh) * 2004-08-13 2007-08-08 因迪维姆德有限公司 运甲状腺素蛋白作为结肠直肠腺瘤和/或癌的生物标志的用途;检测方法和测试系统
CN101283280A (zh) * 2005-08-18 2008-10-08 Zadec私人有限公司 用于诊断结直肠癌的蛋白质标记和所述标记作为所述癌症类型治疗的药物靶点的用途
CN101896818A (zh) * 2007-12-10 2010-11-24 霍夫曼-拉罗奇有限公司 作为癌症的标记物的Seprase

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BERNACKA K 等: "THE LEVELS OF ALPHA-1-ANTITRYPSIN AND ALPHA-1-ANTICHYMOTRYPSIN IN THE SERA OF PATIENTS WITH GASTROINTESTINAL CANCERS DURING DIAGNOSIS", 《CANCER》 *
MURAKOSHI YUSUKE 等: "Plasma biomarker discovery and validation for colorectal cancer by quantitative shotgun mass spectrometry and protein microarray", 《CANCER SCIENCE》 *
QIU YINGHUA 等: "Plasma glycoprotein profiling for colorectal cancer biomarker identification by lectin glycoarray and lectin blot", 《JOURNAL OF PROTEOME RESEARCH》 *
TANAKA TAKUJI 等: "Biomarkers for Colorectal Cancer", 《INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES》 *

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CN115616230A (zh) * 2020-03-18 2023-01-17 龙海市第一医院 用于肝癌早期诊断的检测岩藻糖基化载脂蛋白h的elisa试剂盒
CN112194719A (zh) * 2020-09-01 2021-01-08 中日友好医院(中日友好临床医学研究所) Crt抗原和mage-a1抗原的制备及其应用
CN113447658A (zh) * 2021-07-01 2021-09-28 浙江大学医学院附属儿童医院 一种检测抗过氧化物还原酶-1-IgG抗体的试剂盒
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US20150111220A1 (en) 2015-04-23
AU2013351947A1 (en) 2015-06-18
EP2926138A4 (en) 2016-09-14
US20170285033A1 (en) 2017-10-05
US20150111221A1 (en) 2015-04-23
JP2016507723A (ja) 2016-03-10
MX2015006757A (es) 2015-11-30
WO2014085826A3 (en) 2014-10-23
BR112015012616A2 (pt) 2017-09-12
WO2014085826A2 (en) 2014-06-05
SG11201504241QA (en) 2015-06-29
US20150111230A1 (en) 2015-04-23
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US20150111223A1 (en) 2015-04-23
US20140234854A1 (en) 2014-08-21

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