CN201200660Y

CN201200660Y - DNA immunoadsorption column

Info

Publication number: CN201200660Y
Application number: CNU200820047982XU
Authority: CN
Inventors: 董凡
Original assignee: ZHUHAI LIZHU MEDICAL BIO-MATERIAL Co Ltd
Current assignee: Jafron Biomedical Co Ltd
Priority date: 2008-05-21
Filing date: 2008-05-21
Publication date: 2009-03-04
Anticipated expiration: 2018-05-21

Abstract

The utility model relates to a DNA immunoabsorbent column which comprises an immunoabsorbent column with a hollow filtering chamber, and two end parts of the filtering chamber corresponding to the axial direction of the immunoabsorbent column have openings; retaining nuts are respectively fixed at two end parts at the axial direction of the immunoabsorbent column through the threaded connection; the openings are covered by end covers; a blood nozzle which passes through an end cover and is communicated with the filtering chamber and the outside is arranged on the end cover; the end opening of the blood nozzle against the filtering chamber is covered with a cap; one side of the end cover against the filtering chamber is provided with a plurality of independent spherical floating points surrounding the blood nozzle and sharing the same axis with the blood nozzle at the periphery of the blood nozzle; the end surface of the cap facing to the end cover along the axial direction is provided with positioning slots of the immunoabsorbent column, and the quantity and the distribution of the positioning slots are corresponding to the spherical floating points; and the spherical floating points are pressed into the positioning slots when the cap is buckled on the blood nozzle. A perfusion device has good sealing performance and high rate of fine variety.

Description

The dna immunization adsorption column

Technical field

This utility model relates to the blood purification medical apparatus and instruments, particularly can be used to remove exogenous and endogenous poisonous substance in the human blood, adopt the disposable dna immunization adsorption column of resin material preparation, also can be referred to as dna immunization adsorber, perhaps blood perfusion device.

Background technology

Blood absorption (being hemoperfusion) is the important component part of blood purification therapy, and it is outside the blood lead body with the patient, contact with solid-state adsorbent, removes some exogenous and endogenous poisonous substance in the mode of absorption, reaches the therapeutic purposes that purify the blood.Blood absorption basic procedure is seen shown in Figure 1.

The blood of drawing through human body artery end K1 under the effect of extracorporeal circulation power set K2, enters gas trapping equipment K3 along transducer potector K71, the K72 of two sections serial connections and carries out the seizure of gas in the blood and get rid of gas by exhaustor K81.Blood after the degasification enters along transducer potector K73 and purifies assembled unit K4, and by purified treatment, diameter is bigger in the blood middle molecule or macromole toxin are eliminated.Blood after the purification arrives gas trapping equipment K5 along transducer potector K74 to carry out the secondary seizure of gas in the blood and gets rid of gas by exhaustor K82, at last, purification finishes and fully the blood after the degasification is along transducer potector K75, and K6 feeds back in the human vein blood vessel through the human vein end.

Above-mentioned purification assembled unit K4, because it directly contacts with blood of human body in therapeutic process, therefore, it is between storage, delivery period, and when specifically being applied to treat, must guarantee to recharge the clean level of the intravital blood of people and with the isolation between the external environment condition.That is to say, behind product export during be applied to treat in, purify assembled unit K4 and invade its internal work chamber can not for the external contamination thing to stay the leak that can take advantage of.This just requires to purify assembled unit K4, and especially its core component blood perfusion device should have good sealing characteristics, is subjected to the pollution of other impurity to avoid the adsorbent in its perfusion device operating room, and then influences the blood purification effect.

Moreover the blood perfusion device of current application is that raw material adopts the injection moulding mode to produce with medical Merlon usually.Like this, the perfusion device that injection moulding obtains is at the connecting portion of its different parts, usually be to need emphasis to consider to be improved the object of sealing characteristics, but because these parts in the problem that stores, can occur between the delivery period follow-up deformation, make the sealing characteristics of perfusion device occur gliding.

At last, when adopting the injection moulding mode to produce the perfusion device, the complex structure degree of its each parts often causes the sealing effectiveness of product bad, and defect rate is high, and processing difficulties.From the complexity of structure between each parts of structure angle consideration simplification of parts, the desirable technical conceive of can yet be regarded as.

The utility model content

This utility model purpose is to provide a kind of dna immunization adsorption column.This adsorption column or adsorber can improve the sealing characteristics of its blood mouth under the accumulating state effectively, and the block that can stop to be used to seal the blood mouth comes off from the blood mouth because of the slight rotating force that is tightened onto in contrast to it on blood mouth.

Dna immunization adsorption column according to the above-mentioned purpose design comprises adsorption column.Adsorption column has the filter chamber of hollow.The filter chamber is rendered as opening port corresponding to the axial both ends of adsorption column.Be fixed with locking nut respectively by screw thread butt joint form on the axial both ends of adsorption column.Opening port is sealed by end cap.End cap is provided with and runs through end cap, and is communicated with the blood mouth of filter chamber and external environment condition.The blood mouth is sealed by block back to the port of filter chamber.In the side of end cap back to the filter chamber, be provided with several independently spherical floating-points around the blood mouth, these several spherical floating-point form around the blood mouth and with the co-axial annular ring of blood mouth.Block is provided with quantity and the distribution form locating slot corresponding to spherical floating-point along the end face of adsorption column axially facing end cap.Spherical floating-point is pushed down in the locating slot at the state that block snaps on the blood mouth.

Usually, aforementioned dna immunization adsorption column, its locking nut along the end wall of the axial end of adsorption column radially middle position be provided with the transitional pore that runs through end wall.End cap is between locking nut and filter chamber.The blood mouth is holding covering position corresponding to transitional pore.

Preferably, aforementioned dna immunization adsorption column, its blood mouth axially extend outwardly out one section along adsorption column and are used for the butt joint post that connects with the external infusion pipe.Spherical floating-point is looped around around the butt joint post.

More preferably, aforementioned dna immunization adsorption column, its butt joint post radial outer periphery around with the co-axial reference column of blood mouth.This reference column is being stated the end covering position between spherical floating-point and butt joint post.

This utility model dna immunization adsorption column, under the accumulating state, need the requirement of further enhanced leaktightness characteristic at its blood mouth, and the purpose that comes off from the blood mouth because of the slight rotating force that is tightened onto in contrast to it on blood mouth of the block of stopping to be used to seal the blood mouth, by in the side of end cap back to the filter chamber, several independently spherical floating-points are set around the blood mouth, and make these several spherical floating-point form around the blood mouth and with the co-axial annular ring of blood mouth, blocking a shot along quantity and the distribution form locating slot corresponding to spherical floating-point is set on the end face of adsorption column axially facing end cap simultaneously, and keep spherical floating-point to snap into state on the blood mouth being pushed down into mode in the locating slot at block, effective state of isolation can be provided between blood mouth and external environment condition, realize the required sealing characteristics of blood mouth, can also prevent that block from coming off from the blood mouth simultaneously.

The drawing explanation

The present hemoperfusion base therapy of Fig. 1 schematic flow sheet.

Fig. 2 this utility model dna immunization adsorption column perspective view.

Fig. 3 this utility model dna immunization adsorption column STRUCTURE DECOMPOSITION perspective view one.

Fig. 4 this utility model dna immunization adsorption column STRUCTURE DECOMPOSITION perspective view two.

The capping structure decomposition diagram of Fig. 5 this utility model dna immunization adsorption column.

The block cutaway view of Fig. 6 this utility model dna immunization adsorption column.

The block of Fig. 7 this utility model dna immunization adsorption column and end wall mated condition sketch map.

The locking nut perspective view of Fig. 8 this utility model dna immunization adsorption column.

The specific embodiment

Describe this utility model dna immunization adsorption column or adsorber in detail below in conjunction with accompanying drawing.In institute's drawings attached, identical Reference numeral will be used to refer to identical parts, feature or structure.Embodiment introduce in the process at concrete structure or the parts reference illustration of only understanding this utility model dna immunization adsorber as those skilled in the art, those skilled in the art can also design under the enlightenment of this technical scheme and not exceed the various of this utility model dna immunization adsorber technology scope and essence and be equal to or the similar techniques structure.Thus; if it is unfavorable limiting the protection domain that this utility model dna immunization adsorber claim included with this exemplary illustration, be equal to or the technical scheme that is similar to this utility model dna immunization adsorber still belongs to the protection domain of this utility model dna immunization adsorber claim.And for simple and clear needs, the applicant has here omitted or has simplified description to known function and structure.

Referring to Fig. 2～8, show the configuration state and the structure matching relationship of this utility model dna immunization adsorber and associated components thereof.This adsorber A is a core apparatus of bearing exogenous and endogenous poisonous substance in the aforementioned removing blood, is the basic element of character that constitutes the purification assembled unit K4 that preamble describes.

The component parts of adsorber A comprises an adsorption column 7 and is used for sealing respectively two cover closing devices 8 of adsorption column 7 axial two-port.In the interior pipe of adsorption column 7, can be installed in various types of adsorbents according to different treatment orders, for example immunoadsorbent, acticarbon, resin sorbent etc.Two cover closing devices 8 are made of two filter screens 6, two sealing plain cushions 5, two end caps 4, two locking nuts 3 and two blocks 1 etc.Wherein, adsorption column 7, end cap 4,

locking nut

3 and 1 four members of blocking a shot all adopt medical Merlon as raw material with Shooting Technique production; Sealing plain cushion 5 and be fixed in sealed bolster 2 on the block 1 all adopt silicone rubber as raw material with Shooting Technique production; Filter screen 6 normally use nylon yarn as raw material with weaving manner production.Hereinafter the content of Jie Shaoing will be with adsorption column 7 and two covers the cover of one in the closing devices 8, promptly adsorption column 7 and filter screen 6, sealing plain cushion 5, end cap 4, a locking nut 3 and a block 1 are as description object.Present embodiment is used the reason of Merlon, be to should be it to have following characteristic, be the impact strength height, dimensional stability is good, water white transparency, coloring is good, electrical insulating property, corrosion resistance, wearability be characteristics preferably, but its self lubricity is poor, and the tendency of stress cracking is arranged, hydrolysis at high temperature takes place easily, and the intermiscibility between other resin is relatively poor.

The adsorption column 7 of adsorber A has the form of cylinder 701.The interior pipe hollow of cylinder 701, this hollow space is formed for holding the filter chamber 705 of granular adsorption agent and so on material.At the axial both ends of cylinder 701, be respectively arranged with a radially expansible column butt joint ring 702,703.On the external cylindrical surface of column butt joint ring 702,703, all be respectively arranged with outstanding external screw thread 704 outwardly.

Filter screen 6 is by fixedly obtaining after the nylon knitmesh 602 with chemical adhesive, fusion or ultra-sonic welded mode on annular framework 601.

Sealing plain cushion 5 is the annular cushion rubbers that adopt the silicone rubber preparation.

End cap 4 is shape disk and thin plates 401 corresponding to one of adsorption column 7 axial both ends.On disk and thin plate 401 sidewall 408 vertically, extend and disk and thin plate 401 co-axial column circular orientation circles 402.At disk and thin plate 401 middle position radially, be provided with the blood supply that runs through disk and thin plate 401 and starch mobile blood mouth 403.Vertically on the sidewall 409 at circular orientation circle 402 places, blood mouth 403 is along axially extend outwardly out the cylindrical butt joint post 405 of one section predetermined length of disk and thin plate 401 at disk and thin plate 401.In the radial outer periphery of butt joint post 405, around one and disk and thin plate 401 co-axial reference columns 404.The outer post jamb of reference column 404 is the vertebral body form approximately, and its end near sidewall 409 has bigger diameter.The inner wall of reference column 404 is the cylindrical cavity form.Reference column 404 is top with sidewall 409, stretches out and docks post 405 about identical length along the bearing of trend identical with butt joint post 405, and its inner cylindrical wall is provided with female thread 407.In the radial outer periphery of reference column 404, be provided with several independently spherical floating-points 406 in sidewall 409, these spherical floating-points 406 form around reference column 404 with disk and thin plate 401 co-axial annular rings (referring to Fig. 3,4,7).

Locking nut 3 is the lids with cylindric shirt rim 303, be used for sealing on the end cap 302 of corresponding container at it, in its radially medium position be provided with run through end cap 302 and with locking nut 3 co-axial circular transitional pores 304.At the periphery of transitional pore 304, in end cap 302 back to the shirt rim side of 303, be provided with the independent grooves 301 of several recessed end caps 302.These grooves 301 form around transitional pore 304 and with locking nut 3 co-axial annular rings.Groove 301 helps being released in the internal stress that produces in the injection moulding process effectively after formed product, avoids causing locking nut 3 to be out of shape and to cause the decline of adsorber A sealing effect.On the inner cylinder face of shirt rim 303, be provided with female thread 305, so that realize with the butt joint of the knob between the external screw thread 704 of aforementioned adsorption column 7 (referring to Fig. 3,4,8).

Referring to Fig. 3,4,5,6,7, block 1 is the lid with cylindric shirt rim 105, and its axial end is in open state, correspondingly constitutes opening port 107, and its opposite end is by end cap 106 sealings.The block 1 inside, from end cap 106 radially medium position along the shirt rim 105 identical directions extend the cylindrical seal post 103 of hollow.The external cylindrical surface of sealing column 103 is provided with successive

external screw thread

104,1 snap on the reference column 404 so that will block a shot by the engagement system between external screw thread 104 and the aforementioned female thread 407, and under this buckle state, keep reference column 404 position radially between shirt rim 105 and sealing column 103.Before shirt rim 105 is corresponding to block 1, state opening port 107 and on the end face that radially extends, be provided with several location-independent grooves 102 of edge block 1 axial indent.105 circumferencial direction forms and block 1 co-axial annular ring these locating slots 102 along the shirt rim.Under block 1 state that snaps on the reference column 404, the radial position of locating slot 102 is corresponding to spherical floating-point 406, so that the mode that is pressed into locating slot 102 by spherical floating-point 406 makes block 1 circumferencial direction at reference column 404 upper edge reference columns 404 obtain the location.Like this, when block 1 is screwed onto on the reference column 404, because spherical floating-point 406 is pressed into locating slot 102, the rotating force that non-warp is bigger, block 1 will be difficult to come off from reference column 404 by reverse mode of circling round.Sealed bolster 2 is fixed in the inner chamber of sealing column 103 and near end cap 106 1 sides with the interference way of contact.Sealed bolster 2 is the silicone rubber plates that have conical contact piece 202 on the axial end middle position of cylindric matrix 201.Be fixed in situation in sealing column 103 inner chambers at sealed bolster 2, the awl point of conical contact piece 202 is back to end cap 106, so that when block 1 is screwed onto on the reference column 404, conical contact piece 202 envelopes are pressed onto on the butt joint post 405 that constitutes blood mouth 403, and blood mouth 403 is sealed.

When the above-mentioned adsorber A of assembling, at first sealed bolster 2 is pressed in the sealing column 103 of block 1, make on its inner cylindrical wall that is close to end cap 106 surfaces and sealing column 103.

Subsequently one of them filter screen 6 is placed in an axial end portion of adsorption column 7.Under installment state, there is not the gap in the periphery that should keep filter screen 6 between filter screen 6 and the adsorption column 7 between the chamber wall with the filter chamber 705 of adsorption column 7, to avoid blood plasma from these gaps, to see through, cause the blood plasma of filter screen 6 both sides to confuse mutually, that is to say that the whole blood plasma that should make every effort to keep pending are filtered by the knitmesh 602 of filter screen 6.For making filter screen 6 axially obtain the location along adsorption column 7, can corresponding annular step 706 be set in the end that adsorption column 7 is laid filter screen 6, filter screen 6 is placed on this ring-shaped step 706.

Then, one of them sealing plain cushion 5 is nested with on the face of cylinder outside the circular orientation circle 402 of end cap 4.In this step, should keep usually sealing on the external cylindrical surface that plain cushion 5 is locked on circular orientation circle 402, split away off from circular orientation circle 402 to avoid sealing plain cushion 5.

Afterwards, overlay the end of laying filter screen 6 at adsorption column 7 having an end cap 4 that seals plain cushion 5, the knitmesh 602 that keeps filter screen 6 is between the filter chamber 705 and end cap 4 of adsorption column 7.Then, to the end that adsorption column 7 is laid filter screen 6, filter screen 6, sealing plain cushion 5 and end cap 4 all are fixed locking nut 3 knobs.At this stationary state, end cap 4 nut 3 that is locked overlays between adsorption column 7 and locking nut 3, and the butt joint post 405 that constitutes blood mouth 403 all reaches the outside of locking nut 3 together with reference column 404 from the transitional pore 304 of locking nut 3, make the filter chamber 705 of adsorption column 7 be able to keep being communicated with external environment condition by blood mouth 403.

Secondly, one of them is blocked a shot 1 knob to the reference column 404 that surrounds blood mouth 403.In this installment state, block 1 covers the outer end of butt joint post 405, conical contact piece 202 envelopes of sealed bolster 2 are pressed onto on the external port of butt joint post 405, make filter chamber 705 be able to be blocked, for blood mouth 403 provides good sealing at the position, place of blood mouth 403 with the connected relation between the external environment condition.

At last, an other cover closing device 8, that is its each component parts filter screen 6, sealing plain cushion 5, end cap 4,

locking nut

3 and 1 order of blocking a shot be installed to another end of adsorption column 7, can obtain complete adsorber A according to aforementioned installation step.

Claims

1.DNA immunoabsorbent column, comprise adsorption column, described adsorption column has the filter chamber of hollow, described filter chamber is rendered as opening port corresponding to the axial both ends of described adsorption column, be fixed with locking nut respectively by screw thread butt joint form on the axial both ends of described adsorption column, described opening port is sealed by end cap, described end cap is provided with the blood mouth that runs through described end cap and be communicated with described filter chamber and external environment condition, it is characterized in that described blood mouth is sealed by block back to the port of described filter chamber, be provided with several independently spherical floating-points at described end cap around back to a side of described filter chamber in described blood mouth, described several spherical floating-points form around described blood mouth and with the co-axial annular ring of described blood mouth, described block is provided with quantity and the distribution form locating slot corresponding to described spherical floating-point along the end face of the described end cap of described adsorption column axially facing, and described spherical floating-point is pushed down in the described locating slot at the state that described block snaps on the described blood mouth.

2. according to the described dna immunization adsorption column of claim 1, it is characterized in that described locking nut along the end wall of the axial end of described adsorption column radially middle position be provided with the transitional pore that runs through described end wall, described end cap between described locking nut and described filter chamber, described blood mouth in described end covering position corresponding to described transitional pore.

3. according to the described dna immunization adsorption column of claim 2, it is characterized in that described blood mouth axially extends outwardly out one section along described adsorption column and be used for the butt joint post that connects with the external infusion pipe that described spherical floating-point is looped around around the described butt joint post.

4. according to the described dna immunization adsorption column of claim 3, it is characterized in that the radial outer periphery of described butt joint post around with the co-axial reference column of described blood mouth, described reference column in described end covering position between described spherical floating-point and described butt joint post.