CN110495607A - A kind of procyanidine oligosaccharide endocrine metabolic diseases powder and preparation method - Google Patents

A kind of procyanidine oligosaccharide endocrine metabolic diseases powder and preparation method Download PDF

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CN110495607A
CN110495607A CN201910908057.4A CN201910908057A CN110495607A CN 110495607 A CN110495607 A CN 110495607A CN 201910908057 A CN201910908057 A CN 201910908057A CN 110495607 A CN110495607 A CN 110495607A
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powder
procyanidine
oligosaccharide
mct
parts
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陈星�
白新鹏
刘亚雯
何坤明
司德洋
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Hainan Dabai Kangjian Pharmaceutical Co Ltd
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Hainan Dabai Kangjian Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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    • A23L29/06—Enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

The present invention provides a kind of procyanidine oligosaccharide endocrine metabolic diseases powder and preparation method, compare according to parts by weight, including following component: 10-20 parts of 70~90 parts of 3~6 parts of plant extracts, inulin, the MCT powder of procyanidine >=95%, 1-2 parts of ground coffee, tea polyphenols >=95% 0.5-1.5 parts of 0.5-1.5 parts of tea extraction, water soluble pearl powder.The present invention selects procyanidine to be combined with inulin, MCT powder, ground coffee, tea polyphenols and water soluble pearl powder, obtained procyanidine oligosaccharide endocrine metabolic diseases powder, not only with the good synergistic effect for adjusting and digesting and assimilating, increase absorption rate, and the inoxidizability that is conducive to procyanidine, tea polyphenols etc. in body, it improves and removes interior free yl ability, conditioning effect is more significant, it takes after mixing it with water conveniently, effective in the powder class health product of facial area skin disorder caused by treatment dyschromicum skin disease and skin gland secretion obstacle disease.

Description

A kind of procyanidine oligosaccharide endocrine metabolic diseases powder and preparation method
Technical field
The present invention relates to technical field of health care food, in particular to a kind of procyanidine oligosaccharide endocrine metabolic diseases powder and system Preparation Method.
Background technique
It is confirmed through modern medicine theory, the skin disorders such as chloasma, freckle, dark sore, acne belong to dyschromicum and skin more Skin gland obstacle dermatoses, though suffering from facial area skin, the cause of disease is derived from that interior free yl is excessive, pituitary or hypothalamus Endocrine disturbance, the reasons such as enteron aisle digestive system is bad, caused cell survival shorten, and dysovarism is just secreted, and make ovary Generation estrogen function is low, and sex hormone excitement melanocyte and pregnant reward influence menoxenia, sebaceous glands caused to increase Greatly, sebum secretion increases, and melanin increase, stasis of blood product, are in crineous, yellowish-brown, reddish brown color spot after ultraviolet light irradiates at skin lesion The problems such as point or such as hatpin head size cone acne.
The product of the skin disorders such as chloasma, freckle, the acne that treatment facial area suffers from present is broadly divided into the painting of external application Cloth product and health food for oral administration, but the coated product of external application tends not to the problem of eradicating skin disorder, or even is easy to produce The case where raw recurrence, high recurrence rate is palliative；And for health food for oral administration, such as oral solution, capsule health care food Product contain the plant extracts such as inoxidizability using it, and for adjusting the endocrine and digestion and absorption of body, but working as will be different Function ingredients are combined compounding, into body after the inoxidizability of effective component that often contains reduce, efficacy effect is unknown Aobvious, cannot be decomposed absorption completely, and absorption rate is low, and conditioning effect is not significant, and patient's treatment cost is caused to greatly increase The problem of, therefore, it is necessary to develop, a kind of absorption rate is high, the significant endocrine metabolic diseases product of function and effect.
Summary of the invention
In consideration of it, the present invention proposes in a kind of promotion absorption rate and the significant procyanidine oligosaccharide of conditioning effect point It secretes and adjusts powder and preparation method.
The technical scheme of the present invention is realized as follows:
The present invention provides a kind of procyanidine oligosaccharide endocrine metabolic diseases powder, compares according to parts by weight, including following component:
A kind of procyanidine oligosaccharide endocrine metabolic diseases powder proposed by the present invention not only selects procyanidine and tea polyphenols etc. Function ingredients, while to protect the biochemical composition of intraor extracellular from free radical attack, further preferably inulin, MCT powder, coffee Powder and water soluble pearl powder are combined, and are obtained procyanidine oligosaccharide endocrine metabolic diseases powder, can not only be reached effective tune The synergistic effect digested and assimilated is saved, the decomposition of effective component is promoted to absorb, increases absorption rate, and be conducive to former cyanine The inoxidizability in body such as element, tea polyphenols extends its effective component in people's intracorporal action time, effectively removes in vivo freely Base, conditioning effect is more significant, takes after mixing it with water conveniently, can hinder effectively as treating dyschromicum skin disease and skin gland secretion Hinder the powder class health product of facial area skin disorder caused by disease.
It further illustrates, compares according to parts by weight, further include the plant extracts of 0-1 parts of isoflavone content >=40%.Institute The plant for stating isoflavone content >=40% is the plant rich in isoflavones such as pueraria lobata and soybean, sesame, red clover, mass ratio Are as follows: pueraria lobata: soybean: red clover=1:(0~0.5): (0~0.5).
It further illustrates, compares according to parts by weight, further include 0-1 parts of digestant 200,000 unit of activity/gram edible proteins Enzyme.The digestant edible protein enzyme includes papain, bromelain, ficin, wherein Papain The mass ratio of enzyme and bromelain is 1:(0~0.5).
It further illustrates, compares according to parts by weight, including following component:
It further illustrates, the extraction raw material of procyanidine >=95% are as follows: grape pip, pine bark and black fruit fructus lycii, The mass ratio of Semen Vitis viniferae extract, Pine Bark and black fruit fructus lycii extract is (1~2): (1~3): (0.5~1).Root According to the mass ratio of the procyanidin extract of above-mentioned raw materials, be allowed to inulin, MCT powder, ground coffee combination acts synergistically under, mention High definition removes the ability of interior free yl.
The extraction raw material of procyanidine >=95% can be with are as follows: Grape Skin, ginkgo leaf, tealeaves and Nelumbonaceae axis, leaf, Root, fruit, skin and cocoa, ' Heijialun ' seed, sea-buckthorn, lichee, hawthorn, strawberry, the other plants such as beans.The tea of tea polyphenols >=95% mentions Taking object is green-tea extract, and the tea of tea polyphenols >=95% is that the Theaceaes plants and sesame, purple perilla etc. such as green tea, black tea are rich in tea polyphenols Other plant.
It further illustrates, the inulin is the glycosylation inulin of the zeins containing mass ratio 0.05~0.1% Mixture.It is combined by using a certain amount of inulin with the plant extracts of procyanidine >=95%, using by corn alcohol It is molten it is protein modified after glycosylation inulin mixtures, fat metabolism and the absorption of minerals can not only be effectively improved, tieed up simultaneously It is active in body to hold procyanidine, tea polyphenols etc., extends its effective component in people's intracorporal action time, improves and remove in vivo The ability of free radical.
It further illustrates, it is 0.3~1% maltodextrin and 0.1~2% monoglyceride that the MCT powder, which is containing mass ratio, MCT powder mixture.By using above-mentioned MCT powder mixture, can not only be inhaled with group subassembly, effectively adjusting digestion such as inulin The synergistic effect of receipts maintains to stablize the release and absorption rate of medium chain triglyceride (MCT) in human body, and enhances original simultaneously Anthocyanidin extends action time the body the effect of.
It further illustrates, the preparation method of the MCT powder includes the following steps:
(1) MCT, maltodextrin, monoglyceride are weighed in proportion, is added to the water dissolution, and 5~10min is mixed, obtains MCT mixed solution；
(2) MCT mixed solution is recycled 2~3 times under 80~100Mpa pressure using high pressure homogenizer, obtains MCT cream Liquid；
(3) MCT emulsion spray is dry, sieving obtains finished product MCT powder.
It further illustrates, the ground coffee is that either shallow bakes 6~10min at 160~180 DEG C, and is ground to partial size and is 15~20 μm of coffee bean powder.Obtained coffee bean powder is baked and ground by using either shallow at a certain temperature, is adjusted to people PH value in body enteron aisle is conducive to the diffusion of the activity and effective component that maintain procyanidine in body, promotes to digest and assimilate.
A kind of preparation method of procyanidine oligosaccharide endocrine metabolic diseases powder, includes the following steps:
(1) tea of the plant extracts of procyanidine >=95%, inulin, MCT powder, ground coffee, tea polyphenols >=95% is mentioned Take the plant extracts of object, water soluble pearl powder, isoflavone content >=40%, digestant 200,000 unit of activity/gram table egg White enzyme crosses 80~100 meshes through heated-air drying and obtains even-grained dry fine powder respectively after ultraviolet disinfection；
(2) weigh the drying fine powder that step (1) obtains in proportion: the plant extracts of procyanidine >=95%, inulin, MCT powder, ground coffee, enter and mix 30-40min in three-dimensional mixer；Obtain preliminary mixed powder；
(3) the drying fine powder that step (1) obtains: tea extraction, the water-soluble pearl of tea polyphenols >=95% is weighed in proportion Powder, the plant extracts of isoflavone content >=40%, in digestant 200,000 unit of activity/gram edible protein enzyme, with step (2) Preliminary mixed powder mix 20~30min in three-dimensional mixer, packing, sterilizing obtain packed procyanidine oligosaccharide Endocrine metabolic diseases medicinal granules of powder.
Compared with prior art, the beneficial effects of the present invention are: the present invention not only selects the function such as procyanidine and tea polyphenols Can component, while to protect the biochemical composition of intraor extracellular from free radical attack, further preferably inulin, MCT powder, ground coffee It is combined with water soluble pearl powder, obtains procyanidine oligosaccharide endocrine metabolic diseases powder, effective adjusting can not only be reached The synergistic effect of digestion and absorption promotes the decomposition of effective component to absorb, increase absorption rate, and be conducive to procyanidine, The inoxidizability in body such as tea polyphenols extends its effective component in people's intracorporal action time, effectively removes interior free yl, Conditioning effect is more significant, takes after mixing it with water conveniently, can be effectively as treating dyschromicum skin disease and skin gland secretion obstacle The powder class health product of facial area skin disorder caused by disease.
Specific embodiment
In order to be best understood from the technology of the present invention content, specific embodiment is provided below, the present invention is described further.
Experimental method used in the embodiment of the present invention is conventional method unless otherwise specified.
Material used in the embodiment of the present invention, reagent etc., are commercially available unless otherwise specified.
According to modernization of Chinese medicine theory, grape seed extract of the present invention, Pine Bark, black fruit fructus lycii extract, green tea The effective ingredients such as extract have the function of removing interior free yl based on polyphenol.
Inulin (inulin) is as fructose through linear straight chain polysaccharide made of β (2 → 1) key connection, and end often has one Glucose, the degree of polymerization are 2~60.Inulin is actually also the mixture of a variety of different polymerization degree levulan, wherein the degree of polymerization compared with The levulan of low (DP=2~9) is commonly referred to as oligofructose.According to inulin sources difference.Oligofructose content one in inulin As differ for 5%~35%.Inulin is not decomposed in oral cavity, stomach, small enteral, absorbs.In colon by beneficial bacterium (bifid bar Bacterium, lactobacillus etc.) it utilizes, it is a kind of soluble dietary fiber and a kind of fat substitute, while still a kind of effective double Discrimination bacillus proliferation factor.It is a kind of novel feed addictive as a kind of beneficial microbial substrates, alternative promotes to have Beneficial bacteria growth, in animal body noresidue do not develop drug resistance, can improve the fat metabolism of animal, improve the suction of minerals It receives.Inulin is a kind of worth exploitation and the product resource applied to feedstuff industry.
MCT powder.Blood triglyceride levels can preferably be maintained using the medium chain fatty acid in medium chain triglyceride, to II diabetic of hypertriglyceridemia is advantageous, and medium chain triglyceride loses weight to type II diabetes (T2DM) patient, The risk that the complication such as coronary heart disease occur is reduced to have very great help.Type II diabetes (T2DM) patient is usually than non-diabetic person With higher weight, the risk that the complication such as coronary heart disease occur for T2DM can be reduced by losing weight.Subtract by adjusting diet Fertilizer, safety are substantially better than drug effect, but the long-term tradition low-fat diet that carries out may cause the loss of liposoluble vitamin, institute On the basis of controlling gross energy, to improve lipid intake quality and constitute extremely important.Medium chain triglyceride (MCT) is easy to inhale It receives, directly liver is transported to by portal vein and does not depend on carnitine and can directly be aoxidized rapidly, do not easily cause fat Storage, can replace parts of traditional diet grease long chain triglycerides (LCT).Use the sunflower for being rich in monounsaturated fatty acids The compound grease such as oil, olive oil, palm oil can reduce the level of triglycerides and total cholesterol in patients blood plasma, reduce painstaking effort Pipe disease is dangerous, improves immune function since monounsaturated fatty acids contains only single unsaturated double-bond and is not susceptible to peroxidating, It is smaller to lipid.
Kudzu root extract can effectively increase cortex hormone of aadrenaline secretion activity, exclude dysovarism, improve ovary Hypofunction morbid state, accelerates estrogen secretion, controls melanocyte and progesterone steadily breeds and withers away, so that sebaceous glands be made to contract Small, sebum secretion is reduced, and is promoted melanin at patient face skin lesion to reduce, and have activation to the regeneration of Skin Cell, is made The reproduction speed of Skin Cell can be improved as many as 22-35 times；Water soluble pearl powder contains several physiological active substances, Papain Enzyme has the effect for adjusting system of assimilating；There are also flavonoid glycosides for Pine Bark effective ingredient, have invigorating qi for strengthening superficies, diuresis anti- Poison arranges dense, expelling pus and promoting granulation function；The collaboration of each effective component in patient's body collective effect, can not only from remove interior free yl, It adjusts endocrine and is acted in terms of adjusting digestive system three, and strengthen absorption rate and Scavenging ability, improve Effect is more significant, takes after mixing it with water conveniently, has no toxic side effect.
A kind of procyanidine oligosaccharide endocrine metabolic diseases powder of embodiment 1-, compares, including following component according to parts by weight: former The tea extraction of 10 parts of 70 parts of 3 parts of plant extracts, inulin, the MCT powder of anthocyanidin >=95%, 2 parts of ground coffee, tea polyphenols >=95% 1.5 parts of object, 0.5 part of water soluble pearl powder.
A kind of procyanidine oligosaccharide endocrine metabolic diseases powder of embodiment 2-, compares, including following component according to parts by weight: former The tea extraction of 12 parts of 80 parts of 6 parts of plant extracts, inulin, the MCT powder of anthocyanidin >=95%, 1 part of ground coffee, tea polyphenols >=95% 1.2 parts of object, 1.5 parts of water soluble pearl powder.
Wherein, the extraction raw material of procyanidine >=95% are as follows: grape pip, pine bark and black fruit fructus lycii, grapestone The mass ratio of extract, Pine Bark and black fruit fructus lycii extract is 1:1:0.5.
A kind of procyanidine oligosaccharide endocrine metabolic diseases powder of embodiment 3-, compares, including following component according to parts by weight: former 20 parts of 90 parts of 4 parts of plant extracts, inulin, the MCT powder of anthocyanidin >=95%, 1.5 parts of ground coffee, tea polyphenols >=95% tea mention 0.5 part of object, 0.8 part of water soluble pearl powder, 0.5 part of the plant extracts of isoflavone content >=40%, digestant 200,000 are taken to live Unit of force/1 part of gram edible protein enzyme.
Wherein, the extraction raw material of procyanidine >=95% are as follows: grape pip, pine bark and black fruit fructus lycii, grapestone The mass ratio of extract, Pine Bark and black fruit fructus lycii extract is 1:1:0.5；The inulin is to contain mass ratio The glycosylation inulin mixtures of 0.05% zeins；The MCT powder be containing mass ratio be 0.3% maltodextrin and The MCT powder mixture of 0.1% monoglyceride；The ground coffee is that either shallow bakes 10min at 160 DEG C, and being ground to partial size is 15 ~20 μm of coffee bean powder.
The preparation method of the MCT powder, includes the following steps:
(1) MCT, maltodextrin, monoglyceride are weighed in proportion, is added to the water dissolution, 5min is mixed, and it is mixed to obtain MCT Close solution；
(2) MCT mixed solution is recycled 2 times under 100Mpa pressure using high pressure homogenizer, obtains MCT lotion；
(3) MCT emulsion spray is dry, sieving obtains finished product MCT powder.
A kind of procyanidine oligosaccharide endocrine metabolic diseases powder of embodiment 4-, compares, including following component according to parts by weight: former 15 parts of 85 parts of 4.5 parts of plant extracts, inulin, the MCT powder of anthocyanidin >=95%, 1.3 parts of ground coffee, tea polyphenols >=95% tea 1.0 parts of extract, 1.2 parts of water soluble pearl powder, 1 part of the plant extracts of isoflavone content >=40%, digestant 200,000 are lived Unit of force/0.6 part of gram edible protein enzyme.Wherein, the extraction raw material of procyanidine >=95% are as follows: grape pip, pine bark And black fruit fructus lycii, the mass ratio of Semen Vitis viniferae extract, Pine Bark and black fruit fructus lycii extract are 2:3:1；The inulin For the glycosylation inulin mixtures of the zeins containing mass ratio 0.1%；It is 1% that the MCT powder, which is containing mass ratio, The MCT powder mixture of maltodextrin and 2% monoglyceride；The ground coffee is that either shallow bakes 6min at 180 DEG C, and is ground to grain The coffee bean powder that diameter is 15~20 μm.
The preparation method of the MCT powder, includes the following steps:
(1) MCT, maltodextrin, monoglyceride are weighed in proportion, is added to the water dissolution, 10min is mixed, and it is mixed to obtain MCT Close solution；
(2) MCT mixed solution is recycled 3 times under 80Mpa pressure using high pressure homogenizer, obtains MCT lotion；
(3) MCT emulsion spray is dry, sieving obtains finished product MCT powder.
A kind of preparation method of procyanidine oligosaccharide endocrine metabolic diseases powder of embodiment 5-, includes the following steps: that (1) will be former Plant extracts, inulin, MCT powder, ground coffee, the tea extraction of tea polyphenols >=95%, water-soluble pearl of anthocyanidin >=95% The plant extracts of powder, isoflavone content >=40%, digestant 200,000 unit of activity/gram edible protein enzyme, respectively through ultraviolet After line sterilizing, 80~100 meshes are crossed through heated-air drying and obtain even-grained dry fine powder；
(2) by the component ratio in embodiment 4, the drying fine powder that step (1) obtains: the plant of procyanidine >=95% is weighed Object extract, inulin, MCT powder, ground coffee, enter and mix 30-40min in three-dimensional mixer；Obtain preliminary mixed powder；
(3) by the component ratio in embodiment 4, weigh the drying fine powder that step (1) obtains: the tea of tea polyphenols >=95% is mentioned Take object, water soluble pearl powder, the plant extracts of isoflavone content >=40%, digestant 200,000 unit of activity/gram table egg White enzyme mixes 20~30min with the preliminary mixed powder in step (2) in three-dimensional mixer, and packing, sterilizing obtain packed Procyanidine oligosaccharide endocrine metabolic diseases medicinal granules of powder
A kind of procyanidine oligosaccharide endocrine metabolic diseases powder of comparative example 1-, the difference with embodiment 4 are: procyanidine >= 95% extraction raw material are as follows: grape pip, ' Heijialun ' seed and ginkgo leaf, Semen Vitis viniferae extract, ' Heijialun ' seed and ginkgo leaf extract The mass ratio of object is 2:3:1, remaining described parameter is same as Example 4.
A kind of procyanidine oligosaccharide endocrine metabolic diseases powder of comparative example 2-, the difference with embodiment 4 are: procyanidine >= 95% 2.5 parts of plant extracts, 100 parts of inulin, remaining parameter are same as Example 4.
A kind of procyanidine oligosaccharide endocrine metabolic diseases powder of comparative example 3-, the difference with embodiment 4 are: the inulin is Glycosylation inulin mixtures containing the zeins that mass ratio is 0.5%, remaining parameter are same as Example 4.
A kind of procyanidine oligosaccharide endocrine metabolic diseases powder of comparative example 4-, the difference with embodiment 4 are: the MCT powder For the MCT powder mixture for containing mass ratio being 1% maltodextrin and 2% stearoyl lactate, remaining parameter with 4 phase of embodiment Together.
A kind of procyanidine oligosaccharide endocrine metabolic diseases powder of comparative example 5-, the difference with embodiment 4 are: the ground coffee For at 210 DEG C either shallow bake 10min, and be ground to partial size be 15~20 μm, remaining parameter is same as Example 4.
A kind of preparation method of procyanidine oligosaccharide endocrine metabolic diseases powder of comparative example 6-, the difference with embodiment 5 are: First by the plant extracts of procyanidine >=95%, the tea extraction of tea polyphenols >=95%, water soluble pearl powder, isoflavone content >=40% plant extracts, digestant 200,000 unit of activity/gram edible protein enzyme enter after mixing in three-dimensional mixer, then It is mixed with inulin, MCT powder, ground coffee, remaining step is same as Example 5.
1, pass through the procyanidine oligosaccharide endocrine metabolic diseases being prepared into detection Examples 1 to 5 and comparative example 1~6 Powder is as antioxidant, to the Scavenging activity (%) and inhibitory activity against tyrosinase (%) of DPPH free radical, more different originals The antioxidant activity function of anthocyanidin oligosaccharide endocrine metabolic diseases powder, statistics and comparison result are as follows:
As can be seen from the above table, the procyanidine oligosaccharide endocrine metabolic diseases powder being prepared by the embodiment of the present invention 1~5, It is apparently higher than comparative example 1~6 to the Scavenging activity and inhibitory activity against tyrosinase of DPPH free radical, and embodiment 3~5 Product is substantially better than Examples 1 to 2 to the inhibitory effect of tyrosinase.
Wherein, the plant extracts of procyanidine >=95% and inulin ratio are adjusted in comparative example 2, procyanidine is low The inoxidizability of glycan endocrine metabolic diseases powder is substantially reduced, by embodiment 4 and the comparison of comparative example 3~5 as can be seen that using containing The glycosylation inulin mixtures of the zeins of certain mass ratio, using the maltodextrin containing certain mass ratio and single sweet The MCT powder mixture of rouge, and using the ground coffee baked by low temperature either shallow, Scavenging activity to the DPPH free radical of product and Inhibitory activity against tyrosinase has large effect.Procyanidine oligosaccharide endocrine metabolic diseases powder is prepared by the present invention, It can be conducive to the inoxidizability in body such as procyanidine, tea polyphenols, extend its effective component in people's intracorporal action time, mention High definition removes interior free yl ability.
2, it is directed to product of the present invention, is special medicine purposes food.It is related to the health of human body, therefore we have done phase The test of pass uses be prepared by Examples 1 to 5 and comparative example 1~6 respectively through every group of 35~65 years old 100 women personnel Procyanidine oligosaccharide endocrine metabolic diseases powder this product after body be no different paradoxical reaction, can be seen using the skin behind after this product three days To the effect that improves significantly.
(1) result judgement standard:
A. take 7 days: sleep improvement, energetic, the moon is improved, free movement of the bowels, vagina are wet, secretion elasticity increases Add, enhancement of environment.
B. 15 days are taken: being had rosy cheeks, skin smooth, full of vitality, nympholepsy；Irregular menstruation, dysmenorrhea, leukorrhea, warp Phase discomfort etc. mitigates；The recessiveness menopause symptom such as flush, hectic fever, perspiration, headache, palpitaition, vexed mitigates.
C. take 1~2 month: color spot shoals, breast is very swollen, elastic increase, nipple is stood upright, mammary areola color is pink, mammary gland increases It is raw to mitigate；Eumenorrhea is obviously improved menstrual period discomfort, dysmenorrhea, leukorrhea, gynaecological imflammation etc.；Sexual desire enhancing, life quality mention It is high；Maternity blues, fat improvement；Climacteric syndrome is eliminated；Cardiovascular and cerebrovascular disease, osteoporosis, pain in waist and lower extremities, cramp etc. are obvious Improve.
D. take (> 2 months) for a long time: plump tall and straight, skin slip is in a cheerful frame of mind, is dynamic；Eumenorrhea, menstrual period are not Suitable, dysmenorrhea, leukorrhea, gynaecological imflammation etc. are eliminated；Life quality improves；It postpones menopause, delay senescence；Climacteric disease is eliminated comprehensively Shape；Effectively prevent cardiovascular and cerebrovascular disease, senile dementia, osteoporosis, the proliferation of mammary gland, breast cancer, uterine cancer, oophoroma and swells Block.
Every group of personnel take under rear fruitful percentage such as table:
Embodiment It takes 7 days It takes 15 days It takes 1~2 month It takes for a long time
Embodiment 1 90% 92% 94% 96%
Embodiment 2 88% 90% 93% 95%
Embodiment 3 91% 93% 96% 97%
Embodiment 4 92% 94% 96% 98%
Embodiment 5 92% 96% 98% 99%
Comparative example 1 63% 65% 68% 70%
Comparative example 2 40% 43% 45% 48%
Comparative example 3 35% 38% 40% 43%
Comparative example 4 42% 44% 47% 49%
Comparative example 5 38% 41% 44% 46%
Comparative example 6 58% 60% 63% 65%
As can be seen from the above table, by procyanidine oligosaccharide endocrine metabolic diseases powder obtained of the invention, have good The synergistic effect for adjusting endocrine and digestion and absorption, promotes the decomposition of effective component to absorb, and increases absorption rate and curative effect is fast, Conditioning effect outstanding feature.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention Within mind and principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.

Claims (10)

1. a kind of procyanidine oligosaccharide endocrine metabolic diseases powder, it is characterised in that: compare according to parts by weight, including following component:
2. a kind of procyanidine oligosaccharide endocrine metabolic diseases powder according to claim 1, it is characterised in that: according to parts by weight Number ratio, further includes the plant extracts of 0-1 parts of isoflavone content >=40%.
3. a kind of preparation method of procyanidine oligosaccharide endocrine metabolic diseases powder according to claim 2, it is characterised in that: Compare according to parts by weight, further includes 0-1 parts of digestant 200,000 unit of activity/gram edible protein enzyme.
4. a kind of procyanidine oligosaccharide endocrine metabolic diseases powder according to claim 3, it is characterised in that: according to parts by weight Number ratio, including following component:
5. a kind of procyanidine oligosaccharide endocrine metabolic diseases powder according to claim 1, it is characterised in that: the original cyanine The extraction raw material of element >=95% are as follows: grape pip, pine bark and black fruit fructus lycii, Semen Vitis viniferae extract, Pine Bark and black The mass ratio of fruit wolfberry fruit extract is (1~2): (1~3): (0.5~1).
6. a kind of procyanidine oligosaccharide endocrine metabolic diseases powder according to claim 1, it is characterised in that: the inulin is The glycosylation inulin mixtures of zeins containing mass ratio 0.05~0.1%.
7. a kind of procyanidine oligosaccharide endocrine metabolic diseases powder according to claim 1, it is characterised in that: the MCT powder For the MCT powder mixture for containing mass ratio being 0.3~1% maltodextrin and 0.1~2% monoglyceride.
8. a kind of procyanidine oligosaccharide endocrine metabolic diseases powder according to claim 7, it is characterised in that: the MCT powder Preparation method, include the following steps:
(1) MCT, maltodextrin, monoglyceride are weighed in proportion, is added to the water dissolution, 5~10min is mixed, and it is mixed to obtain MCT Close solution；
(2) MCT mixed solution is recycled 2~3 times under 80~100Mpa pressure using high pressure homogenizer, obtains MCT lotion；
(3) MCT emulsion spray is dry, sieving obtains finished product MCT powder.
9. a kind of procyanidine oligosaccharide endocrine metabolic diseases powder according to claim 1, it is characterised in that: the ground coffee For at 160~180 DEG C either shallow bake 6~10min, and being ground to partial size is 15~20 μm of coffee bean powder.
10. a kind of preparation side of the procyanidine oligosaccharide endocrine metabolic diseases powder as described in any one of claim 1~9 Method, characterized by the following steps:
(1) by the plant extracts of procyanidine >=95%, inulin, MCT powder, ground coffee, tea polyphenols >=95% tea extraction, The plant extracts of water soluble pearl powder, isoflavone content >=40%, digestant 200,000 unit of activity/gram edible protein enzyme, Respectively after ultraviolet disinfection, 80~100 meshes are crossed through heated-air drying and obtain even-grained dry fine powder；
(2) weigh the drying fine powder that step (1) obtains in proportion: the plant extracts of procyanidine >=95%, inulin, MCT powder, Ground coffee enters and mixes 30-40min in three-dimensional mixer；Obtain preliminary mixed powder；
(3) the drying fine powder that step (1) obtains is weighed in proportion: the tea extraction of tea polyphenols >=95%, water soluble pearl powder, different It is first in the plant extracts of flavones content >=40%, digestant 200,000 unit of activity/gram edible protein enzyme, with step (2) Step mixed powder mixes 20~30min in three-dimensional mixer, and packing, sterilizing obtain dividing in packed procyanidine oligosaccharide Secrete adjusting medicinal granules of powder.
CN201910908057.4A 2019-09-25 2019-09-25 A kind of procyanidine oligosaccharide endocrine metabolic diseases powder and preparation method Pending CN110495607A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111296728A (en) * 2020-04-10 2020-06-19 武汉轻工大学 Inulin compound induced by pulsed electric field and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1709383A (en) * 2005-06-22 2005-12-21 白新鹏 Beauty spot-eliminating capsule agent
CN103815048A (en) * 2014-02-12 2014-05-28 合肥康龄养生科技有限公司 Inulin healthcare soybean milk and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1709383A (en) * 2005-06-22 2005-12-21 白新鹏 Beauty spot-eliminating capsule agent
CN103815048A (en) * 2014-02-12 2014-05-28 合肥康龄养生科技有限公司 Inulin healthcare soybean milk and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111296728A (en) * 2020-04-10 2020-06-19 武汉轻工大学 Inulin compound induced by pulsed electric field and preparation method thereof
CN111296728B (en) * 2020-04-10 2023-03-07 武汉轻工大学 Inulin compound induced by pulsed electric field and preparation method thereof

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Application publication date: 20191126