CN110433266A - It is a kind of to treat leucoderma Chinese materia medica preparation and its preparation method and application - Google Patents
It is a kind of to treat leucoderma Chinese materia medica preparation and its preparation method and application Download PDFInfo
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
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Abstract
Leucoderma Chinese materia medica preparation and its preparation method and application is treated the invention particularly discloses a kind of；It includes following raw material that the present invention, which treats leucoderma Chinese materia medica preparation: Chinese herbaceous peony, Radix Rehmanniae, peach kernel, radix bupleuri, the root of Dahurain angelica, cattail pollen, psoralea corylifolia, duckweed, donkey-hide gelatin, ramulus cinnamomi, Radix Curcumae, Radix Glycyrrhizae, trigone, the fruit of glossy privet, Herba Epimedii and radix cyathulae.The treatment leucoderma Chinese materia medica preparation preparation method comprises the steps of: that S1. gets out various raw material by formula；S2. various raw material are crushed, and is impregnated with water；S3. then, 70~80 DEG C of progress 35~45min of refluxing extraction take filtrate；S4. again by dregs of a decoction refluxing extraction 1~2 time under the conditions of 75~85 DEG C, 50~60min, takes filtrate every time, abandons filter residue；S5. then, merging filtrate, membrane filtration, and carry out concentration and medicinal extract is made；S6 again pelletized it by granulator, dry and whole grain to get.
Description
Technical field
The present invention relates to pharmaceutical formulation techniques fields, and in particular to a kind of to treat leucoderma Chinese materia medica preparation and preparation method thereof
And application.
Background technique
Leucoderma is a kind of common primary, limitation or general hair property depigmentation skin disease, typical clinical table
It is existing are as follows: the complete depigmentation of pigment at skin lesion, be creamy white irregular dotted or sheet, and indefinite border when skin lesion is initial gradually expands
The greatly clear depigmentation spot of boundary, can migrate to normal skin.Hair visible decoloration or normal in hickie is clinical common
Serious discosmetic dermatosis.
About the cause of disease of leucoderma, there are many hypothesis for educational circles at present, but white without the exact explanation of any of which energy
The pathogenesis of purplish or white patches on the skin wind.The cause of disease of leucoderma may be summarized to be: leucoderma is with genetic predisposition, due to immune, endocrine, mind
Cause melanosome through spirit, metabolic function etc. disorder so as to cause the inhibition of enzyme system or the destruction of melanocyte
Generation or melanism obstacle, eventually lead to depigmentation.
Leucoderma is painless, but the skin injury as caused by it directly influences the beauty of patient, and is easy to trouble
The life of person, study, the various aspects such as work bring many unfavorable factors, to influence the mental health and life matter of patient
Amount.Leucoderma is easily examined and refractory, and the course of disease is longer, and therapeutic effect is often unsatisfied with.Therefore, the curative effect that research improves leucoderma has ten
Divide important meaning.
Theory Of heredity, oxidative stress, immunologic mechanism (autoimmunity are concentrated mainly on for the research of leucoderma at present
Reaction) and the self-destruction of melanocyte etc..Many scholars think that the melanocyte of patients with vitiligo gradually decreases or disappears
The trend of mistake, in addition to melanocyte, factor (such as tyrosine, TYR enzyme, DOPA, copper, the ultraviolet light of any influence melanin genesis
Deng) it can influence the synthesis of melanocyte.The pathogenic factor of leucoderma and the complexity of mechanism.Currently, the auxiliary for leucoderma is examined
Disconnected technology is constantly updated, while dermatoscopy has valuable help for early diagnosis, the antidiastole of leucoderma, can help
Its therapeutic effect of dynamic observation.The treatment method for the treatment of leucoderma has oral drugs, physiotherapy and operative treatment etc. at present；Though
Right above-mentioned therapy achieves certain curative effect, but effect is unobvious, and long-time service can generate various adverse reactions.
Summary of the invention
The case where more lacking is treated for imitating preferable treatment leucoderma Chinese materia medica preparation in the market for current, this makes
Clinically the case where treatment of leucoderma, produces the drug pair of certain limitation and inconvenient and existing some treatment leucoderma
The also ideal not to the utmost problem of the therapeutic effect of some leucoderma treats leucoderma Chinese materia medica preparation it is an object of that present invention to provide a kind of
And its preparation method and application.
Because the related drug effect of current therapy of vitiligo drug cannot meet associated treatment needs, for further expansion
Treatment use scope is restricted；Radix Rehmanniae is the fresh or dried root of scrophulariaceae rehmannia glutinosa plant, and nature and flavor sweetness and bitterness is trembled with fear, returned
The heart, liver and kidney channel, clearing heat and cooling blood, nourishing Yin and promoting production of body fluid, main heat enter ying blood, the deep red polydipsia of tongue, macula hematemesis；Yin asthenia generating intrinsic heat, hectic fever due to yin labor heat；
Injury thirst, Heat Diabetes, dry constipation of intestines；Ramulus cinnamomi, it is sweet, pungent, warm.With sweating expelling pathogenic factors from muscles and skin, warming meridian, helps yang transforming qi function,
Modern pharmacological research, ramulus cinnamomi have expansion blood vessel, promote sweating, is decompression, antipyretic, spasmolysis, analgesia, platelet aggregation-against, anticoagulant
Blood improves a variety of effects such as microcirculation；Radix Glycyrrhizae, sweet and neutral have and invigorate the spleen and benefit qi, and expelling phlegm and arresting coughing, relieving spasm to stop pain is clearing heat and detoxicating, existing
Show for pharmacology: it is immune and other effects with anti-inflammatory, antiviral and antitumor, anti-arrhythmia, adjusting；Chinese herbaceous peony is held back with blood-nourishing
The function of yin, suppressing liver-YANG has the effects that calmness, analgesia, anti-inflammatory, liver protection, adjusting are immune；Duckweed is plant and of its applications duckweed
Drying herb, nature and flavor are pungent, tremble with fear.Return lung, bladder meridian.Inducing sweat and dispelling exogenous evils, promoting eruption is antipruritic, inducing diuresis to remove edema；The fruit of glossy privet is Oleaceae plant
The ripening fruits of object glossy privet.Nature and flavor sweetness and bitterness, it is cool, have return liver and kidney channel, it is nourishing liver and kidney, crow must improving eyesight the effect of；Donkey-hide gelatin, it is sweet,
It is flat, tepor.Function with blood enriching and yin nourishing, moistening lung, hemostasis, donkey-hide gelatin, which has, enriches blood, stops blooding, rises white, enhancing immunity of organisms, is anti-
The effects of tired；Peach kernel has promoting blood circulation, relax bowel and defecation, relieving cough and asthma effect.For amenorrhea and algomenorrhea, lump in the abdomen lump in the abdomen lump in the abdomen, lung
Carbuncle acute appendicitis, injury from falling down, dry constipation of intestines, cough and asthma；Radix bupleuri is bitter in taste, slightly cold, returns liver, gallbladder channel.Have in inducing diaphoresis, soothing the liver liter
The effect of positive, can be used for cold, fever, fevers and chills alternate, malaria, liver depression and qi stagnation, chest and rib distending pain, rectal prolapse, uterine prolapse, menstruation
Uncomfortable treatment；Cattail pollen is for spitting blood, bleeding from five sense organs or subcutaneous tissue, hemoptysis, metrorrhagia and metrostaxis, traumatic hemorrhage, menostasis promoting menstruation, chest and abdomen shouting pain, tumbling and swelling, blood
Drench puckery pain；Psoralea corylifolia has the function of tonifying kidney and strengthening yang, good efficacy to suffering from a deficiency of the kidney, and can control the skin diseases such as psoriasis；Trigone has blood-breaking row
The effect of gas, clearing stagnation and killing pain, is used for abdominal mass lump in the abdomen, dysmenorrhea, blood stasis closed, chest impediment and cardialgia, dyspepsia distending pain；Herba Epimedii cures mainly impotence
The effect of premature ejaculation, pain in low back and legs, numb limb, hemiplegia, neurasthenia, amnesia, tinnitus, dizzy equal diseases；By will be above-mentioned
Being used in conjunction can not only play the role of separately taking various drugs, mitigate patient's medicining times and clinical treatment not
Just, while it being combined the effect that can preferably play and enhance various drugs, treatment leucoderma wind action can be played；Meanwhile
The leucoderma Chinese materia medica preparation stability prepared by this preparation method is more preferable, is convenient for daily preservation management；And with commercially available part
Leucoderma medicament it is more preferable compared to the safety of leucoderma Chinese materia medica preparation of the invention, adverse reaction is few, for a wider population, more
It is suitable for that clinical treatment uses, more can guarantee that the safety of patient, curative effect are relatively preferable.Thus the present invention passes through in exploitation leucoderma
Medicine preparation not only can solve the drug for treating leucoderma now with effect and more be short of and current clinically leucoderma medicament preparation effect
The not satisfactory problem of fruit, is more able to satisfy Treatment need clinically.
To realize that above-mentioned target, the present invention are achieved by the following technical programs:
A kind of to treat leucoderma Chinese materia medica preparation, score meter by weight is made of following raw material: 4~8 portions of Chinese herbaceous peonies, 15~25 parts
Radix Rehmanniae, 7~15 parts of peach kernels, 8~16 parts of radix bupleuri, 10~18 parts of roots of Dahurain angelica, 9~18 parts of cattail pollens, 7~15 parts of psoralea corylifolias, 7~15 parts it is floating
Duckweed, 5~10 parts of donkey-hide gelatin, 8~15 parts of ramulus cinnamomi, 3~8 portions of Radix Curcumaes, 3~7 portions of Radix Glycyrrhizaes, 5~12 parts of trigones, 3~8 portions of fruit of glossy privets and 5
~9 parts of Herba Epimedii and auxiliary material are several.
Preferably, it is described it is a kind of treat leucoderma Chinese materia medica preparation, score meter by weight is made of following raw material: 4~8 parts
Chinese herbaceous peony, 15~25 parts of Radix Rehmanniaes, 7~15 parts of peach kernels, 8~16 parts of radix bupleuri, 10~18 parts of roots of Dahurain angelica, 9~18 parts of cattail pollens, 7~15 parts of benefits
Bone fat, 7~15 portions of duckweeds, 5~10 parts of donkey-hide gelatin, 8~15 parts of ramulus cinnamomi, 3~8 portions of Radix Curcumaes, 3~7 portions of Radix Glycyrrhizaes, 5~12 parts of trigones, 3
~8 portions of fruit of glossy privets, 5~9 parts of Herba Epimedii and 5~10 portions of radix cyathulaes and auxiliary material are several.
Preferably, it is described it is a kind of treat leucoderma Chinese materia medica preparation, score meter by weight is made of following raw material: 4~8 parts
Chinese herbaceous peony, 15~25 parts of Radix Rehmanniaes, 7~15 parts of peach kernels, 8~16 parts of radix bupleuri, 10~18 parts of roots of Dahurain angelica, 9~18 parts of cattail pollens, 7~15 parts of benefits
Bone fat, 7~15 portions of duckweeds, 5~10 parts of donkey-hide gelatin, 8~15 parts of ramulus cinnamomi, 3~8 portions of Radix Curcumaes, 3~7 portions of Radix Glycyrrhizaes, 5~12 parts of trigones, 3
~8 portions of fruit of glossy privets, 5~9 parts of Herba Epimedii and 6~13 portions of Radix Curcumaes and auxiliary material are several.
Preferably, it is described it is a kind of treat leucoderma Chinese materia medica preparation, score meter by weight is made of following raw material: 4~8 parts
Chinese herbaceous peony, 15~25 parts of Radix Rehmanniaes, 7~15 parts of peach kernels, 8~16 parts of radix bupleuri, 10~18 parts of roots of Dahurain angelica, 9~18 parts of cattail pollens, 7~15 parts of benefits
Bone fat, 7~15 portions of duckweeds, 5~10 parts of donkey-hide gelatin, 8~15 parts of ramulus cinnamomi, 3~8 portions of Radix Curcumaes, 3~7 portions of Radix Glycyrrhizaes, 5~12 parts of trigones, 3
~8 portions of fruit of glossy privets, 5~9 parts of Herba Epimedii and 5~11 parts of pueraria lobatas and auxiliary material are several.
Preferably, it is described it is a kind of treat leucoderma Chinese materia medica preparation, score meter by weight is made of following raw material: 4~8 parts
Chinese herbaceous peony, 15~25 parts of Radix Rehmanniaes, 7~15 parts of peach kernels, 8~16 parts of radix bupleuri, 10~18 parts of roots of Dahurain angelica, 9~18 parts of cattail pollens, 7~15 parts of benefits
Bone fat, 7~15 portions of duckweeds, 5~10 parts of donkey-hide gelatin, 8~15 parts of ramulus cinnamomi, 3~8 portions of Radix Curcumaes, 3~7 portions of Radix Glycyrrhizaes, 5~12 parts of trigones, 3
~8 portions of fruit of glossy privets, 5~9 parts of Herba Epimedii, 3~8 portions of Chinese yams and 4~9 portions of Amomum cardamomums and auxiliary material are several.
Preferably, it is described it is a kind of treat leucoderma Chinese materia medica preparation, score meter by weight is made of following raw material: 4~8 parts
Chinese herbaceous peony, 15~25 parts of Radix Rehmanniaes, 7~15 parts of peach kernels, 8~16 parts of radix bupleuri, 10~18 parts of roots of Dahurain angelica, 9~18 parts of cattail pollens, 7~15 parts of benefits
Bone fat, 7~15 portions of duckweeds, 5~10 parts of donkey-hide gelatin, 8~15 parts of ramulus cinnamomi, 3~8 portions of Radix Curcumaes, 3~7 portions of Radix Glycyrrhizaes, 5~12 parts of trigones, 3
~8 portions of fruit of glossy privets, 5~9 parts of Herba Epimedii, 3~8 portions of rhizoma alismatis and 4~9 parts of Poria cocos and auxiliary material are several.
Preferably, the Chinese materia medica preparation is one of tablet, capsule, intersection, pill and particle electuary or a variety of.
Preferably, the auxiliary material is filler and Icing Sugar.
It is highly preferred that the Icing Sugar is sucrose；The filler is maltodextrin or microcrystalline cellulose.
Preferably, a kind of preparation method for treating leucoderma Chinese medicinal capsule comprising the steps of:
S1. various raw material are got out by formula；
S2. various raw material are crushed, and carries out 30~45min of immersion with water；
S3. then, 35~45min of refluxing extraction is carried out under the conditions of 70~80 DEG C, melt cinder separation takes filtrate；
S4. again by the dregs of a decoction refluxing extraction 1~2 time under the conditions of 75~85 DEG C, 50~60min, takes filtrate every time, abandons filter
Slag；
S5. then, the leaching that density is 1.25~1.30 is made with membrane filtration filtrate, and by filtrate concentration in merging filtrate
Cream；
S6. it is dried and crushes under the conditions of 60~70 DEG C, smash it through 100 meshes；
S7. it by smashed fine powder, is fitted into capsule shells to obtain the final product.
It is preferably, described a kind of to treat leucoderma Chinese medicinal granule preparation method comprising the steps of:
S1. various raw material are got out by formula；
S2. various raw material are crushed, and carries out 30~45min of immersion with water；
S3. then, 35~45min of refluxing extraction is carried out under the conditions of 70~80 DEG C, melt cinder separation takes filtrate；
S4. again by the dregs of a decoction refluxing extraction 1~2 time under the conditions of 75~85 DEG C, 50~60min, takes filtrate every time, abandons filter
Slag；
S5. then, the leaching that density is 1.25~1.30 is made with membrane filtration filtrate, and by filtrate concentration in merging filtrate
Cream；
S6. the auxiliary material of 3~5 times of medicinal extract amounts is added inward again, wherein the sugar of auxiliary material: filler is that 2~4:1 mixing is equal
It is even, softwood is made；
S7. it is pelletized by granulator again, dry and whole grain to get.
Preferably, a kind of preparation method for treating leucoderma Chinese medicinal tablet comprising the steps of:
S1. various raw material are got out by formula；
S2. various raw material are crushed, and carries out 30~45min of immersion with water；
S3. then, 35~45min of refluxing extraction is carried out under the conditions of 70~80 DEG C, melt cinder separation takes filtrate；
S4. again by the dregs of a decoction refluxing extraction 1~2 time under the conditions of 75~85 DEG C, 50~60min, takes filtrate every time, abandons filter
Slag；
S5. then, the leaching that density is 1.25~1.30 is made with membrane filtration filtrate, and by filtrate concentration in merging filtrate
Cream；
S6. again toward auxiliary material is added in medicinal extract, the wherein sugar of auxiliary material: filler is uniformly mixed for 2~4:1, and softwood is made；
S7. again by its by granulator carry out tabletting and it is dry to get.
Specific embodiment
The present invention is further elaborated combined with specific embodiments below, the embodiment is served only for explaining this hair
It is bright, it is not intended to limit the scope of the present invention.Test method as used in the following examples is routine unless otherwise specified
Method；Used material, reagent etc., unless otherwise specified, for the reagent and material commercially obtained.
Embodiment 1
A kind of to treat leucoderma Chinese materia medica preparation, score meter by weight is made of following raw material: 5 portions of Chinese herbaceous peonies, 16 parts of Radix Rehmanniaes, 9
Part peach kernel, 10 parts of radix bupleuri, 10 parts of roots of Dahurain angelica, 10 parts of cattail pollens, 9 parts of psoralea corylifolias, 7 portions of duckweeds, 5 parts of donkey-hide gelatin, 10 parts of ramulus cinnamomi, 5 portions of Radix Curcumaes,
3 portions of Radix Glycyrrhizaes, 5 parts of trigones, 4 portions of fruit of glossy privets and 6 parts of Herba Epimedii and auxiliary material are several.
A kind of preparation method for treating leucoderma Chinese medicinal capsule, which is characterized in that comprise the steps of:
S1. various raw material are got out by formula；
S2. various raw material are crushed, and carries out immersion 30min with water；
S3. then, refluxing extraction 40min is carried out under the conditions of 70 DEG C, melt cinder separation takes filtrate；
S4. again by the dregs of a decoction refluxing extraction 1 time, each 50min under the conditions of 75 DEG C, filtrate is taken, abandons filter residue；
S5. then, the leaching that density is 1.25~1.30 is made with membrane filtration filtrate, and by filtrate concentration in merging filtrate
Cream；
S6. medicinal extract is dried and is crushed under the conditions of 60 DEG C, smash it through 100 meshes；
S7. by smashed fine powder, pill, tablet, particle and capsule is made.
Embodiment 2
A kind of to treat leucoderma Chinese materia medica preparation, score meter by weight is made of following raw material: 6 portions of Chinese herbaceous peonies, 20 parts of Radix Rehmanniaes, 11
Part peach kernel, 12 parts of radix bupleuri, 13 parts of roots of Dahurain angelica, 10 parts of cattail pollens, 8 parts of psoralea corylifolias, 9 portions of duckweeds, 7 parts of donkey-hide gelatin, 10 parts of ramulus cinnamomi, 4 portions of Radix Curcumaes,
4 portions of Radix Glycyrrhizaes, 6 parts of trigones, 5 portions of fruit of glossy privets, 6 parts of Herba Epimedii and 7 portions of radix cyathulaes and auxiliary material are several.
It is a kind of to treat leucoderma Chinese medicinal granule preparation method comprising the steps of:
S1. various raw material are got out by formula；
S2. various raw material are crushed, and carries out immersion 40min with water；
S3. then, refluxing extraction 40min is carried out under the conditions of 75 DEG C, melt cinder separation takes filtrate；
S4. again by the dregs of a decoction refluxing extraction 2 times, each 55min under the conditions of 80 DEG C, filtrate is taken, abandons filter residue；
S5. then, the leaching that density is 1.25~1.30 is made with membrane filtration filtrate, and by filtrate concentration in merging filtrate
Cream；
S6. medicinal extract is dried and is crushed under the conditions of 60 DEG C, smash it through 100 meshes；
S7. by smashed fine powder, pill, tablet, particle and capsule is made.
Embodiment 3
A kind of to treat leucoderma Chinese materia medica preparation, score meter by weight is made of following raw material: 6 portions of Chinese herbaceous peonies, 22 parts of Radix Rehmanniaes, 7
Part peach kernel, 9 parts of radix bupleuri, 11 parts of roots of Dahurain angelica, 10 parts of cattail pollens, 8 parts of psoralea corylifolias, 12 portions of duckweeds, 8 parts of donkey-hide gelatin, 10 parts of ramulus cinnamomi, 6 portions of Radix Curcumaes,
4 portions of Radix Glycyrrhizaes, 5 parts of trigones, 5 portions of fruit of glossy privets, 7 parts of Herba Epimedii and 9 portions of Radix Curcumaes and auxiliary material are several.
A kind of preparation method for treating leucoderma Chinese materia medica preparation comprising the steps of:
S1. various raw material are got out by formula；
S2. various raw material are crushed, and carries out immersion 45min with water；
S3. then, refluxing extraction 45min is carried out under the conditions of 70 DEG C, melt cinder separation takes filtrate；
S4. again by the dregs of a decoction refluxing extraction 1 time, each 55min under the conditions of 75 DEG C, filtrate is taken, abandons filter residue；
S5. then, the leaching that density is 1.25~1.30 is made with membrane filtration filtrate, and by filtrate concentration in merging filtrate
Cream；
S6. medicinal extract is dried and is crushed under the conditions of 60 DEG C, smash it through 100 meshes；
S7. by smashed fine powder, pill, tablet, particle and capsule is made.
Embodiment 4
A kind of to treat leucoderma Chinese materia medica preparation, score meter by weight is made of following raw material: 7 portions of Chinese herbaceous peonies, 22 parts of Radix Rehmanniaes, 12
Part peach kernel, 15 parts of radix bupleuri, 16 parts of roots of Dahurain angelica, 15 parts of cattail pollens, 10 parts of psoralea corylifolias, 8 portions of duckweeds, 6 parts of donkey-hide gelatin, 8 parts of ramulus cinnamomi, 4 portions of Radix Curcumaes,
5 portions of Radix Glycyrrhizaes, 8 parts of trigones, 5 portions of fruit of glossy privets, 6 parts of Herba Epimedii and 10 parts of pueraria lobatas and auxiliary material are several.
It is a kind of to treat leucoderma Chinese materia medica preparation preparation method comprising the steps of:
S1. various raw material are got out by formula；
S2. various raw material are crushed, and carries out immersion 45min with water；
S3. then, refluxing extraction 45min is carried out under the conditions of 80 DEG C, melt cinder separation takes filtrate；
S4. again by the dregs of a decoction refluxing extraction 2 times, each 60min under the conditions of 85 DEG C, filtrate is taken, abandons filter residue；
S5. then, the leaching that density is 1.25~1.30 is made with membrane filtration filtrate, and by filtrate concentration in merging filtrate
Cream；
S6. medicinal extract is dried and is crushed under the conditions of 60 DEG C, smash it through 100 meshes；
S7. by smashed fine powder, pill, tablet, particle and capsule is made.
One, toxicological test
1. average daily dose toxicological test:
Test object and drug: removing healthy rat, and the rat of 200 ± 5g of weight 100 is randomly divided into 4 groups, every group 25
Only；Sample prepared by Example 1, embodiment 2, embodiment 3 and embodiment 4, daily takes dose to rat according to 2 times of adults
Stomach-filling is carried out, 3 times a day, 8 hours primary, and successive administration 7d after daily administration, is observed, test result such as table 1
It is shown.
1 rat toxicological test test result of table
Each group rat takes the embodiment of dose in 2 times of stomach-filling average daily adults it can be seen from the test data in table 1
Without there are the significant discomfort conjunction phenomena of mortality after 1~4 sample 7d, this shows in the treatment leucoderma of preparation of the embodiment of the present invention
The medicine quality of the pharmaceutical preparations is preferable, average daily dose be it is safe and reliable, meet the security requirement of clinical treatment.
2. taking toxicological test for a long time
Test object and drug: removing healthy rat, and the rat of 200 ± 5g of weight 120 is randomly divided into 6 groups, every group 20
Only；Sample prepared by Example 1, embodiment 2, embodiment 3 and embodiment 4 is test group 1~4, one group of daily stomach-filling of rat
The pure water of identical capacity is blank control group, another group of Chinese medicine system by the other famous treatment leucoderma of identical dose stomach-filling
Agent as a control group 1 daily takes dose according to 2 times and 3 times of adults and carries out stomach-filling, 1 time a day, successive administration 90 to rat
It, daily observes and records the behavior of rat, the results are shown in Table 2.
The test of 2 long_term toxcity of table
From the test data in table 2 it is recognised that control group 1, blank control group and give test group 1~4 treatment it is white
The Chinese materia medica preparation of purplish or white patches on the skin wind is before stomach-filling, behavioural habits, reaction and the diet and relevant blood, kidney function and liver function of each group rat
Etc. parameters it is similar；To rat carry out stomach-filling 90d after, observation as the result is shown: blank control group and give stomach-filling test group 1~
The each group behavior and reaction and relevant kidney function, liver function and blood etc. of the rat of the Chinese materia medica preparation of 4 treatment leucoderma are joined
Number with it is similar before stomach-filling, and then there is lags in response in the partial rat of stomach-filling control group 1, and diet reduces and relevant ginseng
The case where number detection changes, this display is compared with control group 1, the Chinese materia medica preparation for the treatment of leucoderma prepared by test group 1~4
Take for a long time safer, toxic side effect is smaller, and clinical treatment is suitble to use.
Two, pharmacodynamic test
Test object and drug: removing healthy rat, and the rat of 200 ± 5g of weight 180 is randomly divided into 9 groups, every group 20
Only；Example 2 is test group 1~3 and embodiment 3 is test group 4~6, wherein 1~6 group of test is respectively high concentration test
Group 1 (normal dosage 100%), middle concentration determination group 1 (normal dosage 50%), (the normal dosage of low concentration test group 1
30%), high concentration test group 2 (normal dosage 100%), middle concentration determination group 2 (normal dosage 50%), low concentration test
Certain commercially available well-known treatment leucoderma medicament is administered for control group 1 in group one group of 2 (normal dosage 30%): control group 1 (it is commercially available certain know
100%), another group is the daily stomach-filling equal amount of distilled water of blank control group to the administration of name treatment leucoderma medicament, and last 1 group is model
Group；By each group neck unhairing, the area of light about 3*3cm is shaved, in addition to blank control group, remaining each group is used outside 5% hydrogen peroxide
Apply rat epilating area, 2 times a day, continuous 45d；After 45d, in addition to model group, blank control group smears the physiological saline of equivalent；
Other each groups press above-mentioned beginning gastric infusion, and continuous 45d, during test, hydrogen peroxide is smeared at the neck back of each group rat
Region, cropping is shaved light 1 time weekly.
After 80d, 20% urethane of rat is anaesthetized, blood plasma monoamine oxidase (MAP), blood plasma are surveyed in abdominal aorta blood drawing
Cholinesterase (ChE) and blood plasma tyrosinase activity (TYR)；Position center, which is smeared, in 5% hydrogen peroxide takes 1*1cm skin,
It is fixed, paraffin embedding, is sliced with neutral formalin；And melanin dyeing is carried out, and choose the visual field to the melanin area in the visual field
(the as surface density (sd) of melanin) is analyzed with the ratio of field area.(test data is as shown in table 3)
Can be seen that compared with model group and blank control group from the test data in table 3, test group 1 and test group 2 with
And significant difference has occurred in the test number of control group 1, has statistical significance, and test group 1 and test group 2 and right
It is superior to model group according to the test data of group 1, shows it for having preferable effect for treatment Rat Experimental leucoderma；
And in the identical dose of stomach-filling, compared with control group 1, the survey of MAP, ChE and TYR and SD of test group 1 and test group 2
Examination numerical value is substantially better than control group 1, this shows test group 1~2, and for treatment Rat Experimental leucoderma, curative effect is better.
3 MAP, ChE and TYR test result of table
Three, clinical treatment
Test object and drug: it chooses and clinically meets leucoderma doctor trained in Western medicine, tcm diagnosis standard and be included in, exclusion criteria
The similar patients with vitiligo patient of the state of an illness totally 120 is divided into three groups using random controls principle according to its sequencing of going to a doctor:
Treatment group, control group A, control group B, every group 40.
Treatment group: the Chinese materia medica preparation Chinese medicine for giving the treatment leucoderma of preparation of the embodiment of the present invention for oral administration warmly takes after the meal, often
Day is one, and 2 times/day, 200ml/ times；
Control group A: it is oral using thymic peptide enteric coatel tablets, 3 times/day, 2 tablets/time；
Control group B: it is oral using thin sesame piece, 3 times/day, 2 tablets/time；
4 weeks as a treatment course, and 6 courses for the treatment of are observed continuously.Photo is routinely left and taken before treatment and when each further consultation, and respectively
It has a blood test, urinate, stool routine examination and hepatic and renal function.Changed according to pretherapy and post-treatment skin lesion, objectively evaluates the clinical efficacy of pink leucoderma side.
The skin lesion before treatment group and control group A, control group B treatment and after treatment at the end of each course for the treatment of is observed and recorded respectively changes feelings
Condition calculates obvious effective rate and total effective rate and carries out Comparison of therapeutic.
The discrimination standard for the treatment of are as follows: recovery from illness: skin lesion is all subsided, and restores normal skin tone；
Effective: skin lesion partial remission or diminution, the area for restoring normal skin tone account for former skin lesion area >=50%；
Improve: skin lesion partial remission or diminution, the area for restoring normal skin tone account for former skin lesion area < 50%；
Invalid: the regeneration of skin lesion non-pigment or area expand.(treatment results are as shown in table 4)
4 leucoderma clinical treatment outcome of table
As can be known from Table 4, by using the Chinese materia medica preparation for the treatment of leucoderma of this example preparation, thymic peptide enteric coatel tablets and thin
The sesame piece patients with vitiligo similar to the state of an illness is after the treatment of 5 courses for the treatment of, the results show that controlling by using the preparation of this example
Chinese materia medica preparation, thymic peptide enteric coatel tablets and the Bao Zhi piece for the treatment of leucoderma carry out the state of an illness of most of patient for the treatment of leucoderma all respectively
Alleviated and substantial portion of patient is cured, this shows that this 3 groups of drugs have preferably treatment leucoderma
Curative effect；And pass through comparison display: the obvious effective rate and total effective rate of the Chinese materia medica preparation for the treatment of leucoderma manufactured in the present embodiment are more
The curative effect of height, the Chinese materia medica preparation for the treatment of leucoderma manufactured in the present embodiment is better than the curative effect of thymic peptide enteric coatel tablets and Bao Zhi piece,
The treatment leucoderma disease being more suitable on Linchuan uses.
Finally it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention, rather than the present invention is protected
The limitation of range is protected, although explaining in detail referring to preferred embodiment to the present invention, those skilled in the art are answered
Work as understanding, it can be with modification or equivalent replacement of the technical solution of the present invention are made, without departing from the reality of technical solution of the present invention
Matter and range.
Claims (10)
1. a kind of treat leucoderma Chinese materia medica preparation, which is characterized in that score meter by weight is made of following raw material: 4~8 parts of Chinese herbaceous peonies
Medicine, 15~25 parts of Radix Rehmanniaes, 7~15 parts of peach kernels, 8~16 parts of radix bupleuri, 10~18 parts of roots of Dahurain angelica, 9~18 parts of cattail pollens, 7~15 parts of Psoralens
Rouge, 7~15 portions of duckweeds, 5~10 parts of donkey-hide gelatin, 8~15 parts of ramulus cinnamomi, 3~8 portions of Radix Curcumaes, 3~7 portions of Radix Glycyrrhizaes, 5~12 parts of trigones, 3~8
Part fruit of glossy privet and 5~9 parts of Herba Epimedii and auxiliary material are several.
2. a kind of treat leucoderma Chinese materia medica preparation, which is characterized in that score meter by weight is made of following raw material: 4~8 parts of Chinese herbaceous peonies
Medicine, 15~25 parts of Radix Rehmanniaes, 7~15 parts of peach kernels, 8~16 parts of radix bupleuri, 10~18 parts of roots of Dahurain angelica, 9~18 parts of cattail pollens, 7~15 parts of Psoralens
Rouge, 7~15 portions of duckweeds, 5~10 parts of donkey-hide gelatin, 8~15 parts of ramulus cinnamomi, 3~8 portions of Radix Curcumaes, 3~7 portions of Radix Glycyrrhizaes, 5~12 parts of trigones, 3~8
Part fruit of glossy privet, 5~9 parts of Herba Epimedii and 5~10 portions of radix cyathulaes and auxiliary material are several.
3. a kind of treat leucoderma Chinese materia medica preparation, which is characterized in that score meter by weight is made of following raw material: 4~8 parts of Chinese herbaceous peonies
Medicine, 15~25 parts of Radix Rehmanniaes, 7~15 parts of peach kernels, 8~16 parts of radix bupleuri, 10~18 parts of roots of Dahurain angelica, 9~18 parts of cattail pollens, 7~15 parts of Psoralens
Rouge, 7~15 portions of duckweeds, 5~10 parts of donkey-hide gelatin, 8~15 parts of ramulus cinnamomi, 3~8 portions of Radix Curcumaes, 3~7 portions of Radix Glycyrrhizaes, 5~12 parts of trigones, 3~8
Part fruit of glossy privet, 5~9 parts of Herba Epimedii and 6~13 portions of Radix Curcumaes and auxiliary material are several.
4. a kind of treat leucoderma Chinese materia medica preparation, which is characterized in that score meter by weight is made of following raw material: 4~8 parts of Chinese herbaceous peonies
Medicine, 15~25 parts of Radix Rehmanniaes, 7~15 parts of peach kernels, 8~16 parts of radix bupleuri, 10~18 parts of roots of Dahurain angelica, 9~18 parts of cattail pollens, 7~15 parts of Psoralens
Rouge, 7~15 portions of duckweeds, 5~10 parts of donkey-hide gelatin, 8~15 parts of ramulus cinnamomi, 3~8 portions of Radix Curcumaes, 3~7 portions of Radix Glycyrrhizaes, 5~12 parts of trigones, 3~8
Part fruit of glossy privet, 5~9 parts of Herba Epimedii and 5~11 parts of pueraria lobatas and auxiliary material are several.
5. a kind of treat leucoderma Chinese materia medica preparation, which is characterized in that score meter by weight is made of following raw material: 4~8 parts of Chinese herbaceous peonies
Medicine, 15~25 parts of Radix Rehmanniaes, 7~15 parts of peach kernels, 8~16 parts of radix bupleuri, 10~18 parts of roots of Dahurain angelica, 9~18 parts of cattail pollens, 7~15 parts of Psoralens
Rouge, 7~15 portions of duckweeds, 5~10 parts of donkey-hide gelatin, 8~15 parts of ramulus cinnamomi, 3~8 portions of Radix Curcumaes, 3~7 portions of Radix Glycyrrhizaes, 5~12 parts of trigones, 3~8
Part fruit of glossy privet, 5~9 parts of Herba Epimedii, 3~8 portions of Chinese yams and 4~9 portions of Amomum cardamomums and auxiliary material are several.
6. a kind of treat leucoderma Chinese materia medica preparation, which is characterized in that score meter by weight is made of following raw material: 4~8 parts of Chinese herbaceous peonies
Medicine, 15~25 parts of Radix Rehmanniaes, 7~15 parts of peach kernels, 8~16 parts of radix bupleuri, 10~18 parts of roots of Dahurain angelica, 9~18 parts of cattail pollens, 7~15 parts of Psoralens
Rouge, 7~15 portions of duckweeds, 5~10 parts of donkey-hide gelatin, 8~15 parts of ramulus cinnamomi, 3~8 portions of Radix Curcumaes, 3~7 portions of Radix Glycyrrhizaes, 5~12 parts of trigones, 3~8
Part fruit of glossy privet, 5~9 parts of Herba Epimedii, 3~8 portions of rhizoma alismatis and 4~9 parts of Poria cocos and auxiliary material are several.
7. a kind of leucoderma Chinese materia medica preparation is treated according to claims 1 to 6, which is characterized in that the Chinese materia medica preparation
For one of tablet, capsule, intersection, pill and particle electuary or a variety of.
8. a kind of leucoderma Chinese materia medica preparation is treated according to claims 1 to 6, which is characterized in that the auxiliary material is to fill out
Fill agent and Icing Sugar.
9. a kind of leucoderma Chinese materia medica preparation is treated according to claim 8, which is characterized in that the Icing Sugar is sucrose,
The filler is maltodextrin or microcrystalline cellulose.
A kind of treat leucoderma Chinese materia medica preparation preparation method 10. according to claims 1 to 6, which is characterized in that comprising with
Lower step:
S1. various raw material are got out by formula；
S2. various raw material are crushed, and carries out 30~45min of immersion with water；
S3. then, 35~45min of refluxing extraction is carried out under the conditions of 70~80 DEG C, melt cinder separation takes filtrate；
S4. again by the dregs of a decoction refluxing extraction 1~2 time under the conditions of 75~85 DEG C, 50~60min, takes filtrate every time, abandons filter residue；
S5. then, the medicinal extract that density is 1.25~1.30 is made with membrane filtration filtrate, and by filtrate concentration in merging filtrate；
S6. the auxiliary material of 3~5 times of medicinal extract is added inward again, wherein sugar: filler is uniformly mixed for 2~4:1, and softwood is made；
S7. it is pelletized by granulator again, dry and whole grain to get.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111643635A (en) * | 2020-05-20 | 2020-09-11 | 甘肃百草堂医药科技有限公司 | Traditional Chinese medicine composition for treating leucoderma and external traditional Chinese medicine preparation |
| CN115282240A (en) * | 2022-08-22 | 2022-11-04 | 李伟 | Traditional Chinese medicine composition for treating leucoderma, preparation method, preparation containing traditional Chinese medicine composition and application |
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2019
- 2019-08-23 CN CN201910786009.2A patent/CN110433266A/en active Pending
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| Title |
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| 中华中医药学会皮肤科分会: "白癜风中医治疗专家共识", 《中国中西医结合皮肤性病学杂志》 * |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111643635A (en) * | 2020-05-20 | 2020-09-11 | 甘肃百草堂医药科技有限公司 | Traditional Chinese medicine composition for treating leucoderma and external traditional Chinese medicine preparation |
| CN115282240A (en) * | 2022-08-22 | 2022-11-04 | 李伟 | Traditional Chinese medicine composition for treating leucoderma, preparation method, preparation containing traditional Chinese medicine composition and application |
| CN115282240B (en) * | 2022-08-22 | 2023-11-24 | 李伟 | Traditional Chinese medicine composition for treating leucoderma and preparation method thereof, preparation containing traditional Chinese medicine composition and application of traditional Chinese medicine composition |
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Application publication date: 20191112 |
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