CN110590652B - 2-氨基-5-碘吡啶的合成方法 - Google Patents
2-氨基-5-碘吡啶的合成方法 Download PDFInfo
- Publication number
- CN110590652B CN110590652B CN201910912461.9A CN201910912461A CN110590652B CN 110590652 B CN110590652 B CN 110590652B CN 201910912461 A CN201910912461 A CN 201910912461A CN 110590652 B CN110590652 B CN 110590652B
- Authority
- CN
- China
- Prior art keywords
- amino
- iodopyridine
- iodine
- temperature
- aminopyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- IVILGUFRMDBUEQ-UHFFFAOYSA-N 5-iodopyridin-2-amine Chemical compound NC1=CC=C(I)C=N1 IVILGUFRMDBUEQ-UHFFFAOYSA-N 0.000 title claims abstract description 21
- 238000001308 synthesis method Methods 0.000 title claims description 5
- ICSNLGPSRYBMBD-UHFFFAOYSA-N 2-aminopyridine Chemical compound NC1=CC=CC=N1 ICSNLGPSRYBMBD-UHFFFAOYSA-N 0.000 claims abstract description 28
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract description 24
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229910052740 iodine Inorganic materials 0.000 claims abstract description 17
- 239000011630 iodine Substances 0.000 claims abstract description 17
- 238000004321 preservation Methods 0.000 claims abstract description 13
- 238000001914 filtration Methods 0.000 claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 238000006243 chemical reaction Methods 0.000 claims abstract description 10
- 238000001816 cooling Methods 0.000 claims abstract description 9
- 238000003756 stirring Methods 0.000 claims abstract description 9
- 238000001035 drying Methods 0.000 claims abstract description 6
- 239000012065 filter cake Substances 0.000 claims abstract description 6
- 238000010438 heat treatment Methods 0.000 claims abstract description 6
- 239000005457 ice water Substances 0.000 claims abstract description 6
- 238000010992 reflux Methods 0.000 claims abstract description 6
- 238000000034 method Methods 0.000 claims description 5
- 230000002194 synthesizing effect Effects 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 239000012295 chemical reaction liquid Substances 0.000 claims description 2
- 238000003786 synthesis reaction Methods 0.000 abstract description 6
- 230000015572 biosynthetic process Effects 0.000 abstract description 4
- 239000002904 solvent Substances 0.000 abstract description 4
- 239000003960 organic solvent Substances 0.000 abstract description 3
- 238000010189 synthetic method Methods 0.000 abstract 1
- 238000001514 detection method Methods 0.000 description 6
- 239000013078 crystal Substances 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 3
- 238000004811 liquid chromatography Methods 0.000 description 3
- 239000007791 liquid phase Substances 0.000 description 3
- 239000010815 organic waste Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 2
- WGOLHUGPTDEKCF-UHFFFAOYSA-N 5-bromopyridin-2-amine Chemical compound NC1=CC=C(Br)C=N1 WGOLHUGPTDEKCF-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000008570 general process Effects 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
Abstract
Description
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201910912461.9A CN110590652B (zh) | 2019-09-25 | 2019-09-25 | 2-氨基-5-碘吡啶的合成方法 |
Applications Claiming Priority (1)
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CN201910912461.9A CN110590652B (zh) | 2019-09-25 | 2019-09-25 | 2-氨基-5-碘吡啶的合成方法 |
Publications (2)
Publication Number | Publication Date |
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CN110590652A CN110590652A (zh) | 2019-12-20 |
CN110590652B true CN110590652B (zh) | 2022-08-30 |
Family
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Family Applications (1)
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CN201910912461.9A Active CN110590652B (zh) | 2019-09-25 | 2019-09-25 | 2-氨基-5-碘吡啶的合成方法 |
Country Status (1)
Country | Link |
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CN (1) | CN110590652B (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113773247A (zh) * | 2021-07-23 | 2021-12-10 | 无锡海伦生物科技有限公司 | 一种2-氨基-5-碘吡啶的制备方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106432069A (zh) * | 2016-09-09 | 2017-02-22 | 安徽工业大学 | 一种2‑氨基‑5‑氯‑吡啶的制备方法 |
CN107759514A (zh) * | 2017-10-26 | 2018-03-06 | 苏州盖德精细材料有限公司 | 一种2‑氨基‑5‑氟吡啶的制备方法 |
-
2019
- 2019-09-25 CN CN201910912461.9A patent/CN110590652B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106432069A (zh) * | 2016-09-09 | 2017-02-22 | 安徽工业大学 | 一种2‑氨基‑5‑氯‑吡啶的制备方法 |
CN107759514A (zh) * | 2017-10-26 | 2018-03-06 | 苏州盖德精细材料有限公司 | 一种2‑氨基‑5‑氟吡啶的制备方法 |
Non-Patent Citations (3)
Title |
---|
A Practical Iodination of Aromatic Compounds by Using Iodine and Iodic Acid;Avinash T. Shinde等;《Synthetic Communications》;20101231;第40卷(第23期);全文,尤其是第3507页最后一段,第3508页表1 * |
A simple and improved regioselective bromination of aromatic compounds using N-methylpyrolidin-2-one hydrotribromide and aqueous hydrogen peroxide under mild reaction conditions;Sweety Singhal等;《Journal of Molecular Catalysis A: Chemical》;20060630;第258卷(第1-2期);第198-202页 * |
Preparation and properties of pyridine-analog of TCNQ dianion salt;Hama, Yoshiyuki等;《Bulletin of the Chemical Society of Japan》;19881231;第61卷(第5期);第1683-1686页 * |
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Publication number | Publication date |
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CN110590652A (zh) | 2019-12-20 |
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Address after: 223300 No. 216 Changjiang East Road, Huaiyin District, Jiangsu, Huaian Patentee after: Wanxiang Technology Group Co.,Ltd. Country or region after: China Patentee after: JIANGSU HONGBANG CHEMICAL TECHNOLOGY Co.,Ltd. Address before: 223300 No. 216 Changjiang East Road, Huaiyin District, Jiangsu, Huaian Patentee before: Wanxiang Technology Co.,Ltd. Country or region before: China Patentee before: JIANGSU HONGBANG CHEMICAL TECHNOLOGY Co.,Ltd. |