CN103655786B - A kind of Chinese medicine composition for the treatment of hyperuricemia and gout - Google Patents

Abstract

The invention provides a kind of Chinese medicine composition for the treatment of hyperuricemia and gout, its formula of described Chinese medicine composition comprises each component of following weight portion: Herba Portulacae 15 ~ 30 parts, Herba Agrimoniae 15 ~ 30 parts, Rhizoma Atractylodis 5 ~ 15 parts, Radix Glycyrrhizae Preparata 3 ~ 9 parts, Cortex Cinnamomi 1 ~ 5 part.The Chinese medicine composition for the treatment of hyperuricemia provided by the invention and gout, has feature that is evident in efficacy, treating both the principal and secondary aspects of a disease, can tonifying speen and tonifying kidney, except diarrhea due to damp pathogen is turbid, have the merit of eliminating toxic substances to remove stasis, removing heat from blood tonify deficiency concurrently, make that expectorant is turbid dispels, damp and hotly to remove, ecchymosis solution.

Description

A kind of Chinese medicine composition for the treatment of hyperuricemia and gout

Technical field

The present invention relates to a kind of Chinese medicine composition for the treatment of hyperuricemia and gout.

Background technology

Hyperuricemia is the metabolic disease that disorders of purine metabolism causes.Be divided into constitutional and the large class of Secondary cases two clinically, the former is many caused by congenital purine metabolic disturbance, and normal gathering with obesity, glucose-lipid metabolism disorder, hypertension, arteriosclerosis and coronary heart disease etc. occurs, and latter is caused by some systemic disease or medicine.According to the report of various places prevalence of hyperuricemia in recent years, about there is hyperuricemia person 1.2 hundred million in current China, accounts for 10% of total population, and the age occurred frequently is middle-aging male and postmenopausal women, but has rejuvenation trend in recent years.

Simple blood uric acid raises, and TCM Document, without clearly recording, sends out well the fat excessive phlegm of the many existence of crowd, addicted to the feature of eating delicious food savoury according to it.Current medical circle generally believes that the morbidity of asymptomatic hyperuricemia is spleen, deficiency of the kidney void at all, and make raw expectorant turbid, forming the stasis of blood for a long time, is the result that the pathological product such as " turbid damp ", " the expectorant stasis of blood " acts on human body.Hyperuricemia is the important biochemical basis of gout.About gouty hyperuricemia, TCM Document early has discussion, the severe and migratory arthralgia of " Medical Treasures of the Golden Chamber " meaning, also has to think genus arthralgia aggravated by cold or migratory arthralgia; " all source of disease marquis opinion " says " there is knot thing underfooting, firm riveting as stone, pain as bore cutter sting ", its discussion is similar to tophus.According to its etiology and pathogenesis and clinical manifestation, it can be belonged to respectively the category such as the traditional Chinese medical science " gout ", " arthromyodynia ", " severe and migratory arthralgia ".ZHU Dan-xi " Further Discourses on the Properties of Things gout " proposes: " those sick wind persons, large rate is heated because of blood, self-boiling, thereafter or paddle, or vertical wetland, or partially gets cool, or sleeping wetland, and cold and cool outer rich, warm blood must be trembled with fear, dirty solidifying puckery, so have a pain, night then pain very, row in the moon also." think that primary disease is that self blood system is heated, then feel wind and cold wet send out.Many according to typically local red and swollen heat pain performance during gout acute attack at present, and be developed to the feature of later stage ankylosis distortion, its pathogenesis is summarized as noxious dampness and is retarded by silt with the passing of time, stagnation of pathogen converted into heat, wet and become expectorant, blood, expectorant, the stasis of blood are tied mutually, numbness resistance passages through which vital energy circulates.

Hyperuricemia mostly betides more than 40 years old male overweight person, has substantial connection with diet and body constitution.Insobriety or monophagia greasy and surfeit flavour, make spleen transport mistake and be good for, help humidogene expectorant.Phlegm-damp oozing in the body human body, is formed fat, therefore has " saying of the how wet excessive phlegm of fertile people ".And phlegm resistance, affect again QI-blood circulation, the many stasis of bloods of prolonged illness, raw in blood stasis, form the pathologic basis that the phlegm-damp stasis of blood is turbid.Because human righteousness is not enough. imbalance of YIN and YANG, the pathological products such as the wet hot phlegm stasis of blood gather in body, meridians of being detained; Multiple because of improper diet and overtiredness, intemperate sexual intercourse, being invaded by exogenous pathogen, inside and outside combined pathogens, coagulation of QI-blood is not all right, therefore primary disease occurs.Now think that its basic pathogenesis is deficiency in origin and excess in superficiality, deficiency of kidney-QI can not regulating fluid apssage and cause spleen renal dysfunction more.Spleen fortune is lost strong, helps humidogene expectorant, and QI and blood stops up knot, and qi depression to blood stasis, stops in phlegm-damp, cause the phlegm-damp stasis of blood turbid in accumulate.Make real more real, void is more empty, deficiency and excess is interlocked, the final card forming deficiency in origin and excess in superficiality.Recurrent exerbation person deficiency in origin is more obvious, therefore on eliminating evil basis, strengthening vital QI to eliminate pathogenic factors use, turns round and look at and protects spleen kidney.Treatment is dispelled turbid with spleen invigorating, the kidney warming blood stasis dispelling is method, holds concurrently with heat-clearing and toxic substances removing, removing heat from blood tonify deficiency.

At present, although also have some treatment hyperuricemias and Chinese medicine preparation of gout, often have that formula complexity, cost are high, the dissatisfactory defect of curative effect.

Summary of the invention

The object of the invention is to make up the deficiencies in the prior art, there is provided a kind of Chinese medicine composition for the treatment of hyperuricemia and gout, its evident in efficacy, treating both the principal and secondary aspects of a disease, can tonifying speen and tonifying kidney, except diarrhea due to damp pathogen turbid, have the merit of eliminating toxic substances to remove stasis, removing heat from blood tonify deficiency concurrently, expectorant can be made turbidly to dispel, damp and hot except, ecchymosis solution.

The present invention is for reaching its object, and the technical scheme of employing is as follows:

Treat a Chinese medicine composition for hyperuricemia and gout, its formula of described Chinese medicine composition comprises each component of following weight portion: Herba Portulacae 15 ~ 30 parts, Herba Agrimoniae 15 ~ 30 parts, Rhizoma Atractylodis 5 ~ 15 parts, Radix Glycyrrhizae Preparata 3 ~ 9 parts, Cortex Cinnamomi 1 ~ 5 part.

Preferably, its formula of described Chinese medicine composition comprises each component of following weight portion: Herba Portulacae 30 parts, Herba Agrimoniae 30 parts, Rhizoma Atractylodis 15 parts, Radix Glycyrrhizae Preparata 9 parts, Cortex Cinnamomi 5 parts.

Preferably, its formula of described Chinese medicine composition comprises each component of following weight portion: Herba Portulacae 15 parts, Herba Agrimoniae 15 parts, Rhizoma Atractylodis 5 parts, Radix Glycyrrhizae Preparata 3 parts, Cortex Cinnamomi 1 part.

Preferably, its formula of described Chinese medicine composition comprises each component of following weight portion: Herba Portulacae 24 parts, Herba Agrimoniae 21 parts, Rhizoma Atractylodis 12 parts, Radix Glycyrrhizae Preparata 6 parts, Cortex Cinnamomi 3 parts.

Its dosage form of Chinese medicine composition of the present invention can be the common dosage form in this areas such as granule, pill, mixture, tablet, capsule.

Chinese medicine composition of the present invention can adopt existing preparation process to make the dosage forms such as granule, pill, mixture, tablet, capsule.Chinese medicine composition of the present invention, the better extraction process of its effective ingredient comprises the steps:

1) ingredients is taken by formula;

2) mixed by each medical material, add the soak by water twice of 10 times amount wherein, each decocting time is 1 ~ 1.5 hour, decocts after extracting and filters, merge extractive liquid;

3) extracting solution to be concentrated into relative density be 1.0 ~ 1.35(is relative density under 60 DEG C of conditions) clear paste.Then clear paste directly can be carried out vacuum drying, pulverizing, according to pharmaceutics conventional formulation technique, be made into the dosage form such as granule or pill; Also can add ethanol to alcohol content in clear paste is 6.5%, leaves standstill a period of time, then reclaims ethanol, after reclaiming ethanol, is condensed into thick paste, then further thick paste is made the dosage forms such as granule, pill or mixture according to pharmaceutics conventional formulation technique.

Chinese medicine composition of the present invention, the extraction process of its effective ingredient also can adopt the technique comprised the steps to extract:

1) ingredients is taken by formula;

2) by Rhizoma Atractylodis, Cortex Cinnamomi mixing, add the water soaking 0.5h of 8 times amount, then distillating extracting oil 6h, collect volatile oil, the aqueous solution after medicinal residues and distillation is stored respectively;

3) by the mixing of the medicinal residues of Herba Portulacae, Herba Agrimoniae, Radix Glycyrrhizae Preparata and step 2, add the water boiling and extraction twice of 10 times amount, each 1.5h, filter, aqueous solution after distillation in filtrate and step 2 is merged, and amalgamation liquid to be concentrated into relative density be 1.05 ~ 1.15(is relative density under 60 DEG C of conditions) clear paste.By clear paste spraying dry, pulverizing, granule, tablet, capsule or pill can be made further according to pharmaceutics conventional formulation technique.

When treating with Chinese medicine composition of the present invention, patient generally each need takes the pharmaceutical preparation being equivalent to make containing, for example the formula of lower Chinese crude drug: Herba Portulacae 15 ~ 30 parts, Herba Agrimoniae 15 ~ 30 parts, Rhizoma Atractylodis 5 ~ 15 parts, Radix Glycyrrhizae Preparata 3 ~ 9 parts, Cortex Cinnamomi 1 ~ 5 part, every part all by gram (g).

Technical scheme of the present invention has following beneficial effect:

Its prescription of Chinese medicine composition of the present invention is made up of Herba Agrimoniae, Herba Portulacae, Rhizoma Atractylodis, Cortex Cinnamomi, Radix Glycyrrhizae Preparata Chinese medicine of the five flavours.Herba Agrimoniae astringing to arrest bleeding in side, dysentery relieving tonify deficiency is monarch drug.Herba Portulacae heat-clearing and toxic substances removing, cooling blood for hemostasis; Rhizoma Atractylodis are drying damp and strengthening spleen, expelling wind and cold, are all ministerial drug.Cortex Cinnamomi benefit fire is supporing yang, promoting the flow of QI-blood by warming the meridian is adjuvant drug.Be equipped with Radix Glycyrrhizae Preparata spleen reinforcing and middle QI invigorating to think and make medicine.All medicines share plays tonifying speen and tonifying kidney, altogether except diarrhea due to damp pathogen is turbid, the merit of eliminating toxic substances to remove stasis, removing heat from blood tonify deficiency, make that expectorant is turbid dispels, damp and hotly to remove, ecchymosis solution, full side's strengthening vital QI to eliminate pathogenic factors, treating both the principal and secondary aspects of a disease, make body intracellular metabolite produce the formation speed of uric acid and reach dynamic equilibrium relation through the kidney velocity of discharge, thus it is normal that endogenous metabolism disturbance state is able to again.

Herba Agrimoniae bitter in the mouth, puckery, property is put down, and enters lung, liver, spleen channel.Mainly contain astringing to arrest bleeding effect, be generally used for various hemorrhage.So according to textual criticism Herba Agrimoniae still have induce sweat bring down a fever, the good action such as the tonify deficiency that nourishes blood, Qiangxin Fumai, blood sugar lowering, only dizzy, antitumor.During document is in ancient times recorded, the another name of Herba Agrimoniae is numerous, has serratd edge, Herba Agrimoniae, Indigofera pseudotinctoria, Agrimony, HUANGLONG tail, goldentop dragon bud, Herba Verbenae, Herba silenes fortunei, Herba Salviae Chinensis etc." BAICAO mirror " meaning can " therapeutic method to keep the adverse QI flowing downwards be invigorated blood circulation, reason all kinds of diseases and ailments "." medicine mirror pick up any lost article from the road tax " carries " who recognizes Herba Salviae Chinensis ... wear intestinal and wear stomach and can assault fortified position, collect stem and leaf and smash juice use, sugarcane slurry Chinese liquor assistant makes complete, and choke every expectorant verticalization of drink, Tianjin is swallowed and calmed down merit at first ".Herba Agrimoniae is blood system medicine, and has the magical effect of the therapeutic method to keep the adverse QI flowing downwards.The function summarizing Herba Agrimoniae in " modern Practical Chinese medicinal " " is the agent of robustness astringing to arrest bleeding, has cardiotonic concurrently." the righting tonify deficiency function of traditional Chinese medical science great master Zhu Liangchun also kind Herba Agrimoniae, alone this product " treatment deficient qi and blood dizzy, have certain effect ".The tonify deficiency and Herba Agrimoniae nourishes blood, have the merit of Radix Ginseng and the dry fraud of helpless transconversion into heat, as Mr. Xie Haizhou claims, " the medicinal match Radix Ginseng of Herba Agrimoniae ", was not really.Well-known doctor Ding Fubao called Herba Agrimoniae and had " light benefit effect, dredge and not stagnant " modern age.The strong righting tonify deficiency of this medicine, distinguishes in the diseases such as Zhi Tuoli impairment caused by overstrain, spiritlessness and weakness and can obtain good curative effect.This medicine also can stop blooding and tonify deficiency is invigorated blood circulation, and may have the use of two-ways regulation, blood circulation promoting and blood stasis dispelling, promoting tissue regeneration by removing blood stasis.Modern study shows, Herba Agrimoniae main component has agrimonine, agrimophol, Herba Agrimoniae lactone, tannin, sterol, volatile oil, organic acid, Saponin and vitamin C, K etc.For main pathogenic and the pathogenic characteristic of current hyperuricemia, we are with the Herba Agrimoniae of righting tonify deficiency, blood circulation promoting and blood stasis dispelling, promoting tissue regeneration by removing blood stasis for monarch drug, and effect is unique, irreplaceable.

Herba Portulacae sour in the mouth, cold in nature, enter liver, large intestine channel.There is heat-clearing and toxic substances removing, blood cooling and hemostatic functions, for toxic-heat and blood stasis, the swollen furuncle of pain, eczema, erysipelas, snake bite and insect sting, have blood in stool, the disease of hemorrhoidal bleeding, metrostaxis.Modern pharmacological research shows, Herba Portulacae contains a large amount of component for reducing blood fat A-linolenic acid, vitamin E, vitamin C, glutathion; And trace elements iron, manganese, zinc etc., there are blood fat reducing, blood sugar lowering, antitumor, antioxidation, anti-inflammation, enhancing immunity, anti-ageing multiple effect of waiting for a long time.Compendium of Material Medica is said: " Herba Portulacae fall apart blood detumescence, sharp intestinal habitual abortion, detoxify treating stranguria, manage property after sweating due to debility "." Herba Portulacae leads all diseases, all only get its loose blood disappear kind merit also." " Bencao Jingshu " say: " and Herba Portulacae pungent cold can removing heat from blood heat radiation, therefore main Epileptic note of the ancient Chinese knot, carbuncle skin ulcer furuncle are swollen, bald and 36 kinds of wind knot skin ulcers in vain; Smash and apply then swollen loose furuncle root and dial, strand juice clothes then dislike thing instantly, inside and outside execute all also.Pungent cold tonneau, therefore cold and heat go, large and small facility is also." " Newly Revised Canon of Materia Medica " be referred to as " drink juice main regurgitation, Zhu Lin, gold wound blood flow, removing blood stasis addiction lump in the abdomen, children's You Liang." and the cold and sliding profit of Dens Equi overgrown with weeds nature and flavor acid, can heat-clearing and toxic substances removing, again can removing heat from blood and promoting blood circulation, kind subduing inflammation, " book on Chinese herbal medicine justice " meaning " look for by Dens Equi ... removing blood stasis addiction lump in the abdomen ", " hold concurrently can disappear painful abdominal mass, intestine moistening, removing food stagnancy stagnant ".In formula of the present invention, adopt Herba Portulacae, turbid with hyperuricemia wet hot phlegm, ecchymosis retardance pathogenesis very closes, and is just accord with the reason of the traditional Chinese medical science " promoting tissue regeneration by removing blood stasis " with it, has good curative effect to hyperuricemia card.

Rhizoma Atractylodis acrid in the mouth, hardship, warm in nature, enter spleen, stomach, Liver Channel.There is effect that is drying damp and strengthening spleen, expelling wind and cold.Clinically be usually used in dampness taste, distension and fullness in the abdomen, the diseases such as stomachache is had loose bowels, inappetence, edema, beriberi flaccidity syndrome and arthralgia syndrome.Modern pharmacology research proves, Rhizoma Atractylodis rhizome, mainly containing atractylol, atractylone, contains vitamin A sample material, vitamin B, inulin and multiple inorganic elements etc. in addition.A large amount of pharmacological experiment study document announcement Rhizoma Atractylodis have antiulcer, promote gastrointestinal function, blood sugar lowering, anti-arrhythmia, diuresis, antiinflammatory, the effect such as antibacterial.Rhizoma Atractylodis are key medicines that removing damp-heat reduces phlegm, and " medication on the analogy of natural things " is called: " Rhizoma Atractylodis can dehumidify diaphoresis." Shennong's Herbal is classified as top grade; " main anemofrigid-damp arthralgia, dead flesh convulsion subcutaneous ulcer is claimed in " herbal classic ".Decoct bait to take for a long time, making light of one's life by commiting suicide, it is not hungry to prolong life." Rhizoma Atractylodis enter lunar, Yangming Channel, and be longer than spleen invigorating and adjust stomach, " Mingyi Bielu " is called: " except spasm in the epigastrium is full and cholera is told incessantly lower, warming the stomach rapid digestion of food is addicted to food." " medication on the analogy of natural things ": " Rhizoma Atractylodis stomach invigorating peace spleen." Rhizoma Atractylodis can treat edema again, " jade seizes medicine solution " has cloud " the dry native diuretic of Rhizoma Atractylodis lets out drink expectorant ", says again: " Rhizoma Atractylodis Macrocephalae is kept and do not walk, and Rhizoma Atractylodis are walked and do not keep, therefore the Rhizoma Atractylodis Macrocephalae is kind mends, Rhizoma Atractylodis benefaction.Its Na Gu that helps digestion, preventing or arresting vomiting firmly lets out the also same Rhizoma Atractylodis Macrocephalae, and the dissipating depression of QI that sluices, Rhizoma Atractylodis are solely long." in addition, helped with Rhizoma Atractylodis spleen sun, sun foot then spleen is transported, and edema can have the reason do not disappeared." not Lu " carries: " main headache, expectorant water, swollen by edema due to wind pathogen joint between skin." " bright greatly " say: " cure mainly muscles and bones weakness.”

Herba Portulacae and Rhizoma Atractylodis, one is main clear, and a master disappears; Herba Portulacae clearing heat and expelling damp heat is stagnant, and the Rhizoma Atractylodis removing dampness expectorant turbid damp stasis of blood, two medicines share plays the spleen strengthening and damp drying altogether, and the merit that blood stasis dispellingization is turbid is all ministerial drug.Herba Portulacae, the combined effect of both Rhizoma Atractylodis, antibacterial, diuresis, control blood glucose can rise, alleviate aorta wall lipidosis, improve cellular immune function, have significant effect to blood fat reducing, blood sugar lowering, antitumor, antioxidation, anti-inflammation, enhancing immunity, anti-ageing aspect of waiting for a long time.In we, the two fit applications, has important function preventing and treating in hyperuricemia and gout.

Cortex Cinnamomi acrid-sweet flavor, extremely hot in nature, returns kidney, spleen, the heart, Liver Channel.Major function is warming the kidney to activate YANG, dispersing cold for relieving pain, and sun leads to stagnant.Clinically be mainly used in insufficiency of kidney-YANG, congestion stagnates, arthralgia due to cold lumbago, yang deficiency cold coagulation, stasis stagnation of phlegm etc.Clinical compatibility is appropriate, above can rescue cardiopulmonary anxious, in taste of can dispelling wet, the void of lower adjustable Liver and kidney; Be really upper and lower traffic, coordinating water and fire, tonifying Yin and Yang, the good merchantable brand that consolidating is turbid.Cortex Cinnamomi begins to be loaded in Shennong's Herbal, is classified as top grade.Shennong's Herbal is recorded " taste produces temperature, main all kinds of diseases and ailments, supports spirit, and color, sharp joint, invigorating the spleen and replenishing QI.For logical making first engaged by all medicines, the logical god of clothes, makes light of one's life by commiting suicide not old for a long time." " book on Chinese herbal medicine converges and says " record: " Cortex Cinnamomi controls the medicine of chronic diseases also.All units are empty not enough and YANG-depletion is fainted inverse, or trusted subordinate's cold type of pain vomiting and having loose bowels, or heart kidney prolonged deficiency and syndrome of aversion to cold lasting day and night with cold limbs is timid cold, or renal mass colic of cold type and attack punching for extremely, or cold syndrome of the stomach ascarid goes out and heart diaphragm is full swollen, or QI and blood condensation and passages through which vital energy circulates checks, add this rich sweet pungent large heat, thing in lower walking, the sun of the strong gate of vitality, plants the gas of heart kidney, a surname leads hundred medicines, without avoided out of fear, make sun long then cloudy from disappearing, and front all diseases are from moving back." Cortex Cinnamomi is pungent and hot greatly, pungent loose temperature is led to, and can break Yin and Yang, declare smooth QI and blood, have and lead to stagnant effect with sun." book on Chinese herbal medicine is looked for the truth " also calls it: " the large benefit gate of vitality is mutually fiery, Yiyang Zhi Yin.All chronic diseaseses, battalion defends cold type of pain in wind and cold, spontaneous perspiration due to yang insufficiency, abdomen, cough with dyspnea stagnation of QI, insufficiency of the spleen evil food, wet Sheng is had loose bowels, blood vessels are obstructed, retention of placenta, conjunctival congestion and swelling pain, because of cold because of the stagnant and person of obtaining, control with this and invariably imitate." " must join book on Chinese herbal medicine " also say: " all deficiency and coldness are sick also should control it." Cortex Cinnamomi can replenishing vital QI with drugs of warm nature QI and blood, sayed just as releasing decoction of ten powerful tonics in Zhang Bingcheng " becoming conveniently to read ": " Cortex Cinnamomi homoiothermy arteries and veins and and nutrient blood, and make all medicines obtain the power of replenishing vital QI with drugs of warm nature, then benefit property is more enough, takes effect more." just " beautiful Chinese catalpa medicine solution Cortex Cinnamomi " return and receive it: the warm color tone warm in nature of Cortex Cinnamomi is smooth, and it is with the wet in enriching blood greatly, and its embody rule has two, one, removing blood stasis to resolve lump; Two, pain relieving of dispeling cold.

Modern study finds, main containing polytype compounds such as volatile oil, polysaccharide, sesquiterpene and glucosides thereof, diterpene and glucosides, flavonol and polymers thereof in Cortex Cinnamomi.Corresponding Cortex Cinnamomi has multiple pharmacological effect, is mainly manifested in blood vessel dilating, promotes blood circulation, increases arteria coronaria and cerebral blood flow, vascular resistance is declined, increase urine volume and promote the effects such as sodium chlorine excretion.And all effects of modern pharmacology research, all nothing more than the imbody of Cortex Cinnamomi removing blood stasis to resolve lump with pain relieving of dispeling cold." dialectical record ": " and the one-tenth of BI-syndrome involved the kidney; non-to the greatest extent because wind and cold is wet also; though the cold dirty and own fire in its Central Plains of husband's kidney; have fire then water cold and wind and cold wet without thus enter; helpless people too does by force, and by congenital water everyday to letting out, water goes and fire also goes with stream; make source of vital energy unexpectedly become the cave of hiding ice, and fire can not oppose trembles with fear and cold-evil invades.Cold directly enters kidney palace, and recruit evil with heresy, and rheumatism mutually thus extremely, then arthromyodynia is raw." emphasize to suffer from a deficiency of the kidney (insufficiency of kidney-YANG) be the precondition that arthromyodynia occurs.Pathogenesis is deficiency in origin and excess in superficiality, and it is dirty that sick position relates generally to Pi kidney two.Help with Cortex Cinnamomi simply in we, and other component combineds effect, there is the effect that can not despise in side.

Radix Glycyrrhizae Preparata sweet in the mouth, property is put down, GUIXIN, lung, spleen, stomach warp.Primary efficacy invigorating the spleen and replenishing QI, relieving spasm to stop pain, heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription.Processed with honey property of medicine tepor, and the gas effect that can strengthen invigorating the heart and spleen.Shennong's Herbal is classified as top grade, Yun Qi: " gas of main vital organs of the human body cold and heat, hard muscles and bones, longue meat." " Mingyi Bielu ": " warming the middle warmer and descending qi, stuffy sensation with restlessness is losed heart, and hinders that dirty cough inkstone quenches the thirst, qualcomm meridian, sharp vim and vigour, separates the poison of hundred medicines." and " peace and 72 kinds of stones, 1,200 kinds of grass." " book on Chinese herbal medicine converges and says ": " with middle QI invigorating, the medicine of tonify deficiency removing toxic substances is also." Li Dong Yuan claims it: " its heat slow that the medicine of a warm nature obtains, slow its that cold medicine obtains is trembled with fear, and cold and heat are assorted person mutually, the get Qi Ping of use." " the then temperature of processing mends three burnt vigour." state of an illness complexity, using medicines of both cold and hot natures simultaneously, reinforcement and elimination in combination, inside and outside up and down close control, when making different medicine play coordinative role, can be selected it.Modern pharmacological research also confirms that it has the effects such as good blood fat reducing, antiinflammatory, anti-immunity, antioxidation, antiviral.We, as making medicine, make medicine slow lasting, soft and not high.

Chinese medicine composition of the present invention, in its formula, all medicines are according to specific proportioning collocation application, play tonifying speen and tonifying kidney altogether, except diarrhea due to damp pathogen is turbid, the merit of eliminating toxic substances to remove stasis, removing heat from blood tonify deficiency, make that expectorant is turbid dispels, and damp and hotly remove, ecchymosis solution, full side's strengthening vital QI to eliminate pathogenic factors, treating both the principal and secondary aspects of a disease.Be applicable to the deficiency in origin table reality of hyperuricemia or have the treatment of the turbid damp and hot syndrome of expectorant concurrently.

Chinese medicine composition of the present invention has following feature: 1) for the pathogen and pathology of tcm of hyperuricemia and the pathogenetic understanding of modern medicine and prescription of making laws, not only meet the basic theories of Chinese medicine and pharmacy, is not also contrary in the viewpoint of modern medicine and understanding; Compatibility is rigorous, and medication is precise and appropriate, cross linking between medicine and medicine, intricately woven together with etiology and pathogenesis, be closely connected; 2) prescription, condemn the feature that determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs that medicine can fully demonstrate the traditional Chinese medical science selects medicine to combine with differential diagnosis of diseases, remarkable and lasting curative effect can be received; 3) principle of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, treatment must aim at the pathogenesis of disease is followed in full side's medication, the expectorant stasis of blood is also controlled, both this current Etiological of hyperuricemia eating and drinking without temperance, surfeit delicious food had been considered, and deficiency in origin and excess in superficiality, blood stasis, main pathogenesis characteristics that expectorant is turbid, take into account again in disease progression easily because the tangible heresies such as expectorant is turbid, the malicious stasis of blood check mechanism of qi, accumulate this pathological change of long-pending heat-transformation.

Chinese medicine composition compatibility of the present invention is reasonable, and each component complements each other, with strong points, has significant curative effect, not easily recur after treatment hyperuricemia and gout.

Detailed description of the invention

Below in conjunction with embodiment, technical scheme of the present invention is described further:

Embodiment 1 is the preparation embodiment of Chinese medicine composition

Take each medical material by formula: by weight, get Herba Portulacae 30 parts, Herba Agrimoniae 30 parts, Rhizoma Atractylodis 15 parts, Radix Glycyrrhizae Preparata 9 parts, Cortex Cinnamomi 5 parts;

Prepare drug particles as follows: mixed by each medical material, add the water boiling and extraction twice of 10 times amount (10 times amount of medical material total amount) respectively, each 1.5h; Decoct after extracting and filter, merge extractive liquid; Extracting solution being concentrated into relative density is 1.25 ~ 1.35(60 DEG C) clear paste; After clear paste is carried out vacuum drying, by broken for gained dried cream powder, make granule.

When adopting the obtained drug particles of embodiment 1 to treat, patient per need take the drug particles being equivalent to adopt the formula containing, for example each medical material of lower weight to make according to the method described above: Herba Portulacae 30g, Herba Agrimoniae 30g, Rhizoma Atractylodis 15g, Radix Glycyrrhizae Preparata 9g, Cortex Cinnamomi 5g.

Embodiment 2 is the preparation embodiment of Chinese medicine composition

Take each medical material by formula: by weight, get Herba Portulacae 15 parts, Herba Agrimoniae 15 parts, Rhizoma Atractylodis 5 parts, Radix Glycyrrhizae Preparata 3 parts, Cortex Cinnamomi 1 part;

Prepare drug particles as follows: mixed by each medical material, add the water boiling and extraction twice of 10 times amount (10 times amount of medical material total amount) respectively, each 1h; Decoct after extracting and filter, merge extractive liquid; Extracting solution being concentrated into relative density is 1.10 ~ 1.25(60 DEG C) clear paste; Add ethanol wherein to alcohol content 65%, leave standstill; After being reclaimed by ethanol, simmer down to thick paste, adds the starch of medical material total amount 1/10 weight portion and the sucrose of 1/10 weight portion, makes granule in thick paste.

When adopting the obtained drug particles of embodiment 2 to treat, patient per need take the drug particles being equivalent to adopt the formula containing, for example each medical material of lower weight to make according to the method described above: Herba Portulacae 15g, Herba Agrimoniae 15g, Rhizoma Atractylodis 5g, Radix Glycyrrhizae Preparata 3g, Cortex Cinnamomi 1g.

Embodiment 3 is the preparation embodiment of Chinese medicine composition

Take each medical material by formula: by weight, get Herba Portulacae 24 parts, Herba Agrimoniae 21 parts, Rhizoma Atractylodis 12 parts, Radix Glycyrrhizae Preparata 6 parts, Cortex Cinnamomi 3 parts;

Prepare drug particles as follows: mixed by each medical material, add the water boiling and extraction twice of 10 times amount (10 times amount of medical material total amount) respectively, each 1.5h; Filter, merge extractive liquid, being concentrated into relative density is 1.25 ~ 1.35(60 DEG C) clear paste; After clear paste vacuum drying, by broken for gained dried cream powder, make granule.

When adopting the obtained drug particles of embodiment 3 to treat, patient per need take the drug particles being equivalent to adopt the formula containing, for example each medical material of lower weight to make according to the method described above: Herba Portulacae 24g, Herba Agrimoniae 21g, Rhizoma Atractylodis 12g, Radix Glycyrrhizae Preparata 6g, Cortex Cinnamomi 3g.

Embodiment 4 is the preparation embodiment of Chinese medicine composition

Take each medical material by formula: by weight, get Herba Portulacae 24 parts, Herba Agrimoniae 21 parts, Rhizoma Atractylodis 12 parts, Radix Glycyrrhizae Preparata 6 parts, Cortex Cinnamomi 3 parts, for subsequent use;

Prepare drug particles as follows: by weight, get Rhizoma Atractylodis 12 parts and Cortex Cinnamomi 3 parts mixing, add the water of 8 times amount (8 times amount for Rhizoma Atractylodis and Cortex Cinnamomi total amount), immersion 0.5h; Then carry out distillating extracting oil 6h, collect volatile oil, medicinal residues and the another device of the aqueous solution after distilling store; Separately get Herba Portulacae 24 parts, Herba Agrimoniae 21 parts, Radix Glycyrrhizae Preparata 6 parts mix with above-mentioned medicinal residues, add 10 times amount (10 times amount for medicinal residues, Herba Portulacae, Herba Agrimoniae, Radix Glycyrrhizae Preparata total amount) water respectively and carry out decoction extraction twice, each 1.5h; Filter, the aqueous solution after filtrate and above-mentioned distillation merges; Amalgamation liquid being concentrated into relative density is 1.05 ~ 1.15(60 DEG C) clear paste; After clear paste spraying dry, by broken for gained dried cream powder, make granule.

When adopting the obtained drug particles of embodiment 4 to treat, patient per need take the drug particles being equivalent to adopt the formula containing, for example each medical material of lower weight to make according to the method described above: Herba Portulacae 24g, Herba Agrimoniae 21g, Rhizoma Atractylodis 12g, Radix Glycyrrhizae Preparata 6g, Cortex Cinnamomi 3g.

Application examples

Application examples 1:

Zhang, man, 46 years old.To seek medical advice between 15 day eve prominent sense right crus of diaphragm hallux toe sole of the foot redness and swelling of joints causalgia, cut-like pain, can not touch.Press acute rheumatic arthritis tcm diagnosis in certain hospital, see patient's obesity, thirsty, red tongue, yellow and greasy fur, wiry and frequent pulse is strong.Blood chemical examination is that anti-" O " is normal, erythrocyte sedimentation rate 39mm/h, blood uric acid 689umol/L, rheumatoid factor ().Be diagnosed as gouty arthritis.Adopt the Drug therapy that embodiment 1 is obtained, daily 1 time, drug administration is after 7 days, and double-legged hallux toe sole of the foot joint and right ankle joint swell and ache and fade away, can lower ground walking.Take 14 days more afterwards, erythrocyte sedimentation rate is down to 20mm/h, and blood uric acid is down to 456umol/L.After continuing to take 7, local joint symptoms sign disappears, and erythrocyte sedimentation rate and blood uric acid are down to normally.Follow up a case by regular visits to and do not send out for 1 year, blood uric acid inspection is normal.

Application examples 2:

Lee so-and-so, man, 73 years old.Medical front 2d night, right sufficient thumb pain was obvious, and outstanding play at nightfall, pain can not be slept, and interruption allopurinol etc. controls symptom.But its right sufficient thumb is red and swollen, aversion to cold and cold limbs, and occasionally have uncomfortable in chest, nocturia, sleeps poor, dreaminess, and light purplish tongue is dark, and tongue is greasy in vain, deep-thready pulse.Through chemical examination, its blood uric acid is 474umol/L.Western medicine diagnose is gout.Tcm diagnosis is arthromyodynia.Adopt the Drug therapy that embodiment 2 is obtained, take 7 days, take 2 every day.During further consultation, find that spirit is comparatively before clearly better, right sufficient thumb pain, fear cold extremities, sleep, frequent urination at night, uncomfortable in chestly all to alleviate.Continue to take 30, daily 2 times, further consultation inspection finds that uric acid is down to 417umol/L.

Application examples 3:

Yang, 53 years old.There is toes arthralgia in patient, be very with hypnalgia, patient often again and again drank before 6 years, surfeit greasy and surfeit flavour before 6 years, time sense toes swell and ache, because of work busier, do not mind.Medical cause tired pain of drinking exacerbates, and swelling and ache more so inside left sufficient thumb, take hypnalgia as play.Check and find blood uric acid 816umol/L, be diagnosed as " gout ", take allopurinol, colchicine etc., the state of an illness takes a turn for the better to some extent, but withdraws because having a stomachache discomfort.Swell and ache after withdrawing and exacerbate, swelling and ache inside left hallux, night more very.Blood uric acid inspection is 714umo l/L, bitter taste, yellow and greasy fur, wiry and frequent pulse.Card belongs to wet hot phlegm turbid stasis blocking, adopts the obtained medicine of embodiment 3 to treat, daily 1 time, and after January, toes swell and ache basic disappearance, continual cure 2 months, and patient's toes swell and ache disappearances, blood uric acid normally, then after treatment January, after follow up a case by regular visits to half a year, do not recur again.

Application examples 4:

Week so-and-so, man, 45 years old.Patient have gout medical history 5 years, and several tophus appears in ears exterior feature portion.There is the red and swollen twinge of left side Metatarsophalangeal joint in this time outbreak, local swelling is out of shape, joint stuffiness, and ears exterior feature portion block scrofula is hardened, and body of the tongue purple is dim, yellow and thin fur, thready and hesitant pulse after having a dinner party because of friend.After inspection, its blood uric acid 684umol/L, c reactive protein 71.6mg/L, Western medicine diagnose is acute gout, tcm diagnosis arthromyodynia, and card belongs to stagnant heat retardance card, adopts the Drug therapy that embodiment 4 is obtained, takes 7, every day 1 time.Further consultation finds that the red and swollen twinge of left Metatarsophalangeal joint obviously alleviates, and the slightly dark black of color of the leather, body of the tongue purple is dim, yellow and thin fur, thready and stringy pulse.After continuing to take 20, redness and swelling of joints twinge disappears, check blood uric acid 381umo l/L, c reactive protein 2mg/L.Effect of follow-up visit by telephone after May, without recurrence.

Application examples 5:

Yuan, man 41 years old, because of the right sufficient Metatarsophalangeal joint pain of burst at night after drinking, pain is difficult to fall asleep like baked wheaten cake.Chemical examination is: blood uric acid 655umo l/L, rheumatoid factor negative, anti-" O " (one), c reactive protein 380mg/L, erythrocyte sedimentation rate 58mm/h.Find time medical: the right sufficient Metatarsophalangeal joint of patient is red and swollen, pain can not be touched, red tongue, yellow and greasy fur, slippery and rapid pulse.Tcm diagnosis is damp-heat arthralgia; Western medicine diagnose is acute gouty arthritis.Adopt the obtained Drug therapy of embodiment 1, daily 1 time, take two days continuously, the symptom such as to swell and ache is clearly better.After continuing to take 60, foot pain disappears, and check blood uric acid, C reactive protein, erythrocyte sedimentation rate are all normal.Follow up a case by regular visits to 1 year, have no recurrence.

Application examples 6:

Pueraria lobota, man, 35 years old.After patient has a dinner party with friend before medical 3d, occur that left ankle joint is red and swollen morning next day, sharp ache, local time has fearness cool, and night is serious.Find time medical: the left ankle joint of patient is red and swollen, tenderness (+++), and red tongue omits dark, yellow and greasy fur, rapid pulse.Uric acid of having a blood test is 537umol/mL, and Western medicine diagnose is gouty arthritis; Tcm diagnosis is arthromyodynia, and card belongs to damp-heat congestion type.The Drug therapy obtained by embodiment 27 days, daily 1 time.Find during further consultation that left ankle joint pain obviously alleviates, can walk voluntarily, tongue is slightly dark, the micro-Huang of tongue is greasy, stringy pulse.Continue to take 14, transference cure, clinical cure.Follow up a case by regular visits to after March, do not reaccess.

Application examples 7:

Liu, male, 56 years old, gout medical history 8 years, caused right crus of diaphragm Metatarsophalangeal joint red and swollen heat pain, joint stuffiness before 2d after drinking, and its pain is heavy for light night in daytime, takes Western medicine analgesic pain relief, but gastrointestinal upset after taking medicine, then arrive department of Chinese medicine diagnosis and treatment.Check its blood uric acid 482umol/L, erythrocyte sedimentation rate 55mm/h.Companion's gastral cavilty is full vexed, feels sick, every day nocturia 4 times, red tongue, yellow and greasy fur, slippery and rapid pulse.Card belongs to retention of damp-heat in the interior, numbness resistance meridians.Adopt the Drug therapy that embodiment 3 is obtained, daily 1 time, after taking 7, joint congestion and swelling pain obviously alleviates, and nocturia slightly takes a turn for the better.Continue to take medicine 3 weeks, all diseases disappear to the greatest extent, blood uric acid 327umol/L, and erythrocyte sedimentation rate 18mm/h visits and has no recurrence half a year.

The above, it is only preferred embodiment of the present invention, not any pro forma restriction is done to the present invention, therefore all contents not departing from technical solution of the present invention, according to technical spirit of the present invention to any simple modification made for any of the above embodiments, equivalent variations and modification, all still belong in the scope of technical solution of the present invention.

Claims (7)

1. treat the Chinese medicine composition of hyperuricemia and gout for one kind, it is characterized in that, its formula of described Chinese medicine composition is made up of each component of following weight portion: Herba Portulacae 15 ~ 30 parts, Herba Agrimoniae 15 ~ 30 parts, Rhizoma Atractylodis 5 ~ 15 parts, Radix Glycyrrhizae Preparata 3 ~ 9 parts, Cortex Cinnamomi 1 ~ 5 part.

2. the Chinese medicine composition for the treatment of hyperuricemia according to claim 1 and gout, it is characterized in that, its formula of described Chinese medicine composition is made up of each component of following weight portion: Herba Portulacae 30 parts, Herba Agrimoniae 30 parts, Rhizoma Atractylodis 15 parts, Radix Glycyrrhizae Preparata 9 parts, Cortex Cinnamomi 5 parts.

3. the Chinese medicine composition for the treatment of hyperuricemia according to claim 1 and gout, it is characterized in that, its formula of described Chinese medicine composition is made up of each component of following weight portion: Herba Portulacae 15 parts, Herba Agrimoniae 15 parts, Rhizoma Atractylodis 5 parts, Radix Glycyrrhizae Preparata 3 parts, Cortex Cinnamomi 1 part.

4. the Chinese medicine composition for the treatment of hyperuricemia according to claim 1 and gout, it is characterized in that, its formula of described Chinese medicine composition is made up of each component of following weight portion: Herba Portulacae 24 parts, Herba Agrimoniae 21 parts, Rhizoma Atractylodis 12 parts, Radix Glycyrrhizae Preparata 6 parts, Cortex Cinnamomi 3 parts.

5. the treatment hyperuricemia according to any one of Claims 1 to 4 and the Chinese medicine composition of gout, is characterized in that, its dosage form of described Chinese medicine composition is granule, pill, mixture, tablet, capsule.

6. the treatment hyperuricemia according to any one of Claims 1 to 4 and the Chinese medicine composition of gout, it is characterized in that, in Chinese medicine composition, the extraction process of effective ingredient comprises the steps:

1) ingredients is taken by formula;

2) mixed by each medical material, add the soak by water twice of 10 times amount wherein, each decocting time is 1 ~ 1.5 hour, decocts after extracting and filters, merge extractive liquid;

3) extracting solution is concentrated into the clear paste that relative density is 1.0 ~ 1.35.

7. the treatment hyperuricemia according to any one of Claims 1 to 4 and the Chinese medicine composition of gout, it is characterized in that, in Chinese medicine composition, the extraction process of effective ingredient comprises the steps:

1) ingredients is taken by formula;

2) by Rhizoma Atractylodis, Cortex Cinnamomi mixing, add the water soaking 0.5h of 8 times amount, then distillating extracting oil 6h, collect volatile oil, the aqueous solution after medicinal residues and distillation is stored respectively;

3) by the mixing of the medicinal residues of Herba Portulacae, Herba Agrimoniae, Radix Glycyrrhizae Preparata and step 2, add the water boiling and extraction twice of 10 times amount, each 1.5h, filter, aqueous solution after distillation in filtrate and step 2 is merged, and amalgamation liquid is concentrated into the clear paste that relative density is 1.05 ~ 1.15.