JP6305981B2 - 標的化治療薬 - Google Patents

標的化治療薬 Download PDF

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JP6305981B2
JP6305981B2 JP2015505991A JP2015505991A JP6305981B2 JP 6305981 B2 JP6305981 B2 JP 6305981B2 JP 2015505991 A JP2015505991 A JP 2015505991A JP 2015505991 A JP2015505991 A JP 2015505991A JP 6305981 B2 JP6305981 B2 JP 6305981B2
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trap
moiety
hsp90
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JP2015512953A (ja
JP2015512953A5 (enExample
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チマナマダ，ディネーシュ，ユー．
イン，ウェイウェン
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マドリガル ファーマシューティカルズ，インコーポレーテッド
マドリガル ファーマシューティカルズ，インコーポレーテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/57496—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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JP2015505991A 2012-04-16 2013-04-16 標的化治療薬 Expired - Fee Related JP6305981B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261624639P 2012-04-16 2012-04-16
US61/624,639 2012-04-16
US13/843,771 US20140079636A1 (en) 2012-04-16 2013-03-15 Targeted therapeutics
US13/843,771 2013-03-15
PCT/US2013/036783 WO2013158644A2 (en) 2012-04-16 2013-04-16 Targeted therapeutics

Related Child Applications (1)

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JP2018040266A Division JP2018135332A (ja) 2012-04-16 2018-03-07 標的化治療薬

Publications (3)

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JP2015512953A JP2015512953A (ja) 2015-04-30
JP2015512953A5 JP2015512953A5 (enExample) 2016-06-09
JP6305981B2 true JP6305981B2 (ja) 2018-04-04

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JP2015505991A Expired - Fee Related JP6305981B2 (ja) 2012-04-16 2013-04-16 標的化治療薬
JP2018040266A Pending JP2018135332A (ja) 2012-04-16 2018-03-07 標的化治療薬
JP2019161628A Expired - Fee Related JP6949911B2 (ja) 2012-04-16 2019-09-05 標的化治療薬
JP2021153930A Pending JP2022000452A (ja) 2012-04-16 2021-09-22 標的化治療薬

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JP2018040266A Pending JP2018135332A (ja) 2012-04-16 2018-03-07 標的化治療薬
JP2019161628A Expired - Fee Related JP6949911B2 (ja) 2012-04-16 2019-09-05 標的化治療薬
JP2021153930A Pending JP2022000452A (ja) 2012-04-16 2021-09-22 標的化治療薬

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US (4) US20140079636A1 (enExample)
EP (2) EP2838909A4 (enExample)
JP (4) JP6305981B2 (enExample)
KR (4) KR102320942B1 (enExample)
CN (2) CN110559446A (enExample)
AU (4) AU2013249429B2 (enExample)
CA (1) CA2870357A1 (enExample)
HK (1) HK1207098A1 (enExample)
IL (4) IL293316A (enExample)
WO (1) WO2013158644A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018135332A (ja) * 2012-04-16 2018-08-30 マドリガル ファーマシューティカルズ，インコーポレーテッド 標的化治療薬
US11377447B2 (en) 2017-06-20 2022-07-05 Madrigal Pharmaceuticals, Inc. Targeted therapeutics
US11491145B2 (en) 2017-06-20 2022-11-08 Madrigal Pharmaceuticals, Inc. Combination therapies comprising targeted therapeutics

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100797283B1 (ko) 2001-08-27 2008-01-23 주식회사 포스코 코일 폭 감지 및 위치 조정 기능을 가진 코일 받침대
US8106083B2 (en) 2008-08-08 2012-01-31 Synta Pharmaceuticals Corp. Triazole compounds that modulate HSP90 activity
EP2879675B1 (en) 2012-08-06 2019-11-13 Duke University Compounds and methods for targeting hsp90
EP2945960A2 (en) * 2013-01-18 2015-11-25 Cortendo AB (publ) Abiraterone and analogs thereof for the treatment of diseases associated with cortisol overproduction
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