CN103655786A - Traditional Chinese medicine composition for treating hyperuricemia and gout - Google Patents

Abstract

The invention provides a traditional Chinese medicine composition for treating hyperuricemia and gout. The traditional Chinese medicine composition has the recipe comprising the following components in part by weight: 15-30 parts of herba portulacae, 15-30 parts of hairyvein agrimony, 5-15 parts of rhizoma atractylodis, 3-9 parts of honey-fried licorice root, and 1-5 parts of cinnamon. The traditional Chinese medicine composition for treating hyperuricemia and gout provided by the invention has the characteristics of being effective in treatment, and treating both symptoms and root causes, and can be used for strenthening the spleen and tonifying the kidney, dehumidificating and dispelling turbidity, detoxifying and dispersing blood stasis, cooling blood and tonifying deficiency, dispelling phlegm, removing damp and hot, and relieving stasis toxin.

Description

A kind of Chinese medicine composition for the treatment of hyperuricemia and gout

Technical field

The present invention relates to a kind of Chinese medicine composition for the treatment of hyperuricemia and gout.

Background technology

Hyperuricemia is the metabolic disease that purine metabolism obstacle causes.Be divided into clinically constitutional and the large class of Secondary cases two, the former is many by due to congenital purine metabolic disturbance, normal and fat, glycolipid metabolism is disorderly, hypertension, arteriosclerosis and coronary heart disease etc. are assembled and occurred, and latter is caused by some systemic disease or medicine.According to the report of various places prevalence of hyperuricemia in recent years, approximately there is hyperuricemia person 1.2 hundred million in China at present, accounts for 10% of total population, and the age occurred frequently is middle-aging male and postmenopausal women, but has in recent years rejuvenation trend.

Simple blood uric acid raises, and TCM Document, without clearly recording, sends out well according to it feature that crowd exists fat excessive phlegm more, has a liking for food delicious food savoury.The morbidity that medical circle generally believes asymptomatic hyperuricemia at present, at all for spleen, deficiency of the kidney void, is made raw expectorant turbid, forms for a long time the stasis of blood, is the result that the pathological products such as " turbid damp ", " the expectorant stasis of blood " act on human body.Hyperuricemia is the important biochemical basis of gout.About gouty hyperuricemia, TCM Document early has discussion, and the severe and migratory arthralgia of < < Medical Treasures of the Golden Chamber > > meaning also has and thinks and belong to arthralgia aggravated by cold or migratory arthralgia; The all source of disease marquis's opinions of < < > > says " there is knot thing underfooting, and firm riveting is as stone, and pain is stung as bored cutter ", and its discussion is similar to tophus.According to its etiology and pathogenesis and clinical manifestation, it can be belonged to respectively to the categories such as the traditional Chinese medical science " gout ", " arthromyodynia ", " severe and migratory arthralgia ".Zhu Dan small stream < < Further Discourses on the Properties of Things gout > > proposes: " those sick wind persons, large rate is heated because of blood, self-boiling; thereafter or paddle; or vertical wetland, or partially gets coolly, or sleeping wetland; cold and cool outer rich; warm blood must be trembled with fear, dirty solidifying puckery, so have a pain; night pain very, row in the moon also." think that primary disease is that self blood system is heated, then feel that wind and cold is wet to be sent out.At present many typical local red and swollen heat pain performances during according to gout acute attack, and be developed to the feature of later stage ankylosis distortion, are summarized as noxious dampness by its pathogenesis and are retarded by silt with the passing of time, and stagnation of pathogen converted into heat wetly becomes expectorant, and blood, expectorant, the stasis of blood are tied mutually, numbness resistance passages through which vital energy circulates.

Hyperuricemia mostly betides 40 years old above male overweight person, has substantial connection with diet and body constitution.Insobriety or monophagia greasy and surfeit flavour, lose spleen fortune strong, helps humidogene expectorant.Phlegm-damp oozing in the body human body, form fat, therefore there be " fertile people how wet excessive phlegm saying ".And phlegm resistance affects again QI-blood circulation, the many stasis of bloods of prolonged illness, raw in blood stasis, form the turbid pathologic basis of the phlegm-damp stasis of blood.Because human righteousness is not enough. imbalance of YIN and YANG, the pathological products such as the wet hot phlegm stasis of blood gather in body, the meridians of being detained; Multiple because of improper diet and overtiredness, intemperate sexual intercourse, being invaded by exogenous pathogen, inside and outside combined pathogens, coagulation of QI-blood is not all right, therefore there is primary disease.Now think that its basic pathogenesis is deficiency in origin and excess in superficiality, deficiency of kidney-QI can not regulating fluid apssage and cause spleen renal dysfunction more.Spleen fortune is lost strong, helps humidogene expectorant, and QI and blood is stopped up knot, and qi depression to blood stasis, stops in phlegm-damp, causes the phlegm-damp stasis of blood and accumulates in turbid.Make real more real, void is more empty, deficiency and excess is staggered, finally forms the card of deficiency in origin and excess in superficiality.Repeatedly send out author's deficiency in origin more obvious, therefore on eliminating evil basis, strengthening vital QI to eliminate pathogenic factors use, turn round and look at and protect spleen kidney.Treatment is dispelled turbid with spleen invigorating, the kidney warming blood stasis dispelling is method, hold concurrently with heat-clearing and toxic substances removing, and removing heat from blood tonify deficiency.

At present, although also there is the Chinese medicine preparation of some treatment hyperuricemias and gouts, often have that formula complexity, cost are high, the dissatisfactory defect of curative effect.

Summary of the invention

The object of the invention is to make up the deficiencies in the prior art, a kind of Chinese medicine composition for the treatment of hyperuricemia and gout is provided, its evident in efficacy, treating both the principal and secondary aspects of a disease, can tonifying speen and tonifying kidney, except diarrhea due to damp pathogen turbid, have the merit of eliminating toxic substances to remove stasis, removing heat from blood tonify deficiency concurrently, can make expectorant turbidly dispel, damp and hot except, ecchymosis solution.

The present invention is for reaching its object, and the technical scheme of employing is as follows:

Treat a Chinese medicine composition for hyperuricemia and gout, its formula of described Chinese medicine composition comprises each component of following weight portion: 15～30 parts of Herba Portulacaes, 15～30 parts of Herba Agrimoniaes, 5～15 parts of Rhizoma Atractylodis, 3～9 parts of Radix Glycyrrhizae Preparatas, 1～5 part of Cortex Cinnamomi.

Preferably, its formula of described Chinese medicine composition comprises each component of following weight portion: 30 parts of Herba Portulacaes, 30 parts of Herba Agrimoniaes, 15 parts of Rhizoma Atractylodis, 9 parts of Radix Glycyrrhizae Preparatas, 5 parts of Cortex Cinnamomis.

Preferably, its formula of described Chinese medicine composition comprises each component of following weight portion: 15 parts of Herba Portulacaes, 15 parts of Herba Agrimoniaes, 5 parts of Rhizoma Atractylodis, 3 parts of Radix Glycyrrhizae Preparatas, 1 part of Cortex Cinnamomi.

Preferably, its formula of described Chinese medicine composition comprises each component of following weight portion: 24 parts of Herba Portulacaes, 21 parts of Herba Agrimoniaes, 12 parts of Rhizoma Atractylodis, 6 parts of Radix Glycyrrhizae Preparatas, 3 parts of Cortex Cinnamomis.

Its dosage form of Chinese medicine composition of the present invention can be the common dosage forms in this area such as granule, pill, mixture, tablet, capsule.

Chinese medicine composition of the present invention can adopt the dosage forms such as the agent of existing preparation process granulation, pill, mixture, tablet, capsule.Chinese medicine composition of the present invention, the better extraction process of its effective ingredient comprises the steps:

1) by formula, take ingredients;

2) each medical material is mixed, add wherein the decocting of 10 times of amounts to boil twice, each decocting time is 1～1.5 hour, and decoction is filtered after extracting, merge extractive liquid;

3) extracting solution being concentrated into relative density is that 1.0～1.35(is 60 ℃ of relative densities under condition) clear paste.Then clear paste directly can be carried out to vacuum drying, pulverizing, according to pharmaceutics conventional formulation technique, be made into the dosage forms such as granule or pill; Also can in clear paste, add ethanol to being 6.5% containing alcohol amount, standing a period of time, then reclaim ethanol, reclaim after ethanol, be condensed into thick paste, then according to pharmaceutics conventional formulation technique further by dosage forms such as the agent of thick paste granulation, pill or mixture.

Chinese medicine composition of the present invention, the extraction process of its effective ingredient also can adopt the technique comprising the steps to extract:

1) by formula, take ingredients;

2) Rhizoma Atractylodis, Cortex Cinnamomi are mixed, add the water soaking 0.5h of 8 times of amounts, then distillating extracting oil 6h, collects volatile oil, and the aqueous solution after medicinal residues and distillation is stored respectively;

3) medicinal residues of Herba Portulacae, Herba Agrimoniae, Radix Glycyrrhizae Preparata and step 2 are mixed, twice of the water boiling and extraction that adds 10 times of amounts, each 1.5h, filter, aqueous solution after distillation in filtrate and step 2 is merged, and amalgamation liquid is concentrated into relative density is that 1.05～1.15(is 60 ℃ of relative densities under condition) clear paste.Clear paste spraying can be dried, pulverize, according to the further granulation agent of pharmaceutics conventional formulation technique, tablet, capsule or pill.

While treating with Chinese medicine composition of the present invention, the general each need of patient are taken the pharmaceutical preparation that the formula that is equivalent to contain following Chinese crude drug is made: 15～30 parts of Herba Portulacaes, 15～30 parts of Herba Agrimoniaes, 5～15 parts of Rhizoma Atractylodis, 3～9 parts of Radix Glycyrrhizae Preparatas, 1～5 part of Cortex Cinnamomi, every part all by gram (g).

Technical scheme of the present invention has following beneficial effect:

Its prescription of Chinese medicine composition of the present invention is comprised of Herba Agrimoniae, Herba Portulacae, Rhizoma Atractylodis, Cortex Cinnamomi, Radix Glycyrrhizae Preparata Chinese medicine of the five flavours.Herba Agrimoniae astringing to arrest bleeding in side, dysentery relieving tonify deficiency is monarch drug.Herba Portulacae heat-clearing and toxic substances removing, cooling blood for hemostasis; Rhizoma Atractylodis are drying damp and strengthening spleen, expelling wind and cold, are all ministerial drug.Cortex Cinnamomi benefit fire is supporing yang, promoting the flow of QI-blood by warming the meridian is adjuvant drug.Being equipped with Radix Glycyrrhizae Preparata spleen reinforcing and middle QI invigorating thinks and makes medicine.All medicines share and play altogether tonifying speen and tonifying kidney, except the merit of turbid, the eliminating toxic substances to remove stasis of diarrhea due to damp pathogen, removing heat from blood tonify deficiency, make that expectorant is turbid dispels, damp and hot removing, ecchymosis solution, full side's strengthening vital QI to eliminate pathogenic factors, treating both the principal and secondary aspects of a disease, make body intracellular metabolite produce the formation speed of uric acid and reach dynamic equilibrium relation through the kidney velocity of discharge, thereby it is normal that endogenous metabolism disturbance state is able to again.

Herba Agrimoniae bitter in the mouth, puckery, property is flat, enters lung, liver, spleen channel.Mainly contain astringing to arrest bleeding effect, be generally used for various hemorrhages.So according to textual criticism Herba Agrimoniae, still have to induce sweat and bring down a fever, nourish blood tonify deficiency, Qiangxin Fumai, blood sugar lowering, the good action such as dizzy, antitumor only.During document is in ancient times recorded, the another name of Herba Agrimoniae is numerous, has serratd edge, Herba Agrimoniae, Herba Agrimoniae grass, Agrimony, HUANGLONG tail, goldentop dragon bud, Herba Verbenae, Herba silenes fortunei, Herba Salviae Chinensis etc.< < BAICAO mirror > > meaning can " therapeutic method to keep the adverse QI flowing downwards be invigorated blood circulation, reason all kinds of diseases and ailments ".< < medicine mirror is picked up any lost article from the road and is composed > > and carry " who recognizes Herba Salviae Chinensis ... wear intestinal and wear stomach and can assault fortified position; collect stem and leaf and smash juice and use; sugarcane slurry Chinese liquor assistant makes complete, chokes every verticalization of expectorant of drink, and Tianjin is swallowed and calmed down merit at first ".Herba Agrimoniae is blood system medicine, and has the magical effect of the therapeutic method to keep the adverse QI flowing downwards.The function of summarizing Herba Agrimoniae in the modern Practical Chinese medicinal > of < < > " for the agent of robustness astringing to arrest bleeding, has cardiotonic concurrently." the also kind righting tonify deficiency function with Herba Agrimoniae of traditional Chinese medical science great master Zhu Liangchun, alone this product " treatment deficient qi and blood dizzy, have certain effect ".And the Herba Agrimoniae tonify deficiency that nourishes blood, has the merit of Radix Ginseng and the dry fraud of helpless transconversion into heat, and as Mr. Xie Haizhou claims, " the medicinal match Radix Ginseng of Herba Agrimoniae ", was not really.Modern age, well-known doctor Ding Fubao meaning Herba Agrimoniae had " light benefit effect, thin and not stagnant ".The strong righting tonify deficiency of this medicine, distinguishes in the diseases such as Zhi Tuoli impairment caused by overstrain, spiritlessness and weakness and can obtain good curative effect.This medicine also can stop blooding and tonify deficiency is invigorated blood circulation, and may have the use of two-ways regulation, blood circulation promoting and blood stasis dispelling, promoting tissue regeneration by removing blood stasis.Modern study shows, Herba Agrimoniae main component has agrimonine, agrimophol, Herba Agrimoniae lactone, tannin, sterol, volatile oil, organic acid, Saponin and vitamin C, K etc.For main pathogenic and the pathogenic characteristic of current hyperuricemia, our Herba Agrimoniae of take righting tonify deficiency, blood circulation promoting and blood stasis dispelling, promoting tissue regeneration by removing blood stasis is monarch drug, and effect is unique, irreplaceable.

Herba Portulacae sour in the mouth, cold in nature, enter liver, large intestine channel.There is heat-clearing and toxic substances removing, blood cooling and hemostatic functions, for toxic-heat and blood stasis, pain swollen furuncle, eczema, erysipelas, snake bite and insect sting, have blood in stool, the disease of hemorrhoidal bleeding, metrostaxis.Modern pharmacological research shows, Herba Portulacae contains a large amount of component for reducing blood fat A-linolenic acid, vitamin E, vitamin C, glutathion; And trace elements iron, manganese, zinc etc., there are blood fat reducing, blood sugar lowering, antitumor, antioxidation, anti-inflammation, enhancing immunity, the anti-ageing multiple effect of waiting for a long time.< < Compendium of Materia Medica > > says: " Herba Portulacae fall apart blood detumescence, sharp intestinal habitual abortion, detoxify treating stranguria, manage property after sweating due to debility "." Herba Portulacae is led all diseases, all only get its loose blood disappear kind merit also." < < Bencao Jingshu > > says: " and Herba Portulacae pungent cold can removing heat from blood heat radiation, therefore main Epileptic note of the ancient Chinese knot, swollen, the white bald and 36 kinds of wind knot skin ulcers of carbuncle skin ulcer furuncle; Smash and apply swollen loose furuncle root and dial, strand juice clothes are disliked thing instantly, inside and outside execute all also.Pungent cold tonneau, therefore cold and heat go, large and small facility also." < < Newly Revised Canon of Materia Medica > > is referred to as " drink juice main regurgitation, all pouring, gold wound blood flow, removing blood stasis addiction lump in the abdomen, children's You Liang." and the overgrown with weeds nature and flavor acid of Dens Equi is cold and sliding profit; can heat-clearing and toxic substances removing; again can removing heat from blood and promoting blood circulation; kind subduing inflammation; the just > > meaning of < < book on Chinese herbal medicine " look for by Dens Equi ... removing blood stasis addiction lump in the abdomen ", " hold concurrently can disappear painful abdominal mass, intestine moistening, removing food stagnancy stagnant ".In formula of the present invention, adopt Herba Portulacae, turbid with hyperuricemia wet hot phlegm, ecchymosis retardance pathogenesis very closes, and with it, is just accord with the reason of the traditional Chinese medical science " promoting tissue regeneration by removing blood stasis ", and hyperuricemia card is had to good curative effect.

Rhizoma Atractylodis acrid in the mouth, hardship, warm in nature, enter spleen, stomach, Liver Channel.There is effect drying damp and strengthening spleen, expelling wind and cold.The clinical dampness taste that are usually used in, distension and fullness in the abdomen, stomachache is had loose bowels, inappetence, edema, the diseases such as beriberi flaccidity syndrome and arthralgia syndrome.Modern pharmacology studies have shown that, Rhizoma Atractylodis rhizome mainly contains atractylol, atractylone, contains in addition vitamin A sample material, vitamin B, inulin and multiple inorganic elements etc.A large amount of pharmacological experiment study document announcements Rhizoma Atractylodis there is antiulcer, promote gastrointestinal function, blood sugar lowering, anti-arrhythmia, diuresis, antiinflammatory, the effect such as antibacterial.Rhizoma Atractylodis are key medicines that removing damp-heat reduces phlegm, < < medication on the analogy of natural things > > meaning: " the Rhizoma Atractylodis diaphoresis that can dehumidify." < < Sheng Nong's herbal classic > > classified as top grade; In < < herbal classic > >, claim " main anemofrigid-damp arthralgia, dead flesh convulsion subcutaneous ulcer.Decoct bait and take for a long time, making light of one's life by commiting suicide, it is not hungry to prolong life." Rhizoma Atractylodis enter lunar, Yangming Channel, and be longer than spleen invigorating and adjust stomach, < < Mingyi Bielu > > meaning: " except spasm in the epigastrium is full and cholera is told lower incessantly, warming the stomach rapid digestion of food is had a liking for food." < < medication on the analogy of natural things > >: " Rhizoma Atractylodis stomach invigorating peace spleen." Rhizoma Atractylodis can treat edema again, < < jade is seized medicine solution > > cloud " the dry native diuretic of Rhizoma Atractylodis is let out drink expectorant "; say again: " Rhizoma Atractylodis Macrocephalae is kept and do not walked, Rhizoma Atractylodis are walked and are not kept, and mend Rhizoma Atractylodis benefaction therefore the Rhizoma Atractylodis Macrocephalae is kind.Its Na Gu that helps digestion, preventing or arresting vomiting is firmly let out the also same Rhizoma Atractylodis Macrocephalae, and sluicing dissipating depression of QI, Rhizoma Atractylodis are solely long." in addition, with Rhizoma Atractylodis spleen sun, helped, sun foot spleen is transported, and edema can have the reason not disappearing.< < does not record > > and carries: " main headache, expectorant water, swollen by edema due to wind pathogen joint between skin." large bright > > says < <: " cure mainly muscles and bones weakness.”

Herba Portulacae and Rhizoma Atractylodis, one is main clear, main disappearing; Herba Portulacae clearing heat and expelling damp heat is stagnant, the Rhizoma Atractylodis removing dampness expectorant turbid damp stasis of blood, and two medicines share plays the spleen strengthening and damp drying altogether, and the merit that blood stasis dispellingization is turbid, is all ministerial drug.Herba Portulacae, the two combined effect of Rhizoma Atractylodis, can be antibacterial, diuresis, control blood glucose rise, alleviate aorta wall lipidosis, improve cellular immune function, and there is to significant effect blood fat reducing, blood sugar lowering, antitumor, antioxidation, anti-inflammation, enhancing immunity, the anti-ageing aspect of waiting for a long time.In we, the two fit applications has important function in preventing and treating hyperuricemia and gout.

Cortex Cinnamomi acrid-sweet flavor, extremely hot in nature, returns kidney, spleen, the heart, Liver Channel.Major function is warming the kidney to activate YANG, dispersing cold for relieving pain, and sun is logical stagnant.The clinical insufficiency of kidney-YANG that is mainly used in, congestion is stagnant, arthralgia due to cold lumbago, yang deficiency cold coagulation, stasis stagnation of phlegm etc.Clinical compatibility is appropriate, above can rescue cardiopulmonary anxious, in the taste of can dispelling wet, the void of lower adjustable Liver and kidney; Really be upper and lower traffic, coordinating water and fire, tonifying YIN is supporing yang, the good merchantable brand that consolidating is turbid.Cortex Cinnamomi begins to be loaded in < < Sheng Nong's herbal classic > >, classifies as top grade.< < Sheng Nong's herbal classic > > records " taste product temperature, main all kinds of diseases and ailments, foster spirit, and color, sharp joint, invigorating the spleen and replenishing QI.For all medicines are first engaged logical making, the logical god of clothes, makes light of one's life by commiting suicide not old for a long time." < < book on Chinese herbal medicine remittance speech > > record: " Cortex Cinnamomi is controlled the medicine of chronic diseases also.It is contrary that the empty deficiency of all units and YANG-depletion are fainted, or trusted subordinate's cold type of pain vomiting and having loose bowels, or heart kidney prolonged deficiency and syndrome of aversion to cold lasting day and night with cold limbs is timid cold, or renal mass colic of cold type and attack punching and want deadly, or cold syndrome of the stomach ascarid goes out and heart diaphragm is full swollen, or QI and blood condensation and passages through which vital energy circulates checks, add this rich sweet pungent large heat, thing in lower walking, the strong gate of vitality's sun, plants the gas of heart kidney, a surname leads hundred medicines, without institute, avoid out of fear, make sun long cloudy from disappearing, and front all diseases are from moving back." Cortex Cinnamomi is pungent and hot greatly, pungent loose temperature is logical, can break Yin and Yang, declares smooth QI and blood, has and positively leads to stagnant effect.The < < book on Chinese herbal medicine > > that looks for the truth also calls it: " mend greatly gate of vitality's fire mutually, Yiyang Zhi Yin.All chronic diseaseses, battalion defend cold type of pain in wind and cold, spontaneous perspiration due to yang insufficiency, abdomen, cough with dyspnea stagnation of QI, insufficiency of the spleen evil food, wet contain have loose bowels, blood vessels are obstructed, retention of placenta, conjunctival congestion and swelling pain, because of cold, because of the stagnant person of obtaining, with this, control invariably and imitate." < < must join herbal > > and also say: " all deficiency and coldness are sick and should control it." Cortex Cinnamomi can replenishing vital QI with drugs of warm nature QI and blood; just as Zhang Bingcheng < <, become conveniently to read to release decoction of ten powerful tonics in > > to say: " Cortex Cinnamomi homoiothermy arteries and veins and and nutrient blood, and make all medicines obtain the power of replenishing vital QI with drugs of warm nature, benefit property is more sufficient, takes effect more." with regard to the beautiful Chinese catalpa medicine of < < solution Cortex Cinnamomi > >, return and receive it: the warm color tone warm in nature of Cortex Cinnamomi is smooth, and it has two, one, removing blood stasis to resolve lump with the wet in enriching blood greatly, its concrete application; Two, the pain relieving of dispeling cold.

Modern study is found, is mainly contained polytype compounds such as volatile oil, polysaccharide, sesquiterpene and glucosides thereof, diterpene and glucosides thereof, flavonol and polymer thereof in Cortex Cinnamomi.Corresponding Cortex Cinnamomi has multiple pharmacological effect, is mainly manifested in blood vessel dilating, promotes blood circulation, increases arteria coronaria and cerebral blood flow, and vascular resistance is declined, and increases urine amount and promotes the effects such as sodium chlorine excretion.And all effects of modern pharmacology research, all imbody with the pain relieving of dispeling cold nothing more than Cortex Cinnamomi removing blood stasis to resolve lump.The dialectical record of < < > >: " and the one-tenth of BI-syndrome involved the kidney; non-to the greatest extent because wind and cold is wet also; the own fire in its Central Plains though husband's kidney is cold dirty; water is cold and wind and cold is wet without entering thereby there is fire; helpless people too does by force, will congenital water everyday runs quickly and let out, and water goes and fire also goes with stream; make source of vital energy unexpectedly become the cave of Tibetan ice, and fire can not oppose trembles with fear and cold-evil invades.Cold directly enters kidney palace, recruits evilly with heresy, and rheumatism mutually thereby extremely, and arthromyodynia is raw." emphasize to suffer from a deficiency of the kidney (insufficiency of kidney-YANG) be the precondition that arthromyodynia occurs.Pathogenesis is deficiency in origin and excess in superficiality, and it is dirty that sick position relates generally to Pi kidney two.In we, help with Cortex Cinnamomi simply, and other component combineds effect, the effect that can not despise in side, there is.

Radix Glycyrrhizae Preparata sweet in the mouth, property is flat, GUIXIN, lung, spleen, stomach warp.Main effect invigorating the spleen and replenishing QI, relieving spasm to stop pain, heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription.Processed with honey property of medicine tepor, and can strengthen the gas effect of invigorating the heart and spleen.< < Sheng Nong's herbal classic > > classifies as top grade, cloud its: " gas of main vital organs of the human body cold and heat, hard muscles and bones, longue meat." < < Mingyi Bielu > >: " warming the middle warmer and descending qi, stuffy sensation with restlessness is losed heart, and hinders that dirty cough inkstone quenches the thirst, qualcomm meridian, sharp vim and vigour, separates the poison of hundred medicines." also " pacify and 72 kinds of stones 1,200 kinds of grass." < < book on Chinese herbal medicine remittance speech > >: " with middle QI invigorating, the medicine of tonify deficiency removing toxic substances is also." Li Dongyuan claims it: " and slow its heat that the medicine of a warm nature obtains, cold medicine obtains, and slow it is cold, and cold and heat are assorted person mutually, the get Qi Ping using." " the temperature of processing is mended three warmers vigour." state of an illness complexity, using medicines of both cold and hot natures simultaneously, reinforcement and elimination in combination, inside and outsidely close and control up and down, while wanting to make different medicines to play coordinative role, can select it.Modern pharmacological research also confirms that it has the effects such as good blood fat reducing, antiinflammatory, anti-immunity, antioxidation, antiviral.We, as making medicine, make medicine slow lasting, soft and not high.

Chinese medicine composition of the present invention, in its formula all medicines according to specific proportioning collocation application, play altogether tonifying speen and tonifying kidney, except diarrhea due to damp pathogen is turbid, the merit of eliminating toxic substances to remove stasis, removing heat from blood tonify deficiency, make that expectorant is turbid dispels, damp and hot removing, ecchymosis solution, full side's strengthening vital QI to eliminate pathogenic factors, treating both the principal and secondary aspects of a disease.Be applicable to the deficiency in origin table reality of hyperuricemia or have the treatment of the turbid damp and hot syndrome of expectorant concurrently.

Chinese medicine composition of the present invention has following feature: 1) for the pathogen and pathology of tcm of hyperuricemia and the pathogenetic understanding of modern medicine and the prescription of making laws, not only meet the basic theories of Chinese medicine and pharmacy, be not also contrary in viewpoint and the understanding of modern medicine; Compatibility is rigorous, and medication is precise and appropriate, and cross linking between medicine and medicine is intricately woven together with etiology and pathogenesis, closely connected; 2) prescription, condemn the feature that determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs that medicine can fully demonstrate the traditional Chinese medical science selects medicine to combine with differential diagnosis of diseases, can receive remarkable and lasting curative effect; 3) principle of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, treatment must aim at the pathogenesis of disease is followed in full side's medication, the expectorant stasis of blood is also controlled, both hyperuricemia eating and drinking without temperance, this current Etiological of surfeit delicious food had been considered, and deficiency in origin and excess in superficiality, blood stasis, main pathogenic characteristic that expectorant is turbid, take into account again in disease progression process easily because the tangible heresies such as expectorant is turbid, the malicious stasis of blood check mechanism of qi, accumulate long-pending this pathological change of heat-transformation.

Chinese medicine composition compatibility of the present invention is reasonable, and each component complements each other, with strong points, and hyperuricemia and gout are had to significant curative effect, is difficult for recurrence after treatment.

The specific embodiment

Below in conjunction with embodiment, technical scheme of the present invention is described further:

The Preparation Example that embodiment 1 is Chinese medicine composition

By formula, take each medical material: by weight, get 30 parts of Herba Portulacaes, 30 parts of Herba Agrimoniaes, 15 parts of Rhizoma Atractylodis, 9 parts of Radix Glycyrrhizae Preparatas, 5 parts of Cortex Cinnamomis;

Prepare as follows drug particles: each medical material is mixed, add respectively the water boiling and extraction twice of 10 times of amounts (10 times of amounts of medical material total amount), each 1.5h; After decocting extraction, filter merge extractive liquid; It is 1.25～1.35(60 ℃ that extracting solution is concentrated into relative density) clear paste; Clear paste is carried out after vacuum drying, gained dried cream powder is broken, granulation.

While adopting drug particles that embodiment 1 makes to treat, patient need take the drug particles that is equivalent to adopt the formula that contains following each medical material of weight to make according to the method described above at every turn: Herba Portulacae 30g, Herba Agrimoniae 30g, Rhizoma Atractylodis 15g, Radix Glycyrrhizae Preparata 9g, Cortex Cinnamomi 5g.

The Preparation Example that embodiment 2 is Chinese medicine composition

By formula, take each medical material: by weight, get 15 parts of Herba Portulacaes, 15 parts of Herba Agrimoniaes, 5 parts of Rhizoma Atractylodis, 3 parts of Radix Glycyrrhizae Preparatas, 1 part of Cortex Cinnamomi;

Prepare as follows drug particles: each medical material is mixed, add respectively the water boiling and extraction twice of 10 times of amounts (10 times of amounts of medical material total amount), each 1h; After decocting extraction, filter merge extractive liquid; It is 1.10～1.25(60 ℃ that extracting solution is concentrated into relative density) clear paste; Add wherein ethanol to containing alcohol amount 65%, standing; After ethanol is reclaimed, simmer down to thick paste adds the starch of medical material total amount 1/10 weight portion and the sucrose of 1/10 weight portion, granulation in thick paste.

While adopting drug particles that embodiment 2 makes to treat, patient need take the drug particles that is equivalent to adopt the formula that contains following each medical material of weight to make according to the method described above at every turn: Herba Portulacae 15g, Herba Agrimoniae 15g, Rhizoma Atractylodis 5g, Radix Glycyrrhizae Preparata 3g, Cortex Cinnamomi 1g.

The Preparation Example that embodiment 3 is Chinese medicine composition

By formula, take each medical material: by weight, get 24 parts of Herba Portulacaes, 21 parts of Herba Agrimoniaes, 12 parts of Rhizoma Atractylodis, 6 parts of Radix Glycyrrhizae Preparatas, 3 parts of Cortex Cinnamomis;

Prepare as follows drug particles: each medical material is mixed, add respectively the water boiling and extraction twice of 10 times of amounts (10 times of amounts of medical material total amount), each 1.5h; Filter, merge extractive liquid,, being concentrated into relative density is 1.25～1.35(60 ℃) clear paste; By after clear paste vacuum drying, gained dried cream powder is broken, granulation.

While adopting drug particles that embodiment 3 makes to treat, patient need take the drug particles that is equivalent to adopt the formula that contains following each medical material of weight to make according to the method described above at every turn: Herba Portulacae 24g, Herba Agrimoniae 21g, Rhizoma Atractylodis 12g, Radix Glycyrrhizae Preparata 6g, Cortex Cinnamomi 3g.

The Preparation Example that embodiment 4 is Chinese medicine composition

By formula, take each medical material: by weight, get 24 parts of Herba Portulacaes, 21 parts of Herba Agrimoniaes, 12 parts of Rhizoma Atractylodis, 6 parts of Radix Glycyrrhizae Preparatas, 3 parts of Cortex Cinnamomis, standby;

Prepare as follows drug particles: by weight, get 12 parts of Rhizoma Atractylodis and 3 parts of mixing of Cortex Cinnamomi, add the water of 8 times of amounts (for 8 times of amounts of Rhizoma Atractylodis and Cortex Cinnamomi total amount), soak 0.5h; Then carry out distillating extracting oil 6h, collect volatile oil, the another device storage of aqueous solution after medicinal residues and distillation; Separately get 6 parts of 24 parts of Herba Portulacaes, 21 parts of Herba Agrimoniaes, Radix Glycyrrhizae Preparata and mix with above-mentioned medicinal residues, add respectively 10 times of amounts (for 10 times of amounts of medicinal residues, Herba Portulacae, Herba Agrimoniae, Radix Glycyrrhizae Preparata total amount) water and decocts and extract twice, at every turn 1.5h; Filter, the aqueous solution after filtrate and above-mentioned distillation merges; It is 1.05～1.15(60 ℃ that amalgamation liquid is concentrated into relative density) clear paste; After clear paste spraying is dry, gained dried cream powder is broken, granulation.

While adopting drug particles that embodiment 4 makes to treat, patient need take the drug particles that is equivalent to adopt the formula that contains following each medical material of weight to make according to the method described above at every turn: Herba Portulacae 24g, Herba Agrimoniae 21g, Rhizoma Atractylodis 12g, Radix Glycyrrhizae Preparata 6g, Cortex Cinnamomi 3g.

Application examples

Application examples 1:

Zhang, man, 46 years old.Seek medical advice and dashed forward and feel right crus of diaphragm hallux toe sole of the foot redness and swelling of joints causalgia between 15 day eve, cut-like pain, can not touch.Acute rheumatic arthritis tcm diagnosis is pressed by Mou hospital, sees patient's obesity, thirsty, red tongue, and yellow and greasy fur, wiry and frequent pulse is strong.Blood chemical examination is that anti-" O " is normal, erythrocyte sedimentation rate 39mm/h, blood uric acid 689umol/L, rheumatoid factor ().Be diagnosed as gouty arthritis.The Drug therapy that adopts embodiment 1 to make, takes 1 every day, and drug administration is after 7 days, and double-legged hallux toe sole of the foot joint and right ankle joint swell and ache and fade away, can lower ground walking.Take afterwards 14 days, erythrocyte sedimentation rate is down to 20mm/h again, and blood uric acid is down to 456umol/L.Continue to take after 7 days, local joint symptom and sign disappears, and erythrocyte sedimentation rate and blood uric acid are down to normally.Follow up a case by regular visits to and do not send out for 1 year, blood uric acid inspection is normal.

Application examples 2:

Lee so-and-so, man, 73 years old.Medical front 2d night, right sufficient thumb pain was obvious, outstanding play at nightfall, and pain can not be slept, and interruption allopurinol etc. is controlled symptom.But its right sufficient thumb is red and swollen, aversion to cold and cold limbs, idol has uncomfortable in chest, and nocturia, sleeps poor, dreaminess, light purplish tongue is dark, and tongue is greasy in vain, deep-thready pulse.Through chemical examination, its blood uric acid is 474umol/L.Western medicine diagnose is gout.Tcm diagnosis is arthromyodynia.The Drug therapy that adopts embodiment 2 to make, takes 7 days, takes every day 2 times.During further consultation, find that spirit is before clearly better, right sufficient thumb pain, fear cold extremities, sleep, frequent urination at night, uncomfortable in chestly all alleviate.Continue to take 30, take every day 2 times, further consultation inspection discovery uric acid is down to 417umol/L.

Application examples 3:

Yang, 53 years old.There is toes arthralgia in patient, with hypnalgia, for very, patient often again and again drank before 6 years before 6 years, surfeit greasy and surfeit flavour, and in time, is felt toes and swells and ache, busier because of work, does not mind.The medical cause tired pain of drinking exacerbates, and swelling and ache more so in left sufficient thumb inner side, take hypnalgia as acute.Check to find blood uric acid 816umol/L, be diagnosed as " gout ", take allopurinol, colchicine etc., the state of an illness takes a turn for the better to some extent, but withdraws because of the discomfort of having a stomachache.After withdrawing, swelling and ache and exacerbate, swells and ache in left hallux inner side, and night more very.Blood uric acid inspection is 714umo l/L, bitter taste, yellow and greasy fur, wiry and frequent pulse.Card belongs to the turbid stasis blocking of wet hot phlegm, and the medicine that adopts embodiment 3 to make is treated, take every day 1 time, toes basic disappearance of swelling and ache after January, continual cure 2 months, the disappearance of swelling and ache of patient's toes, blood uric acid is normal, then after treatment January, after follow up a case by regular visits to half a year, do not recur again.

Application examples 4:

Week so-and-so, man, 45 years old.Patient have gout medical history 5 years, and several tophus appear in ears exterior feature portion.After having a dinner party because of friend, there is the red and swollen twinge of left side the first metatarsophalangeal joints in this time outbreak, local swelling distortion, and joint stuffiness, the piece scrofula scleroma of ears exterior feature portion, body of the tongue purple is dim, yellow and thin fur, thready and hesitant pulse.After inspection, its blood uric acid 684umol/L, c reactive protein 71.6mg/L, Western medicine diagnose is acute gout, tcm diagnosis arthromyodynia, card belongs to stagnant heat retardance card, and the Drug therapy that adopts embodiment 4 to make, takes every day 1 time 7.Further consultation finds that the red and swollen twinge of left the first metatarsophalangeal joints obviously alleviates, the slightly dark black of color of the leather, and body of the tongue purple is dim, yellow and thin fur, thready and stringy pulse.Continue to take after 20 days, redness and swelling of joints twinge disappears, check blood uric acid 381umo l/L, c reactive protein 2mg/L.Effect of follow-up visit by telephone after May, without recurrence.

Application examples 5:

Yuan, man 41 years old, because of right foot the first metatarsophalangeal joints pain that happens suddenly night after drinking, pain is difficult to fall asleep like burning.Chemical examination is: blood uric acid 655umo l/L, rheumatoid factor negative, anti-" O " (one), c reactive protein 380mg/L, erythrocyte sedimentation rate 58mm/h.When medical, find: right foot the first metatarsophalangeal joints of patient is red and swollen, pain can not be touched, red tongue, yellow and greasy fur, slippery and rapid pulse.Tcm diagnosis is damp-heat arthralgia; Western medicine diagnose is acute gouty arthritis.Adopt the Drug therapy making of embodiment 1, take every day 1 time, take continuously two days, the symptom such as swell and ache is clearly better.Continue to take after 60 days, foot disappears bitterly, and check blood uric acid, C reactive protein, erythrocyte sedimentation rate are all normal.Follow up a case by regular visits to 1 year, have no recurrence.

Application examples 6:

Pueraria lobota, man, 35 years old.After patient has a dinner party with friend before medical 3d, occur that left ankle joint is red and swollen morning next day, sharp ache, local time has fearness cool, and night is serious.When medical, find: the left ankle joint of patient is red and swollen, tenderness (+++), red tongue is slightly dark, yellow and greasy fur, rapid pulse.The uric acid of having a blood test is 537umol/mL, and Western medicine diagnose is gouty arthritis; Tcm diagnosis is arthromyodynia, and card belongs to damp-heat congestion type.The Drug therapy making with embodiment 27 days, takes 1 every day.During further consultation, find that left ankle joint pain obviously alleviates, can walk voluntarily, tongue is slightly dark, the micro-Huang of tongue is greasy, stringy pulse.Continue to take transference cure, clinical cure 14.After March, follow up a case by regular visits to, do not reaccess.

Application examples 7:

Liu, male, 56 years old, gout medical history 8 years, caused right crus of diaphragm the first metatarsophalangeal joints red and swollen heat pain before 2d after drinking, joint stuffiness, its pain is heavy light night in daytime, take Western medicine analgesic pain relief, but gastrointestinal upset after taking medicine arrives department of Chinese medicine diagnosis and treatment then.Check its blood uric acid 482umol/L, erythrocyte sedimentation rate 55mm/h.Companion's gastral cavilty is full vexed, feels sick, and every day, nocturia was 4 times, red tongue, yellow and greasy fur, slippery and rapid pulse.Card belongs to retention of damp-heat in the interior, numbness resistance meridians.The Drug therapy that adopts embodiment 3 to make, takes 1 every day, takes after 7 days, and joint congestion and swelling pain obviously alleviates, and nocturia slightly take a favorable turn.Continue to take medicine 3 weeks, all diseases disappear to the greatest extent, blood uric acid 327umol/L, and erythrocyte sedimentation rate 18mm/h, visits and has no recurrence half a year.

The above, it is only preferred embodiment of the present invention, not the present invention is done to any pro forma restriction, the content that does not depart from technical solution of the present invention therefore all, according to technical spirit of the present invention, to any simple modification made for any of the above embodiments, equivalent variations and modification, all still belong in the scope of technical solution of the present invention.

Claims (7)

1. a Chinese medicine composition for the treatment of hyperuricemia and gout, it is characterized in that, its formula of described Chinese medicine composition comprises each component of following weight portion: 15～30 parts of Herba Portulacaes, 15～30 parts of Herba Agrimoniaes, 5～15 parts of Rhizoma Atractylodis, 3～9 parts of Radix Glycyrrhizae Preparatas, 1～5 part of Cortex Cinnamomi.

2. the Chinese medicine composition for the treatment of hyperuricemia according to claim 1 and gout, it is characterized in that, its formula of described Chinese medicine composition comprises each component of following weight portion: 30 parts of Herba Portulacaes, 30 parts of Herba Agrimoniaes, 15 parts of Rhizoma Atractylodis, 9 parts of Radix Glycyrrhizae Preparatas, 5 parts of Cortex Cinnamomis.

3. the Chinese medicine composition for the treatment of hyperuricemia according to claim 1 and gout, it is characterized in that, its formula of described Chinese medicine composition comprises each component of following weight portion: 15 parts of Herba Portulacaes, 15 parts of Herba Agrimoniaes, 5 parts of Rhizoma Atractylodis, 3 parts of Radix Glycyrrhizae Preparatas, 1 part of Cortex Cinnamomi.

4. the Chinese medicine composition for the treatment of hyperuricemia according to claim 1 and gout, it is characterized in that, its formula of described Chinese medicine composition comprises each component of following weight portion: 24 parts of Herba Portulacaes, 21 parts of Herba Agrimoniaes, 12 parts of Rhizoma Atractylodis, 6 parts of Radix Glycyrrhizae Preparatas, 3 parts of Cortex Cinnamomis.

5. according to the treatment hyperuricemia described in claim 1～4 any one and the Chinese medicine composition of gout, it is characterized in that, its dosage form of described Chinese medicine composition is granule, pill, mixture, tablet, capsule.

6. according to the treatment hyperuricemia described in claim 1～4 any one and the Chinese medicine composition of gout, it is characterized in that, in Chinese medicine composition, the extraction process of effective ingredient comprises the steps:

1) by formula, take ingredients;

2) each medical material is mixed, add wherein the decocting of 10 times of amounts to boil twice, each decocting time is 1～1.5 hour, and decoction is filtered after extracting, merge extractive liquid;

3) extracting solution being concentrated into relative density is 1.0～1.35 clear paste.

7. according to the treatment hyperuricemia described in claim 1～4 any one and the Chinese medicine composition of gout, it is characterized in that, in Chinese medicine composition, the extraction process of effective ingredient comprises the steps:

1) by formula, take ingredients;

2) Rhizoma Atractylodis, Cortex Cinnamomi are mixed, add the water soaking 0.5h of 8 times of amounts, then distillating extracting oil 6h, collects volatile oil, and the aqueous solution after medicinal residues and distillation is stored respectively;

3) medicinal residues of Herba Portulacae, Herba Agrimoniae, Radix Glycyrrhizae Preparata and step 2 are mixed, the water boiling and extraction twice that adds 10 times of amounts, each 1.5h, filters, aqueous solution after distillation in filtrate and step 2 is merged, and amalgamation liquid is concentrated into relative density is 1.05～1.15 clear paste.