CN110564699A - 一种新型番鸭腺病毒株、灭活疫苗及其制备方法 - Google Patents
一种新型番鸭腺病毒株、灭活疫苗及其制备方法 Download PDFInfo
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- CN110564699A CN110564699A CN201910953029.4A CN201910953029A CN110564699A CN 110564699 A CN110564699 A CN 110564699A CN 201910953029 A CN201910953029 A CN 201910953029A CN 110564699 A CN110564699 A CN 110564699A
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- muscovy duck
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- A—HUMAN NECESSITIES
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
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- C12N2710/10234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Biomedical Technology (AREA)
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Abstract
Description
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CN201910953029.4A CN110564699B (zh) | 2019-09-30 | 2019-09-30 | 一种新型番鸭腺病毒株、灭活疫苗及其制备方法 |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113198011A (zh) * | 2021-04-28 | 2021-08-03 | 重庆永健生物技术有限责任公司 | 一种鸭腺病毒3型菌株灭活疫苗及其应用 |
CN113278595A (zh) * | 2021-04-28 | 2021-08-20 | 重庆永健生物技术有限责任公司 | 一种鸭腺病毒3型菌株、鸭腺病毒卵黄抗体及其制备方法和应用 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107982529A (zh) * | 2017-12-14 | 2018-05-04 | 天津瑞普生物技术股份有限公司 | 一种鸭2型腺病毒灭活疫苗的制备方法 |
CN108330108A (zh) * | 2017-12-26 | 2018-07-27 | 华南农业大学 | 鸭腺病毒3型灭活疫苗ch-gd-12-2014株 |
CN110117576A (zh) * | 2019-04-23 | 2019-08-13 | 广东迈科特生物科技有限公司 | 一种鸭腺病毒3型病毒株及其卵黄抗体制备和应用 |
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107982529A (zh) * | 2017-12-14 | 2018-05-04 | 天津瑞普生物技术股份有限公司 | 一种鸭2型腺病毒灭活疫苗的制备方法 |
CN108330108A (zh) * | 2017-12-26 | 2018-07-27 | 华南农业大学 | 鸭腺病毒3型灭活疫苗ch-gd-12-2014株 |
CN110117576A (zh) * | 2019-04-23 | 2019-08-13 | 广东迈科特生物科技有限公司 | 一种鸭腺病毒3型病毒株及其卵黄抗体制备和应用 |
Non-Patent Citations (3)
Title |
---|
LIJUAN YIN,ET AL.: ""Recombinant fiber-2 protein protects Muscovy ducks against duck adenovirus 3 (DAdV-3)"", 《VIROLOGY》 * |
吴梧桐 等: "《生物制药工艺》", 31 August 2015, 北京:中国医药科技出版社 * |
姜平: "《兽医生物制品学实验指导》", 29 February 2008, 北京:中国农业出版社 * |
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CN113198011A (zh) * | 2021-04-28 | 2021-08-03 | 重庆永健生物技术有限责任公司 | 一种鸭腺病毒3型菌株灭活疫苗及其应用 |
CN113278595A (zh) * | 2021-04-28 | 2021-08-20 | 重庆永健生物技术有限责任公司 | 一种鸭腺病毒3型菌株、鸭腺病毒卵黄抗体及其制备方法和应用 |
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