CN110559446A - 靶向治疗学 - Google Patents

靶向治疗学 Download PDF

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Publication number
CN110559446A
CN110559446A CN201910863968.XA CN201910863968A CN110559446A CN 110559446 A CN110559446 A CN 110559446A CN 201910863968 A CN201910863968 A CN 201910863968A CN 110559446 A CN110559446 A CN 110559446A
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CN
China
Prior art keywords
sdc
trap
moiety
hsp90
binding
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Pending
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CN201910863968.XA
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English (en)
Chinese (zh)
Inventor
D.U.基马纳马达
英伟文
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Madrigal Pharmaceuticals Inc
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Madrigal Pharmaceuticals Inc
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Publication of CN110559446A publication Critical patent/CN110559446A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/57595—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving intracellular compounds

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201910863968.XA 2012-04-16 2013-04-16 靶向治疗学 Pending CN110559446A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261624639P 2012-04-16 2012-04-16
US61/624639 2012-04-16
US13/843771 2013-03-15
US13/843,771 US20140079636A1 (en) 2012-04-16 2013-03-15 Targeted therapeutics
CN201380031377.7A CN104470941B (zh) 2012-04-16 2013-04-16 靶向治疗学

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201380031377.7A Division CN104470941B (zh) 2012-04-16 2013-04-16 靶向治疗学

Publications (1)

Publication Number Publication Date
CN110559446A true CN110559446A (zh) 2019-12-13

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN201910863968.XA Pending CN110559446A (zh) 2012-04-16 2013-04-16 靶向治疗学
CN201380031377.7A Expired - Fee Related CN104470941B (zh) 2012-04-16 2013-04-16 靶向治疗学

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CN201380031377.7A Expired - Fee Related CN104470941B (zh) 2012-04-16 2013-04-16 靶向治疗学

Country Status (10)

Country Link
US (4) US20140079636A1 (enExample)
EP (2) EP3466416A3 (enExample)
JP (4) JP6305981B2 (enExample)
KR (4) KR20210132238A (enExample)
CN (2) CN110559446A (enExample)
AU (4) AU2013249429B2 (enExample)
CA (1) CA2870357A1 (enExample)
HK (1) HK1207098A1 (enExample)
IL (4) IL293316A (enExample)
WO (1) WO2013158644A2 (enExample)

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EP2879675B1 (en) 2012-08-06 2019-11-13 Duke University Compounds and methods for targeting hsp90
CA2898573A1 (en) * 2013-01-18 2014-07-24 Cortendo Ab (Publ) Abiraterone and analogs thereof for the treatment of diseases associated with cortisol overproduction
EP3738594A1 (en) * 2013-09-10 2020-11-18 Madrigal Pharmaceuticals, Inc. Targeted therapeutics having an hsp90 ligand as binding moiety
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JP6576942B6 (ja) * 2014-03-03 2019-11-27 マドリガル ファーマシューティカルズ インコーポレイテッド 標的治療薬
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