CN110438069B - 一种连翘脂素用于体外促进人脂肪间充质干细胞成软骨分化的用途 - Google Patents
一种连翘脂素用于体外促进人脂肪间充质干细胞成软骨分化的用途 Download PDFInfo
- Publication number
- CN110438069B CN110438069B CN201910779324.2A CN201910779324A CN110438069B CN 110438069 B CN110438069 B CN 110438069B CN 201910779324 A CN201910779324 A CN 201910779324A CN 110438069 B CN110438069 B CN 110438069B
- Authority
- CN
- China
- Prior art keywords
- forsythiaside
- mesenchymal stem
- hadscs
- stem cells
- chondrogenic differentiation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 210000002901 mesenchymal stem cell Anatomy 0.000 title claims abstract description 27
- DTOUWTJYUCZJQD-QJDQKFITSA-N Forsythiaside Natural products C[C@@H]1O[C@H](OC[C@H]2O[C@@H](OCCc3ccc(O)c(O)c3)[C@H](O)[C@@H](O)[C@@H]2OC(=O)C=Cc4ccc(O)c(O)c4)[C@H](O)[C@H](O)[C@H]1O DTOUWTJYUCZJQD-QJDQKFITSA-N 0.000 title claims abstract description 23
- DTOUWTJYUCZJQD-UJERWXFOSA-N Forsythiaside Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](OC(=O)\C=C\C=2C=C(O)C(O)=CC=2)[C@H](O)[C@@H](O)[C@H](OCCC=2C=C(O)C(O)=CC=2)O1 DTOUWTJYUCZJQD-UJERWXFOSA-N 0.000 title claims abstract description 23
- 230000009816 chondrogenic differentiation Effects 0.000 title claims abstract description 21
- 238000000338 in vitro Methods 0.000 title claims abstract description 11
- 230000001737 promoting effect Effects 0.000 title claims abstract description 11
- 102000000503 Collagen Type II Human genes 0.000 abstract description 11
- 108010041390 Collagen Type II Proteins 0.000 abstract description 11
- 239000001963 growth medium Substances 0.000 abstract description 11
- 230000035755 proliferation Effects 0.000 abstract description 9
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 abstract description 8
- 229950003937 tolonium Drugs 0.000 abstract description 7
- HNONEKILPDHFOL-UHFFFAOYSA-M tolonium chloride Chemical compound [Cl-].C1=C(C)C(N)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 HNONEKILPDHFOL-UHFFFAOYSA-M 0.000 abstract description 7
- 229920002683 Glycosaminoglycan Polymers 0.000 abstract description 6
- 210000001612 chondrocyte Anatomy 0.000 abstract description 6
- 238000010186 staining Methods 0.000 abstract description 6
- 230000004069 differentiation Effects 0.000 abstract description 4
- 239000003814 drug Substances 0.000 abstract description 3
- 230000001172 regenerating effect Effects 0.000 abstract description 3
- 238000003757 reverse transcription PCR Methods 0.000 abstract description 3
- 210000000845 cartilage Anatomy 0.000 abstract description 2
- 210000004027 cell Anatomy 0.000 description 18
- 239000002609 medium Substances 0.000 description 9
- 230000000694 effects Effects 0.000 description 6
- 239000006285 cell suspension Substances 0.000 description 5
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 4
- 238000002835 absorbance Methods 0.000 description 4
- 238000012258 culturing Methods 0.000 description 4
- 102100022464 5'-nucleotidase Human genes 0.000 description 3
- ATEFPOUAMCWAQS-UHFFFAOYSA-N 7,8-dihydroxycoumarin Chemical compound C1=CC(=O)OC2=C(O)C(O)=CC=C21 ATEFPOUAMCWAQS-UHFFFAOYSA-N 0.000 description 3
- 102100037241 Endoglin Human genes 0.000 description 3
- KFFCKOBAHMGTMW-LGQRSHAYSA-N Forsythin Chemical compound C1=C(OC)C(OC)=CC=C1[C@H]1[C@@H](CO[C@@H]2C=3C=C(OC)C(O[C@H]4[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O4)O)=CC=3)[C@@H]2CO1 KFFCKOBAHMGTMW-LGQRSHAYSA-N 0.000 description 3
- 102000006354 HLA-DR Antigens Human genes 0.000 description 3
- 108010058597 HLA-DR Antigens Proteins 0.000 description 3
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 description 3
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 description 3
- 101000881679 Homo sapiens Endoglin Proteins 0.000 description 3
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 description 3
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 description 3
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 description 3
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 3
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 description 3
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 description 3
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 description 3
- 230000003698 anagen phase Effects 0.000 description 3
- 238000004113 cell culture Methods 0.000 description 3
- YBGKGTOOPNQOKH-UHFFFAOYSA-N daphnetin Natural products OC1=CC=CC2=C1OC(=O)C=C2O YBGKGTOOPNQOKH-UHFFFAOYSA-N 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000012894 fetal calf serum Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 102000029816 Collagenase Human genes 0.000 description 2
- 108060005980 Collagenase Proteins 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- 102100031181 Glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 2
- 210000000577 adipose tissue Anatomy 0.000 description 2
- 238000000246 agarose gel electrophoresis Methods 0.000 description 2
- 229960002424 collagenase Drugs 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 2
- 208000030159 metabolic disease Diseases 0.000 description 2
- 230000000877 morphologic effect Effects 0.000 description 2
- 229930014626 natural product Natural products 0.000 description 2
- 201000008482 osteoarthritis Diseases 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- DJHDOMQWAUJNKX-UHFFFAOYSA-N phillygenin Natural products COc1ccc(cc1O)C2OCC3C2COC3c4ccc(OC)c(OC)c4 DJHDOMQWAUJNKX-UHFFFAOYSA-N 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- CPJKKWDCUOOTEW-UHFFFAOYSA-N sylvatesmin Natural products C1=C(OC)C(OC)=CC=C1C1C(COC2C=3C=C(OC)C(O)=CC=3)C2CO1 CPJKKWDCUOOTEW-UHFFFAOYSA-N 0.000 description 2
- 238000011144 upstream manufacturing Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 208000003947 Knee Osteoarthritis Diseases 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 101710160107 Outer membrane protein A Proteins 0.000 description 1
- 238000002944 PCR assay Methods 0.000 description 1
- 241000350580 Zenia Species 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 239000001045 blue dye Substances 0.000 description 1
- 210000003321 cartilage cell Anatomy 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000012091 fetal bovine serum Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000000684 flow cytometry Methods 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 238000007443 liposuction Methods 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000002894 multi-fate stem cell Anatomy 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000007430 reference method Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 238000011476 stem cell transplantation Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0655—Chondrocytes; Cartilage
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
- C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
- C12N2506/1384—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from adipose-derived stem cells [ADSC], from adipose stromal stem cells
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Description
单克隆抗体 | 表达率 |
CD73 | 99.8% |
CD90 | 97.1% |
CD105 | 99.5% |
CD34 | 0.72% |
CD45 | 0.69% |
HLA-DR | 0.61% |
组别 | 24h | 48h | 72h |
对照组 | 0.17±0.05 | 0.28±0.05 | 0.47±0.06 |
实验组(100nM) | 0.20±0.05 | 0.26±0.04 | 0.51±0.07 |
实验组(200nM) | 0.19±0.04 | 0.29±0.06 | 0.52±0.06 |
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910779324.2A CN110438069B (zh) | 2019-08-22 | 2019-08-22 | 一种连翘脂素用于体外促进人脂肪间充质干细胞成软骨分化的用途 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910779324.2A CN110438069B (zh) | 2019-08-22 | 2019-08-22 | 一种连翘脂素用于体外促进人脂肪间充质干细胞成软骨分化的用途 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN110438069A CN110438069A (zh) | 2019-11-12 |
CN110438069B true CN110438069B (zh) | 2022-11-22 |
Family
ID=68437170
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201910779324.2A Active CN110438069B (zh) | 2019-08-22 | 2019-08-22 | 一种连翘脂素用于体外促进人脂肪间充质干细胞成软骨分化的用途 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN110438069B (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111686102B (zh) * | 2020-05-29 | 2023-07-14 | 上海市伤骨科研究所 | 连翘脂素在制备用于预防或治疗骨质疏松的药物中的用途 |
CN112592891B (zh) * | 2020-12-17 | 2023-05-12 | 黑龙江省恒生干细胞工程有限公司 | 一种乌拉尔醇在体外促进人脂肪间充质干细胞成骨分化方面的应用 |
CN113583945B (zh) * | 2021-07-28 | 2023-02-03 | 广东省第二中医院(广东省中医药工程技术研究院) | 杜仲苷促进脂肪间充质干细胞增殖和成软骨分化的应用及方法 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20120140450A (ko) * | 2011-06-21 | 2012-12-31 | (주)아모레퍼시픽 | 인간 중간엽줄기세포의 분화 촉진용 조성물 |
CN105754934A (zh) * | 2016-03-08 | 2016-07-13 | 大连大学 | 牙髓干细胞、制备方法及其相关骨组织工程材料 |
CN106520685A (zh) * | 2016-12-21 | 2017-03-22 | 江西宜信堂医疗科技有限公司 | 一种适用于软骨细胞体外培养的无血清培养基及其制备方法 |
CN106834220A (zh) * | 2016-12-24 | 2017-06-13 | 叶宗耀 | 一种无血清软骨细胞培养基及其制备方法 |
CN109316491A (zh) * | 2018-11-05 | 2019-02-12 | 北京世纪劲得生物技术有限公司 | Nk细胞联合间充质干细胞在治疗肝炎及肝纤维化中的应用 |
CN109453199A (zh) * | 2018-11-05 | 2019-03-12 | 北京世纪劲得生物技术有限公司 | 间充质干细胞、组合物及注射液在制备治疗糖尿病药物的应用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR3049194B1 (fr) * | 2016-03-23 | 2019-10-04 | Sederma | Utilisation d’un ingredient cosmetique comprenant un materiel vegetal issu de marrubium vulgare pour un traitement cosmetique |
-
2019
- 2019-08-22 CN CN201910779324.2A patent/CN110438069B/zh active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20120140450A (ko) * | 2011-06-21 | 2012-12-31 | (주)아모레퍼시픽 | 인간 중간엽줄기세포의 분화 촉진용 조성물 |
CN105754934A (zh) * | 2016-03-08 | 2016-07-13 | 大连大学 | 牙髓干细胞、制备方法及其相关骨组织工程材料 |
CN106520685A (zh) * | 2016-12-21 | 2017-03-22 | 江西宜信堂医疗科技有限公司 | 一种适用于软骨细胞体外培养的无血清培养基及其制备方法 |
CN106834220A (zh) * | 2016-12-24 | 2017-06-13 | 叶宗耀 | 一种无血清软骨细胞培养基及其制备方法 |
CN109316491A (zh) * | 2018-11-05 | 2019-02-12 | 北京世纪劲得生物技术有限公司 | Nk细胞联合间充质干细胞在治疗肝炎及肝纤维化中的应用 |
CN109453199A (zh) * | 2018-11-05 | 2019-03-12 | 北京世纪劲得生物技术有限公司 | 间充质干细胞、组合物及注射液在制备治疗糖尿病药物的应用 |
Non-Patent Citations (2)
Title |
---|
Forsythiaside inhibits bacterial adhesion on titanium alloy and attenuates Ti-induced activation of nuclear factor-κB signaling-mediated macrophage inflammation;Haifeng Li等;《Journal of Orthopaedic Surgery and Research》;20180605;第1-10页 * |
The Androgenic Alopecia Protective Effects of Forsythiaside-A and the Molecular Regulation in a Mouse Model;Heon-Sub Shin等;《PHYTOTHERAPY RESEARCH》;20150324;第870-876页 * |
Also Published As
Publication number | Publication date |
---|---|
CN110438069A (zh) | 2019-11-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103805562B (zh) | 培养胎盘间充质干细胞的无血清培养基 | |
CN110438069B (zh) | 一种连翘脂素用于体外促进人脂肪间充质干细胞成软骨分化的用途 | |
CN103266081B (zh) | 从脐带中分离培养间充质干细胞的高效方法 | |
CN101748096A (zh) | 亚全能干细胞、其制备方法及其用途 | |
CN1548529A (zh) | 一种人胎盘间充质干细胞的分离方法 | |
CN101314766A (zh) | 一种分离培养人脂肪间充质干细胞的方法及其专用培养基 | |
WO2020233119A1 (zh) | 一种促间充质干细胞增殖的无血清多肽组合物 | |
CN1778905B (zh) | 一种脂肪间充质干细胞的分离培养方法及其应用 | |
CN102146359A (zh) | 从胎盘中提取原始间充质干细胞及无血清扩增的方法 | |
Chai et al. | Dedifferentiation of human adipocytes after fat transplantation | |
CN104694469A (zh) | 胎盘底蜕膜间充质干细胞的制备方法 | |
Yu et al. | Autologous decellularized extracellular matrix protects against H2O2-induced senescence and aging in adipose-derived stem cells and stimulates proliferation in vitro | |
CN106834217B (zh) | 一种促进人羊膜上皮细胞体外扩增的方法及应用 | |
CN109966500B (zh) | 含枸杞多糖保护液及其在提高间充质干细胞应对体内病理微环境中的应用方法 | |
CN105886462A (zh) | 用于ADSCs培养的组合物及ADSCs培养方法 | |
CN111849878A (zh) | 一种提高间充质干细胞成骨能力的方法 | |
Jankowski et al. | The differentiation and transdifferentiation of epithelial cells in vitro–is it a new strategy in regenerative biomedicine? | |
CN103305465B (zh) | 一种颅神经嵴源性干细胞的培养方法和鉴定方法 | |
CN101054572B (zh) | 人脐血干细胞培养及定向分化为多巴胺能神经细胞的方法及得到的多巴胺能神经细胞的应用 | |
CN116218772A (zh) | 一种尿源混合细胞培养方法 | |
CN105087475A (zh) | 一种细胞培养液及其应用以及诱导牙髓干细胞向神经样细胞分化的方法 | |
CN114410579A (zh) | 组合物、包含其的间充质干细胞无血清培养基及其制备和应用 | |
Mahboudi et al. | Comparison between high cell-density culture systems for chondrogenic differentiation and articular cartilage reconstruction of human mesenchymal stem cells: a literature review | |
Zou et al. | Isolation and osteogenic differentiation of skeletal muscle‑derived stem cells for bone tissue engineering | |
CN110438070B (zh) | 一种苦参酮用于体外促进人脂肪间充质干细胞增殖的用途 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20221031 Address after: 518000 401, Building A, No. 3 Binhai Second Road, Buxin Community, Dapeng Street, Dapeng New District, Shenzhen, Guangdong Applicant after: Shenzhen Zeyi Cell Therapy Group Co.,Ltd. Address before: 210028 No. 100, cross street, Hongshan Road, Nanjing, Jiangsu Province (Jiangsu Academy of traditional Chinese Medicine) Applicant before: Shi Xuegao |
|
TA01 | Transfer of patent application right | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Application of Forsythia suspensa extract in promoting chondrogenic differentiation of human adipose derived mesenchymal stem cells in vitro Granted publication date: 20221122 Pledgee: Shenzhen Rural Commercial Bank Co.,Ltd. Dapeng Branch Pledgor: Shenzhen Zeyi Cell Therapy Group Co.,Ltd. Registration number: Y2024980033826 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right |