CN115025376A - Cerebrospinal fluid immunoadsorption device and control method - Google Patents
Cerebrospinal fluid immunoadsorption device and control method Download PDFInfo
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- CN115025376A CN115025376A CN202210459884.1A CN202210459884A CN115025376A CN 115025376 A CN115025376 A CN 115025376A CN 202210459884 A CN202210459884 A CN 202210459884A CN 115025376 A CN115025376 A CN 115025376A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M27/00—Drainage appliance for wounds or the like, i.e. wound drains, implanted drains
- A61M27/002—Implant devices for drainage of body fluids from one part of the body to another
- A61M27/006—Cerebrospinal drainage; Accessories therefor, e.g. valves
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Abstract
The invention discloses a cerebrospinal fluid immunoadsorption device and a control method thereof, the cerebrospinal fluid immunoadsorption device comprises a host, wherein one side surface of the host is respectively provided with a first mounting groove and a second mounting groove which are communicated with each other, a peristaltic pump head assembly is detachably mounted in the first mounting groove, the back of the first mounting groove is provided with a motor matched with the peristaltic pump head assembly, a protein A immunoadsorption column is detachably mounted in the second mounting groove, one end of the peristaltic pump head assembly is connected with one end of the protein A immunoadsorption column, and the other end of the peristaltic pump head assembly and the other end of the protein A immunoadsorption column are respectively used for being connected with a drainage tube. The invention has the beneficial effects that: after the puncture is finished, only need to install the drainage tube and accomplish the operation promptly, the patient wait by oneself protein A immunoadsorption column gradually with target antibody adsorption filtration can, practiced thrift patient and doctor both sides a large amount of time to the patient does not have cerebrospinal fluid loss, effectively avoids postoperative patient to appear uncomfortable symptom.
Description
Technical Field
The invention relates to the technical field of cerebrospinal fluid extracorporeal circulation, in particular to a cerebrospinal fluid immunoadsorption device and a control method.
Background
Autoimmune Encephalitis (AE) is a recognized type of encephalitis in more than ten years, an inflammatory encephalopathy mediated by an autoimmune mechanism, accounting for 10% -20% of cases of encephalitis. Patients show severe symptoms such as coma, mental disorder, myoclonus, tremor, epileptic seizure and sleep disorder, and are mostly patients with severe neurological symptoms. The vast majority of AEs were antibody-mediated central nervous system injuries characterized by the presence of anti-neuronal antibodies in the blood and/or cerebrospinal fluid. These pathogenic antibodies are usually triggered by tumor, infection, etc. causative factors, synthesized in the blood or cerebrospinal fluid system, and enter the relevant brain region through the blood-cerebrospinal fluid barrier, blood-brain barrier, cerebrospinal fluid-brain barrier, thereby causing encephalitis.
The treatment of these diseases is mainly achieved by various methods, such as removal of pathogenic antibodies and elimination of inflammation, and the conventional methods include glucocorticoid, intravenous immunoglobulin, rituximab, cyclophosphamide, plasmapheresis, and the like. Immunoadsorption (IA) therapy is a blood purification technique developed in recent years, in which highly specific antigens, antibodies or substances (ligands) with specific physicochemical affinity are combined with an adsorption material (carrier) to prepare an adsorbent (column) which selectively or specifically removes pathogenic factors in blood, thereby achieving the purposes of purifying blood and relieving disease conditions. The protein A immunoadsorption column takes gene engineering recombinant staphylococcal protein A molecules as the core, has high affinity to the Fc part of human immunoglobulin, and the autoantibody level can be reduced by about 70 percent after single immunoadsorption. In recent years, protein a has been used as an adsorbent to remove pathogenic antibodies in blood circulation by blood purification techniques, and thus, the treatment of AE has been performed with some effect. However, the above methods are directed to the clearance or antagonism of antibodies in the blood system, which prevents the free transfer of drugs into the cerebrospinal fluid and macromolecular antibodies due to the presence of the blood-cerebrospinal fluid barrier, and these methods, including blood-adsorption purification techniques, have poor clearance of the antibodies present in the cerebrospinal fluid. It was found that antibodies in cerebrospinal fluid are more important for the pathogenic effects of AE, as exemplified by the most common anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis (accounting for about 80%) and that the positive rate and titer of antibodies in cerebrospinal fluid are higher than in serum and correlated with the severity of the disease. Therefore, how to rapidly remove pathogenic antibodies in cerebrospinal fluid is the most critical to the treatment of patients.
The treatment group used a lumbar puncture method of cerebrospinal fluid replacement and blood immunoadsorption (two cases of treating autoimmune encephalitis by cerebrospinal fluid replacement and protein A immunoadsorption), and the treatment group treated autoimmune encephalitis with certain effect. However, there are many disadvantages to cerebrospinal fluid replacement in lumbar puncture: 1. low efficiency of replacement, about 50ml per replacement (about 1/3 total cerebrospinal fluid stock and 1/10 daily production); 2. the operation time is long, each replacement operation lasts for about 4 hours, the patient needs to keep a lateral position, and the patient is difficult to cooperate with the patient suffering from serious diseases or agitation; 3. the doctor has high working intensity, and the patient condition needs to be closely observed in the process, and the symptomatic treatment is carried out; 4. the lumbar puncture every day increases the pain of the patient and increases the complication chances of infection and low cranial pressure isosceles vertebra puncture; 5. the replacement fluid is artificial cerebrospinal fluid or normal saline, which has irritant damage to brain tissue. Although the Chinese patent gazette also discloses some instruments for assisting cerebrospinal fluid flushing or replacement, such as "a cerebrospinal fluid pressure monitoring and automatic flushing instrument" (CN2412577) and "cerebrospinal fluid external replacement instrument" (CN201040109), they are improvements on the basis of lumbar puncture and cerebrospinal fluid replacement, and still cannot fundamentally overcome the above disadvantages.
Disclosure of Invention
Aiming at the problems, the invention provides a cerebrospinal fluid immunoadsorption device and a control method thereof, aiming at solving the problems of the existing lumbar puncture cerebrospinal fluid replacement.
In order to solve the technical problems, the invention provides a cerebrospinal fluid immunoadsorption device in a first aspect, which comprises a host, wherein one side surface of the host is respectively provided with a first mounting groove and a second mounting groove which are communicated with each other, a peristaltic pump head assembly is detachably mounted in the first mounting groove, a motor matched with the peristaltic pump head assembly is mounted at the back of the first mounting groove, a protein A immunoadsorption column is detachably mounted in the second mounting groove, one end of the peristaltic pump head assembly is connected with one end of the protein A immunoadsorption column, and the other end of the peristaltic pump head assembly and the other end of the protein A immunoadsorption column are respectively used for being connected with a drainage tube.
In some embodiments, the distal end of one of said drains is affixed to the middle of another of said drains.
In some embodiments, a third installation groove is arranged inside the first installation groove, and two sides of the peristaltic pump head assembly are respectively provided with a buckle matched with the third installation groove.
In some embodiments, the peristaltic pump head assembly comprises a pump cover, a pump pipe and a wheel set, wherein the pump pipe is installed inside the pump cover and is led out in a U shape, the wheel set is installed at a bending section of the pump pipe, the wheel set comprises a lower cover in transition fit with the opening end of the pump cover, a fixing rod is arranged on one end face of the pump cover, a rotating wheel is sleeved on the fixing rod, and a connecting hole matched with an output shaft of a motor is formed in the center of the lower cover.
In some embodiments, the coupling hole is hexagonal and the output shaft of the motor is a hexagonal shaft.
In some embodiments, a pull-down resistor is embedded in the pump cover, two ends of the pull-down resistor are provided with conducting wires, end portions of the two conducting wires are led out from an end face of an opening end of the pump cover to form a first contact and a second contact respectively, and a first detection contact and a second detection contact which coincide with the first contact and the second contact respectively are arranged in the first mounting groove.
In some embodiments, a hinge type baffle is arranged at one side of the opening end of the second mounting groove.
In some embodiments, one side of the first mounting groove is provided with a first drainage tube receiving groove communicated with the first mounting groove, one side of the second mounting groove is provided with a second drainage tube receiving groove communicated with the second mounting groove, and openings of the first drainage tube receiving groove and the second drainage tube receiving groove are in the same direction.
In some embodiments, a protective cover is disposed around the periphery of the motor.
Furthermore, the second aspect of the present invention provides a method for controlling a cerebrospinal fluid immunoadsorption device, which is used for the cerebrospinal fluid immunoadsorption device, and comprises the following steps:
and inputting a high level signal to the first detection contact, continuously detecting the level state of the second detection contact, driving the motor to run at a constant speed according to a preset rotating speed if the level state of the second detection contact is a low level, and cutting off the power supply input of the motor if the level state of the second detection contact is a high level.
The invention has the beneficial effects that: set up first mounting groove and second mounting groove on the host computer and be used for installing peristaltic pump head subassembly and albumen A immunoadsorption column respectively, through the cerebrospinal fluid flow that peristaltic pump head subassembly control was taken out, target protein in the cerebrospinal fluid passes through protein A immunoadsorption column's absorption and purifies the internal completion circulation of reentrant patient, after the puncture, only need install the drainage tube and accomplish the operation promptly, the patient waits for albumen A immunoadsorption column by oneself gradually with target antibody adsorption filtration can, patient and doctor both sides a large amount of time have been practiced thrift, and the patient does not have cerebrospinal fluid loss, effectively avoid postoperative patient uncomfortable symptom to appear.
Drawings
FIG. 1 is a schematic perspective view of a cerebrospinal fluid immunoadsorption apparatus 1 according to an embodiment of the present invention;
FIG. 2 is a schematic perspective view of a cerebrospinal fluid immunoadsorption apparatus disclosed in one embodiment of the present invention 2;
fig. 3 is a schematic perspective view of a cerebrospinal fluid immunoadsorption device of the present invention after a peristaltic pump head assembly is hidden;
FIG. 4 is a schematic perspective view of a pump head assembly of a peristaltic pump as disclosed in one embodiment of the present invention;
FIG. 5 is an exploded view of a peristaltic pump head assembly as disclosed in one embodiment of the present invention;
wherein: 1-a host, 2-a peristaltic pump head assembly, 3-a motor, 4-a protein A immunoadsorption column, 5-a drainage tube, 6-a protective cover, 101-a first installation groove, 1011-a first detection contact, 1012-a second detection contact, 102-a second installation groove, 1021-a hinge type baffle, 103-a third installation groove, 104-a first drainage tube accommodating groove, 105-a second drainage tube accommodating groove, 201-a pump cover, 2011-a first contact, 2012-a second contact, 202-a pump tube, 203-a lower cover, 204-a fixed rod, 205-a rotating wheel, 206-a connecting hole, 207-a buckle and 301-an output shaft.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all of the embodiments. All other embodiments obtained by a person of ordinary skill in the art based on the embodiments in the present application without making any creative effort belong to the protection scope of the present application.
It should be noted that the terms "first," "second," and the like in the description and claims of the present invention and in the drawings described above are used for distinguishing between similar elements and not necessarily for describing a particular sequential or chronological order. It is to be understood that the data so used is interchangeable under appropriate circumstances such that the embodiments of the invention described herein are capable of operation in other sequences than those illustrated or described herein. Furthermore, the terms "comprises," "comprising," and any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements expressly listed, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.
It will be understood that the terms "central," "longitudinal," "transverse," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," "circumferential," and the like are used in an orientation or positional relationship indicated in the drawings for convenience and simplicity of description only and do not indicate or imply that the device or element so referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus should not be considered as limiting the invention.
In the description of the present invention, "a plurality" means at least two, e.g., two, three, etc., unless specifically limited otherwise. Furthermore, unless expressly stated or limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, as they may be fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in a specific case to those of ordinary skill in the art.
In the present invention, unless otherwise expressly stated or limited, the first feature "on" or "under" the second feature may be directly contacting the first and second features or indirectly contacting the first and second features through an intermediate. Also, a first feature "on," "over," and "above" a second feature may be directly or diagonally above the second feature, or may simply indicate that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature may be directly under or obliquely under the first feature, or may simply mean that the first feature is at a lesser elevation than the second feature.
Example one
This embodiment has proposed a cerebrospinal fluid immunoadsorption device, receives lumbar puncture postoperative when the patient, can connect peristaltic pump head subassembly 2 and albumen A immunoadsorption post 4 respectively with two drainage tubes 5 to form a loop, the patient need not to lie on one's side for a long time and waits that the doctor takes out and reinject normal saline in turn cerebrospinal fluid. After the puncture is finished, only need install drainage tube 5 and accomplish the operation promptly, the patient wait by oneself protein A immunoadsorption column 4 gradually with target antibody adsorption filtration can, practiced thrift patient and doctor both sides a large amount of time to the patient does not have the cerebrospinal fluid loss, effectively avoids postoperative patient to appear uncomfortable symptom.
As shown in fig. 1-3, the cerebrospinal fluid immunoadsorption device comprises a host 1, wherein one side surface of the host 1 is respectively provided with a first mounting groove 101 and a second mounting groove 102 which are communicated with each other, a peristaltic pump head assembly 2 is detachably mounted in the first mounting groove 101, a motor 3 matched with the peristaltic pump head assembly 2 is mounted at the back of the first mounting groove 101, a protein a immunoadsorption column 4 is detachably mounted in the second mounting groove 102, one end of the peristaltic pump head assembly 2 is connected with one end of the protein a immunoadsorption column 4, and the other end of the peristaltic pump head assembly 2 and the other end of the protein a immunoadsorption column 4 are respectively used for being connected with a drainage tube 5.
In this embodiment, the first mounting groove 101 and the second mounting groove 102 are disposed on the main machine 1 and are used for respectively mounting the peristaltic pump head assembly 2 and the protein a immunoadsorption column 4, the flow rate of the pumped cerebrospinal fluid is controlled by the peristaltic pump head assembly 2, and the target protein in the cerebrospinal fluid is adsorbed and purified by the protein a immunoadsorption column 4 and then is re-input into the patient, so as to complete the circulation. Meanwhile, as the pipeline in the peristaltic pump head assembly 2 is extruded by high strength for a long time, the self elastic recovery is influenced after the extrusion, the uniformity of the inner diameter of the pipeline is influenced, the conveying precision of the peristaltic pump is influenced, and the pipeline is repeatedly used and has cross infection risk, therefore, the peristaltic pump head assembly 2 can be quickly replaced by a doctor due to the detachable arrangement.
Since the two drainage tubes 5 cannot be too close to each other to avoid affecting the filtering effect, as another important inventive point of the present invention, the end of one of the drainage tubes 5 is fixed to the middle of the other drainage tube 5, and in some preferred schemes, the end of one of the drainage tubes 5 is at least 15cm away from the end of the other drainage tube 5. Under this design, the doctor only needs to carry out lumbar puncture once, puts into the subarachnoid space of spinal cord along the puncture port with a longer drainage tube 5 earlier, then continues to push into a shorter drainage tube 5 along the puncture port again, and the port of a shorter drainage tube 5 submerges completely in the subarachnoid space of spinal cord, and this connected mode is favorable to strengthening the intensity of a shorter drainage tube 5, makes the pipe delivery easier, need not to select two lumbar puncture positions at the waist and carries out lumbar puncture respectively.
The detachable structure of the peristaltic pump head assembly 2 can be any quick-connection structure, and is compared with a buckle structure, a spring plate structure and the like, the buckle structure is taken as an example for explanation, in the embodiment, the third mounting groove 103 is arranged inside the first mounting groove 101, and the buckles 207 matched with the third mounting groove 103 are respectively arranged on two sides of the peristaltic pump head assembly 2. During the installation, only need to aim at the locking part of two buckles 207 and press down the third mounting groove 103 and can accomplish the locking, during the dismantlement, then only need thumb and forefinger to pinch the fin of two buckles 207 respectively, can contact the locking, take out the locking part of buckle 207 from third mounting groove 103.
The peristaltic pump head assembly 2 may be any detachable assembly capable of achieving fluid extrusion and delivery, and a pump head assembly structure is provided in this embodiment, as shown in fig. 4-5, the peristaltic pump head assembly 2 includes a pump cover 201, a pump tube 202 installed inside the pump cover 201 and led out in a U-shape, and a wheel set installed at a bending section of the pump tube 202, the wheel set includes a lower cover 203 in transition fit with an open end of the pump cover 201, a fixing rod 204 is provided on a end face of the lower cover 203 facing the pump cover 201, a rotating wheel 205 is sleeved on the fixing rod 204, a coupling hole 206 matched with an output shaft 301 of the motor 3 is provided at the center of the lower cover 203, and a buckle 207 is installed on two outer side walls of the pump cover 201 in a mirror image manner. In this scheme, there is not actual fixedly between lower cover 203 and the pump cover 201, through the locking of buckle 207 with lower cover 203 and pump cover 201 lock, in the output shaft 301 of motor 3 stretched into the cavity of first mounting groove 101, drive lower cover 203 carried out rotary motion to drive dead lever 204 and swiveling wheel 205 and carry out rotary motion, carry out one-way flow in the extrusion pump line 202 cerebrospinal fluid.
Furthermore, the present embodiment proposes a connection manner between the lower cover 203 and the motor 3, in which the coupling hole 206 is hexagonal, the output shaft 301 of the motor 3 is a hexagonal shaft, and the output shaft 301 directly drives the lower cover 203 to rotate without generating friction extrusion by the way that the output shaft 301 directly contacts with the rotating wheel 205, so as to avoid the output shaft 301 and the rotating wheel 205 from slipping, which affects the conveying precision.
As another important aspect of the present invention, a pull-down resistor is embedded in the pump cover 201, lead wires are provided at both ends of the pull-down resistor, end portions of the two lead wires are led out from an end surface of the open end of the pump cover 201 to form a first contact 2011 and a second contact 2012, respectively, and a first detection contact 1011 and a second detection contact 1012 are provided in the first mounting groove 101, which overlap with the first contact 2011 and the second contact 2012, respectively. In the scheme, the pull-down resistor is embedded in the pump cover 201, and the wires at two ends of the pull-down resistor are led out to form the first contact 2011 and the second contact 2012 to serve as detection points for judging whether the pump cover 201 is fastened in place, meanwhile, the first installation groove 101 is internally provided with the first detection contact 1011 and the second detection contact 1012, positions of the first detection contact 2011 and positions of the second detection contact 2012 correspond to those of the first contact 2011 and the second contact 2012 respectively, when the buckle 207 and the third installation groove 103 are locked, the first contact 2011 is in contact with the first detection contact 1011 or the second detection contact 1012, the second contact 2012 is in contact with the second detection contact 1012 or the first detection contact, the whole peristaltic pump head assembly 2 is not limited in the forward and reverse directions, and the detection function can be realized on the basis that the buckle 207 is fastened in place.
In this embodiment, a first detection contact 1011 in the first mounting groove 101 is connected to a first pin of a control module disposed inside the host 1, and the first pin inputs a high level signal, so that the first detection contact 1011 is at a high level at this time, if the first detection contact 1011 and the first contact 2011 are in normal contact, the high level signal is input to the first contact 2011, and after voltage division by a pull-down resistor, the second contact 2012 outputs a low level signal, so that the second detection contact 1012 in contact with the second contact 2012 is also at a low level, the second detection contact 1012 is connected to a second pin of the control module, the control module queries a level state of the second pin in real time, and if the second pin is at a low level, it is proved that the pump cover 201 is fastened in place, and the control module controls the motor 3 to operate according to a predetermined rotation speed. If the second pin is always at a high level (the suspension pin is at a high level), it is proved that at least one of the first detection contact 1011 or the second detection contact 1012 is not smoothly contacted with the first contact 2011 or the second contact 2012, and the high level output by the first detection contact 1011 cannot be reduced by the pull-down resistor, so that the second detection contact 1012 does not receive a low level signal, which indicates that the pump cover 201 is not fastened in place, the control module needs to cut off the power supply of the motor 3, thereby preventing the peristaltic pump head assembly 2 from falling off and the motor 3 from continuing to operate and burying a potential safety hazard. The control module can be any MCU, and the first pin and the second pin are any two pins in the MCU.
The protein a immunoadsorption column 4 may be installed in the second installation groove 102 by interference fit, in order to protect the protein a immunoadsorption column 4, in some optional embodiments, a hinge type baffle 1021 is provided at one side of an opening end of the second installation groove 102, the hinge type baffle 1021 protects the protein a immunoadsorption column 4 from being directly impacted and broken by an external force, and when the protein a immunoadsorption column 4 needs to be replaced, the protein a immunoadsorption column 4 can be taken out from the second installation groove 102 only by opening the hinge type baffle 1021.
This embodiment has proposed an optional scheme and has been used for optimizing the setting of two drainage tubes 5, in this scheme, one side of first mounting groove 101 is provided with the first drainage tube holding tank 104 of intercommunication, one side of second mounting groove 102 is provided with the second drainage tube holding tank 105 of intercommunication, the opening syntropy of first drainage tube holding tank 104 and second drainage tube holding tank 105, two drainage tubes 5 of receiving peristaltic pump head subassembly 2 and albumen A immunoadsorption post 4, can draw forth in same direction through first drainage tube holding tank 104 and second drainage tube holding tank 105 respectively, this scheme is the optimization that the combination scheme of foretell two drainage tubes 5 goes on, can guide, protect two drainage tubes 5, be difficult for excessive folding in the use, lead to extracting cerebrospinal fluid failure.
In the above scheme, because first mounting groove 101 needs to occupy a large amount of spaces of host computer 1 and is used for holding peristaltic pump head assembly 2, simultaneously in order to reduce the size of host computer 1, motor 3 installs at the back of first mounting groove 101, and for further protecting exposed motor 3, the week side of motor 3 is provided with safety cover 6, avoids motor 3 to suffer external force collision and leads to failing. More preferably, the outside of host computer 1 still is provided with the fixed band for fix host computer 1 on patient, the patient can the free activity in the postoperative, needn't lie in bed for a long time.
Example two
The embodiment provides a control method of a cerebrospinal fluid immunoadsorption device, which is used for the cerebrospinal fluid immunoadsorption device of the embodiment one, and the method comprises the following steps:
a high level signal is input to the first detection contact 1011, the level state of the second detection contact 1012 is continuously detected, if the level state of the second detection contact 1012 is a low level, the driving motor 3 operates at a constant speed according to a preset rotation speed, and if the level state of the second detection contact 1012 is a high level, the power input of the motor 3 is cut off.
In the following example of this embodiment, a first detection contact 1011 in the first mounting groove 101 is connected to a first pin of a control module disposed inside the host 1, and the first pin inputs a high level signal, so that the first detection contact 1011 is at a high level at this time, if the first detection contact 1011 and the first contact 2011 are in normal contact, the high level signal is input to the first contact 2011, and after voltage division by a pull-down resistor, the second contact 2012 outputs a low level, so that a second detection contact 1012 in contact with the second contact 2012 is also at a low level, the second detection contact 1012 is connected to a second pin of the control module, the control module queries a level state of the second pin in real time, and if the second pin is at a low level, it is proved that the pump cover 201 is already buckled in place, and the control module controls the motor 3 to operate according to a predetermined rotation speed. If the second pin is always at a high level (the suspension pin is at a high level), it is proved that at least one of the first detection contact 1011 or the second detection contact 1012 is not smoothly contacted with the first contact 2011 or the second contact 2012, and the high level output by the first detection contact 1011 cannot be reduced by the pull-down resistor, so that the second detection contact 1012 does not receive a low level signal, which indicates that the pump cover 201 is not fastened in place, the control module needs to cut off the power supply of the motor 3, thereby preventing the peristaltic pump head assembly 2 from falling off and the motor 3 from continuing to operate and burying a potential safety hazard. The control module can be any MCU, and the first pin and the second pin are any two pins in the MCU.
In the description herein, references to the description of the term "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above are not necessarily intended to refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, various embodiments or examples and features of different embodiments or examples described in this specification can be combined and combined by one skilled in the art without contradiction.
The above embodiments are only for illustrating the technical concept and features of the present invention, and the purpose thereof is to enable those skilled in the art to understand the contents of the present invention and implement the present invention accordingly, and not to limit the protection scope of the present invention accordingly. All equivalent changes or modifications made in accordance with the spirit of the present disclosure are intended to be covered by the scope of the present disclosure.
Claims (10)
1. The utility model provides a cerebrospinal fluid immunoadsorption device, includes the host computer, its characterized in that, one of them side of host computer is equipped with first mounting groove and the second mounting groove that communicates each other respectively, demountable installation has peristaltic pump head subassembly in the first mounting groove, the back of first mounting groove install with peristaltic pump head subassembly complex motor, demountable installation has albumen A immunoadsorption post in the second mounting groove, wherein one end of peristaltic pump head subassembly with the wherein one end of albumen A immunoadsorption post is connected, the other end of peristaltic pump head subassembly with the other end of albumen A immunoadsorption post is used for being connected with the drainage tube respectively.
2. The cerebrospinal fluid immunoadsorption device of claim 1, wherein the end of one of said drainage tubes is fixed to the middle of the other of said drainage tubes.
3. The cerebrospinal fluid immunoadsorption device according to claim 1, wherein a third mounting groove is provided inside the first mounting groove, and both sides of the peristaltic pump head assembly are respectively provided with a buckle which is matched with the third mounting groove.
4. The cerebrospinal fluid immunoadsorption device according to claim 3, wherein the peristaltic pump head assembly comprises a pump cover, a pump tube installed inside the pump cover and leading out in a U-shape, and a wheel set installed at a bending section of the pump tube, the wheel set comprises a lower cover in transition fit with an opening end of the pump cover, a fixing rod is arranged at one end face of the lower cover opposite to the pump cover, a rotating wheel is sleeved on the fixing rod, and a coupling hole matched with an output shaft of the motor is formed in the center of the lower cover.
5. The cerebrospinal fluid immunoadsorption device of claim 4, wherein the coupling hole is hexagonal and the output shaft of the motor is a hexagonal shaft.
6. The cerebrospinal fluid immunoadsorption device according to claim 4, wherein a pull-down resistor is embedded inside the pump cover, wires are disposed at both ends of the pull-down resistor, ends of the two wires are led out from an end face of the open end of the pump cover to form a first contact and a second contact, respectively, and a first detection contact and a second detection contact are disposed in the first mounting groove and coincide with the first contact and the second contact, respectively.
7. The cerebrospinal fluid immunoadsorption device of claim 1, wherein a hinge-type baffle is disposed at one side of the open end of the second mounting groove.
8. The cerebrospinal fluid immunoadsorption device of claim 1, wherein one side of the first mounting groove is provided with a first drainage tube receiving groove communicated therewith, one side of the second mounting groove is provided with a second drainage tube receiving groove communicated therewith, and openings of the first drainage tube receiving groove and the second drainage tube receiving groove are in the same direction.
9. The cerebrospinal fluid immunoadsorption device of claim 1, wherein a protective cover is disposed around the motor.
10. A method for controlling a cerebrospinal fluid immunoadsorption device according to claim 6, comprising the steps of:
and inputting a high level signal to the first detection contact, continuously detecting the level state of the second detection contact, driving the motor to operate at a constant speed according to a preset rotating speed if the level state of the second detection contact is a low level, and cutting off the power supply input of the motor if the level state of the second detection contact is a high level.
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Citations (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07313589A (en) * | 1994-05-27 | 1995-12-05 | Nissho Corp | Dialyzing liquid control device for blood dialyzing device |
| KR19990046985A (en) * | 1997-12-02 | 1999-07-05 | 구자홍 | Pump of In Vitro Blood Treatment System |
| CN1674955A (en) * | 2002-08-13 | 2005-09-28 | 阿尔比奥技术公司 | Selective plasma exchange therapy |
| CN2817856Y (en) * | 2005-06-23 | 2006-09-20 | 王拥军 | Cerebrospinal fluid purifier |
| CN2822644Y (en) * | 2005-07-13 | 2006-10-04 | 缪志俊 | Protein A immunoadsorbent system |
| WO2007001915A2 (en) * | 2005-06-20 | 2007-01-04 | Scantibodies Laboratory, Inc. | Methods and devices for removing pathogens and detrimental substances from bodily fluids |
| CN201679696U (en) * | 2010-05-28 | 2010-12-22 | 桂林市啄木鸟医疗器械有限公司 | Peristaltic pump head |
| US20110004142A1 (en) * | 2000-03-24 | 2011-01-06 | Matson James R | Hemofiltration methods for treatment of diseases in a mammal |
| US20120060622A1 (en) * | 2010-09-10 | 2012-03-15 | Carolyn Anne Harris | Systems and methods for simulating flow of cerebrospinal fluid |
| CN105464952A (en) * | 2015-12-10 | 2016-04-06 | 威海威高血液净化制品有限公司 | Peristaltic pump |
| CN107789679A (en) * | 2016-08-30 | 2018-03-13 | 张小曦 | A kind of extraventricular drainage and hematoma clearance device |
| CN110575573A (en) * | 2019-09-24 | 2019-12-17 | 福建医科大学附属第一医院 | Disposable pipeline installation system for continuous purification treatment of artificial cerebrospinal fluid |
| CN110585504A (en) * | 2019-10-22 | 2019-12-20 | 常州市第一人民医院 | Improved protein A immunoadsorption column |
| CN110624150A (en) * | 2019-10-24 | 2019-12-31 | 常州市第一人民医院 | Plasma separation protein A immunoadsorption device |
| CN111450234A (en) * | 2020-04-07 | 2020-07-28 | 中山大学附属第三医院 | Application of normal saline and serum antibody adsorbent in preparation of medicine for treating autoimmune encephalitis |
| US20210052866A1 (en) * | 2017-08-04 | 2021-02-25 | Aethlon Medical, Inc. | Multiplex cerebrospinal fluid processing system |
| CN112654387A (en) * | 2018-07-02 | 2021-04-13 | 米奈特朗尼克斯神经有限公司 | Systems, catheters and methods for treatment along the central nervous system |
| CN112657004A (en) * | 2020-12-17 | 2021-04-16 | 中南大学 | Protein immunoadsorption device based on rotation mechanism |
| CN113038331A (en) * | 2021-03-25 | 2021-06-25 | 华勤技术股份有限公司 | Method and device for detecting wireless earphone in and out box |
| CN215256719U (en) * | 2021-04-21 | 2021-12-21 | 广东诗奇制造有限公司 | Peristaltic pump |
| CN113975512A (en) * | 2021-11-29 | 2022-01-28 | 中国人民解放军东部战区总医院 | Plasma treatment device for reducing volume load of patient |
-
2022
- 2022-04-24 CN CN202210459884.1A patent/CN115025376B/en active Active
Patent Citations (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07313589A (en) * | 1994-05-27 | 1995-12-05 | Nissho Corp | Dialyzing liquid control device for blood dialyzing device |
| KR19990046985A (en) * | 1997-12-02 | 1999-07-05 | 구자홍 | Pump of In Vitro Blood Treatment System |
| US20110004142A1 (en) * | 2000-03-24 | 2011-01-06 | Matson James R | Hemofiltration methods for treatment of diseases in a mammal |
| CN1674955A (en) * | 2002-08-13 | 2005-09-28 | 阿尔比奥技术公司 | Selective plasma exchange therapy |
| WO2007001915A2 (en) * | 2005-06-20 | 2007-01-04 | Scantibodies Laboratory, Inc. | Methods and devices for removing pathogens and detrimental substances from bodily fluids |
| CN2817856Y (en) * | 2005-06-23 | 2006-09-20 | 王拥军 | Cerebrospinal fluid purifier |
| CN2822644Y (en) * | 2005-07-13 | 2006-10-04 | 缪志俊 | Protein A immunoadsorbent system |
| CN201679696U (en) * | 2010-05-28 | 2010-12-22 | 桂林市啄木鸟医疗器械有限公司 | Peristaltic pump head |
| US20120060622A1 (en) * | 2010-09-10 | 2012-03-15 | Carolyn Anne Harris | Systems and methods for simulating flow of cerebrospinal fluid |
| CN105464952A (en) * | 2015-12-10 | 2016-04-06 | 威海威高血液净化制品有限公司 | Peristaltic pump |
| CN107789679A (en) * | 2016-08-30 | 2018-03-13 | 张小曦 | A kind of extraventricular drainage and hematoma clearance device |
| US20210052866A1 (en) * | 2017-08-04 | 2021-02-25 | Aethlon Medical, Inc. | Multiplex cerebrospinal fluid processing system |
| CN112654387A (en) * | 2018-07-02 | 2021-04-13 | 米奈特朗尼克斯神经有限公司 | Systems, catheters and methods for treatment along the central nervous system |
| CN110575573A (en) * | 2019-09-24 | 2019-12-17 | 福建医科大学附属第一医院 | Disposable pipeline installation system for continuous purification treatment of artificial cerebrospinal fluid |
| CN110585504A (en) * | 2019-10-22 | 2019-12-20 | 常州市第一人民医院 | Improved protein A immunoadsorption column |
| CN110624150A (en) * | 2019-10-24 | 2019-12-31 | 常州市第一人民医院 | Plasma separation protein A immunoadsorption device |
| CN111450234A (en) * | 2020-04-07 | 2020-07-28 | 中山大学附属第三医院 | Application of normal saline and serum antibody adsorbent in preparation of medicine for treating autoimmune encephalitis |
| CN112657004A (en) * | 2020-12-17 | 2021-04-16 | 中南大学 | Protein immunoadsorption device based on rotation mechanism |
| CN113038331A (en) * | 2021-03-25 | 2021-06-25 | 华勤技术股份有限公司 | Method and device for detecting wireless earphone in and out box |
| CN215256719U (en) * | 2021-04-21 | 2021-12-21 | 广东诗奇制造有限公司 | Peristaltic pump |
| CN113975512A (en) * | 2021-11-29 | 2022-01-28 | 中国人民解放军东部战区总医院 | Plasma treatment device for reducing volume load of patient |
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