CN110582500A - 双并环类核衣壳抑制剂和其作为药物用于治疗乙型肝炎的用途 - Google Patents
双并环类核衣壳抑制剂和其作为药物用于治疗乙型肝炎的用途 Download PDFInfo
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- CN110582500A CN110582500A CN201880029396.9A CN201880029396A CN110582500A CN 110582500 A CN110582500 A CN 110582500A CN 201880029396 A CN201880029396 A CN 201880029396A CN 110582500 A CN110582500 A CN 110582500A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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Abstract
本发明涉及一种双并环类核衣壳抑制剂和其作为药物用于治疗乙型肝炎的用途。具体地,本发明公开了一种可作HBV抑制剂的具有化学式A所示结构的化合物、或其立体异构体或互变异构体、或其药学上可接受的盐、水合物或溶剂化物,各基团的定义详见说明书。本发明还涉及包含上述化合物的药物组合物及其在治疗乙型肝炎中的用途。
Description
PCT国内申请,说明书已公开。
Claims (14)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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CN201710308759X | 2017-05-04 | ||
CN201710308759 | 2017-05-04 | ||
PCT/CN2018/085695 WO2018202155A1 (zh) | 2017-05-04 | 2018-05-04 | 双并环类核衣壳抑制剂和其作为药物用于治疗乙型肝炎的用途 |
Publications (2)
Publication Number | Publication Date |
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CN110582500A true CN110582500A (zh) | 2019-12-17 |
CN110582500B CN110582500B (zh) | 2022-04-05 |
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CN201880029396.9A Active CN110582500B (zh) | 2017-05-04 | 2018-05-04 | 双并环类核衣壳抑制剂和其作为药物用于治疗乙型肝炎的用途 |
CN201810421553.2A Active CN108794487B (zh) | 2017-05-04 | 2018-05-04 | 双并环类核衣壳抑制剂和其作为药物用于治疗乙型肝炎的用途 |
Family Applications After (1)
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CN201810421553.2A Active CN108794487B (zh) | 2017-05-04 | 2018-05-04 | 双并环类核衣壳抑制剂和其作为药物用于治疗乙型肝炎的用途 |
Country Status (5)
Country | Link |
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US (1) | US11591334B2 (zh) |
EP (1) | EP3628674A4 (zh) |
JP (1) | JP7123429B2 (zh) |
CN (2) | CN110582500B (zh) |
WO (1) | WO2018202155A1 (zh) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110582500B (zh) * | 2017-05-04 | 2022-04-05 | 上海长森药业有限公司 | 双并环类核衣壳抑制剂和其作为药物用于治疗乙型肝炎的用途 |
CN110437232B (zh) * | 2018-05-04 | 2022-04-12 | 上海长森药业有限公司 | 双并环脲类核衣壳抑制剂及其药物用途 |
CN110437132B (zh) * | 2018-05-04 | 2022-04-01 | 上海长森药业有限公司 | 双并杂环核衣壳抑制剂及其药物用途 |
CN113549079A (zh) * | 2018-05-25 | 2021-10-26 | 正大天晴药业集团股份有限公司 | 2,3-二氢-1h-吡咯嗪-7-甲酰胺类衍生物及其应用 |
BR112021021652A2 (pt) | 2019-04-30 | 2021-12-21 | Aicuris Gmbh & Co Kg | Oxalil piperazinas inovadoras ativas contra o vírus da hepatite b (hbv) |
MX2021013085A (es) | 2019-04-30 | 2021-11-17 | Aicuris Gmbh & Co Kg | Nuevas indol-2-carboxamidas activas contra el virus de la hepatitis b (vhb). |
AU2020265390A1 (en) | 2019-04-30 | 2021-12-23 | Aicuris Gmbh & Co. Kg | Novel phenyl and pyridyl ureas active against the hepatitis B virus (HBV) |
JP2022533007A (ja) | 2019-04-30 | 2022-07-21 | アイクリス ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | B型肝炎ウイルス(hbv)に対し活性な新規のインドリジン-2-カルボキサミド |
CN113200956B (zh) * | 2021-05-18 | 2022-04-22 | 潍坊医学院 | 一种磺胺苯甲酰胺类衍生物及其制备方法和应用 |
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NZ503491A (en) * | 1997-11-10 | 2002-08-28 | Bristol Myers Squibb Co | 2-substituted amino-1,3-benzothiazole derivatives useful as protein tyrosine kinase inhibitors |
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WO2005000793A1 (ja) * | 2003-06-26 | 2005-01-06 | Taisho Pharmaceutical Co., Ltd. | 2位置換シクロアルキルカルボン酸誘導体 |
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EP3458455B1 (en) | 2016-05-20 | 2021-06-16 | F. Hoffmann-La Roche AG | Novel pyrazine compounds with oxygen, sulfur and nitrogen linker for the treatment of infectious diseases |
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2018
- 2018-05-04 CN CN201880029396.9A patent/CN110582500B/zh active Active
- 2018-05-04 EP EP18794916.9A patent/EP3628674A4/en active Pending
- 2018-05-04 WO PCT/CN2018/085695 patent/WO2018202155A1/zh unknown
- 2018-05-04 JP JP2020511855A patent/JP7123429B2/ja active Active
- 2018-05-04 CN CN201810421553.2A patent/CN108794487B/zh active Active
- 2018-05-04 US US16/610,400 patent/US11591334B2/en active Active
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CN103224466A (zh) * | 2013-04-15 | 2013-07-31 | 北京大学 | 具有β-分泌酶抑制功能的化合物及其制备方法与应用 |
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CN108794487B (zh) * | 2017-05-04 | 2020-11-10 | 上海长森药业有限公司 | 双并环类核衣壳抑制剂和其作为药物用于治疗乙型肝炎的用途 |
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Also Published As
Publication number | Publication date |
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US20200354366A1 (en) | 2020-11-12 |
CN108794487B (zh) | 2020-11-10 |
JP2020518671A (ja) | 2020-06-25 |
CN110582500B (zh) | 2022-04-05 |
WO2018202155A1 (zh) | 2018-11-08 |
JP7123429B2 (ja) | 2022-08-23 |
US11591334B2 (en) | 2023-02-28 |
EP3628674A4 (en) | 2020-11-25 |
EP3628674A1 (en) | 2020-04-01 |
CN108794487A (zh) | 2018-11-13 |
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