CN103251867A - Chinese herbal compound medicine for treating diabetes mellitus and preparation method thereof - Google Patents
Chinese herbal compound medicine for treating diabetes mellitus and preparation method thereof Download PDFInfo
- Publication number
- CN103251867A CN103251867A CN2013102152235A CN201310215223A CN103251867A CN 103251867 A CN103251867 A CN 103251867A CN 2013102152235 A CN2013102152235 A CN 2013102152235A CN 201310215223 A CN201310215223 A CN 201310215223A CN 103251867 A CN103251867 A CN 103251867A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- rhizoma
- fructus
- herba
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a Chinese herbal compound medicine for treating diabetes mellitus and a preparation method thereof. The Chinese herbal compound medicine is prepared from the following ingredients by weight percentage: rhizoma atractylodis, Ligusticum wallichii, ephedra, Rhizoma Dioscoreae Nipponicae, cynanchum paniculatum, pinellia ternate, inula flower, radix aconiti lateralis preparata, pepper, fructus evodiae, pharbitis seed, coptis powder, uncaria, raw liquorice, polygonum multiflorum, radices trichosanthis, rhizoma anemarrhenae, sealwort, radix ophiopogonis, Chinese yarn, the fruit of Chinese wolfberry, aloes, euonymus alatus sieb semen litchi, cornus, cortex lycii radicis, bitter gourd, ephedra, potentilla discolor, purslane, guava, fourstamen stephania root, angelica sinensis, ginseng, galangal, acanthopanax, cinnamon, burdock, radix polygonati officinalis, astragalus membranaceus, the root bark of the peony tree, peach blossom, glossy privet fruit, rhizoma alismatis, the bark of eucommia, the root of kudzu vine, five leaf gynostemma herb, china root greenbier rhizome, the root bark of white mulberry, root of common peony, parasitic loranthus, rhodiola elongate, selaginella tamariscina, ginkgo leaf, semen coicis, lychee seed, morinda officinalis and dendrobium officinale. According to the invention, the preparation method is simple, various traditional Chinese medicines are matched, the utilization rate of the medicines is high, the toxic and side effect is small, and the curative effect in the diabetes mellitus and complication thereof is remarkable, and the total efficiency reaches 92%.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of traditional Chinese compound medicine for the treatment of diabetes and preparation method thereof.
Background technology
Diabetes be a kind of be the incretion metabolism disease of feature with the blood sugar concentration rising, its characteristics are because the absolute or relative deficiency of insulin and target cell to the sensitivity reduction of insulin, cause the metabolism disorder of carbohydrate, protein, fat, electrolyte and water.
Diabetes are the third-largest killers of human health, can cause the damage of each internal organs, and diabetics is many to be caused death by all kinds of complication, and diabetics cerebrovascular, evidence of coronary heart diseases exceed normal person 3-5 doubly, and nephropathy, retinopathy exceed 10 times of normal persons.Along with the raising of living standards of the people, the onset diabetes rate have gradually increase, trend that age of onset has rejuvenation.The tenth time the academic meeting report of national diabetes points out that present global diabetics has reached about 1.8 hundred million, and China's onset diabetes rate also is ascendant trend year by year, and the ill crowd of diabetes has sharply risen nearly 8 times in the past 25 years.Among the metropolitan adult crowds such as in Beijing, Shanghai, port and fringe, its sickness rate has approached or more 10%, and China has become second the diabetes big country that is only second to India.Early diabetes does not have tangible clinical symptoms, part is first symptom with complication, diabetic angiopathy is the common chronic complicating diseases of diabetes, seriously influence patient's life quality, jeopardize patient's physical and mental health, be to cause the wounded or disabled dead major reason of patient, also bring great economic loss to patient; Diabetic nephropathy is the diabetes most common complication, also is one of major causes of death of diabetics; Diabetic renal papillary necrosis is the common blinding oculopathy day after tomorrow of middle age in the world wide.Diabetic complication is many and serious, but still lacks effective prophylactic treatment measure at present.Therefore, strengthen the understanding to diabetes, effectively preventing and treating complication is problem demanding prompt solution.
The application of life style adjustment and hypoglycemic medicine is the main means of control type 2 diabetes mellitus and complication.Hypoglycemic medicine is based on Western medicine at present, but not only there are toxic and side effects such as hypoglycemia, gastrointestinal reaction with western medicine, and according to the perspective diabetes study demonstration of Britain, no matter be conventional therapy group or intensive treatment group, though glucose-lowering treatment is effective during beginning, but blood glucose still raises year by year, and two groups of glycolated hemoglobin levels differ less than one of percentage after 15 years, thereby the antidiabetic drug of searching high-efficiency low-toxicity is still the target that medical expert pursues.
Chinese medicine thinks that the generation development of any disease all be unable to do without causing harm of heresy, as " the Huang di's Canon of Medicine element is asked the regulating menstruation opinion " cloud: " life of husband's heresy also, or be born in the moon, or be born in sun.It is born in positive person, the wind and rain cold and summer-heat that gets; It is born in cloudy person, the place, diet residence that gets, intemperance of sexual intercourse and emotional irritation ".More clearly propose in the Zhang Zihe " Confucian's Duties to Their Parents " " one of husband's disease thing, the non-person have also.Or ab extra, or by interior and give birth to, all pathogen is also ", Song dynasty Xu Shuwei penetrating proposition in " general Ji ability side " " institute of heresy gathers, and its gas must be empty, stays and does not go, and its disease is then real " proposes pathogen clearly at the developing mastery reaction of the generation of disease.
We to the basic understanding of disease and a large amount of clinical practices, think that type 2 diabetes mellitus pathology character is " domination of pathogen " according to the traditional Chinese medical science, and its pathogen is " phlegm retention ", and its disease is equivalent to the sick category of the traditional Chinese medical science " phlegm retention ".The formation of its phlegm retention or because greasy and surfeit flavour usually, the surfeit delicious food, taste lose fortune, accumulatively wet raise phlegm, or because depression of liver-QI, the liver failing to dredge the spleen is given birth in the dysfunction of the spleen in transportation, phlegm-damp, i.e. " the Huang di's Canon of Medicine element is asked the regulating menstruation opinion " " it is born in cloudy person; diet residence place, intemperance of sexual intercourse and emotional irritation ", that is " Confucian's Duties to Their Parents " " or by interior and give birth to ".
Type 2 diabetes mellitus is phlegm retention sun heat stagnation knot originally, and pathogenic factor is at table, and patient's condition is still light; And then Sheng accompanies sun heat, invasion of pathogen toward the interior, exacerbation of disease in the phlegm retention; And then then phlegm retention is stopped up Sheng, and pathogenic factor is deep, and disease becomes to increasing the weight of and stubbornness.Its pathology development, following from the superficial to the deep, by gently going into heavy law of development, with going deep into of pathogenic factor, yang-energy is stranded volt further, treat difficult further thorny, say just as " the Huang di's Canon of Medicine element asks YIN YANG classification of natural phenomena big opinion " " old pathogen wind extremely, so disease such as wind and rain are the kind person's of controlling treating disorders in the skin and hairs; treating disorders in muscles and skin secondly; secondly treating disorders in tendons and vessels, secondly treating disorders in six FU-organs, secondly treating disorders in five ZANG-organs.The treating disorders in five ZANG-organs person, an unfavorable prognosis with a half possibili ty of death is also ", " Confucian's Duties to Their Parents " also points out " people among husband's heresy ... quite very then pass for a long time and difficulty, more very then die of a sudden illness ".
The Chinese medicine diabetes have its special advantages,, action temperature little as toxic and side effects and lasting, have the Comprehensive Treatment effect, can alleviate and complication prevention etc.But the general composition of raw materials of the medicine of existing treatment by Chinese herbs diabetes is more, complicated process of preparation, and the quality control difficulty, dose is more, and curative effect is dissatisfied etc.
Summary of the invention
The present invention is directed to the etiology and pathogenesis of diabetes, start with to set upright from eliminating evil, traditional Chinese compound medicine of a kind of medical material utilization rate height, technology is simple, evident in efficacy, side effect is little treatment diabetes and preparation method thereof is provided, both clearing away phlegm and removing blood stasis its heresies of dispelling, again with tonifying speen and tonifying kidney, nourishing YIN is supporing yang, benefiting QI and nourishing blood holds up it just, the homergy of blood glucose can be recovered, the appearance with complication prevention can be controlled again.
The technical solution adopted for the present invention to solve the technical problems is: a kind of traditional Chinese compound medicine for the treatment of diabetes, it is characterized in that, made by following Chinese medicine raw materials by weight proportion: Rhizoma Atractylodis 0.5-2 part, Rhizoma Chuanxiong 0.5-2 part, Herba Ephedrae 0.5-2 part, Rhizoma Dioscoreae Nipponicae 2-4 part, Radix Cynanchi Paniculati 4-6 part, Rhizoma Pinelliae 0.5-2 part, Flos Inulae 0.5-2 part, Radix Aconiti Lateralis Preparata 0.5-2 part, Pericarpium Zanthoxyli 0.5-2 part, Fructus Evodiae 2-4 part, fry Semen Pharbitidis 60-70 part, Rhizoma Coptidis 12-16 part, Ramulus Uncariae Cum Uncis 0.5-2 part, Radix Glycyrrhizae 2-4 part, Radix Polygoni Multiflori 4-6 part, Radix Trichosanthis 7-9 part, Rhizoma Anemarrhenae 7-9 part, Rhizoma Polygonati 8-12 part, Radix Ophiopogonis 4-6 part, Rhizoma Dioscoreae 4-6 part, Fructus Lycii 4-6 part, Aloe 1-3 part, Ramulus Euonymi 0.5-2 part, Fructus Corni 4-6 part, Cortex Lycii 1-3 part, Fructus Momordicae charantiae 4-6 part, Herba Ephedrae 3-5 part, Herba Potentillae Discoloris 4-6 part, Herba Portulacae 2-4 part, Fructus psidii guajavae immaturus 4-6 part, Radix Stephaniae Tetrandrae 2-4 part, Radix Angelicae Sinensis 0.5-2 part, Radix Ginseng 4-6 part, Rhizoma Alpiniae Officinarum 1-3 part, Radix Et Caulis Acanthopanacis Senticosi 1-3 part, Cortex Cinnamomi 30-35 part, Fructus Arctii 0.5-2 part, Rhizoma Polygonati Odorati 4-6 part, Radix Astragali 4-6 part, Cortex Moutan 0.5-2 part, Flos persicae 5-8 part, Fructus Ligustri Lucidi 0.5-2 part, Rhizoma Alismatis 0.5-2 part, Cortex Eucommiae 0.5-2 part, Radix Puerariae 0.5-2 part, Herb Gynostemmae Pentaphylli 1-3 part, Chinaroot Greenbier Rhizome 0.5-2 part, Cortex Mori 0.5-2 part, Radix Paeoniae Rubra 0.5-2 part, Herba Taxilli 0.5-2 part, Radix Rhodiolae 10-15 part, Herba Selaginellae 4-6 part, Folium Ginkgo 2-4 part, Semen Coicis 2-4 part, Semen Litchi 2-4 part, Radix Morindae Officinalis 2-4 part, Herba Dendrobii 5-8 part.
Preferably, a kind of traditional Chinese compound medicine for the treatment of diabetes is made by following Chinese medicine raw materials by weight proportion: 1 part of Rhizoma Atractylodis, 1 part of Rhizoma Chuanxiong, 1 part in Herba Ephedrae, 3 parts of Rhizoma Dioscoreae Nipponicae, 5 parts of Radix Cynanchi Paniculatis, 1 part of the Rhizoma Pinelliae, 1 part of Flos Inulae, 1 part of Radix Aconiti Lateralis Preparata, 1 part in Pericarpium Zanthoxyli, 3 parts of Fructus Evodiaes, fry 64 parts of Semen Pharbitidis, 15 parts of Rhizoma Coptidis, 1 part of Ramulus Uncariae Cum Uncis, 3 parts of Radix Glycyrrhizae, 5 parts of Radix Polygoni Multiflori, 8 parts of Radix Trichosanthis, 8 parts of the Rhizoma Anemarrhenaes, 10 parts of Rhizoma Polygonatis, 5 parts of Radix Ophiopogonis, 5 parts of Rhizoma Dioscoreaes, 5 parts of Fructus Lycii, 2 parts of Aloes, 1 part of Ramulus Euonymi, 5 parts of Fructus Corni, 2 parts of Cortex Lycii, 5 parts in Fructus Momordicae charantiae, 4 parts in Herba Ephedrae, 5 parts of Herba Potentillae Discoloris, 3 parts of Herba Portulacaes, 5 parts of Fructus psidii guajavae immaturus, 3 parts of Radix Stephaniae Tetrandrae, 1 part of Radix Angelicae Sinensis, 5 parts of Radix Ginsengs, 2 parts of Rhizoma Alpiniae Officinarums, 2 parts of Radix Et Caulis Acanthopanacis Senticosis, 32 parts of Cortex Cinnamomis, 1 part of Fructus Arctii, 5 parts of Rhizoma Polygonati Odorati, 5 parts of the Radixs Astragali, 1 part of Cortex Moutan, 7 parts in Flos persicae, 1 part of Fructus Ligustri Lucidi, 1 part of Rhizoma Alismatis, 1 part of the Cortex Eucommiae, 1 part of Radix Puerariae, 2 parts of Herb Gynostemmae Pentaphylli, 1 part of Chinaroot Greenbier Rhizome, 1 part of Cortex Mori, 1 part of Radix Paeoniae Rubra, 1 part of Herba Taxilli, 13 parts of Radix Rhodiolaes, 5 parts of Herba Selaginellaes, 3 parts of Folium Ginkgos, 3 parts of Semen Coiciss, 3 parts of Semen Litchis, 3 parts of Radix Morindae Officinaliss, 7 parts of Herba Dendrobii.
The preparation method of the traditional Chinese compound medicine for the treatment of diabetes may further comprise the steps:
(1) with Radix Ginseng, Rhizoma Atractylodis, Radix Angelicae Sinensis, the Ramulus Euonymi oven dry of above-mentioned weight proportion, micronizing gets powder;
(2) other raw material of Chinese medicine conventional extraction by weight ratio, filter medicinal liquid, the medicinal liquid drying under reduced pressure is got dry extract, be ground into powder, described drying under reduced pressure controlled pressure is-0.08Mpa that temperature is 60～70 ℃;
(3) with the abundant mix homogeneously of powder that makes in step (1), the step (2), make capsule.
Nature and flavor, the pharmacology of the raw material of Chinese medicine that the present invention adopts and act on as follows:
Rhizoma Atractylodis: hot, bitter, warm, return spleen, stomach, Liver Channel, cure mainly the fortune imbalance that the spleen being blocked by dampness causes, inappetence, vomiting is unhappy, and abdominal distention is had loose bowels, arthralgia.
Rhizoma Chuanxiong: acrid in the mouth, warm in nature, return liver, gallbladder, pericardium channel, blood circulation promoting and blood stasis dispelling, activating QI to alleviate the depression, wind-expelling pain-stopping.
Herba Ephedrae: hot, little hardship, temperature is returned lung, urinary bladder channel, diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.
Rhizoma Dioscoreae Nipponicae: warm in nature, sweet in the mouth, hardship are returned liver, kidney, lung meridian, relaxing muscles and tendons to promote blood circulation, relieving cough and resolving phlegm, wind-expelling pain-stopping.
Radix Cynanchi Paniculati: suffering, temperature is returned Liver Channel, stomach warp, the removing dampness of dispeling the wind, antalgesic-antipruritic is used for rheumatic arthralgia, stomachache distension, toothache, lumbago, injury from falling down, urticaria, eczema.
The Rhizoma Pinelliae: suffering, temperature is returned spleen, stomach, lung meridian, drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.Control the damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm headache, dizzy sleeplessness.
Flos Inulae: sweet, warm, return lung, liver, stomach warp, expectorant, the therapeutic method to keep the adverse QI flowing downwards, softening the hard mass, row water is controlled expectorant knot in the heart, and the side of body is distension down, cough with asthma, singultus, saliva such as shellac varnish, epigastric oppression whip, eructation unrelieved, extensive abdominal edema.
Radix Aconiti Lateralis Preparata: hot, sweet, GUIXIN, kidney, spleen channel, recuperating depleted YANG and rescuing the patient from collapse, it is supporing yang to mend fire, by wind-cold damp pathogen.Be used for the YANG-depletion collapse, the cold extremities faint pulse, sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness is vomited and diarrhoea, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, arthralgia due to cold-dampnes.
Pericarpium Zanthoxyli: hot, warm, fragrant stomach invigorating, warming spleen and stomach for dispelling cold, removing damp and stopping pain.
Fructus Evodiae: hot, bitter, hot, return liver, spleen, stomach, kidney channel, dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.Be used for headache due to JUE YIN disorder, colic of cold type stomachache, the disturbance of lower legs due to pathogenic cold and dampness, dysmenorrhea, abdominal pain during menstruation, abdominal distention, the vomiting acid regurgitation is had loose bowels just before dawn,
Fry Semen Pharbitidis: cold, bitter, the removing water retention by purgation relieving constipation, drink is washed in expectorant, and parasite killing is attacked long-pending.Be used for the edema distension, constipation and anuresis, phlegm retention is gathered, and QI rising in reverse order is breathed with cough, abdominal pain due to worm stagnation.
Rhizoma Coptidis: hardship, cold, GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel, heat clearing and damp drying, eliminating fire and detoxication.Be used for damp and hot feeling of fullness, the vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told nosebleed, conjunctival congestion, the carbuncle furuncle is quenched one's thirst in toothache.
Ramulus Uncariae Cum Uncis: bitter, be slightly cold, return liver, heart channel, the heat clearing away suppressing the hyperactive liver; Relieving spasm by subduing liver-wind.
Radix Glycyrrhizae: sweet, flat, GUIXIN, lung, spleen, stomach warp, invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Radix Polygoni Multiflori: bitter, sweet, puckery, tepor, enrich and benefit essence and blood cures mainly the blood deficiency anemia, Light-headedness, cardiopalmus, insomnia, the soreness of the waist and knees of the hepatic and renal YIN deficiency, early whitening of beard and hair.
Radix Trichosanthis: sweet, little hardship is slightly cold.Attach to the lung and stomach meridians.Clearing away heat and promoting production of body fluid, detumescence and apocenosis.Be used for the calentura excessive thirst, lung-heat type cough, interior-heat is quenched one's thirst, sore swollen toxin.
The Rhizoma Anemarrhenae: bitter, sweet, cold, return lung, stomach, kidney channel, clearing away heat-fire promotes the production of body fluid and moisturizes, and is used for fever caused by exogenous pathogenic factors, high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, the dryness of the intestine constipation.
Rhizoma Polygonati: sweet, flat, return spleen, lung, kidney channel, boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying cures mainly deficiency of YIN chronic cough; The xeropulmonary cough; Insufficiency of the spleen weak; The lack of appetite xerostomia; Quench one's thirst; The deficiency of the kidney soreness of the waist and knees; Impotence and seminal emission; The tinnitus order is dark; Early whitening of beard and hair; The empty win of body is thin.
Radix Ophiopogonis: sweet, little hardship, be slightly cold, GUIXIN, lung, stomach warp, YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.Be used for dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, the sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation.
Rhizoma Dioscoreae: sweet, flat, return spleen, lung, kidney channel, spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.Be used for insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, deficiency-heat is quenched one's thirst.
Fructus Lycii: sweet, flat, return liver, kidney, lung meridian, nourishing the liver, nourishing kidney, lung moistening cure mainly caused by liver and kidney deficiency, have a dizzy spell, and be visual unclear, soreness of the waist and knees.
Aloe: bitter, cold, return liver, the heart, spleen channel, cure mainly constipation with heat retention; The liver-fire headache, the conjunctival congestion infantile convulsion, abdominal pain due to worm stagnation, scabies is separated the Fructus Crotonis poison.
Ramulus Euonymi: hardship, the heart, cold, return Liver Channel, removing blood stasis stimulates the menstrual flow, removing toxic substances and promoting subsidence of swelling; Parasite killing.Primary symptom abdominal mass caking, trusted subordinate's pain, amenorrhea, dysmenorrhea, metrorrhagia and metrostaxis, the stasis of blood stagnated and suffered from abdominal pain puerperal, retention of lochia, hernia, the severe and migratory arthralgia arthralgia pain, skin ulcer is swollen, traumatic pain, abdominal pain due to worm stagnation.
Fructus Corni: sour, puckery, tepor, return liver, kidney channel, liver and kidney tonifying, restrain astringent or styptic treatment for spontaneous sweating, the controlling nocturnal emission with astringent drugs reducing urination, leukorrhagia stopping only collapses, hidroschesis, promoting the production of body fluid to quench thirst.Be used for soreness of waist and knee joint, dizziness and tinnitus, enuresis frequent micturition, profuse sweating collapse.
Cortex Lycii: sweet, cold, return lung, liver, kidney channel, heat clearing away, removing heat from blood.Control asthenia hectic fever night sweat, the lung-heat cough with asthma is spitted blood, and stranguria with blood is quenched one's thirst, hypertension.
Fructus Momordicae charantiae: bitter, cold, GUIXIN, liver, spleen, lung meridian have clearing summer heat, the detoxifcation that makes eye bright, reducing pressure and sugar, diuresis removing heat from blood, separate that labor clears away heart-fire, the effect of QI invigorating tonifying YANG.Have cool, thirst-quenching, heat-clearing and toxic substances removing, clear away heart-fire make eye bright, QI invigorating recovers from fatigue, the kidney tonifying diuretic actions.Contain multivitamin, mineral in the Fructus Momordicae charantiae, contain the magistery of fat eliminating, fat-reducing, can accelerate toxin expelling.Also have good blood sugar lowering, antiviral and anti-cancer effect.
Herba Ephedrae: hot, little hardship, temperature, return lung, urinary bladder channel.The diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.Be used for chill exterior syndrome, uncomfortable in chest breathing with cough, edema due to wind pathogen edema, rheumatic arthralgia, carbuncle of yin nature, sucutaneous nodule.Honey Herba Ephedrae inclined to one side profit warm in nature, suffering are distributed the antiperspirant effect and are relaxed, and have strengthened the merit of nourishing the lung to arrest cough, win with depressed lung-energy dispersing cough-relieving power.
Herba Potentillae Discoloris: sweet, little hardship, flat, heat clearing away, detoxifcation, the dysentery relieving hemostasis can be controlled women's red and white leukorrhea and menorrhagia disease, and through clinical verification, this product has therapeutic efficiency to diabetes.
Herba Portulacae: acid, cold, GUIXIN, liver, spleen, large intestine channel, heat-clearing and toxic substances removing, diuretic dries, the blood detumescence of loosing, dedusting sterilization, anti-inflammatory analgetic, hemostasis removing heat from blood.Cure mainly dysentery, enteritis, nephritis.
Fructus psidii guajavae immaturus: sweet, puckery, flat, cure mainly and have loose bowels, chronic dysentery, eczema, wound hemorrhage.
Radix Stephaniae Tetrandrae: bitter, cold, return bladder, spleen, kidney channel, inducing diuresis to remove edema, wind-expelling pain-stopping cures mainly the edema beriberi, dysuria, eczema sore, rheumatic arthralgia, vascular hypertension.
Radix Angelicae Sinensis: hot, bitter, warm, return liver, the heart, spleen channel, enrich blood, to invigorate blood circulation, menstruction regulating and pain relieving is moisturized laxation.
Radix Ginseng: flat, sweet, little hardship, tepor, return spleen, lung, heart channel, strongly invigorating primordial QI, multiple arteries and veins takes off invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, the Fructus Alpiniae Oxyphyllae of calming the nerves admittedly.Cure mainly that impairment caused by overstrain is deficient, lack of appetite, asthenia, regurgitation are told food, stool lingering diarrhea, empty cough with asthma are short, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, the disease of all qi-blood-body fluid deficiencies.
Rhizoma Alpiniae Officinarum: hot, hot, return spleen, stomach warp, warming stomach for dispelling cold, pain relieving helps digestion.Be used for coldness and pain in the epigastrium, gastrofrigid vomiting, belch acid regurgitation.
Radix Et Caulis Acanthopanacis Senticosi: hot, bitter, little sweet, warm, return liver, kidney channel, wind-damp dispelling, invigorating the liver and kidney, bone and muscle strengthening, the arteries and veins of invigorating blood circulation cures mainly anemofrigid-damp arthralgia, lumbocrural pain, the muscles and bones flaccidity is soft, is slow in action, a little less than the body weakness with emaciation, edema.
Cortex Cinnamomi: big heat, hot, sweet, return kidney, spleen, the heart, Liver Channel, it is supporing yang to mend fire, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.Warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Control decline of the fire from the gate of life, the cold extremities faint pulse, the YANG-depletion collapse, stomachache is had loose bowels, the colic of cold type renal mass, chills and pain of the waist and kness, the amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.
Fructus Arctii: hot, bitter, cold, attach to the lung and stomach meridians, dispelling wind and heat pathogens, the heat-clearing and toxic substances removing rash, the lung qi dispersing sore-throat relieving looses swollen.
Rhizoma Polygonati Odorati: sweet, be slightly cold, flat, attach to the lung and stomach meridians nourishing YIN and moistening the lung, promoting the production of body fluid to quench thirst.Be used for cough caused by dryness, chronic cough, the dry throat and mouth of the cloudy liquid consumption of calentura wound, interior-heat is quenched one's thirst, and deficiency of YIN diseases caused by exogenous pathogenic factor are dizzy dizzy, muscle arteries and veins spasm and pain.
The Radix Astragali: sweet, tepor, return lung, spleen, liver, kidney channel, benefiting QI for strengthening the superficies, arresting sweating takes off admittedly, holder skin ulcer granulation promoting, inducing diuresis to remove edema, it is weak to be used for the treatment of the deficiency of vital energy, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, carbuncle is difficult bursts, burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.
Cortex Moutan: bitter, hot, be slightly cold GUIXIN, liver, kidney channel, clearing away heat and cooling blood, promoting blood circulation to remove blood stasis.The epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, the calentura later stage, hot Fu Yin divided heating, deficiency of YIN osteopyrexia and fever, carbuncle sore tumefacting virus falls and pounces on the pain of injury, the rheumatism pyretic arthralgia.
Flos persicae: bitter, flat, relieving constipation by purgation, inducing diuresis to remove edema.Be used for edema, ascites, constipation.
Fructus Ligustri Lucidi: sweet, bitter, flat, return liver, kidney channel, liver and kidney tonifying, strong waist knee joint, improve visual and auditory acuity, black beard and hair.
Rhizoma Alismatis: sweet, light, cold, return kidney, urinary bladder channel, promoting diuresis to eliminate damp pathogen; It is treating stranguria to expel the heat-evil.Main dysuria; The puckery pain of pyretic stranguria; The edema distension; Have loose bowels; Dizziness due to fluid-retention.
The Cortex Eucommiae: sweet, little suffering, temperature, return liver, kidney channel, invigorating the liver and kidney, bone and muscle strengthening.Control the spinal column ache, foot and knee flaccidity, hypertension.
Radix Puerariae: cool, sweet, hot, induce sweat and bring down a fever, promote the production of body fluid rash, yang invigorating antidiarrheal.Be used for fever caused by exogenous pathogens headache, hypertension neck pain, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, have loose bowels.
Herb Gynostemmae Pentaphylli: bitter, little sweet, cool, return lung, spleen, kidney channel, replenishing QI to invigorate the spleen, preventing phlegm from forming and stopping coughing, heat-clearing and toxic substances removing.It is weak to cure mainly body void, nephrasthenia emission, leukopenia, hyperlipemia.
Chinaroot Greenbier Rhizome: sweet, sour, flat, return Liver Channel, kidney channel, expelling wind and removing dampness, removing toxicity for eliminating carbuncles.
Cortex Mori: sweet, cold, return lung meridian, eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.Be used for the lung-heat cough with asthma, the edema of the face, diseases such as dysuria.
Radix Paeoniae Rubra: bitter, be slightly cold, return Liver Channel, clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.
Herba Taxilli: bitter, sweet, flat, return liver, kidney channel, invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive.Main soreness of waist and knee joint, a little less than the muscles and bones flaccidity, limbs are hemiplegia, rheumatic arthralgia, head is wrong dizzy.
Radix Rhodiolae: sweet, bitter, flat, return lung, heart channel, benefiting QI for activating blood circulation is promoted blood circulation and is relievingd asthma, and cures mainly for blood stasis due to qi deficiency obstruction of qi in the chest and cardialgia, apoplectic hemiplegia, asthenia asthma.
Herba Selaginellae: hot, flat, return liver, heart channel, promoting blood circulation to restore menstrual flow is used for the amenorrhea dysmenorrhea.， WEIJIA mass in the abdomen, injury from falling down.
Folium Ginkgo: sweet, bitter, puckery, flat, GUIXIN, lung meridian are astringed the lung, and relieving asthma blood circulation promoting and blood stasis dispelling, pain relieving.Be used for cough and asthma due to lung deficiency, coronary heart disease, angina pectoris, hyperlipidemia.
Semen Coicis: sweet, be slightly cold, return spleen, stomach lung meridian, invigorating spleen for diuresis, the dampness removing eliminating impediment, clearing away heat and discharging pus, eliminating damp-heat can be played the effect of blood vessel dilating and blood sugar lowering.
Semen Litchi: sweet, little hardship, temperature, return liver, kidney channel, promoting QI to circulate and dispersing the agglomeration of the pathogens, cold relieving pain relieving.
Radix Morindae Officinalis: hot, sweet, tepor, return liver, kidney channel, kidney invigorating and YANG supporting, expelling wind and removing dampness, bone and muscle strengthening.
Herba Dendrobii: sweet, be slightly cold, the nourishing the stomach of promoting the production of body fluid, nourishing YIN and clearing away heat, the lung moistening kidney tonifying, strong waist makes eye bright.
Rhizoma Atractylodis, Rhizoma Chuanxiong, Herba Ephedrae, Chinaroot Greenbier Rhizome, Rhizoma Dioscoreae Nipponicae, Radix Cynanchi Paniculati, the Rhizoma Pinelliae, the hot temperature of Flos Inulae is dispersed and Radix Aconiti Lateralis Preparata, Pericarpium Zanthoxyli, Fructus Evodiae, Rhizoma Alpiniae Officinarum, Radix Et Caulis Acanthopanacis Senticosi, the hot temperature of Cortex Cinnamomi is supporing yang jointly to declare logical three warmers yang-energy, fry Semen Pharbitidis, the Flos persicae bitter cold is with the turbid blood stasis of water damp-phlegm of the three warmers meridians of removing heat by catharsis, Aloe, Rhizoma Alismatis, Cortex Mori, Fructus Arctii, Herb Gynostemmae Pentaphylli, Cortex Lycii, Radix Trichosanthis, the Rhizoma Anemarrhenae, Ramulus Euonymi, Fructus Momordicae charantiae, Rhizoma Coptidis, Ramulus Uncariae Cum Uncis, the Radix Glycyrrhizae bitter cold is to remove heat within the strongly fragrant volt, Radix Polygoni Multiflori, Radix Paeoniae Rubra, Radix Angelicae Sinensis, Radix Ophiopogonis, Radix Puerariae, Fructus Corni, Herba Taxilli, the Cortex Eucommiae, Fructus Ligustri Lucidi, Radix Ginseng, Rhizoma Polygonati Odorati, Rhizoma Dioscoreae, Fructus Lycii, Rhizoma Polygonati is equipped with the negative and positive interpromoting relation in five elements mutually with Radix Aconiti Lateralis Preparata, promote the biochemistry of QI and blood, below make the human functional activity of vital energy ascending, descending, exiting and entering recover normal altogether, the unobstructed and sick body rehabilitation of QI and blood.All medicines are harmonious, and QI invigorating is drying damp and strengthening spleen, the vital energy regualting and blood circulation-promoting clearing away phlegm, then clear person can rise, turbid person can fall, body qi and blood abounding, the logical blood of gas are smooth, operation in order, diabetes and complication thereof are eased or fully recover.
The present invention has following beneficial effect: the present invention reaches 92% through diabetics clinical trial proof to treatment diabetes and complication total effective rate thereof by the plurality of Chinese compatibility.Traditional Chinese compound medicine preparation technology of the present invention is simple, and medical material utilization rate height is compared with traditional Therapeutic Method, and toxic and side effects is little, and diabetes and complication thereof are had the obvious treatment effect.
Animal experiment of the present invention is observed as follows:
Get 48 of SPF level Wistar rats, male and female are not limit, and body weight (250 ± 20) g is divided into 5 groups at random, difference gastric infusion, normal group, model group, the large and small dosage group of medicine of the present invention, positive control metformin group, 8 every group.After the modeling success, the administration volume is all 1ml/250g respectively, normal group is irritated the stomach pure water, and the large and small dosage group filling of medicine of the present invention stomach drug dose is equivalent to 20 times, 10 times of people's consumption respectively, and positive controls filling stomach metformin dosage is equivalent to 10 times of people's consumption.Irritate the Weishang respectively and state medicine after 15 days, the every biochemical indicator of blood sampling chemical examination, draw as drawing a conclusion: medicine of the present invention is blood sugar lowering concentration obviously, alleviate the symptom of diabetic complication, improve lipid metabolism, (namely be equivalent to 10 times of amounts of clinical usefulness) under the clinical equivalent amount, medicine of the present invention and matched group relatively have significant difference.
The present invention is as follows to the treatment clinical observation of diabetics: adopt random contrast clinical trial.
The analysis of diabetes curative effect before and after table 1 treatment
Table 2 liang group blood glucose, blood viscosity index are relatively
Annotate: relatively preceding with treatment, △ P＜0.05, ▲ P＜0.01
Diagnostic criteria: with reference to the diagnostic criteria in " the new Chinese medicine treatment diabetes clinical research guideline " of Ministry of Public Health promulgation, and the weight grade scale of diabetes.
Therapeutic Method: matched group: the metformin enteric coatel tablets, the 0.5g/ sheet, each 2, every day 3 times, 4 weeks were 1 course for the treatment of.Treatment group: use medicine of the present invention.
Criterion of therapeutical effect: with reference to the criterion of therapeutical effect in " new Chinese medicine treatment diabetes clinical research guideline ", recording method: press the diabetes point system.
The result shows: two groups of curative effects compare: in matched group 12 examples, and produce effects 7 examples, effective 3 examples, invalid 2 examples, total effective rate is 67%; In 25 examples for the treatment of group, produce effects 19 examples, effective 4 examples, invalid 2 examples, total effective rate is 92%.Treatment group and matched group compare, P＜0.05.
Treatment group remission situation is observed: the patient for the treatment of group, and blurred vision, numbness of hands and feet, the purple symptom such as dark of lip is obviously improved; Blood examination: blood glucose, blood fat, blood viscosity are all in normal range etc.Above-mentioned effect all is better than the patient of matched group, particularly medication 14 days, 30 days the time, all demonstrate tangible difference.
Below be model case of the present invention:
The king * *, man, 65 years old.Diabetes 12 years took multiple medicine, but curative effect are not obvious at diabetic complication apoplexy half a year, and blood glucose is difficult to control, about fasting glucose 13.5mmol/L.Took medicine of the present invention 14 days, blood glucose drops to 8.9mmol/L, and is conscious, and all symptoms are obviously improved.Take one and a half months, blood glucose maintains 7.5mmol/L, and all the other symptoms are all obviously improved.
Grandson * *, the woman, 54 years old, diabetes 8 years take multiple medicine, but curative effect were not obvious, about fasting glucose 9.4mmol/L, began to occur blurred vision, the symptom of numbness of hands and feet.Take medicine of the present invention in the time of 14 days, numb sensation obviously alleviates eyesight improving.Took one month, blood glucose is down to 7.2mmol/L, and all the other symptoms are obviously improved.
The specific embodiment
The present invention is described in detail below in conjunction with specific embodiment
Embodiment 1
A kind of Chinese medicine combination drug for the treatment of diabetes is made by following Chinese medicine raw materials by weight proportion: 1 part of Rhizoma Atractylodis, 1 part of Rhizoma Chuanxiong, 1 part in Herba Ephedrae, 3 parts of Rhizoma Dioscoreae Nipponicae, 5 parts of Radix Cynanchi Paniculatis, 1 part of the Rhizoma Pinelliae, 1 part of Flos Inulae, 1 part of Radix Aconiti Lateralis Preparata, 1 part in Pericarpium Zanthoxyli, 3 parts of Fructus Evodiaes, fry 64 parts of Semen Pharbitidis, 15 parts of Rhizoma Coptidis, 1 part of Ramulus Uncariae Cum Uncis, 3 parts of Radix Glycyrrhizae, 5 parts of Radix Polygoni Multiflori, 8 parts of Radix Trichosanthis, 8 parts of the Rhizoma Anemarrhenaes, 10 parts of Rhizoma Polygonatis, 5 parts of Radix Ophiopogonis, 5 parts of Rhizoma Dioscoreaes, 5 parts of Fructus Lycii, 2 parts of Aloes, 1 part of Ramulus Euonymi, 5 parts of Fructus Corni, 2 parts of Cortex Lycii, 5 parts in Fructus Momordicae charantiae, 4 parts in Herba Ephedrae, 5 parts of Herba Potentillae Discoloris, 3 parts of Herba Portulacaes, 5 parts of Fructus psidii guajavae immaturus, 3 parts of Radix Stephaniae Tetrandrae, 1 part of Radix Angelicae Sinensis, 5 parts of Radix Ginsengs, 2 parts of Rhizoma Alpiniae Officinarums, 2 parts of Radix Et Caulis Acanthopanacis Senticosis, 32 parts of Cortex Cinnamomis, 1 part of Fructus Arctii, 5 parts of Rhizoma Polygonati Odorati, 5 parts of the Radixs Astragali, 1 part of Cortex Moutan, 7 parts in Flos persicae, 1 part of Fructus Ligustri Lucidi, 1 part of Rhizoma Alismatis, 1 part of the Cortex Eucommiae, 1 part of Radix Puerariae, 2 parts of Herb Gynostemmae Pentaphylli, 1 part of Chinaroot Greenbier Rhizome, 1 part of Cortex Mori, 1 part of Radix Paeoniae Rubra, 1 part of Herba Taxilli, 13 parts of Radix Rhodiolaes, 5 parts of Herba Selaginellaes, 3 parts of Folium Ginkgos, 3 parts of Semen Coiciss, 3 parts of Semen Litchis, 3 parts of Radix Morindae Officinaliss, 7 parts of Herba Dendrobii.
Its preparation method may further comprise the steps:
(1) with Radix Ginseng, Rhizoma Atractylodis, Radix Angelicae Sinensis, the Ramulus Euonymi oven dry of above-mentioned weight proportion, micronizing gets powder;
(2) other raw material of Chinese medicine conventional extraction by weight ratio, filter medicinal liquid, the medicinal liquid drying under reduced pressure is got dry extract, be ground into powder, described drying under reduced pressure controlled pressure is-0.08Mpa that temperature is 65 ℃;
(3) with the abundant mix homogeneously of powder that makes in step (1), the step (2), make capsule.
Embodiment 2
A kind of traditional Chinese compound medicine for the treatment of diabetes is made by following Chinese medicine raw materials by weight proportion: 0.5 part of Rhizoma Atractylodis, 0.5 part of Rhizoma Chuanxiong, 0.5 part in Herba Ephedrae, 2 parts of Rhizoma Dioscoreae Nipponicae, 4 parts of Radix Cynanchi Paniculatis, 0.5 part of the Rhizoma Pinelliae, 0.5 part of Flos Inulae, 0.5 part of Radix Aconiti Lateralis Preparata, 0.5 part in Pericarpium Zanthoxyli, 2 parts of Fructus Evodiaes, fry 60 parts of Semen Pharbitidis, 12 parts of Rhizoma Coptidis, 0.5 part of Ramulus Uncariae Cum Uncis, 2 parts of Radix Glycyrrhizae, 4 parts of Radix Polygoni Multiflori, 7 parts of Radix Trichosanthis, 7 parts of the Rhizoma Anemarrhenaes, 8 parts of Rhizoma Polygonatis, 4 parts of Radix Ophiopogonis, 4 parts of Rhizoma Dioscoreaes, 4 parts of Fructus Lycii, 1 part of Aloe, 0.5 part of Ramulus Euonymi, 4 parts of Fructus Corni, 1 part of Cortex Lycii, 4 parts in Fructus Momordicae charantiae, 3 parts in Herba Ephedrae, 4 parts of Herba Potentillae Discoloris, 2 parts of Herba Portulacaes, 4 parts of Fructus psidii guajavae immaturus, 2 parts of Radix Stephaniae Tetrandrae, 0.5 part of Radix Angelicae Sinensis, 4 parts of Radix Ginsengs, 1 part of Rhizoma Alpiniae Officinarum, 1 part of Radix Et Caulis Acanthopanacis Senticosi, 30 parts of Cortex Cinnamomis, 0.5 part of Fructus Arctii, 4 parts of Rhizoma Polygonati Odorati, 4 parts of the Radixs Astragali, 0.5 part of Cortex Moutan, 5 parts in Flos persicae, 0.5 part of Fructus Ligustri Lucidi, 0.5 part of Rhizoma Alismatis, 0.5 part of the Cortex Eucommiae, 0.5 part of Radix Puerariae, 1 part of Herb Gynostemmae Pentaphylli, 0.5 part of Chinaroot Greenbier Rhizome, 0.5 part of Cortex Mori, 0.5 part of Radix Paeoniae Rubra, 0.5 part of Herba Taxilli, 10 parts of Radix Rhodiolaes, 4 parts of Herba Selaginellaes, 2 parts of Folium Ginkgos, 2 parts of Semen Coiciss, 2 parts of Semen Litchis, 2 parts of Radix Morindae Officinaliss, 5 parts of Herba Dendrobii.
Its preparation method may further comprise the steps:
(1) with Radix Ginseng, Rhizoma Atractylodis, Radix Angelicae Sinensis, the Ramulus Euonymi oven dry of above-mentioned weight proportion, micronizing gets powder;
(2) other raw material of Chinese medicine conventional extraction by weight ratio, filter medicinal liquid, the medicinal liquid drying under reduced pressure is got dry extract, be ground into powder, described drying under reduced pressure controlled pressure is-0.08Mpa that temperature is 60 ℃;
(3) with the abundant mix homogeneously of powder that makes in step (1), the step (2), make capsule.
Embodiment 3
A kind of traditional Chinese compound medicine for the treatment of diabetes is made by following Chinese medicine raw materials by weight proportion: 2 parts of Rhizoma Atractylodis, 2 parts of Rhizoma Chuanxiongs, 2 parts in Herba Ephedrae, 4 parts of Rhizoma Dioscoreae Nipponicae, 6 parts of Radix Cynanchi Paniculatis, 2 parts of the Rhizoma Pinelliaes, 2 parts of Flos Inulae, 2 parts of Radix Aconiti Lateralis Preparata, 2 parts in Pericarpium Zanthoxyli, 4 parts of Fructus Evodiaes, fry 70 parts of Semen Pharbitidis, 16 parts of Rhizoma Coptidis, 2 parts of Ramulus Uncariae Cum Uncis, 4 parts of Radix Glycyrrhizae, 6 parts of Radix Polygoni Multiflori, 9 parts of Radix Trichosanthis, 9 parts of the Rhizoma Anemarrhenaes, 12 parts of Rhizoma Polygonatis, 6 parts of Radix Ophiopogonis, 6 parts of Rhizoma Dioscoreaes, 6 parts of Fructus Lycii, 3 parts of Aloes, 2 parts of Ramulus Euonymis, 6 parts of Fructus Corni, 3 parts of Cortex Lycii, 6 parts in Fructus Momordicae charantiae, 5 parts in Herba Ephedrae, 6 parts of Herba Potentillae Discoloris, 4 parts of Herba Portulacaes, 6 parts of Fructus psidii guajavae immaturus, 4 parts of Radix Stephaniae Tetrandrae, 2 parts of Radix Angelicae Sinensis, 6 parts of Radix Ginsengs, 3 parts of Rhizoma Alpiniae Officinarums, 3 parts of Radix Et Caulis Acanthopanacis Senticosis, 35 parts of Cortex Cinnamomis, 2 parts of Fructus Arctiis, 6 parts of Rhizoma Polygonati Odorati, 6 parts of the Radixs Astragali, 2 parts of Cortex Moutans, 8 parts in Flos persicae, 2 parts of Fructus Ligustri Lucidi, 2 parts of Rhizoma Alismatis, 2 parts of the Cortexs Eucommiae, 2 parts of Radix Puerariaes, 3 parts of Herb Gynostemmae Pentaphylli, 2 parts of Chinaroot Greenbier Rhizomes, 2 parts of Cortex Mori, 2 parts of Radix Paeoniae Rubra, 2 parts of Herba Taxillis, 15 parts of Radix Rhodiolaes, 6 parts of Herba Selaginellaes, 4 parts of Folium Ginkgos, 4 parts of Semen Coiciss, 4 parts of Semen Litchis, 4 parts of Radix Morindae Officinaliss, 8 parts of Herba Dendrobii.
Its preparation method may further comprise the steps:
(1) with Radix Ginseng, Rhizoma Atractylodis, Radix Angelicae Sinensis, the Ramulus Euonymi oven dry of above-mentioned weight proportion, micronizing gets powder;
(2) other raw material of Chinese medicine conventional extraction by weight ratio, filter medicinal liquid, the medicinal liquid drying under reduced pressure is got dry extract, be ground into powder, described drying under reduced pressure controlled pressure is-0.08Mpa that temperature is 70 ℃;
(3) with the abundant mix homogeneously of powder that makes in step (1), the step (2), make capsule.
Claims (3)
1. traditional Chinese compound medicine for the treatment of diabetes, it is characterized in that, made by following Chinese medicine raw materials by weight proportion: Rhizoma Atractylodis 0.5-2 part, Rhizoma Chuanxiong 0.5-2 part, Herba Ephedrae 0.5-2 part, Rhizoma Dioscoreae Nipponicae 2-4 part, Radix Cynanchi Paniculati 4-6 part, Rhizoma Pinelliae 0.5-2 part, Flos Inulae 0.5-2 part, Radix Aconiti Lateralis Preparata 0.5-2 part, Pericarpium Zanthoxyli 0.5-2 part, Fructus Evodiae 2-4 part, fry Semen Pharbitidis 60-70 part, Rhizoma Coptidis 12-16 part, Ramulus Uncariae Cum Uncis 0.5-2 part, Radix Glycyrrhizae 2-4 part, Radix Polygoni Multiflori 4-6 part, Radix Trichosanthis 7-9 part, Rhizoma Anemarrhenae 7-9 part, Rhizoma Polygonati 8-12 part, Radix Ophiopogonis 4-6 part, Rhizoma Dioscoreae 4-6 part, Fructus Lycii 4-6 part, Aloe 1-3 part, Ramulus Euonymi 0.5-2 part, Fructus Corni 4-6 part, Cortex Lycii 1-3 part, Fructus Momordicae charantiae 4-6 part, Herba Ephedrae 3-5 part, Herba Potentillae Discoloris 4-6 part, Herba Portulacae 2-4 part, Fructus psidii guajavae immaturus 4-6 part, Radix Stephaniae Tetrandrae 2-4 part, Radix Angelicae Sinensis 0.5-2 part, Radix Ginseng 4-6 part, Rhizoma Alpiniae Officinarum 1-3 part, Radix Et Caulis Acanthopanacis Senticosi 1-3 part, Cortex Cinnamomi 30-35 part, Fructus Arctii 0.5-2 part, Rhizoma Polygonati Odorati 4-6 part, Radix Astragali 4-6 part, Cortex Moutan 0.5-2 part, Flos persicae 5-8 part, Fructus Ligustri Lucidi 0.5-2 part, Rhizoma Alismatis 0.5-2 part, Cortex Eucommiae 0.5-2 part, Radix Puerariae 0.5-2 part, Herb Gynostemmae Pentaphylli 1-3 part, Chinaroot Greenbier Rhizome 0.5-2 part, Cortex Mori 0.5-2 part, Radix Paeoniae Rubra 0.5-2 part, Herba Taxilli 0.5-2 part, Radix Rhodiolae 10-15 part, Herba Selaginellae 4-6 part, Folium Ginkgo 2-4 part, Semen Coicis 2-4 part, Semen Litchi 2-4 part, Radix Morindae Officinalis 2-4 part, Herba Dendrobii 5-8 part.
2. a kind of traditional Chinese compound medicine for the treatment of diabetes according to claim 1, it is characterized in that, made by following Chinese medicine raw materials by weight proportion: 1 part of Rhizoma Atractylodis, 1 part of Rhizoma Chuanxiong, 1 part in Herba Ephedrae, 3 parts of Rhizoma Dioscoreae Nipponicae, 5 parts of Radix Cynanchi Paniculatis, 1 part of the Rhizoma Pinelliae, 1 part of Flos Inulae, 1 part of Radix Aconiti Lateralis Preparata, 1 part in Pericarpium Zanthoxyli, 3 parts of Fructus Evodiaes, fry 64 parts of Semen Pharbitidis, 15 parts of Rhizoma Coptidis, 1 part of Ramulus Uncariae Cum Uncis, 3 parts of Radix Glycyrrhizae, 5 parts of Radix Polygoni Multiflori, 8 parts of Radix Trichosanthis, 8 parts of the Rhizoma Anemarrhenaes, 10 parts of Rhizoma Polygonatis, 5 parts of Radix Ophiopogonis, 5 parts of Rhizoma Dioscoreaes, 5 parts of Fructus Lycii, 2 parts of Aloes, 1 part of Ramulus Euonymi, 5 parts of Fructus Corni, 2 parts of Cortex Lycii, 5 parts in Fructus Momordicae charantiae, 4 parts in Herba Ephedrae, 5 parts of Herba Potentillae Discoloris, 3 parts of Herba Portulacaes, 5 parts of Fructus psidii guajavae immaturus, 3 parts of Radix Stephaniae Tetrandrae, 1 part of Radix Angelicae Sinensis, 5 parts of Radix Ginsengs, 2 parts of Rhizoma Alpiniae Officinarums, 2 parts of Radix Et Caulis Acanthopanacis Senticosis, 32 parts of Cortex Cinnamomis, 1 part of Fructus Arctii, 5 parts of Rhizoma Polygonati Odorati, 5 parts of the Radixs Astragali, 1 part of Cortex Moutan, 7 parts in Flos persicae, 1 part of Fructus Ligustri Lucidi, 1 part of Rhizoma Alismatis, 1 part of the Cortex Eucommiae, 1 part of Radix Puerariae, 2 parts of Herb Gynostemmae Pentaphylli, 1 part of Chinaroot Greenbier Rhizome, 1 part of Cortex Mori, 1 part of Radix Paeoniae Rubra, 1 part of Herba Taxilli, 13 parts of Radix Rhodiolaes, 5 parts of Herba Selaginellaes, 3 parts of Folium Ginkgos, 3 parts of Semen Coiciss, 3 parts of Semen Litchis, 3 parts of Radix Morindae Officinaliss, 7 parts of Herba Dendrobii.
3. a kind of traditional Chinese compound medicine for the treatment of diabetes according to claim 1 is characterized in that its preparation method may further comprise the steps:
(1) with Radix Ginseng, Rhizoma Atractylodis, Radix Angelicae Sinensis, the Ramulus Euonymi oven dry of above-mentioned weight proportion, micronizing gets powder;
(2) other raw material of Chinese medicine conventional extraction by weight ratio, filter medicinal liquid, the medicinal liquid drying under reduced pressure is got dry extract, be ground into powder, described drying under reduced pressure controlled pressure is-0.08Mpa that temperature is 60～70 ℃;
(3) with the abundant mix homogeneously of powder that makes in step (1), the step (2), make capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310215223.5A CN103251867B (en) | 2013-06-03 | 2013-06-03 | Chinese herbal compound medicine for treating diabetes mellitus and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310215223.5A CN103251867B (en) | 2013-06-03 | 2013-06-03 | Chinese herbal compound medicine for treating diabetes mellitus and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103251867A true CN103251867A (en) | 2013-08-21 |
| CN103251867B CN103251867B (en) | 2014-08-13 |
Family
ID=48956300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310215223.5A Expired - Fee Related CN103251867B (en) | 2013-06-03 | 2013-06-03 | Chinese herbal compound medicine for treating diabetes mellitus and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103251867B (en) |
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103566227A (en) * | 2013-11-06 | 2014-02-12 | 上海世道健康科技有限公司 | Traditional Chinese medicinal composition for preventing and treating II-type diabetes mellitus and preparation method thereof |
| CN103656076A (en) * | 2013-12-18 | 2014-03-26 | 南昌大学 | Probiotics and Chinese herbal medicine compound preparation with hypoglycemic function |
| CN103690783A (en) * | 2013-12-25 | 2014-04-02 | 大连民族学院 | Chinese herba preparation for treating diabetes and preparation method of Chinese herba preparation |
| CN103751723A (en) * | 2014-01-15 | 2014-04-30 | 赵文革 | Traditional Chinese medicine for treating diabetic peripheral neuropathy |
| CN104306573A (en) * | 2014-11-10 | 2015-01-28 | 李正梅 | Traditional Chinese medicine composition for treating diabetes mellitus as well as preparation method and application thereof |
| CN104606474A (en) * | 2014-04-01 | 2015-05-13 | 张默 | Traditional Chinese medicine for treating diabetes |
| CN104667042A (en) * | 2015-02-05 | 2015-06-03 | 李念虎 | Qi and yin tonifying preparation for diabetes induced by deficiency of both qi and yin and preparation method thereof |
| CN104719511A (en) * | 2015-03-25 | 2015-06-24 | 江西绿源油脂实业有限公司 | Tea oil capable of regulating blood sugar and preparation method of tea oil |
| CN104940639A (en) * | 2015-06-02 | 2015-09-30 | 杨小平 | Dendrobium officinale and rhizoma polygonatum oral liquid and preparation method thereof |
| CN105998543A (en) * | 2016-05-26 | 2016-10-12 | 李青 | Biologically fermented composition with diabetes mellitus resistance and application thereof |
| CN106036818A (en) * | 2016-05-10 | 2016-10-26 | 王斌 | Capsules containing eucommia ulmoides male flowers and pollen |
| CN106075021A (en) * | 2016-07-12 | 2016-11-09 | 佛山杰致信息科技有限公司 | A kind of Chinese medicine composition treating diabetes and preparation method thereof |
| CN106177659A (en) * | 2016-07-14 | 2016-12-07 | 郑州五行舒体商贸有限公司 | Vigor draft liquid |
| CN106509903A (en) * | 2016-12-13 | 2017-03-22 | 青岛嘉瑞生物技术有限公司 | Salicornia europaea health-care oral liquid having effects of treating diabetes |
| CN107789461A (en) * | 2017-11-16 | 2018-03-13 | 李增龙 | A kind of medicine for treating women type II diabetes |
| CN107898908A (en) * | 2017-11-16 | 2018-04-13 | 李增龙 | A kind of medicine for treating male's type II diabetes |
| CN110140741A (en) * | 2018-02-12 | 2019-08-20 | 河南科技学院 | A kind of health cake preventing diabetes |
| CN111467411A (en) * | 2020-04-20 | 2020-07-31 | 鲁南制药集团股份有限公司 | Traditional Chinese medicine composition for preventing and treating diabetic complications and preparation method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101601451A (en) * | 2008-06-11 | 2009-12-16 | 刘泳宏 | A kind of natural five-color glucose-reducing herbal cuisine porridge and preparation method |
| CN101708295A (en) * | 2009-12-04 | 2010-05-19 | 卢速江 | Chinese medicinal preparation for treating diabetes and preparation methods thereof |
| CN102579915A (en) * | 2012-03-06 | 2012-07-18 | 杜中勤 | Medicine for treating wound non-healing of diabetics and preparation method thereof |
-
2013
- 2013-06-03 CN CN201310215223.5A patent/CN103251867B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101601451A (en) * | 2008-06-11 | 2009-12-16 | 刘泳宏 | A kind of natural five-color glucose-reducing herbal cuisine porridge and preparation method |
| CN101708295A (en) * | 2009-12-04 | 2010-05-19 | 卢速江 | Chinese medicinal preparation for treating diabetes and preparation methods thereof |
| CN102579915A (en) * | 2012-03-06 | 2012-07-18 | 杜中勤 | Medicine for treating wound non-healing of diabetics and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 李贺等: "中医药治疗糖尿病的现状和进展", 《中医研究》 * |
Cited By (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103566227B (en) * | 2013-11-06 | 2015-09-16 | 上海世道健康科技有限公司 | A kind of Chinese medicine composition preventing and treating type 2 diabetes mellitus and preparation method thereof |
| CN103566227A (en) * | 2013-11-06 | 2014-02-12 | 上海世道健康科技有限公司 | Traditional Chinese medicinal composition for preventing and treating II-type diabetes mellitus and preparation method thereof |
| CN103656076A (en) * | 2013-12-18 | 2014-03-26 | 南昌大学 | Probiotics and Chinese herbal medicine compound preparation with hypoglycemic function |
| CN103656076B (en) * | 2013-12-18 | 2016-04-13 | 南昌大学 | There is the probiotic bacteria-Chinese herbal medicine complex formulation of function of blood sugar reduction |
| CN103690783A (en) * | 2013-12-25 | 2014-04-02 | 大连民族学院 | Chinese herba preparation for treating diabetes and preparation method of Chinese herba preparation |
| CN103690783B (en) * | 2013-12-25 | 2015-12-30 | 大连民族学院 | Chinese medicine preparation being used for the treatment of diabetes and preparation method thereof |
| CN103751723A (en) * | 2014-01-15 | 2014-04-30 | 赵文革 | Traditional Chinese medicine for treating diabetic peripheral neuropathy |
| CN104606474A (en) * | 2014-04-01 | 2015-05-13 | 张默 | Traditional Chinese medicine for treating diabetes |
| CN104606474B (en) * | 2014-04-01 | 2018-02-06 | 张默 | Treat the Chinese medicine of diabetes |
| CN104306573A (en) * | 2014-11-10 | 2015-01-28 | 李正梅 | Traditional Chinese medicine composition for treating diabetes mellitus as well as preparation method and application thereof |
| CN104667042A (en) * | 2015-02-05 | 2015-06-03 | 李念虎 | Qi and yin tonifying preparation for diabetes induced by deficiency of both qi and yin and preparation method thereof |
| CN104719511A (en) * | 2015-03-25 | 2015-06-24 | 江西绿源油脂实业有限公司 | Tea oil capable of regulating blood sugar and preparation method of tea oil |
| CN104940639A (en) * | 2015-06-02 | 2015-09-30 | 杨小平 | Dendrobium officinale and rhizoma polygonatum oral liquid and preparation method thereof |
| CN106036818A (en) * | 2016-05-10 | 2016-10-26 | 王斌 | Capsules containing eucommia ulmoides male flowers and pollen |
| CN105998543A (en) * | 2016-05-26 | 2016-10-12 | 李青 | Biologically fermented composition with diabetes mellitus resistance and application thereof |
| CN106075021A (en) * | 2016-07-12 | 2016-11-09 | 佛山杰致信息科技有限公司 | A kind of Chinese medicine composition treating diabetes and preparation method thereof |
| CN106177659A (en) * | 2016-07-14 | 2016-12-07 | 郑州五行舒体商贸有限公司 | Vigor draft liquid |
| CN106509903A (en) * | 2016-12-13 | 2017-03-22 | 青岛嘉瑞生物技术有限公司 | Salicornia europaea health-care oral liquid having effects of treating diabetes |
| CN106509903B (en) * | 2016-12-13 | 2019-12-06 | 青岛嘉瑞生物技术有限公司 | salicornia herbacea oral liquid with effect of treating diabetes |
| CN107789461A (en) * | 2017-11-16 | 2018-03-13 | 李增龙 | A kind of medicine for treating women type II diabetes |
| CN107898908A (en) * | 2017-11-16 | 2018-04-13 | 李增龙 | A kind of medicine for treating male's type II diabetes |
| CN110140741A (en) * | 2018-02-12 | 2019-08-20 | 河南科技学院 | A kind of health cake preventing diabetes |
| CN111467411A (en) * | 2020-04-20 | 2020-07-31 | 鲁南制药集团股份有限公司 | Traditional Chinese medicine composition for preventing and treating diabetic complications and preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103251867B (en) | 2014-08-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103251867B (en) | Chinese herbal compound medicine for treating diabetes mellitus and preparation method thereof | |
| CN104689012A (en) | Kidney reinforcing and bone strengthening wine and making method thereof | |
| CN103432475B (en) | Traditional Chinese medicine composition for treating allergic rhinitis and preparation method thereof | |
| CN102362950A (en) | Traditional Chinese medicine for treating leucoderma | |
| CN104940740A (en) | Traditional Chinese medicine composition for treating polycystic ovarian syndrome and preparation method thereof | |
| CN105362650A (en) | Pharmaceutical composition for treating constipation and application method thereof | |
| CN101869640A (en) | Traditional Chinese medicine for treating myopia | |
| CN101912551B (en) | Miscarriage-prevention Chinese medicinal composition | |
| CN103432559A (en) | Traditional Chinese medicine composition for treating spanomenorrhea and dysmenorrhea caused by blood stasis and preparation method and application thereof | |
| CN102988639B (en) | Medicament for treating cervical spondylosis and preparation method of medicament | |
| CN103055066A (en) | Traditional Chinese medicine for improving sleep and preparation method thereof | |
| CN102430013A (en) | Chinese medicine for treating vitiligo | |
| CN104906507A (en) | Traditional Chinese medicine combination for lowering blood pressure and toning physical fitness | |
| CN103690869B (en) | Chinese medicine for the treatment of irritable bowel syndrome and preparation method thereof | |
| CN105362827A (en) | Decoction capable of effectively treating anemia and preparation method thereof | |
| CN104524479A (en) | Traditional Chinese medicine composition for treating premenstrual syndrome and preparation method of traditional Chinese medicine composition | |
| CN101129832A (en) | Traditional Chinese medicine composition for treating diabetes urinary tract infection | |
| CN101085259A (en) | Traditional Chinese medicine decoction for treating chronic nephritis | |
| CN106177404A (en) | A kind of Chinese medicine composition treating the hepatic and renal YIN deficiency and preparation method thereof | |
| CN106310019A (en) | Traditional Chinese medicine composition for treating consumptive lung disease and preparation method thereof | |
| CN105381333A (en) | Traditional Chinese medicine composition with effects of treating spleen-kidney Yang deficiency | |
| CN104096099A (en) | Traditional Chinese medicine composition for treating recurrent oral ulceration | |
| CN105362804A (en) | Traditional Chinese medicine composition for treating mild anemia and method for preparing traditional Chinese medicine composition | |
| CN104940719A (en) | Spleen and kidney tonifying pill for relieving uremia and preparation method of spleen and kidney tonifying pill | |
| CN104623387A (en) | Pharmaceutical composition for treating chronic nephritis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140813 Termination date: 20150603 |
|
| EXPY | Termination of patent right or utility model |