CN105343953A - Disposable plasma immunoadsorption pipeline - Google Patents
Disposable plasma immunoadsorption pipeline Download PDFInfo
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- CN105343953A CN105343953A CN201510637361.1A CN201510637361A CN105343953A CN 105343953 A CN105343953 A CN 105343953A CN 201510637361 A CN201510637361 A CN 201510637361A CN 105343953 A CN105343953 A CN 105343953A
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- immunoadsorption
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
Abstract
The invention provides a disposable pipeline special for plasma immunoadsorption. The pipeline can be in the shape of a single column and two columns and is composed of an arterial end pipeline, a venous end pipeline, an immunoadsorption loop and elution effluent abandonment pipe, an elution balance saline water re-preflushing pipe, a pipeline used before plasma after being separated enters an immunoadsorption column, a plasma separator-filter pressure measuring pipe, an effluent bag for preflushing and an effluent bag for treatment. The disposable pipeline is reasonable in design, clinical needs of plasma immunoadsorption treatment are met, using requirements of various machines are taken into consideration, and suffering of a patient is reduced. The problem of pollution caused by the fact that an existing blood pipeline falls into an effluent bucket due to shedding of a port of the blood pipeline can be avoided, and the concept of fully airtight preflushing and blood return of the plasma immunoadsorption pipeline is realized; the disposable pipeline is supportive of direct operation, and an infusion apparatus does not need to be prepared additionally, so that cross infection possibly occurring in the process of cleaning and disinfecting the effluent bucket is avoided, and the disposable pipeline is simpler, more convenient and safer. Risks of spliced pipelines are avoided, and the disposable pipeline is simple, convenient and standard to use and low in using cost.
Description
Technical field
The invention belongs to Medical Instruments class, relate to a kind of disposable blood plasma immunoadsorption pipeline.
Background technology
Blood plasma immunoadsorption is divided into single-column to adsorb and twin columns absorption, blood plasma immunoadsorption is that serious immune disease (comprising immunity nephropathy etc.) and part patients with renal failure panel antibodies are high and need the essential therapeutic arsenals that the necessary preparation before renal transplantation and Post kidney transplantation repel, when carrying out blood plasma immunoadsorption therapy, first doctor sets up the vascular access of patient, then separator made in advance and adsorption column and disposable blood vessel are connected to the vascular access of patient, set up extracorporeal circulation and start blood plasma immunoadsorption therapy.
Special pipeline is not had when carrying out blood plasma immunoadsorption therapy at present, but 2 secondary half blood vessel and some connection tube montages are formed, some three way cock and several secondary transfusion device is also needed during treatment, when rushing blood vessel before the treatment in advance and in therapeutic process and at the end for the treatment of, need to prepare pail for used dressings 1 in addition, before transfusion device being connected to pump, the infusion connector of blood vessel rushes and blood back in advance.Slurry loop port will be abandoned when rushing in advance, return slurry loop port and pump after blood vessel port be clipped in pail for used dressings along upper, when rushing in advance, rush waste liquid in advance and enter in pail for used dressings.
The risk that the pipeline of the montage mosaic type of current use exists is: 1, easily contaminated during montage pipeline.2, the easy slippage of the pipeline of montage, may cause and lose blood, even threat to life; Open for discarded blood plasma being placed in pail for used dressings over the course for the treatment of, easily pollutes by nurse.3, carry out connecting with 3 secondary transfusion devices and threeway when stripping equilibria saline rushes again in advance after adsorption column absorption is saturated, then carry out operating and make troubles to clinical also nurse, also bring the risk of infection.When 4, using original disposable blood plasma modal cutoff pipeline blood back, can not directly operate, must before pump blood vessel infusion connector on connect 1 secondary transfusion device of subsidiary loop, add chance causing because of misoperation polluting etc.
Summary of the invention
The object of this invention is to provide a kind of easy, safe disposable blood plasma immunoadsorption dedicated line, the risk that the pipeline of original montage mosaic type need be used to exist when mainly solving blood plasma immunoadsorption therapy, namely operate the problems such as easy not and easy pollution and use cost are high, thus provide the treatment articles of simple and convenient specification for blood plasma immunoadsorption therapy.
The present invention's disposable blood plasma immunoadsorption dedicated line comprises
single column and Double-pillar, the treatment waste fluid bag H(2-3 of about 4000ml when pre-punching waste fluid bag G when rushing in advance before pipeline E, plasma separator filter pressure-measuring pipe F, treatment before pre-washing pipe D, blood plasma enter immunoabsorbent column after isolating again by arterial end pipeline A, vein end pipeline B, immunoadsorption loop and eluting waste liquid pipe abandon C, stripping equilibria saline and blood plasma immunoadsorption therapy is only) form.
wherein: arterial end pipeline A: be made up of the pressure-measuring pipe A1 on tremulous pulse kettle, pre-washing pipe or tube for transfusion A2, calparine pipe A3, administration connection tube A4, arterial end pipeline and vascular access connectivity port A5, arterial end pipeline and plasma separator arterial end connectivity port A6, tubing clamp A7.
vein end pipeline B: by the pressure-measuring pipe B1 on venous chambers, delivery tube or pre-washing pipe B2, the drug delivery port B3 on vein end, the connectivity port B4 of vein end pipeline and plasma separator vein end, vein end pipeline and vascular access connectivity port B5 form.
immunoadsorption loop and eluting waste liquid pipe abandon C:
single columnby the connectivity port C1 of immunoadsorption tube loop and immunoabsorbent column, eluting waste liquid pipe abandon with rush waste fluid bag connectivity port C2 in advance, immunoadsorption tube loop and vein end pipeline connectivity port C3 form;
double-pillarby the second connectivity port C2 of the first connectivity port C1 of immunoadsorption tube loop and immunoabsorbent column, immunoadsorption tube loop and immunoabsorbent column, eluting waste liquid pipe abandon and rush waste fluid bag first connectivity port C3, eluting waste liquid pipe abandon in advance and rush waste fluid bag second connectivity port C5, immunoadsorption tube loop and vein end pipeline connectivity port C4 in advance and form.
stripping equilibria saline is pre-washing pipe D again: before by stripping equilibria saline, pre-washing pipe and blood plasma isolate rear immunoabsorbent column again, pipeline connectivity port D1, saline connectivity port D2, eluent connectivity port D3, balance liquid connectivity port D4 form.
blood plasma isolates pipeline E before rear immunoabsorbent column:
single columnisolate rear immunoabsorbent column by blood plasma before pipeline export connectivity port E1 with being separated of plasma separator, blood plasma isolates pipeline first port E2 before rear immunoabsorbent column, blood plasma isolates rear immunoabsorbent column front pipeline second port E3, blood plasma isolate rear immunoabsorbent column before the connectivity port E4 of pipeline and adsorption column form;
double-pillarisolate rear immunoabsorbent column by blood plasma before pipeline export connectivity port E1 with being separated of plasma separator, blood plasma isolates pipeline first port E2 before rear immunoabsorbent column, blood plasma isolates rear immunoabsorbent column front pipeline second port E3, blood plasma isolate rear immunoabsorbent column before pipeline be connected the first port E4 with adsorption column, blood plasma isolates that the front pipeline of rear immunoabsorbent column is connected the second port E5 with adsorption column, blood plasma isolate rear 2 immunoabsorbent columns before pipeline and stripping equilibria saline more pre-washing pipe connectivity port E6 form.
plasma separator filter pressure-measuring pipe F: by the connectivity port F1 of the pressure tap of plasma separator filter pressure-measuring pipe and plasma separator, plasma separator filter pressure-measuring pipe and machine pressure measurement connectivity port F2 form.
pre-punching waste fluid bag Gbe provided with and rush waste liquid pipe abandon connectivity port G1 in advance.
waste fluid bag H is used in treatment:be provided with the first port H1, the second port H2, the 3rd port H3, the 4th port H4, five-port H5, the 6th port H6.The capacity of waste fluid bag selects 4000ml.
by single columnthe first port H1 of the arterial end pipeline in disposable blood plasma immunoadsorption dedicated line and vascular access connectivity port A5, vein end pipeline and vascular access connectivity port B5 and treatment waste fluid bag H, the second port H2 connects; By eluting waste liquid pipe abandon with rush waste fluid bag first connectivity port C3 in advance and be connected with five-port H5; By stripping equilibria saline again saline connectivity port D2, the eluent connectivity port D3 of pre-washing pipe D, balance liquid connectivity port D4 respectively with the 6th port H6, the 3rd port H3 of pre-punching waste fluid bag H, the 4th port H4 connects; Put into outer packaging bag together with pipeline E, plasma separator filter pressure-measuring pipe F, pre-punching waste fluid bag G before isolating rear immunoabsorbent column with blood plasma again, after integral sealing, adopt ethylene oxide sterilizing.Treatment waste fluid bag H selects 2-3.
by Double-pillarthe first port H1 of the arterial end pipeline in disposable blood plasma immunoadsorption dedicated line and vascular access connectivity port A5, vein end pipeline and vascular access connectivity port B5 and treatment waste fluid bag H, the second port H2 connects; By eluting waste liquid pipe abandon with rush waste fluid bag first connectivity port C3 in advance and be connected with five-port H5; By stripping equilibria saline again saline connectivity port D2, the eluent connectivity port D3 of pre-washing pipe D, balance liquid connectivity port D4 respectively with the 6th port H6, the 3rd port H3 of pre-punching waste fluid bag H, the 4th port H4 connects; Put into outer packaging bag together with pipeline E, plasma separator filter pressure-measuring pipe F, pre-punching waste fluid bag G before isolating rear immunoabsorbent column with blood plasma again, after integral sealing, adopt ethylene oxide sterilizing.Treatment waste fluid bag H selects 2-3.
The invention has the beneficial effects as follows: (1) blood plasma of the present invention immunoadsorption circuit design can meet the clinical needs of blood plasma immunoadsorption therapy, and considers that various machine uses, thus handy and safe decrease patient's misery more.(2) blood plasma immunoadsorption pipeline of the present invention in design, and no matter when rushing in advance, nurse, without the need to additionally preparing waste liquid barrel, rushes waste liquid in advance and directly enters in waste fluid bag, avoids original blood vessel port because of slippage and fall in waste liquid barrel the problem causing polluting.(3) blood plasma immunoadsorption circuit design of the present invention with abandon the waste fluid bag starched loop pipe port and be connected, during treatment, nurse is without the need to additionally preparing waste liquid barrel, and the discarded blood plasma for the treatment of directly enters in waste fluid bag, avoids the problem that may cause polluting.(4) blood plasma immunoadsorption circuit design of the present invention achieves disposable blood plasma immunoadsorption pipeline total closed type and rushes the theory with blood back in advance, and can straightforward manipulation when treating and terminating blood back, without the need to additionally preparing transfusion device, thus handy and safe more.(5) problem of the cross infection that may exist in cleaning and sterilizing waste liquid barrel process is avoided.(6) through cost accounting, compared with the pipeline of the montage mosaic type originally used, the present invention is more economical.
Accompanying drawing explanation
Fig. 1 is single column blood plasma immunoadsorption pipeline structure schematic diagram.
Fig. 2 is combination schematic diagram in the packaging bag of single column blood plasma immunoadsorption pipeline.
Fig. 3 is Double-pillar blood plasma immunoadsorption pipeline structure schematic diagram.
Fig. 4 is combination schematic diagram in the packaging bag of single column blood plasma immunoadsorption pipeline.
Detailed description of the invention
The present invention is further described by drawings and Examples.
embodiment 1
See Fig. 1, Fig. 2, the present invention's design
single columnblood plasma immunoadsorption pipeline, the treatment waste fluid bag H(2-3 of about 4000ml when pre-punching waste fluid bag G when rushing in advance before pipeline E, plasma separator filter pressure-measuring pipe F, treatment before pre-washing pipe D, blood plasma enter immunoabsorbent column after isolating again by arterial end pipeline A, vein end pipeline B, immunoadsorption loop and eluting waste liquid pipe abandon C, stripping equilibria saline and blood plasma immunoadsorption therapy is only) form.
wherein: arterial end pipeline A: be made up of the pressure-measuring pipe A1 on tremulous pulse kettle, pre-washing pipe or tube for transfusion A2, calparine pipe A3, administration connection tube A4, arterial end pipeline and vascular access connectivity port A5, arterial end pipeline and plasma separator arterial end connectivity port A6, tubing clamp A7; Arterial end pipeline A is according to arterial end pipeline and the pressure-measuring pipe A1 on plasma separator arterial end connectivity port A6, tremulous pulse kettle, calparine pipe A3, pre-washing pipe or claim tube for transfusion A2, administration connection tube A4, tubing clamp A7, arterial end pipeline to be connected successively with vascular access connectivity port A5.
vein end pipeline B: by the pressure-measuring pipe B1 on venous chambers, delivery tube or pre-washing pipe B2, the drug delivery port B3 on vein end, the connectivity port B4 of vein end pipeline and plasma separator vein end, vein end pipeline and vascular access connectivity port B5 form.
immunoadsorption loop and eluting waste liquid pipe abandon C:
single columnby the connectivity port C1 of immunoadsorption tube loop and immunoabsorbent column, eluting waste liquid pipe abandon with rush waste fluid bag connectivity port C2 in advance, immunoadsorption tube loop and vein end pipeline connectivity port C3 form.
stripping equilibria saline is pre-washing pipe D again: before by stripping equilibria saline, pre-washing pipe and blood plasma isolate rear immunoabsorbent column again, pipeline connectivity port D1, saline connectivity port D2, eluent connectivity port D3, balance liquid connectivity port D4 form.
blood plasma isolates pipeline E before rear immunoabsorbent column:
single columnisolate rear immunoabsorbent column by blood plasma before pipeline export connectivity port E1 with being separated of plasma separator, blood plasma isolates pipeline first port E2 before rear immunoabsorbent column, blood plasma isolates rear immunoabsorbent column front pipeline second port E3, blood plasma isolate rear immunoabsorbent column before the connectivity port E4 of pipeline and adsorption column form.
plasma separator filter pressure-measuring pipe F: by the connectivity port F1 of the pressure tap of plasma separator filter pressure-measuring pipe and plasma separator, plasma separator filter pressure-measuring pipe and machine pressure measurement connectivity port F2 form.
pre-punching waste fluid bag Gbe provided with and rush waste liquid pipe abandon connectivity port G1 in advance.
waste fluid bag H is used in treatment: be provided with the first port H1, the second port H2, the 3rd port H3, the 4th port H4, five-port H5, the 6th port H6.The capacity of waste fluid bag selects 4000ml.
by single columnthe first port H1 of the arterial end pipeline in disposable blood plasma immunoadsorption dedicated line and vascular access connectivity port A5, vein end pipeline and vascular access connectivity port B5 and treatment waste fluid bag H, the second port H2 connects; By eluting waste liquid pipe abandon with rush waste fluid bag first connectivity port C3 in advance and be connected with five-port H5; By stripping equilibria saline again saline connectivity port D2, the eluent connectivity port D3 of pre-washing pipe D, balance liquid connectivity port D4 respectively with the 6th port H6, the 3rd port H3 of pre-punching waste fluid bag H, the 4th port H4 connects; Put into outer packaging bag together with pipeline E, plasma separator filter pressure-measuring pipe F, pre-punching waste fluid bag G before isolating rear immunoabsorbent column with blood plasma again, after integral sealing, adopt ethylene oxide sterilizing.Treatment waste fluid bag H selects 2-3.
embodiment 2
See Fig. 3, Fig. 4, the present invention's design
double-pillarblood plasma immunoadsorption dedicated line comprises, and the treatment waste fluid bag H(2-3 of about 4000ml when pre-punching waste fluid bag G when rushing in advance before pipeline E, plasma separator filter pressure-measuring pipe F, treatment before pre-washing pipe D, blood plasma enter immunoabsorbent column after isolating again by arterial end pipeline A, vein end pipeline B, immunoadsorption loop and eluting waste liquid pipe abandon C, stripping equilibria saline and blood plasma immunoadsorption therapy is only) form.
wherein: arterial end pipeline A: be made up of the pressure-measuring pipe A1 on tremulous pulse kettle, pre-washing pipe or tube for transfusion A2, calparine pipe A3, administration connection tube A4, arterial end pipeline and vascular access connectivity port A5, arterial end pipeline and plasma separator arterial end connectivity port A6, tubing clamp A7; And according to arterial end pipeline and the pressure-measuring pipe A1 on plasma separator arterial end connectivity port A6, tremulous pulse kettle, calparine pipe A3, pre-washing pipe or claim tube for transfusion A2, administration connection tube A4, tubing clamp A7, arterial end pipeline to be connected successively with vascular access connectivity port A5.
vein end pipeline B: by the pressure-measuring pipe B1 on venous chambers, delivery tube or pre-washing pipe B2, the drug delivery port B3 on vein end, the connectivity port B4 of vein end pipeline and plasma separator vein end, vein end pipeline and vascular access connectivity port B5 form.
immunoadsorption loop and eluting waste liquid pipe abandon C:
double-pillarby the second connectivity port C2 of the first connectivity port C1 of immunoadsorption tube loop and immunoabsorbent column, immunoadsorption tube loop and immunoabsorbent column, eluting waste liquid pipe abandon and rush waste fluid bag first connectivity port C3, eluting waste liquid pipe abandon in advance and rush waste fluid bag second connectivity port C5, immunoadsorption tube loop and vein end pipeline connectivity port C4 in advance and form.
stripping equilibria saline is pre-washing pipe D again: before by stripping equilibria saline, pre-washing pipe and blood plasma isolate rear immunoabsorbent column again, pipeline connectivity port D1, saline connectivity port D2, eluent connectivity port D3, balance liquid connectivity port D4 form.
blood plasma isolates pipeline E before rear immunoabsorbent column:
double-pillarisolate rear immunoabsorbent column by blood plasma before pipeline export connectivity port E1 with being separated of plasma separator, blood plasma isolates pipeline first port E2 before rear immunoabsorbent column, blood plasma isolates rear immunoabsorbent column front pipeline second port E3, blood plasma isolate rear immunoabsorbent column before pipeline be connected the first port E4 with adsorption column, blood plasma isolates that the front pipeline of rear immunoabsorbent column is connected the second port E5 with adsorption column, blood plasma isolate rear 2 immunoabsorbent columns before pipeline and stripping equilibria saline more pre-washing pipe connectivity port E6 form.
plasma separator filter pressure-measuring pipe F: by the connectivity port F1 of the pressure tap of plasma separator filter pressure-measuring pipe and plasma separator, plasma separator filter pressure-measuring pipe and machine pressure measurement connectivity port F2 form.
pre-punching waste fluid bag Gbe provided with
pre-punchingwaste liquid pipe abandon connectivity port G1.
waste fluid bag H is used in treatment:be provided with the first port H1, the second port H2, the 3rd port H3, the 4th port H4, five-port H5, the 6th port H6.The capacity of waste fluid bag selects 4000ml.
by Double-pillarthe first port H1 of the arterial end pipeline in disposable blood plasma immunoadsorption dedicated line and vascular access connectivity port A5, vein end pipeline and vascular access connectivity port B5 and treatment waste fluid bag H, the second port H2 connects; By eluting waste liquid pipe abandon with rush waste fluid bag first connectivity port C3 in advance and be connected with five-port H5; By stripping equilibria saline again saline connectivity port D2, the eluent connectivity port D3 of pre-washing pipe D, balance liquid connectivity port D4 respectively with the 6th port H6, the 3rd port H3 of pre-punching waste fluid bag H, the 4th port H4 connects; Put into outer packaging bag together with pipeline E, plasma separator filter pressure-measuring pipe F, pre-punching waste fluid bag G before isolating rear immunoabsorbent column with blood plasma again, after integral sealing, adopt ethylene oxide sterilizing.Treatment waste fluid bag H selects 2-3.
embodiment 3
See Fig. 1, disposable single column blood plasma immunoadsorption pipeline is for connecting hemodialysis patients and blood plasma immunity suction therapy apparatus.
Before treatment starts, open the packaging bag of ethylene oxide sterilizing, in order to first rush disposable single column blood plasma immunoadsorption pipeline and plasma separator and immunoadsorption device in advance, nurse is required first the connectivity port A6 of the arterial end pipeline in disposable single column blood plasma immunoadsorption pipeline and plasma separator arterial end, the connectivity port B4 of vein end pipeline and plasma separator vein end and plasma separator couple together, again the first connectivity port C1 of immunoadsorption tube loop and immunoabsorbent column, before immunoabsorbent column, pipe is connected with blood plasma immunoabsorbent column with two adsorption column first connectivity port E4, export under the blood plasma of plasma separator and export connectivity port E1 be connected with being separated of pipeline before immunoabsorbent column and plasma separator, then stripping equilibria saline more pre-washing pipe be connected with pipeline before immunoabsorbent column second port E3 with pipeline connectivity port D1 before immunoabsorbent column, plasma separator filter pressure-measuring pipe is connected with the blood plasma upper outlet of plasma separator with the connectivity port F1 of the pressure tap of plasma separator, and be mounted on blood plasma immunity suction therapy apparatus, and be placed in clear area (not landing) by unified for punching waste fluid bag G in advance.Get the tube for transfusion A2 on arterial end pipeline before pump or the delivery tube on vein end pipeline or pre-washing pipe B2 connection and rush liquid in advance, open infusion set clip, start to rush in advance, rush waste liquid in advance and then enter in waste fluid bag.After pre-punching terminates, eluting waste liquid pipe abandon second connectivity port C5 is connected with the drug delivery port B3 on vein end, the port H1 be connected with first with the first connectivity port C2 of immunoabsorbent column by immunoadsorption tube loop is connected, and is connected respectively by arterial end pipeline with vascular access connectivity port A5 with vein end pipeline with vascular access connectivity port B5 with the arteriovenous of the vascular access of patient.Open blood pump and blood plasma pump starts blood plasma immunity
absorptiontreat 15 minutes, stop blood plasma pump, open saline connectivity port D2 normal saline and carry out
overfallto in patient body, then open eluent connectivity port D3 eluent and carry out
eluting, then open balance liquid connectivity port D4 and use
balanceliquid neutralizes, then opens saline connectivity port D2 continuation normal saline and carry out
pre-punching, then repeat above absorption-overfall-eluting-balance-rush 10-15 circulation in advance.Stop blood plasma pump to start to terminate blood plasma immunoadsorption therapy, open saline connectivity port D2 normal saline and carry out overfall in patient body, get pre-washing pipe or tube for transfusion A2 connection normal saline, the pressure-measuring pipe A1 on tremulous pulse kettle clamped by clip, open clip on pre-washing pipe or tube for transfusion A2 and blood pump backwater a little, before pass blood pump opens the pump of pre-washing pipe or tube for transfusion A2, arterial line blood returns in body by pipe, before reclamping the pump of the tube for transfusion A2 of arterial line, pipe clamp is sub, opens blood pump and returns in patient body by the blood in filter and venous line again; Open eluent connectivity port D3 eluent again and carry out eluting, open balance liquid connectivity port D4 balance liquid again to neutralize, open saline connectivity port D2 continuation normal saline again to rush in advance, then saline connectivity port D2 is connected with Precerving liquid and pours into Precerving liquid that adsorption column is airtight to be saved backup.
embodiment 4
See Fig. 3, disposable Double-pillar blood plasma immunoadsorption pipeline is for connecting hemodialysis patients and blood plasma immunoadsorption therapy machine.Before treatment starts, open the packaging bag of ethylene oxide sterilizing, in order to first rush disposable Double-pillar blood plasma immunoadsorption pipeline (Fig. 3) and plasma separator and immunoabsorbent column in advance, nurse is required first arterial end pipeline and plasma separator arterial end connectivity port A6, the connectivity port B4 of vein end pipeline and plasma separator vein end and the blood port of plasma separator couple together, again immunoadsorption tube loop and the connectivity port C1/ immunoadsorption tube loop of immunoabsorbent column and the second connectivity port C2 of immunoabsorbent column, blood plasma isolate the front pipeline of rear immunoabsorbent column be connected with adsorption column the first port E4/ blood plasma isolate rear immunoabsorbent column before pipeline be connected the second port E5 respectively with 2 blood plasma immunoabsorbent columns with adsorption column and be connected, then stripping equilibria saline more pre-washing pipe and blood plasma isolate rear immunoabsorbent column front pipeline connectivity port D1 and blood plasma to isolate before rear immunoabsorbent column pipeline and stripping equilibria saline more in advance washing pipe connectivity port E6 be connected, plasma separator filter pressure-measuring pipe is connected with the blood plasma upper outlet of plasma separator with the connectivity port F1 of the pressure tap of plasma separator, and be mounted on blood plasma immunity suction therapy apparatus, and be placed in clear area (not landing) by unified for punching waste fluid bag G in advance.Get pre-washing pipe or tube for transfusion A2 or delivery tube or pre-washing pipe B2 to connect and rush liquid in advance, open infusion set clip, start to rush in advance, rush waste liquid in advance and then enter in waste fluid bag.After pre-punching terminates, immunoadsorption tube loop is connected with the drug delivery port B3 on vein end with vein end pipeline connectivity port C4, by eluting waste liquid pipe abandon with to rush waste fluid bag first connectivity port C3/ eluting waste liquid pipe abandon in advance and rush waste fluid bag second connectivity port C5 respectively with the first port H1 in advance, second port H2 is connected, and is connected respectively by arterial end pipeline with vascular access connectivity port A5 with vein end pipeline with vascular access connectivity port B5 with the arteriovenous end of the vascular access of patient.Folder closes blood plasma and isolates the front pipeline of rear immunoabsorbent column and stripping equilibria saline washing pipe connectivity port E6 and blood plasma isolate the clip before rear immunoabsorbent column on pipeline second port E3 in advance again, open blood pump start to isolate rear immunoabsorbent column with blood plasma with blood plasma pump before pipeline be connected the adsorption column that the first port E4 connects with adsorption column and start blood plasma immunoadsorption therapy 15 minutes, folder close blood plasma isolate rear immunoabsorbent column before pipeline be connected on the first port E4 bubble trap with adsorption column more than clip, open saline connectivity port D2 and carry out Regeneration Treatment, first carry out with normal saline the adsorption column that overfall (blood plasma isolate rear immunoabsorbent column before pipeline be connected the first port E4 with adsorption column) connects, open eluent connectivity port D3 eluent again and carry out the adsorption column that eluting (blood plasma isolate rear immunoabsorbent column before pipeline be connected the first port E4 with adsorption column) connects, open again during balance liquid connectivity port D4 carries out with balance liquid and isolate pipeline before rear immunoabsorbent column with blood plasma and to be connected the adsorption column that the first port E4 connects with adsorption column, open the D2 continuation of saline connectivity port again to carry out with normal saline rushing the adsorption column connected in advance, manage and the clip on two adsorption column second connectivity port E5 before opening immunoabsorbent column simultaneously, the adsorption column continual cure be connected with two adsorption column second connectivity port E5 with pipe before immunoabsorbent column 15 minutes, then alternately repeats above absorption-overfall-eluting-balance-pre-punching 10-15 circulation altogether.After blood plasma immunoadsorption therapy terminates, stop blood plasma pump, open saline connectivity port D2 normal saline and carry out overfall, to get on arterial end pipeline tube for transfusion A2 before pump and connect normal saline, manage before clamping the pump of the pressure-measuring pipe A1 on tremulous pulse kettle, open clip on arterial end pipeline before pump on tube for transfusion A2 and blood pump backwater a little, before pass blood pump opens the pump of tube for transfusion A2 before pump on arterial end pipeline, arterial line blood returns in body by pipe, manage before reclamping the pump of tube for transfusion A2 before pump on arterial end pipeline, open blood pump and again the blood in filter and venous line is returned in body; Open eluent connectivity port D3 eluent again and carry out eluting, open balance liquid connectivity port D4 balance liquid again to neutralize, open saline connectivity port D2 continuation normal saline again to rush in advance, then saline connectivity port D2 is connected 2 airtight preservations of adsorption column of pouring into Precerving liquid with Precerving liquid.
Disposable Double-pillar blood plasma immunoadsorption pipeline shown in Fig. 3 is for connecting hemodialysis patients and blood plasma immunoadsorption therapy machine carries out immunoadsorption therapy, compared with single column blood plasma immunoadsorption, the patient treatment time is short, also can reduce during treatment with anticoagulant dosage.
Claims (6)
1. disposable blood plasma immunoadsorption dedicated line, is characterized in that, comprise
single column and Double-pillar, described blood plasma immunoadsorption dedicated line before by arterial end pipeline (A), vein end pipeline (B), immunoadsorption loop and eluting waste liquid pipe abandon (C), stripping equilibria saline, pre-washing pipe (D), blood plasma enter immunoabsorbent column after isolating again pipeline (E), plasma separator filter pressure-measuring pipe (F), pre-punching waste fluid bag (G) and treatment waste fluid bag (H) form.
2. disposable blood plasma immunoadsorption dedicated line according to claim 1, is characterized in that, in single column disposable blood plasma immunoadsorption dedicated line:
arterial end pipeline (A)be made up of with plasma separator arterial end connectivity port (A6), tubing clamp (A7) the pressure-measuring pipe (A1) on tremulous pulse kettle, pre-washing pipe or tube for transfusion (A2), calparine pipe (A3), administration connection tube (A4), arterial end pipeline and vascular access connectivity port (A5), arterial end pipeline;
vein end pipeline (B)by the pressure-measuring pipe (B1) on venous chambers, delivery tube or pre-washing pipe (B2), the drug delivery port (B3) on vein end, the connectivity port (B4) of vein end pipeline and plasma separator vein end, vein end pipeline and vascular access connectivity port (B5) form;
immunoadsorption loop and eluting waste liquid pipe abandon (C)by the connectivity port (C1) of immunoadsorption tube loop and immunoabsorbent column, eluting waste liquid pipe abandon with rush waste fluid bag connectivity port (C2) in advance, immunoadsorption tube loop and vein end pipeline connectivity port (C3) form;
stripping equilibria saline is pre-washing pipe (D) againby stripping equilibria saline more pre-washing pipe and blood plasma isolate pipeline connectivity port (D1) before rear immunoabsorbent column, saline connectivity port (D2), eluent connectivity port (D3), balance liquid connectivity port (D4) form;
blood plasma isolates pipeline (E) before rear immunoabsorbent columnbefore isolating rear immunoabsorbent column by blood plasma, pipeline exports connectivity port (E1) with being separated of plasma separator, blood plasma isolates pipeline first port (E2) before rear immunoabsorbent column, blood plasma isolates rear immunoabsorbent column front pipeline second port (E3), blood plasma isolate rear immunoabsorbent column before the connectivity port (E4) of pipeline and adsorption column form;
plasma separator filter pressure-measuring pipe (F)be made up of the connectivity port (F1) of the pressure tap of plasma separator filter pressure-measuring pipe and plasma separator and plasma separator filter pressure-measuring pipe and machine pressure measurement connectivity port (F2);
pre-punching waste fluid bag (G)be provided with and rush waste liquid pipe abandon connectivity port (G1) in advance;
treatment waste fluid bag (H)be provided with the first port (H1), the second port (H2), the 3rd port (H3), the 4th port (H4), five-port (H5), the 6th port (H6).
3. disposable blood plasma immunoadsorption dedicated line according to claim 1, is characterized in that,
double-pillarin disposable blood plasma immunoadsorption dedicated line:
arterial end pipeline (A)be made up of with plasma separator arterial end connectivity port (A6), tubing clamp (A7) the pressure-measuring pipe (A1) on tremulous pulse kettle, pre-washing pipe or tube for transfusion (A2), calparine pipe (A3), administration connection tube (A4), arterial end pipeline and vascular access connectivity port (A5), arterial end pipeline,
vein end pipeline (B)by the pressure-measuring pipe (B1) on venous chambers, delivery tube or pre-washing pipe (B2), the drug delivery port (B3) on vein end, the connectivity port (B4) of vein end pipeline and plasma separator vein end, vein end pipeline and vascular access connectivity port (B5) form,
immunoadsorption loop and eluting waste liquid pipe abandon (C)by the second connectivity port (C2 of first connectivity port (C1) of immunoadsorption tube loop and immunoabsorbent column, immunoadsorption tube loop and immunoabsorbent column
), eluting waste liquid pipe abandon with rush waste fluid bag first connectivity port (C3 in advance
), eluting waste liquid pipe abandon with rush waste fluid bag second connectivity port (C5 in advance
), immunoadsorption tube loop and vein end pipeline connectivity port (C4
)composition,
stripping equilibria saline is pre-washing pipe (D) againby stripping equilibria saline more pre-washing pipe and blood plasma isolate pipeline connectivity port (D1) before rear immunoabsorbent column, saline connectivity port (D2), eluent connectivity port (D3), balance liquid connectivity port (D4) form,
blood plasma isolates pipeline (E) before rear immunoabsorbent columnbefore isolating rear immunoabsorbent column by blood plasma, pipeline exports connectivity port (E1) with being separated of plasma separator, blood plasma isolates pipeline first port (E2) before rear immunoabsorbent column, blood plasma isolates pipeline second port (E3) before rear immunoabsorbent column, before blood plasma isolates rear immunoabsorbent column, pipeline is connected the first port (E4) with adsorption column, before blood plasma isolates rear immunoabsorbent column, pipeline is connected the second port (E5) with adsorption column, before blood plasma isolates rear immunoabsorbent column, pipeline and stripping equilibria saline form pre-washing pipe connectivity port (E6) again,
plasma separator filter pressure-measuring pipe (F)be made up of the connectivity port (F1) of the pressure tap of plasma separator filter pressure-measuring pipe and plasma separator and plasma separator filter pressure-measuring pipe and machine pressure measurement connectivity port (F2),
pre-punching waste fluid bag (G)be provided with and rush waste liquid pipe abandon connectivity port (G1) in advance,
treatment waste fluid bag (H)be provided with the first port (H1), the second port (H2), the 3rd port (H3), the 4th port (H4), five-port (H5), the 6th port (H6).
4. disposable blood plasma immunoadsorption dedicated line according to claim 2, it is characterized in that, by the arterial end pipeline in disposable for single column blood plasma immunoadsorption dedicated line and vascular access connectivity port (A5), vein end pipeline and vascular access connectivity port (B5) and first port (H1) for the treatment of with waste fluid bag (H), second port (H2) connects, by eluting waste liquid pipe abandon with rush waste fluid bag first connectivity port (C3) in advance and be connected with five-port (H5), by the saline connectivity port (D2) of stripping equilibria saline pre-washing pipe (D) again, eluent connectivity port (D3), balance liquid connectivity port (D4) respectively with the 6th port (H6), 3rd port (H3), 4th port (H4) connects, then pipeline (E) before rear immunoabsorbent column is isolated with blood plasma, plasma separator filter pressure-measuring pipe (F), pre-punching waste fluid bag (G) puts into outer packaging bag together, ethylene oxide sterilizing is adopted after integral sealing, treatment waste fluid bag (H) selects 2-3.
5. disposable blood plasma immunoadsorption dedicated line according to claim 3, it is characterized in that, by the arterial end pipeline in disposable for Double-pillar blood plasma immunoadsorption dedicated line and vascular access connectivity port (A5), vein end pipeline and vascular access connectivity port (B5) and first port (H1) for the treatment of with waste fluid bag (H), second port (H2) connects, by eluting waste liquid pipe abandon with rush waste fluid bag first connectivity port (C3) in advance and be connected with five-port (H5), by the saline connectivity port (D2) of stripping equilibria saline pre-washing pipe (D) again, eluent connectivity port (D3), balance liquid connectivity port (D4) respectively with the 6th port (H6), 3rd port (H3), 4th port (H4) connects, then pipeline (E) before rear immunoabsorbent column is isolated with blood plasma, plasma separator filter pressure-measuring pipe (F), pre-punching waste fluid bag (G) puts into outer packaging bag together, ethylene oxide sterilizing is adopted after integral sealing, treatment waste fluid bag (H) selects 2-3.
6., according to the arbitrary described disposable blood plasma immunoadsorption dedicated line of claim 1-5, it is characterized in that, the capacity of waste fluid bag selects 4000ml.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510637361.1A CN105343953A (en) | 2015-10-06 | 2015-10-06 | Disposable plasma immunoadsorption pipeline |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510637361.1A CN105343953A (en) | 2015-10-06 | 2015-10-06 | Disposable plasma immunoadsorption pipeline |
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| Publication Number | Publication Date |
|---|---|
| CN105343953A true CN105343953A (en) | 2016-02-24 |
Family
ID=55320104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510637361.1A Pending CN105343953A (en) | 2015-10-06 | 2015-10-06 | Disposable plasma immunoadsorption pipeline |
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| Country | Link |
|---|---|
| CN (1) | CN105343953A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110585504A (en) * | 2019-10-22 | 2019-12-20 | 常州市第一人民医院 | Improved protein A immunoadsorption column |
| CN111529784A (en) * | 2020-05-18 | 2020-08-14 | 廖浩 | CPFA (coherent population FA) bridging pipeline |
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| CN111529784A (en) * | 2020-05-18 | 2020-08-14 | 廖浩 | CPFA (coherent population FA) bridging pipeline |
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Application publication date: 20160224 |