CN220478193U - Polymer microsphere adsorption equipment with gas vent - Google Patents

Abstract

The utility model discloses a high polymer microsphere adsorption device with an exhaust port, which can effectively adjust the air pressure balance in an adsorption column through the arrangement of an exhaust pipe and an exhaust valve, ensure the uniform distribution and adsorption effect of high polymer microspheres, avoid the generation of partial overpressure or negative pressure, improve the performance and service life of the adsorption column, reduce the difficulty and risk of operation, effectively eliminate the redundant gas generated in the column, avoid the problems of breakage, falling, deformation or loss of pore structure and the like caused by the impact or compression of gas on a high polymer microsphere layer, and can select proper high polymer microsphere types and proportions according to different adsorption targets and conditions by using various high polymer microspheres with different types or the same types as fillers, thereby improving the adsorption efficiency and selectivity, realizing the separation and purification of various substances, facilitating the cleaning and maintenance, having high tightness and effectively improving the efficiency and accuracy of the adsorption column.

Description

Polymer microsphere adsorption equipment with gas vent

Technical Field

The utility model relates to the technical field of polymer microspheres, in particular to a polymer microsphere adsorption device with an exhaust port.

Background

The polymer microsphere is a tiny particle made of polymer materials, has the advantages of large specific surface area, strong adsorptivity, good mechanical property, convenient recycling and the like, and is widely applied to the fields of biochemistry, electrochemical detection, catalysts, adsorbents, chromatographic fillers, coatings and the like. The polymer microsphere has various types and structures and can be designed and prepared according to different requirements and purposes. The polymer microsphere adsorption column is an adsorption device using polymer microspheres as a filler, and can be used for effectively removing or enriching pollutants such as organic matters, inorganic matters, heavy metals and the like in water or gas. The performance and effect of the polymeric microsphere adsorption column mainly depend on factors such as the types, particle sizes, pore structures, surface functional groups and the like of the polymeric microspheres.

At present, various types of polymer microsphere adsorption columns have been developed and applied, such as polystyrene microsphere adsorption columns, polystyrene nanoparticle adsorption columns, latex microsphere adsorption columns, amino polystyrene microsphere adsorption columns, carboxyl polystyrene microsphere adsorption columns, streptavidin polystyrene microsphere adsorption columns, porous polystyrene microsphere adsorption columns, polystyrene fluorescent microsphere adsorption columns and the like.

However, the existing polymeric microsphere adsorption columns still have some defects, such as:

1. in the use process, the friction force between the polymer microspheres or between the polymer microspheres and the pipe wall is easy to cause the breakage or the falling of the polymer microspheres, so that the adsorption efficiency is reduced or a pipeline is blocked, or the compression or the deformation of the polymer microspheres is easy to cause the change or the loss of a pore structure due to the impact force of water flow or air flow, so that the adsorption performance is influenced;

2. in the use process, because substances such as impurities or foam are contained in water flow or air flow, the pollution or accumulation of the polymer microspheres is easy to cause, the adsorption effect is influenced, or because the temperature of the water flow or air flow is changed, the shrinkage or expansion of the polymer microspheres is easy to cause, the adsorption stability is influenced, or because the pressure of the water flow or air flow is changed, the discharge or backflow of the polymer microspheres is easy to cause, and the adsorption continuity is influenced.

3. After the adsorbent is poured into the column, certain air bubbles which are difficult to empty are always formed in the column, and the air bubbles can not be completely emptied through various methods, such as an adsorption column applied to blood perfusion, after the air bubbles in the column enter human blood vessels in the treatment process, the air embolism of the blood vessels can be caused, the air enters central veins and even the air embolism of right heart and pulmonary arteries can be caused, and serious cases are difficult to avoid being killed even in time rescue, so that iatrogenic medical accidents are caused.

In view of this, a polymeric microsphere adsorption apparatus having an exhaust port has been designed.

Disclosure of Invention

The present utility model is directed to a polymeric microsphere adsorption apparatus having an exhaust port, and is intended to solve the problems of the conventional polymeric microsphere adsorption apparatus proposed in the prior art.

In order to achieve the above purpose, the utility model provides a technical scheme that a macromolecule microsphere adsorption device with an exhaust port comprises a middle column body, two groups of outer column bodies and a microsphere bearing mechanism;

the top of the middle column body is fixedly connected with an exhaust pipe, an exhaust valve is arranged on the exhaust pipe, a clamping block is fixedly connected to the inner bottom of the middle column body, and mounting rings are fixedly connected to the two sides of the middle column body;

the two groups of outer cylinders are respectively connected to two sides of the middle cylinder, the bottom of one group of outer cylinders is fixedly connected with a pipe inlet, the top of the other group of outer cylinders is fixedly connected with a calandria, and one side, close to the two groups of outer cylinders, of each outer cylinder is provided with a mounting disc;

the microsphere bearing mechanism comprises an outer filter shell, a plurality of groups of inner filter plates and a top cover, wherein:

the outer filter shell is connected in the middle column;

a plurality of groups of inner filter plates are fixedly connected with the inner side of the outer filter shell at equal intervals;

the top cover is connected to the top of the outer filter shell;

the mounting plate is connected with a sealing rubber ring between the mounting rings, a plurality of groups of fastening bolts are connected in the mounting plate, the mounting rings and the sealing rubber ring in a penetrating mode, and nuts are connected with the fastening bolts through threaded structures.

Preferably, a cuboid groove matched with the clamping block is formed in the bottom of the outer filter shell, and the top of the outer filter shell is of an opening structure.

Preferably, one side of the mounting plate far away from the outer column body is integrally connected with a first bulge, and the mounting plate and the first bulge are internally communicated with each other to form a communication hole.

Preferably, the two sides of the mounting ring are fixedly connected with second bulges, and the inner diameter length of the second bulges is matched with the outer diameter length of the first bulges.

Preferably, the outer filter shell is filled with polymer microspheres, and the polymer microspheres include, but are not limited to, polystyrene microspheres, polystyrene nanoparticles, latex microspheres, amino polystyrene microspheres, carboxyl polystyrene microspheres, streptavidin polystyrene microspheres, porous polystyrene microspheres, polystyrene fluorescent microspheres and the like.

Compared with the prior art, the utility model has the beneficial effects that:

1. the high polymer microsphere adsorption device with the exhaust port can effectively adjust the air pressure balance inside the adsorption column through the arrangement of the exhaust pipe and the exhaust valve, ensure the uniform distribution and adsorption effect of the high polymer microsphere, avoid the generation of local overpressure or negative pressure, improve the performance and service life of the adsorption column, and reduce the operation difficulty and risk;

2. the macromolecule microsphere adsorption device with the exhaust port can effectively remove redundant gas generated in the cylinder through the arrangement of the exhaust pipe and the exhaust valve, and avoid the problems of crushing, falling, deformation or loss of pore structures and the like caused by the impact or compression of the gas on the macromolecule microsphere layer;

3. according to the high polymer microsphere adsorption device with the exhaust port, by using a plurality of high polymer microspheres with different types or the same type as a filler, the proper types and proportions of the high polymer microspheres can be selected according to different adsorption targets and conditions, so that the adsorption efficiency and selectivity are improved, and the separation and purification of various substances are realized;

4. the high polymer microsphere adsorption device with the exhaust port is simple to assemble and disassemble, convenient to clean and maintain, high in tightness and capable of effectively improving the efficiency and accuracy of the adsorption column.

Drawings

FIG. 1 is an isometric view of a polymeric microsphere adsorption apparatus having an exhaust port according to the present utility model;

FIG. 2 is a front view of a polymeric microsphere adsorption apparatus having an exhaust port according to the present utility model;

FIG. 3 is a front sectional view of a polymeric microsphere adsorption apparatus having an exhaust port according to the present utility model;

FIG. 4 is a cross-sectional exploded view of a front structure of a polymeric microsphere adsorption device having an exhaust port according to the present utility model;

FIG. 5 is a partial front sectional exploded view of a polymeric microsphere adsorption device having an exhaust port according to the present utility model;

FIG. 6 is a partial front sectional view of a polymeric microsphere adsorption device having an exhaust port according to the present utility model;

FIG. 7 is a partial side view of a polymeric microsphere adsorption apparatus having an exhaust port according to the present utility model.

In the figure:

1. a middle column; 2. an outer cylinder; 3. feeding a pipe;

4. a calandria; 5. an exhaust pipe; 6. a clamping block;

7. a microsphere bearing mechanism; 701. an outer filter shell; 702. an inner filter plate;

703. a top cover;

8. a mounting plate; 801. a first protrusion; 802. a communication hole;

9. a mounting ring; 901. a second protrusion;

10. sealing rubber rings;

11. a fastening bolt; 12. and (3) a nut.

Detailed Description

The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.

In the description of the present utility model, it should be noted that the directions or positional relationships indicated by the terms "upper", "lower", "inner", "outer", "front", "rear", "both ends", "one end", "the other end", etc. are based on the directions or positional relationships shown in the drawings, are merely for convenience of describing the present utility model and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a specific direction, be configured and operated in the specific direction, and thus should not be construed as limiting the present utility model. Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.

In the description of the present utility model, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "provided," "connected," and the like are to be construed broadly, and may be fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present utility model will be understood in specific cases by those of ordinary skill in the art.

Referring to fig. 1-7, the present utility model provides a technical solution: a high molecular microsphere adsorption device with an exhaust port comprises a middle column 1, two groups of outer columns 2 and a microsphere bearing mechanism 7.

Specifically, the middle column 1 is a cylindrical structure, both ends of the middle column 1 are both open structures, the outer column 2 is a hollow structure, and materials of the middle column 1 and the outer column 2 include, but are not limited to, stainless steel, plastics, glass or ceramics, and the like.

The top fixedly connected with blast pipe 5 of middle cylinder 1, install discharge valve on the blast pipe 5, the interior bottom fixedly connected with fixture block 6 of middle cylinder 1, the both sides of middle cylinder 1 are all fixedly connected with collar 9. Specifically, through the setting of blast pipe 5 and discharge valve, can adjust the inside atmospheric pressure balance of adsorption column effectively, guarantee the evenly distributed and the adsorption effect of polymer microballon, avoid the production of local excessive pressure or negative pressure, improve the performance and the life-span of adsorption column, reduce the degree of difficulty and the risk of operation to through the setting of blast pipe 5 and discharge valve, can get rid of the unnecessary gas that the cylinder is inside effectively, avoid polymer microballon layer to receive the gas impact or compress and lead to broken, drop, deformation or loss pore structure scheduling problem.

The two groups of outer cylinders 2 are respectively connected to two sides of the middle cylinder 1, wherein the bottom of one group of outer cylinders 2 is fixedly connected with a pipe inlet 3, the top of the other group of outer cylinders 2 is fixedly connected with a calandria 4, and one side, close to the two groups of outer cylinders 2, is internally provided with a mounting disc 8;

the microsphere bearing mechanism 7 comprises an outer filter shell 701, a plurality of groups of inner filter plates 702 and a top cover 703, wherein:

the outer filter housing 701 is connected in the middle column 1;

a plurality of groups of inner filter plates 702 are fixedly connected to the inner side of the outer filter housing 701 at equal intervals;

a top cover 703 is attached to the top of the outer filter housing 701.

A cuboid groove matched with the clamping block 6 is formed in the bottom of the outer filter shell 701, and the top of the outer filter shell 701 is of an opening structure. Specifically, referring to fig. 3-4 of the specification and fig. 7 of the specification, the clamping block 6 is of a cuboid structure, and has a positioning function on the installation of the outer filter housing 701 through the function of the clamping block 6, and the outer filter housing 701 is prevented from rotating in the middle column 1, so that the installation stability of the outer filter housing 701 is improved.

A sealing rubber ring 10 is connected between the mounting plate 8 and the mounting ring 9, a plurality of groups of fastening bolts 11 are connected in the mounting plate 8, the mounting ring 9 and the sealing rubber ring 10 in a penetrating way, and the fastening bolts 11 are connected with nuts 12 through threaded structures. Specifically, when the mounting plate 8 is connected with the mounting ring 9, a circular area is formed among the mounting plate 8, the mounting ring 9, the first protrusion 801 and the second protrusion 901, the sealing rubber ring 10 is connected in the circular area, and the sealing rubber ring 10 is matched with the shape of the circular area, so that the tightness of the connection part of the mounting plate 8 and the mounting ring 9 is effectively improved through the sealing rubber ring 10, namely, the tightness of the connection part of the middle column 1 and the outer column 2 is improved.

The mounting plate 8 is connected with a first protrusion 801 integrally on one side far away from the outer column 2, and a communication hole 802 is formed in the mounting plate 8 and the first protrusion 801 in a penetrating manner. Specifically, the outer cylinder 2 is communicated with the inner cylinder 1 by the arrangement of the communication hole 802.

The two sides of the mounting ring 9 are fixedly connected with second bulges 901, and the inner diameter length of each second bulge 901 is matched with the outer diameter length of each first bulge 801. Specifically, when the mounting plate 8 is connected with the mounting ring 9, the inner wall of the second protrusion 901 is connected with the surface of the first protrusion 801, and the stability and the tightness of the connection between the mounting plate 8 and the mounting ring 9 are improved by the action of the first protrusion 801 and the second protrusion 901.

Specifically, the outer filter housing 701 and the top cover 703 are combined into a cylindrical housing structure, the combined height of the outer filter housing 701 and the top cover 703 is matched with the inner diameter length of the middle cylinder 1, when the outer filter housing 701 and the top cover 703 are installed in the middle cylinder 1, the top cover 703 has a limiting protection function on the top opening of the outer filter housing 701, two groups of first protrusions 801 are tightly pressed on two sides of the outer filter housing 701 and the top cover 703, liquid is input into an outer cylinder 2 connected with the outer filter housing from the inlet pipe 3, then is input into the middle cylinder 1 through a communication hole 802, and then is discharged through another group of outer cylinders 2 and a calandria 4.

The outer filter housing 701 is filled with polymer microspheres including, but not limited to, polystyrene microspheres, polystyrene nanoparticles, latex microspheres, aminopolystyrene microspheres, carboxyl polystyrene microspheres, streptavidin polystyrene microspheres, porous polystyrene microspheres, polystyrene fluorescent microspheres, and the like. Specifically, by using a plurality of polymer microspheres of different types or the same type as the filler, the types and proportions of the polymer microspheres can be selected appropriately according to different adsorption targets and conditions, the adsorption efficiency and selectivity are improved, and the separation and purification of a plurality of substances are realized.

Specifically, the exhaust valve on the exhaust pipe 5 may be an electromagnetic valve, an overflow valve or a needle valve, etc., the exhaust pipe 5 may be provided with a pressure sensor for detecting the pressure of the gas in the exhaust pipe 5 and the middle cylinder 1 and transmitting the detected signal to a controller, the controller may be disposed outside the device, the controller controls the opening and closing of the exhaust valve according to the detected signal of the pressure sensor, when detecting that the pressure of the gas in the exhaust pipe 5 exceeds a set value, the controller opens the exhaust valve to exhaust the redundant gas from the exhaust pipe 5, and when detecting that the pressure of the gas in the exhaust pipe 5 is lower than the set value, the controller closes the exhaust valve to maintain the pressure balance in the cylinder, and the exhaust valve, the pressure sensor, the controller, etc. are not described in detail herein.

Example 1:

the exhaust pipe 5 is provided with an electromagnetic valve and a pressure sensor, the electromagnetic valve is used for controlling the gas flow in the exhaust pipe 5, the pressure sensor is used for detecting the gas pressure in the exhaust pipe 5, and a detection signal is transmitted to a controller;

connecting a controller with the electromagnetic valve and the pressure sensor, controlling the switch of the electromagnetic valve according to the detection signal of the pressure sensor, and opening the electromagnetic valve by the controller when detecting that the gas pressure in the exhaust pipe 5 exceeds 0.5 bar, and discharging redundant gas from the exhaust pipe 5; when the gas pressure in the exhaust pipe 5 is detected to be lower than 0.5 bar, the controller closes the electromagnetic valve, and the pressure balance in the cylinder is kept;

two different types of polymer microspheres are selected as fillers, one is polystyrene microsphere with the particle size of 0.5 mu m, the other is carboxyl polystyrene microsphere with the particle size of 1 mu m, the polystyrene microsphere and the carboxyl polystyrene microsphere are uniformly mixed according to the proportion of 1:1 to obtain mixed polymer microsphere, the mixed polymer microsphere is filled in an outer filter shell 701, a plurality of groups of inner filter plates 702 are used for separating polymer microsphere layers into a plurality of layers, and the thickness of each polymer microsphere layer is 5cm.

The inlet pipe 3 of the adsorption column is connected to the liquid supply device, and the discharge pipe 4 of the adsorption column is connected to the collector.

Example 2:

protein purification experiments were performed using the polymeric microsphere adsorption column with vent prepared in example 1, which were as follows:

step 1: selecting an aqueous solution containing target protein (BSA) and impurity protein (IgG) as a sample solution, wherein the concentration of the BSA and the IgG in the sample solution is 10 mug/ml;

step 2: passing the sample solution through an adsorption column at a speed of 0.1ml/min, and collecting effluent at a water outlet;

step 3: measuring the concentration of BSA and IgG in the effluent by using an ultraviolet spectrophotometer, and calculating the adsorption rate and selectivity of the adsorption column to the BSA and IgG;

step 4: desorbing BSA and IgG adsorbed on the polymer microsphere by using 0.1M NaOH solution at a speed of 0.1ml/min through an adsorption column, and collecting desorption liquid;

step 5: measuring the concentration of BSA and IgG in the desorption liquid by using an ultraviolet spectrophotometer, and calculating the desorption rate and selectivity of the adsorption column to the BSA and IgG;

repeating the steps 2-5, performing multiple circulation experiments, and observing the stability and the reproducibility of the adsorption column.

Experimental results show that the high-molecular microsphere adsorption column with the exhaust port prepared in the embodiment 1 has higher adsorption rate and selectivity on BSA and IgG, and the performance of the high-molecular microsphere adsorption column is not obviously reduced after a plurality of circulating experiments, so that the high-molecular microsphere adsorption column has good stability and reproducibility.

Specific data for the one-cycle experiment are shown below:

at cycle number 1, BSA adsorption (%), igG adsorption (%), BSA/IgG selectivity were 95.6, 12.4, and 7.71, respectively;

at cycle number 2, the BSA adsorption rate (%), the IgG adsorption rate (%), and the BSA/IgG selectivity were 94.8, 11.9, and 7.97, respectively;

at cycle number 3, the BSA adsorption rate (%) and the BSA/IgG selectivity were 94.2, 11.5 and 8.19, respectively;

at cycle number 4, the BSA adsorption rate (%) and the BSA/IgG selectivity were 93.7, 11.2 and 8.37, respectively;

at cycle number 5, the BSA adsorption rate (%) and the BSA/IgG adsorption rate (%) were 93.3, 10.9 and 8.56, respectively.

Specific data for the secondary cycling experiments are shown below:

at cycle number 1, BSA adsorption (%), igG adsorption (%), BSA/IgG selectivity were 92.4, 8.6, and 10.74, respectively;

at cycle number 2, BSA adsorption (%), igG adsorption (%), BSA/IgG selectivity were 91.9, 8.3, 11.08, respectively;

at cycle number 3, BSA adsorption (%), igG adsorption (%), BSA/IgG selectivity were 91.5, 8.1, 11.30, respectively;

at cycle number 4, BSA adsorption (%), igG adsorption (%), BSA/IgG selectivity were 91.1, 7.9, 11.53, respectively;

at cycle number 5, BSA adsorption (%), igG adsorption (%), and BSA/IgG selectivity were 90.8, 7.7, and 11.79, respectively.

From the above data, the polymer microsphere adsorption column with vent prepared in example 1 has higher adsorption rate and desorption rate for BSA and IgG, and BSA/IgG selectivity increases with the increase of cycle number, which shows that the polymer microsphere adsorption column has good separation effect and regeneration capability.

Although the present utility model has been described with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments described, or equivalents may be substituted for elements thereof, and any modifications, equivalents, improvements and changes may be made without departing from the spirit and principles of the present utility model.

Claims (4)

1. A polymer microsphere adsorption device with an exhaust port is characterized in that: comprises a middle column body (1), two groups of outer column bodies (2) and a microsphere bearing mechanism (7);

the top of the middle column body (1) is fixedly connected with an exhaust pipe (5), an exhaust valve is arranged on the exhaust pipe (5), a clamping block (6) is fixedly connected with the inner bottom of the middle column body (1), and mounting rings (9) are fixedly connected with the two sides of the middle column body (1);

the two groups of outer cylinders (2) are respectively connected to two sides of the middle cylinder (1), wherein the bottom of one group of outer cylinders (2) is fixedly connected with a pipe inlet (3), the top of the other group of outer cylinders (2) is fixedly connected with a pipe discharge (4), and one side, close to the two groups of outer cylinders (2), of the outer cylinders is internally provided with a mounting disc (8);

the microsphere bearing mechanism (7) comprises an outer filter shell (701), a plurality of groups of inner filter plates (702) and a top cover (703), wherein:

the outer filter shell (701) is connected in the middle column body (1);

a plurality of groups of inner filter plates (702) are fixedly connected with the inner side of the outer filter shell (701) at equal intervals;

the top cover (703) is connected to the top of the outer filter shell (701);

the mounting plate (8) and the mounting ring (9) are connected with a sealing rubber ring (10), a plurality of groups of fastening bolts (11) are connected in the mounting plate (8), the mounting ring (9) and the sealing rubber ring (10) in a penetrating mode, and the fastening bolts (11) are connected with nuts (12) through threaded structures.

2. The polymeric microsphere adsorption device with air outlet according to claim 1, wherein: rectangular grooves matched with the clamping blocks (6) are formed in the bottoms of the outer filter shells (701), and the tops of the outer filter shells (701) are of an opening structure.

3. The polymeric microsphere adsorption device with air outlet according to claim 1, wherein: one side of the mounting plate (8) far away from the outer column body (2) is integrally connected with a first bulge (801), and a communication hole (802) is formed in the mounting plate (8) and the first bulge (801) in a penetrating manner.

4. The polymeric microsphere adsorption device with air outlet according to claim 1, wherein: the two sides of the mounting ring (9) are fixedly connected with second bulges (901), and the inner diameter length of the second bulges (901) is matched with the outer diameter length of the first bulges (801).