CN110585504A - Improved protein A immunoadsorption column - Google Patents
Improved protein A immunoadsorption column Download PDFInfo
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- CN110585504A CN110585504A CN201911006268.5A CN201911006268A CN110585504A CN 110585504 A CN110585504 A CN 110585504A CN 201911006268 A CN201911006268 A CN 201911006268A CN 110585504 A CN110585504 A CN 110585504A
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
- A61M1/3633—Blood component filters, e.g. leukocyte filters
- A61M1/3635—Constructional details
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3687—Chemical treatment
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- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3692—Washing or rinsing blood or blood constituents
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- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D163/00—Coating compositions based on epoxy resins; Coating compositions based on derivatives of epoxy resins
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- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D5/00—Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
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- C09D5/00—Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
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- C09D7/00—Features of coating compositions, not provided for in group C09D5/00; Processes for incorporating ingredients in coating compositions
- C09D7/40—Additives
- C09D7/60—Additives non-macromolecular
- C09D7/61—Additives non-macromolecular inorganic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/75—General characteristics of the apparatus with filters
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend
- C08L2205/035—Polymer mixtures characterised by other features containing three or more polymers in a blend containing four or more polymers in a blend
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Abstract
The invention discloses an improved protein A immunoadsorption column, which comprises a connecting unit and a protein A immunoadsorption column body, wherein the connecting unit comprises a liquid inlet pipe and a liquid outlet pipe, the liquid inlet pipe and the liquid outlet pipe are both horizontally arranged, and the liquid inlet pipe is positioned above the liquid outlet pipe; the protein A immunoadsorption column bodies are arranged in two groups, the two groups of protein A immunoadsorption column bodies are arranged in parallel, and the upper end of each group of protein A immunoadsorption column body is communicated with the bottom of the liquid inlet pipe through a first connecting pipe. The invention can realize the scheme of providing uninterrupted treatment for a patient, greatly shortens the time length of treatment which needs 5 hours once to 2.5 hours, saves a large amount of time for the patient and medical personnel, avoids the hidden trouble of sudden adverse reaction of the patient caused by long-time treatment, avoids the problem that a filtering piece is easily installed wrongly during processing and production, and effectively improves the production efficiency.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to an improved protein A immunoadsorption column.
Background
The plasma adsorption is that after being led out, blood enters a plasma separator to separate the visible components (blood cells and blood platelets) of the blood from plasma, the visible components are returned to a patient body, the plasma enters an adsorber (adsorption column) to adsorb and remove certain specific substances, and the plasma is returned to the patient body after adsorption. The plasma adsorption is mainly divided into two categories according to the characteristics of the adsorbent, one category is molecular sieve adsorption, namely substances with corresponding charges and molecular sizes, such as activated carbon, resin, carbonized resin, cationic adsorbent and the like, are nonspecifically adsorbed by utilizing the principle of the molecular sieve through the charges and pores carried by the adsorbent; the other is immunoadsorption, i.e. a therapeutic method for removing a specific substance (ligand) from plasma or whole blood, such as protein a adsorption, bilirubin adsorption, etc., by using a highly specific antigen-antibody reaction or a substance (ligand) having a specific physicochemical affinity bound to an adsorbent material (carrier).
The protein A immunoadsorption column in the prior art can only treat for 15 minutes in one cycle, then needs to be eluted and regenerated for 15 minutes, generally needs 10 cycles for one treatment and takes 5 hours, so that the treatment time is long, a large amount of time is wasted, and meanwhile, the hidden danger of sudden adverse reaction of a patient caused by long-time treatment exists; in addition, the current chinese patent with application number CN201220127328.6 discloses a protein a immunoadsorption column, which comprises a column body, a gasket, a filter membrane, a sealing ring and an end cover, wherein the filter membrane is welded on the gasket and is sleeved with the sealing ring, the sealing ring can be matched with a recess on the column body, the end cover has an internal thread and is matched with an external thread on the column body, and the sealing ring, the gasket and the filter membrane can be pressed tightly after screwing. Although the chinese patent with application number CN201220127328.6 has the advantages of good sealing performance, no dead angle when liquid flows through, and the filter membrane is not easy to be damaged, and is suitable for producing plasma adsorption or plasma perfusion products, the filter membrane is welded on the gasket, and at the liquid inlet end, the filter membrane is outside, and the gasket is inside; including the filter membrane at liquid outlet end, the gasket is outside, can avoid the filter membrane to receive to involve and damage along rivers direction atress like this to ensure that the medium can not reveal, lead to it to have the problem of the mounted position mistake of filter membrane and gasket of installing easily when processing production like this, still influence production efficiency simultaneously, for this reason, propose an improvement protein A immunoadsorption post.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide an improved protein A immunoadsorption column, which can realize a scheme of providing uninterrupted treatment for a patient, can greatly shorten the time length of treatment which needs 5 hours once to 2.5 hours, not only saves a large amount of time for the patient and medical personnel, but also can avoid the hidden trouble of sudden adverse reaction of the patient caused by long-time treatment, can avoid the problem that a filtering piece is easy to be installed incorrectly in processing and production, and effectively improves the production efficiency so as to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme:
an improved protein A immunoadsorption column comprises a connecting unit and a protein A immunoadsorption column body, wherein the connecting unit comprises a liquid inlet pipe and a liquid outlet pipe, the liquid inlet pipe and the liquid outlet pipe are both horizontally arranged, and the liquid inlet pipe is positioned above the liquid outlet pipe;
the protein A immunoadsorption column body is provided with two groups, two groups of the protein A immunoadsorption column bodies are arranged in parallel, each group is arranged on the upper end of each protein A immunoadsorption column body and communicated with the bottom of the liquid inlet pipe through a first connecting pipe, and each group is arranged on the bottom end of each protein A immunoadsorption column body and communicated with the upper part of the liquid outlet pipe through a second connecting pipe.
By adopting the technical scheme, the connecting unit is used for connecting the two groups of protein A immunoadsorption column bodies, conveying blood plasma of a patient and conveying flushing liquid eluted and regenerated by the two groups of protein A immunoadsorption column bodies; two sets of protein A immunoadsorption column bodies are arranged in adsorbing protein A immune antibodies in patient's plasma, in order to reach the purpose of treating diseases, through setting up two sets of protein A immunoadsorption column bodies, and two sets of protein A immunoadsorption column bodies set up in parallel, make two sets of protein A immunoadsorption column bodies can in time switch over the use and elute the regeneration like this, thereby realize providing the scheme of incessant treatment for the patient, can spend 5 hours to carry out the length of time of treatment shorten to 2.5 hours once originally, not only save a large amount of time for patient and medical personnel, still can stop long-time treatment and lead to the hidden danger of patient's proruption adverse reaction.
Furthermore, a liquid inlet is arranged at the upper part of the liquid inlet pipe, and a liquid outlet is arranged at the bottom of the liquid outlet pipe.
By adopting the technical scheme, the liquid inlet is used for entering plasma to be adsorbed by a patient or flushing liquid for eluting and regenerating the protein A immunoadsorption column body; the liquid outlet is used for discharging the blood plasma and used washing liquid waste liquid which are completely absorbed by the patient.
Furthermore, the tip fixed mounting of inlet has first connector, the tip fixed mounting of outlet has the second connector.
Through adopting above-mentioned technical scheme, first connector is used for inserting the equipment of carrying patient's plasma and is used for inserting the washing liquid that albumen A immunoadsorption column body elution regeneration, and the second connector is used for inserting the equipment that sends into the patient internal with the plasma that finishes adsorbing and is used for connecting the container of collecting the used washing liquid waste liquid.
Further, every group albumen A immunoadsorption post body all includes cylindrical housing, two end covers, two sets of filtration pieces and a plurality of granular adsorbent, the both ends of cylindrical housing are the open end, two the end cover spiro union respectively is in the both ends of cylindrical housing, and is two sets of filter piece is respectively through two the end cover encapsulation is in the inside of cylindrical housing, a plurality of granular adsorbent all pack the inside of cylindrical housing, just a plurality of granular adsorbent all are located two sets of filter between the piece.
Through adopting above-mentioned technical scheme, two sets of filter pieces are used for treating the plasma that adsorbs to the patient and filter, can prevent that the inside of albumen A immunoadsorption post body from blockking up, and a plurality of granular adsorbent are used for adsorbing the albumen A immune antibody of patient's plasma.
Furthermore, two one ends of the end covers, which are far away from the cylindrical shell, are arc-shaped ends, and two clamping seats are fixedly arranged on the arc-shaped ends of the end covers, inserting joints are integrally arranged inside the clamping seats, locking sleeves are screwed outside the clamping seats, and the inserting joints are communicated with the insides of the end covers.
By adopting the technical scheme, one ends of the two end covers, which are far away from the cylindrical shell, are respectively arranged as arc-shaped ends, so that dead corners can be prevented from being left in the end covers, and the plasma of a patient can be effectively prevented from remaining in the end covers to cause the loss of the plasma of the patient; the plug is used for connecting first connecting pipe and second connecting pipe respectively, and the tight seat of clamp cooperation lock sleeve can be with the first connecting pipe and the firm locking of second connecting pipe on the plug, can prevent effectively that first connecting pipe and second connecting pipe from coming off from the plug to make this improvement albumen A immunoadsorption post stable performance, safe and reliable.
Furthermore, a plurality of anti-slip strips are uniformly arranged on the outer side surfaces of the two end covers and surround the end covers at equal angles.
Through adopting above-mentioned technical scheme, the non-slip performance of end cover can effectively be strengthened to a plurality of antislip strips, is convenient for when installing the end cover on cylindrical shell, can avoid taking place the phenomenon of skidding between hand and the cylindrical shell.
Further, two the end cover with the external screw thread has all been seted up to the one end outside that cylindrical shell is connected, the both ends of cylindrical shell inside all seted up with external screw thread assorted internal thread.
Through adopting above-mentioned technical scheme, external screw thread and internal thread phase-match set up for the leakproofness when end cover and cylindrical shell combine is better, can effectively prevent albumen A immunoadsorption column body weeping.
Further, every group filter all includes the sealing washer and encapsulates through two plectanes and be in the inside filter membrane of sealing washer, two a plurality of through-holes have all been seted up on the plectane, the filter membrane is located two between the plectane.
Through adopting above-mentioned technical scheme, utilize two plectanes to encapsulate the filter membrane in the inside of sealing washer to a plurality of through-holes have all been seted up on two plectanes, and the filter membrane is located between two plectanes, thereby make and filter a relatively stable structure, when will filtering a piece and install the inside at cylindrical shell, need not distinguish the installation direction of filtering a piece, there is the problem of will filtering a piece installation mistake easily when can avoiding this improvement albumen A immunoadsorption post processing production, production efficiency has effectively been improved simultaneously.
Furthermore, all install first solenoid valve on the first connecting pipe, all install the second solenoid valve on the second connecting pipe.
By adopting the technical scheme, the first electromagnetic valve is used for controlling the on-off of the first connecting pipe, and the second electromagnetic valve is used for controlling the on-off of the second connecting pipe, so that the use, elution and regeneration of the two groups of protein A immunoadsorption column bodies are conveniently switched.
Furthermore, the second connecting pipe is provided with a pH meter at the position close to the protein A immunoadsorption column body.
Through adopting above-mentioned technical scheme, the pH meter is used for real-time detection from the pH value of the inside exhaust flush fluid of albumen A immunoadsorption column body, and whether the medical personnel of being convenient for judge the effect of albumen A immunoadsorption column body elution regeneration according to pH value is qualified to guarantee the safe treatment to the patient.
Further, protective layers are arranged on the outer surfaces of the two end covers, and the protective layers are prepared by the following method:
weighing the following raw materials in parts by weight: 18-25 parts of epoxy resin, 8-12 parts of calcium carbonate powder, 10-12 parts of nano silver powder, 12-16 parts of titanium dioxide powder, 8-10 parts of quartz powder, 15-20 parts of polyurethane, 3-5 parts of paraffin, 2-4 parts of alcohol ester, 2-4 parts of triethanolamine, 1-3 parts of emulsified silicone oil and 30-40 parts of water;
s1, adding the weighed paraffin, alcohol ester dodeca, triethanolamine, emulsified silicone oil and water into a stirrer, and stirring for 20-30min at the stirring speed of 600-;
s2, adding epoxy resin, calcium carbonate powder, nano silver powder, titanium dioxide powder, quartz powder and polyurethane into a grinder to grind until the particle diameter of the material is not more than 500um, so as to prepare a mixed powder material;
s3, adding the mixed solution prepared in the step S1 and the mixed powder material prepared in the step S2 into a reaction kettle, stirring for 22-28min, setting the stirring speed of the reaction kettle to be 700-900r/min and the temperature to be 60-80 ℃, and thus obtaining the protective coating;
s4, cleaning the outer surfaces of the two end covers, drying the outer surfaces by using a hot air blower, and uniformly spraying the protective coating prepared in the step S3 on the outer surfaces of the dried two end covers by using a high-pressure sprayer spray gun;
and S5, placing the two end covers sprayed with the protective paint in the step S4 in an oven for drying and curing, wherein the drying and curing temperature is 80-100 ℃, and the time is set to be 30-40min, so that the protective layers are manufactured on the outer surfaces of the two end covers.
By adopting the technical scheme, the process for preparing the protective coating is simple in step and easy to realize, the prepared protective coating is moderate in viscosity, not easy to stratify, convenient to spray, free of bubbles, good in comprehensive performance, and capable of forming a good coating after spraying, not easy to generate cracks and good in film forming effect, the prepared protective layer has good performances of corrosion resistance, bacteria resistance, skid resistance and ageing resistance, is good in adhesiveness and not easy to fall off, and can effectively increase the performances of corrosion resistance, bacteria resistance, skid resistance and ageing resistance of the two end covers, so that the improved protein A immunoadsorption column is long in service life, and more importantly, the phenomenon of skidding between a hand and the cylindrical shell when the end covers are installed on the cylindrical shell by medical workers can be effectively prevented.
In summary, the invention mainly has the following beneficial effects:
1. according to the invention, two groups of protein A immunoadsorption column bodies are arranged and are arranged in parallel, so that the two groups of protein A immunoadsorption column bodies can be switched to use, elute and regenerate in time, thereby realizing a scheme of providing uninterrupted treatment for a patient, greatly shortening the time length of treatment which needs to be performed for 5 hours once to 2.5 hours, saving a large amount of time for the patient and medical personnel, and avoiding the hidden danger of sudden adverse reaction of the patient caused by long-time treatment;
2. according to the improved protein A immunoadsorption column, the filter membrane is packaged inside the seal ring by utilizing the two circular plates, the through holes are formed in the two circular plates, and the filter membrane is positioned between the two circular plates, so that the structure of the filter element is stable, the mounting direction of the filter element is not needed to be distinguished when the filter element is mounted inside the cylindrical shell, the problem that the filter element is easily mounted wrongly during processing and production of the improved protein A immunoadsorption column can be avoided, and meanwhile, the production efficiency is effectively improved;
3. according to the invention, the prepared protective layer has good performances of corrosion resistance, bacteria resistance, skid resistance and aging resistance, has good adhesion, is not easy to fall off, and can effectively increase the performances of corrosion resistance, bacteria resistance, skid resistance and aging resistance of the two end covers, so that the improved protein A immunoadsorption column has a long service life, and particularly, the phenomenon of skid between a hand and a cylindrical shell when medical personnel install the end covers on the cylindrical shell can be effectively prevented.
Drawings
FIG. 1 is a schematic diagram of an embodiment of a modified protein A immunoadsorption column;
FIG. 2 is a schematic structural view of a protein A immunoadsorption column body according to an embodiment;
FIG. 3 is a schematic diagram of an exploded structure of one embodiment of a protein A immunoadsorption column body;
FIG. 4 is an exploded view of another perspective of one embodiment of a protein A immunoadsorption column body;
FIG. 5 is a schematic front view of a protein A immunoadsorption column body according to an embodiment;
FIG. 6 is a schematic sectional view taken along section line A-A in FIG. 5;
FIG. 7 is an enlarged view of the structure at A in FIG. 6;
FIG. 8 is a schematic structural view of an embodiment of a filter element;
FIG. 9 is a schematic cross-sectional view of one embodiment of a filter element;
fig. 10 is an exploded view of an embodiment of a filter element.
In the figure: 1. a connection unit; 2. a protein A immunoadsorption column body; 3. a liquid inlet pipe; 4. a liquid outlet pipe; 5. a liquid inlet; 6. a liquid outlet; 7. a first connector; 8. a second connector; 9. a first connecting pipe; 10. a second connecting pipe; 11. a pH meter; 12. a first solenoid valve; 13. a second solenoid valve; 14. a cylindrical housing; 15. an end cap; 16. a locking sleeve; 17. anti-slip strips; 18. an internal thread; 19. an external thread; 20. a filter member; 21. a clamping seat; 22. a plug-in connector; 23. a particulate adsorbent; 24. a seal ring; 25. filtering the membrane; 26. a circular plate; 27. and a through hole.
Detailed Description
The present invention is described in further detail below with reference to figures 1-10.
Example 1
An improved protein A immunoadsorption column, as shown in figure 1, comprises a connecting unit 1 and a protein A immunoadsorption column body 2, wherein the connecting unit 1 comprises a liquid inlet pipe 3 and a liquid outlet pipe 4, the liquid inlet pipe 3 and the liquid outlet pipe 4 are both horizontally arranged, and the liquid inlet pipe 3 is positioned above the liquid outlet pipe 4;
as shown in fig. 1, the protein a immunoadsorption column body 2 is provided with two groups, two groups of the protein a immunoadsorption column bodies 2 are arranged in parallel, each group of the protein a immunoadsorption column body 2 is provided with an upper end communicated with the bottom of the liquid inlet pipe 3 through a first connecting pipe 9, and each group of the protein a immunoadsorption column body 2 is provided with a bottom communicated with the upper part of the liquid outlet pipe 4 through a second connecting pipe 10.
By adopting the technical scheme, the connecting unit 1 is used for connecting the two groups of protein A immunoadsorption column bodies 2, conveying blood plasma of a patient and conveying flushing liquid eluted and regenerated by the two groups of protein A immunoadsorption column bodies 2; two sets of protein A immunoadsorption column bodies 2 are arranged in adsorbing protein A immune antibody in patient's plasma, in order to reach the purpose of treating diseases, through setting up two sets of protein A immunoadsorption column bodies 2, and two sets of protein A immunoadsorption column bodies 2 are parallelly connected to be set up, make two sets of protein A immunoadsorption column bodies 2 can in time switch over the use and elute the regeneration like this, thereby realize providing the scheme of incessant treatment for the patient, can spend 5 hours to carry out the length of time of treatment shortening to 2.5 hours once originally, not only save a large amount of time for patient and medical personnel, still can stop long-time treatment and lead to the hidden danger of patient's proruption.
Preferably, as shown in fig. 1, a liquid inlet 5 is disposed at the upper portion of the liquid inlet pipe 3, and a liquid outlet 6 is disposed at the bottom of the liquid outlet pipe 4.
By adopting the technical scheme, the liquid inlet 5 is used for entering plasma to be adsorbed by a patient or washing liquid for eluting and regenerating the protein A immunoadsorption column body 2; the liquid outlet 6 is used for discharging the blood plasma absorbed by the patient and the used waste washing liquid.
Preferably, as shown in fig. 1, a first connector 7 is fixedly installed at an end of the liquid inlet 5, and a second connector 8 is fixedly installed at an end of the liquid outlet 6.
Through adopting above-mentioned technical scheme, first connector 7 is used for the equipment of inserting the transport patient plasma and is used for inserting the washing liquid that albumen A immunoadsorption column body 2 elution regeneration, and second connector 8 is used for inserting and sends into the equipment in the patient and be used for connecting the container of collecting the washing liquid waste liquid that the used of plasma that finishes absorbing.
Preferably, as shown in fig. 2 to 7, each group of the protein a immunoadsorption column body 2 comprises a cylindrical housing 14, two end caps 15, two groups of filter elements 20, and a plurality of granular adsorbents 23, wherein both ends of the cylindrical housing 14 are open ends, the two end caps 15 are respectively screwed on both ends of the cylindrical housing 14, the two groups of filter elements 20 are respectively sealed inside the cylindrical housing 14 through the two end caps 15, the plurality of granular adsorbents 23 are respectively filled inside the cylindrical housing 14, and the plurality of granular adsorbents 23 are respectively located between the two groups of filter elements 20.
Through adopting above-mentioned technical scheme, two sets of filter pieces 20 are used for treating the plasma that adsorbs to the patient and filter, can prevent that the inside of albumen A immunoadsorption column body 2 from blockking up, and a plurality of granular adsorbent 23 are used for adsorbing the albumen A immune antibody of patient's plasma.
Preferably, as shown in fig. 3 and 7, one end of each of the two end caps 15, which is far away from the cylindrical housing 14, is an arc-shaped end, and a clamping seat 21 is fixedly disposed on each of the arc-shaped ends of the two end caps 15, a plug-in connector 22 is integrally disposed inside each of the clamping seats 21, a locking sleeve 16 is screwed outside each of the clamping seats 21, and the plug-in connector 22 is communicated with the inside of the end cap 15.
By adopting the technical scheme, one ends of the two end covers 15 far away from the cylindrical shell 14 are both arranged to be arc-shaped ends, so that dead corners can be prevented from being left in the end covers 15, and the plasma of a patient can be effectively prevented from remaining in the end covers 15 to cause the loss of the plasma of the patient; the plug-in connector 22 is used for connecting the first connecting pipe 9 and the second connecting pipe 10 respectively, the clamping seat 21 is matched with the locking sleeve 16 to stably lock the first connecting pipe 9 and the second connecting pipe 10 on the plug-in connector 22, and the first connecting pipe 9 and the second connecting pipe 10 can be effectively prevented from falling off from the plug-in connector 22, so that the improved protein A immunoadsorption column is stable in performance, safe and reliable.
Preferably, as shown in fig. 3, a plurality of anti-slip strips 17 are integrally arranged on the outer side surfaces of the two end covers 15, and the anti-slip strips 17 are all arranged around the end covers 15 at equal angles.
Through adopting above-mentioned technical scheme, a plurality of antislip strips 17 can effectively strengthen the non-skid property of end cover 15, are convenient for when installing end cover 15 on cylindrical shell 14, can avoid taking place the phenomenon of skidding between hand and cylindrical shell 14.
Preferably, as shown in fig. 3, external threads 19 are respectively formed on the outer portions of the ends of the two end caps 15 connected to the cylindrical shell 14, and internal threads 18 matched with the external threads 19 are respectively formed on the inner portions of the two ends of the cylindrical shell 14.
Through adopting above-mentioned technical scheme, external screw thread 19 and internal thread 18 phase-match set up for the leakproofness when end cover 15 combines with cylindrical shell 14 is better, can effectively prevent 2 weepings of albumen A immunoadsorption column body.
Preferably, as shown in fig. 8-10, each set of the filter elements 20 includes a sealing ring 24 and a filter membrane 25 enclosed inside the sealing ring 24 by two circular plates 26, each of the two circular plates 26 has a plurality of through holes 27, and the filter membrane 25 is located between the two circular plates 26.
Through adopting above-mentioned technical scheme, utilize two plectanes 26 to encapsulate filter membrane 25 in the inside of sealing washer 24, and a plurality of through-holes 27 have all been seted up on two plectanes 26, and filter membrane 25 is located between two plectanes 26, thereby it is relatively stable to make to filter 20 structure, when installing filter 20 in the inside of cylindrical shell 14, need not distinguish the installation direction who filters 20, there is the problem of filtering 20 installation error easily when can avoiding this improvement albumen A immunoadsorption post processing production, production efficiency has effectively been improved simultaneously.
Preferably, as shown in fig. 1, a first solenoid valve 12 is installed on each of the first connection pipes 9, and a second solenoid valve 13 is installed on each of the second connection pipes 10.
By adopting the technical scheme, the first electromagnetic valve 12 is used for controlling the on-off of the first connecting pipe 9, and the second electromagnetic valve 13 is used for controlling the on-off of the second connecting pipe 10, so that the use, elution and regeneration of the two groups of protein A immunoadsorption column bodies 2 are conveniently switched.
Preferably, as shown in fig. 1, a pH meter 11 is installed on each of the second connecting pipes 10 at a position close to the protein a immunoadsorption column body 2.
Through adopting above-mentioned technical scheme, pH meter 11 is used for real-time detection from the pH value of the inside exhaust flush fluid of albumen A immunoadsorption column body 2, and whether the medical personnel of being convenient for judge the effect of albumen A immunoadsorption column body 2 elution regeneration according to pH value is qualified to guarantee the safe treatment to the patient.
It should be noted that, in this embodiment, the pH meter 11 may be a pH meter with a model MT-5000, and when in use, the probe of the pH meter 11 is installed on the second connecting tube 10 at a position close to the protein a immunoadsorption column body 2.
Example 2
The difference from the embodiment 1 is that the outer surfaces of the two end caps 15 are provided with protective layers, and the protective layers are prepared by the following method:
weighing the following raw materials in parts by weight: 18 parts of epoxy resin, 8 parts of calcium carbonate powder, 10 parts of nano silver powder, 12 parts of titanium dioxide powder, 8 parts of quartz powder, 15 parts of polyurethane, 3 parts of paraffin, 2 parts of alcohol ester dodeca, 2 parts of triethanolamine, 1 part of emulsified silicone oil and 30 parts of water;
s1, adding the weighed paraffin, alcohol ester dodeca, triethanolamine, emulsified silicone oil and water into a stirrer, and stirring for 20min at the stirring speed of 600r/min to obtain a mixed solution;
s2, adding epoxy resin, calcium carbonate powder, nano silver powder, titanium dioxide powder, quartz powder and polyurethane into a grinder to grind until the particle diameter of the material is not more than 500um, so as to prepare a mixed powder material;
s3, adding the mixed solution prepared in the step S1 and the mixed powder material prepared in the step S2 into a reaction kettle, stirring for 22min, setting the stirring speed of the reaction kettle to 700r/min and the temperature to 60 ℃, and thus preparing the protective coating;
s4, cleaning the outer surfaces of the two end covers 15, drying the outer surfaces by using a hot air blower, and uniformly spraying the protective coating prepared in the step S3 on the outer surfaces of the dried two end covers 15 by using a high-pressure sprayer spray gun;
and S5, drying and curing the two end covers 15 sprayed with the protective paint in the step S4 in an oven, wherein the drying and curing temperature is 80 ℃, and the time is set to be 30min, so that the protective layer is manufactured on the outer surfaces of the two end covers 15.
Example 3
The difference from the example 2 lies in the preparation of the protective layer, and the specific preparation method is as follows:
weighing the following raw materials in parts by weight: 22 parts of epoxy resin, 10 parts of calcium carbonate powder, 11 parts of nano silver powder, 14 parts of titanium dioxide powder, 9 parts of quartz powder, 18 parts of polyurethane, 4 parts of paraffin, twelve 3 parts of alcohol ester, 3 parts of triethanolamine, 2 parts of emulsified silicone oil and 35 parts of water;
s1, adding the weighed paraffin, alcohol ester dodeca, triethanolamine, emulsified silicone oil and water into a stirrer, and stirring for 25min at the stirring speed of 700r/min to obtain a mixed solution;
s2, adding epoxy resin, calcium carbonate powder, nano silver powder, titanium dioxide powder, quartz powder and polyurethane into a grinder to grind until the particle diameter of the material is not more than 500um, so as to prepare a mixed powder material;
s3, adding the mixed solution prepared in the step S1 and the mixed powder material prepared in the step S2 into a reaction kettle, stirring for 25min, setting the stirring speed of the reaction kettle to be 800r/min, and setting the temperature to be 70 ℃, so as to prepare the protective coating;
s4, cleaning the outer surfaces of the two end covers 15, drying the outer surfaces by using a hot air blower, and uniformly spraying the protective coating prepared in the step S3 on the outer surfaces of the dried two end covers 15 by using a high-pressure sprayer spray gun;
and S5, drying and curing the two end covers 15 sprayed with the protective paint in the step S4 in an oven, wherein the drying and curing temperature is 90 ℃, and the time is set to 35min, so that the protective layer is manufactured on the outer surfaces of the two end covers 15.
Example 4
The difference from the example 2 lies in the preparation of the protective layer, and the specific preparation method is as follows:
weighing the following raw materials in parts by weight: 25 parts of epoxy resin, 12 parts of calcium carbonate powder, 12 parts of nano silver powder, 16 parts of titanium dioxide powder, 10 parts of quartz powder, 15-20 parts of polyurethane, 5 parts of paraffin, 4 parts of alcohol ester dodeca, 4 parts of triethanolamine, 3 parts of emulsified silicone oil and 40 parts of water;
s1, adding the weighed paraffin, alcohol ester dodeca, triethanolamine, emulsified silicone oil and water into a stirrer, and stirring for 30min at the stirring speed of 800r/min to obtain a mixed solution;
s2, adding epoxy resin, calcium carbonate powder, nano silver powder, titanium dioxide powder, quartz powder and polyurethane into a grinder to grind until the particle diameter of the material is not more than 500um, so as to prepare a mixed powder material;
s3, adding the mixed solution prepared in the step S1 and the mixed powder material prepared in the step S2 into a reaction kettle, stirring for 28min, setting the stirring speed of the reaction kettle to be 900r/min, and setting the temperature to be 80 ℃, so as to prepare the protective coating;
s4, cleaning the outer surfaces of the two end covers 15, drying the outer surfaces by using a hot air blower, and uniformly spraying the protective coating prepared in the step S3 on the outer surfaces of the dried two end covers 15 by using a high-pressure sprayer spray gun;
and S5, drying and curing the two end covers 15 sprayed with the protective paint in the step S4 in an oven, wherein the drying and curing temperature is 100 ℃, and the time is set to be 40min, so that the protective layer is manufactured on the outer surfaces of the two end covers 15.
The results of the static coefficient of friction measurements using a static and dynamic coefficient of friction tester on the outer surfaces of the end caps 15 of examples 1-4 under the same conditions in the laboratory are shown below:
| coefficient of static friction | |
| Example 1 | 0.33 |
| Example 2 | 0.67 |
| Example 3 | 0.64 |
| Example 4 | 0.68 |
The comparative analysis of the test results in the table shows that the embodiment 4 is the optimal embodiment, the technical scheme is adopted, the process for preparing the protective coating is simple and easy to realize, the prepared protective coating has moderate viscosity, is not easy to delaminate, is convenient to spray, has no bubble generation, fully combines all components, has better comprehensive performance, the protective coating can form a better coating film after being sprayed, cracks are not easy to generate, the film forming effect is better, the prepared protective layer has better corrosion resistance, bacterium prevention, skid resistance and ageing resistance, the adhesiveness is better, the protective layer is not easy to fall off, the corrosion resistance, bacterium prevention, skid resistance and ageing resistance of the two end covers 15 can be effectively improved, therefore, the service life of the improved protein A immunoadsorption column is long, and particularly, the improved protein A immunoadsorption column can effectively prevent the phenomenon that hands of medical staff slip from the cylindrical shell 14 when the end cover 15 is installed on the cylindrical shell 14.
The working principle is as follows: according to the improved protein A immunoadsorption column, two groups of protein A immunoadsorption column bodies 2 are arranged, and the two groups of protein A immunoadsorption column bodies 2 are arranged in parallel, so that the two groups of protein A immunoadsorption column bodies 2 can be switched to use, elute and regenerate in time, thereby realizing a scheme of providing uninterrupted treatment for a patient, greatly shortening the time length of treatment which needs to be carried out for 5 hours once to 2.5 hours, saving a large amount of time for the patient and medical personnel, and avoiding the hidden danger of sudden adverse reaction of the patient caused by long-time treatment;
the filter membrane 25 is encapsulated inside the seal ring 24 by utilizing the two circular plates 26, the two circular plates 26 are respectively provided with the plurality of through holes 27, and the filter membrane 25 is positioned between the two circular plates 26, so that the structure of the filter element 20 is relatively stable, when the filter element 20 is installed inside the cylindrical shell 14, the installation direction of the filter element 20 is not needed to be distinguished, the problem that the filter element 20 is easily installed wrongly during the processing and production of the improved protein A immunoadsorption column can be avoided, and meanwhile, the production efficiency is effectively improved;
the prepared protective layer has good performances of corrosion resistance, bacteria resistance, skid resistance and aging resistance, has good adhesiveness, is not easy to fall off, and can effectively improve the performances of corrosion resistance, bacteria resistance, skid resistance and aging resistance of the two end covers 15, so that the improved protein A immunoadsorption column has long service life, and more importantly, the phenomenon of skid between hands and the cylindrical shell 14 when medical personnel install the end covers 15 on the cylindrical shell 14 can be effectively prevented.
The using method comprises the following steps: during the use, first connector 7 is used for inserting the equipment of carrying patient's plasma and is used for inserting the washing liquid that albumen A immunoadsorption column body 2 elution regeneration, and second connector 8 is used for inserting the equipment that sends into patient's internal with the plasma that finishes adsorbing and is used for connecting the container of collecting the used washing liquid waste liquid, according to the break-make of the first solenoid valve 12 control first connecting pipe 9 that can operate shown in figure 1, the break-make of operation second solenoid valve 13 control second connecting pipe 10 to the realization switches two sets of albumen A immunoadsorption column bodies 2 and uses and elution regeneration.
The parts not involved in the present invention are the same as or can be implemented by the prior art. The present embodiment is only for explaining the present invention, and it is not limited to the present invention, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present invention.
Claims (10)
1. The utility model provides an improvement protein A immunoadsorption column, includes linkage element (1) and protein A immunoadsorption column body (2), its characterized in that: the connecting unit (1) comprises a liquid inlet pipe (3) and a liquid outlet pipe (4), the liquid inlet pipe (3) and the liquid outlet pipe (4) are both horizontally arranged, and the liquid inlet pipe (3) is positioned above the liquid outlet pipe (4);
protein A immunoadsorption column body (2) are equipped with two sets ofly, two sets ofly protein A immunoadsorption column body (2) parallelly connected setting, every group the upper end of protein A immunoadsorption column body (2) all through first connecting pipe (9) with the bottom of feed liquor pipe (3) is linked together the setting, and every group the bottom of protein A immunoadsorption column body (2) all through second connecting pipe (10) with the upper portion of drain pipe (4) is linked together the setting.
2. The modified protein a immunoadsorption column according to claim 1, wherein: the upper portion of feed liquor pipe (3) is equipped with inlet (5), the bottom of drain pipe (4) is equipped with liquid outlet (6).
3. The modified protein a immunoadsorption column according to claim 2, wherein: the tip fixed mounting of inlet (5) has first connector (7), the tip fixed mounting of liquid outlet (6) has second connector (8).
4. The modified protein a immunoadsorption column according to claim 1, wherein: every group protein A immunoadsorption post body (2) all include cylindrical shell (14), two end covers (15), two sets of filter piece (20) and a plurality of granular adsorbent (23), the both ends of cylindrical shell (14) are the open end, two end cover (15) spiro union respectively is in the both ends of cylindrical shell (14), two sets of filter piece (20) are respectively through two end cover (15) encapsulation is in the inside of cylindrical shell (14), a plurality of granular adsorbent (23) are all filled the inside of cylindrical shell (14), just a plurality of granular adsorbent (23) all are located two sets ofly filter between piece (20).
5. The modified protein A immunoadsorption column according to claim 4, wherein: two the one end that end cover (15) kept away from cylindrical shell (14) is the arc end, and two all fixed clamp seat (21) that is equipped with on the arc end of end cover (15), the inside of pressing from both sides clamp seat (21) all is equipped with bayonet joint (22) integratively, just the outside of pressing from both sides clamp seat (21) all spiro union has lock sleeve (16), bayonet joint (22) with the inside of end cover (15) is linked together the setting.
6. The modified protein A immunoadsorption column according to claim 4, wherein: a plurality of anti-slip strips (17) are uniformly arranged on the outer side faces of the two end covers (15), and the anti-slip strips (17) surround the end covers (15) at equal angles.
7. The modified protein A immunoadsorption column according to claim 4, wherein: two external screw threads (19) are respectively arranged at the outer part of one end of the end cover (15) connected with the cylindrical shell (14), and internal screw threads (18) matched with the external screw threads (19) are respectively arranged at the inner parts of the two ends of the cylindrical shell (14).
8. The modified protein A immunoadsorption column according to claim 4, wherein: every group filter piece (20) all include sealing washer (24) and encapsulate through two plectanes (26) inside filter membrane (25) of sealing washer (24), two a plurality of through-holes (27) have all been seted up on plectane (26), filter membrane (25) are located two between plectane (26).
9. The modified protein a immunoadsorption column according to claim 1, wherein: all install first solenoid valve (12) on first connecting pipe (9), all install second solenoid valve (13) on second connecting pipe (10).
10. The modified protein a immunoadsorption column according to claim 1, wherein: and pH meters (11) are respectively arranged on the second connecting pipe (10) and close to the protein A immunoadsorption column body (2).
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| CN201911006268.5A CN110585504A (en) | 2019-10-22 | 2019-10-22 | Improved protein A immunoadsorption column |
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| CN201911006268.5A CN110585504A (en) | 2019-10-22 | 2019-10-22 | Improved protein A immunoadsorption column |
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| CN110585504A true CN110585504A (en) | 2019-12-20 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112657004A (en) * | 2020-12-17 | 2021-04-16 | 中南大学 | Protein immunoadsorption device based on rotation mechanism |
| CN113509606A (en) * | 2021-08-13 | 2021-10-19 | 江苏恰瑞生物科技有限公司 | Device for reducing uric acid in body |
| CN115025376A (en) * | 2022-04-24 | 2022-09-09 | 中山大学附属第三医院 | Cerebrospinal fluid immunoadsorption device and control method |
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| CN105343953A (en) * | 2015-10-06 | 2016-02-24 | 浙江大学 | Disposable plasma immunoadsorption pipeline |
| CN109876168A (en) * | 2019-03-29 | 2019-06-14 | 南通市第二人民医院 | One kind being used for clinical laboratory equipment chlorination equipment |
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| CN201200660Y (en) * | 2008-05-21 | 2009-03-04 | 珠海丽珠医用生物材料有限公司 | DNA immunoadsorption column |
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| CN112657004A (en) * | 2020-12-17 | 2021-04-16 | 中南大学 | Protein immunoadsorption device based on rotation mechanism |
| CN113509606A (en) * | 2021-08-13 | 2021-10-19 | 江苏恰瑞生物科技有限公司 | Device for reducing uric acid in body |
| CN115025376A (en) * | 2022-04-24 | 2022-09-09 | 中山大学附属第三医院 | Cerebrospinal fluid immunoadsorption device and control method |
| CN115025376B (en) * | 2022-04-24 | 2024-01-16 | 中山大学附属第三医院 | Cerebrospinal fluid immunoadsorption device and control method |
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