CN101417086A - Traditional Chinese medicine preparation for treating myocardial ischemia - Google Patents
Traditional Chinese medicine preparation for treating myocardial ischemia Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation used for treating myocardial ischemia, which comprises the following parts of weight of ingredients: 10 portions to 20 portions of cortex eucommiae, 10 portions to 20 portions of rhizoma et radix notopterygii, 10 portions to 20 portions of radices puerarire, 10 portions to 20 portions of radix salivae miltiorrhizae, 10 portions to 20 portions of angelica, 10 portions to 20 portions of rhizome gastrodiae, 10 portions to 20 portions of astragalus hoangtchy, 10 portions to 20 portions of polygonum cuspidatum, 10 portions to 20 portions of asiatic pennywort herb, 10 portions to 20 portions of rhizoma ligustici wallichii, 10 portions to 20 portions of Tuckahoe, 10 portions to 20 portions of cinnamon, 10 portions to 20 portions of rhizome atractylodis alba, 10 portions to 20 portions of forsythia, 10 portions to 20 portions of rehmanniae vaporata, 10 portions to 20 portions of radices polygoni multiflori, 10 portions to 20 portions of medicinal glue and 10 portions to 20 portions of liquorice. The traditional Chinese medicine used for treating myocardial ischemia is characterized by safety use and avirulence; proven by an acute toxic experiment, the medicine has no side effects, is applicable to patients with different physiques and can be taken for a long time. The traditional Chinese medicine used for treating myocardial ischemia has no drug tolerance and dependent ingredient; therefore, no dependence emerges even patients take the medicine for a long time.
Description
Technical field
The present invention relates to contain the medicinal preparation that derives from plant, animal or raw mineral materials, particularly a kind of Chinese medicine preparation for the treatment of myocardial ischemia.
Background technology
Myocardial ischemia disease is a kind of common disease, is mainly in the mid-aged population, also is temporary transient disability and the people with work capacity maimed modal reason too early.Its fundamental symptoms is the pareordia discomfort, dull pain, and nervous, out of breath, uncomfortable in chest, Mental fatigue is easily tired, whole body muscular soreness, arrhythmia etc.It is relevant that Chinese medicine thinks that this disease and deficiency of heart-blood, blood stasis due to qi deficiency, pathogenic heat are disturbed the heart.The U.S. has 500,000 people to die from primary disease every year approximately, accounts for primary disease number 1/3-1/2, accounts for the 50-70% of deaths from heart disease number.China's sickness rate accounts for more than 40% of death toll about 30%, and increases year by year, has now become the main cause that causes the human mortality.
The morbidity of myocardial ischemia disease is increased with the growth at age, and degree also increases the weight of with the growth at age.There is data to show, from beginning in 40 years old, every increase by 10 years old, the prevalence of myocardial ischemia disease increases 1 times.Male 50 years old, women are after 60 years old, and the coronary atherosclerosis development is rapider, and the danger of same myocardial infarction also increases with advancing age.
At present the medicine of treatment myocardial ischemia disease is more, and the chemicals that is mainly commonly used comprises nitrate preparations, adrenergic (beta-blocker), calcium channel blocker, antiplatelet drug, adjustment hypolipidemic medicine, anticoagulant.Western medicine usually causes some untoward reaction, as brings out bronchial asthma, suppresses heart, causes heart failure etc.The Chinese patent medicine kind of treatment myocardial ischemia disease is quite a few, relatively commonly used have red sage formulation, compound ginkgo agent, SUXIAO JIUXIN WAN or the like, these medicines have certain therapeutical effect, but having certain problem, mainly is that different individual patients body constitution are incomplete same, thus when treatment medicine curative effect also incomplete same, that have even not effect, and some medicine has certain drug resistance in these medicines, and needs of patients is with medicine all the life, influences patient's quality of life like this.
For these reasons, study a kind of safe, effectively and rapidly medicine be effective prevention and the treatment myocardial ischemia disease a vital task.The medicine that development has the prevention of characteristics such as instant effect, determined curative effect, toxic and side effects are little and a treatment myocardial ischemia is a very significant job to reduce cardiovascular disease to the threat of human health.
Summary of the invention
Technical problem to be solved by this invention is to overcome the weak point on the treatment myocardial ischemia disease at present, and a kind of Chinese medicine preparation of the treatment myocardial ischemia easy, easy to prepare, that expense is cheap and cure rate is higher of drawing materials is provided.
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation for the treatment of myocardial ischemia, the ratio of weight and number of various compositions is: 10～20 parts of the Cortexs Eucommiae, 10～20 parts of Rhizoma Et Radix Notopterygiis, 10～20 parts of Radix Puerariaes, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts in Rhizoma Gastrodiae, 10～20 parts of the Radixs Astragali, 10～20 parts of Rhizoma Polygoni Cuspidati, 10～20 parts of Herba Centellaes, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts in Poria, 10～20 parts of Cortex Cinnamomis, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Fructus Forsythiaes, 10～20 parts in Radix Rehmanniae Preparata, 10～20 parts of Radix Polygoni Multiflori, 10～20 parts in Colla Corii Asini, 10～20 parts in Radix Glycyrrhizae.
The Chinese medicine preparation of described treatment myocardial ischemia, the ratio of weight and number of various compositions can also be 10～15 parts of the Cortexs Eucommiae, 10～15 parts of Rhizoma Et Radix Notopterygiis, 10～15 parts of Radix Puerariaes, 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts in Rhizoma Gastrodiae, 10～15 parts of the Radixs Astragali, 10～15 parts of Rhizoma Polygoni Cuspidati, 10～15 parts of Herba Centellaes, 15～20 parts of Rhizoma Chuanxiongs, 15～20 parts in Poria, 15～20 parts of Cortex Cinnamomis, 15～20 parts of the Rhizoma Atractylodis Macrocephalaes, 15～20 parts of Fructus Forsythiaes, 15～20 parts in Radix Rehmanniae Preparata, 15～20 parts of Radix Polygoni Multiflori, 15～20 parts in Colla Corii Asini, 15～20 parts in Radix Glycyrrhizae.
The Chinese medicine preparation of described treatment myocardial ischemia, the ratio of weight and number of various compositions can be 15～20 parts of the Cortexs Eucommiae, 15～20 parts of Rhizoma Et Radix Notopterygiis, 15～20 parts of Radix Puerariaes, 15～20 parts of Radix Salviae Miltiorrhizaes, 15～20 parts of Radix Angelicae Sinensis, 15～20 parts in Rhizoma Gastrodiae, 15～20 parts of the Radixs Astragali, 15～20 parts of Rhizoma Polygoni Cuspidati, 15～20 parts of Herba Centellaes, 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts in Poria, 10～15 parts of Cortex Cinnamomis, 10～15 parts of the Rhizoma Atractylodis Macrocephalaes, 10～15 parts of Fructus Forsythiaes, 10～15 parts in Radix Rehmanniae Preparata, 10～15 parts of Radix Polygoni Multiflori, 10～15 parts in Colla Corii Asini, 10～15 parts in Radix Glycyrrhizae again.
The Chinese medicine preparation of described treatment myocardial ischemia, the ratio of weight and number of various compositions also can be 10～15 parts of the Cortexs Eucommiae, 10～15 parts of Rhizoma Et Radix Notopterygiis, 10～15 parts of Radix Puerariaes, 10～15 parts of Radix Salviae Miltiorrhizaes, 15～20 parts of Radix Angelicae Sinensis, 15～20 parts in Rhizoma Gastrodiae, 15～20 parts of the Radixs Astragali, 15～20 parts of Rhizoma Polygoni Cuspidati, 15～20 parts of Herba Centellaes, 15～20 parts of Rhizoma Chuanxiongs, 10～20 parts in Poria, 10～20 parts of Cortex Cinnamomis, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Fructus Forsythiaes, 10～15 parts in Radix Rehmanniae Preparata, 10～15 parts of Radix Polygoni Multiflori, 10～15 parts in Colla Corii Asini, 10～15 parts in Radix Glycyrrhizae.
The administering mode of described Chinese medicine preparation can be for oral.
Described Chinese medicine preparation dosage form can be decoction, powder, honey refining pill, hydration pill, tablet, capsule, oral liquid, granule or syrup.
The preparation of the powder of described Chinese medicine preparation can may further comprise the steps:
With described raw material water brush, wash clean, pull out and dry;
Radix Angelicae Sinensis, Rhizoma Chuanxiong, Poria, Cortex Cinnamomi, Radix Rehmanniae Preparata are put into the little fire of marmite respectively fried 5～10 minutes, respectively it is ground into smalls, sieve with pulverizer;
The Cortex Eucommiae after will drying, Rhizoma Et Radix Notopterygii, Radix Puerariae, Radix Salviae Miltiorrhizae, Rhizoma Gastrodiae, Fructus Forsythiae, Radix Polygoni Multiflori, Colla Corii Asini are sent into respectively and are cut into flakelet in the microtome, again the raw material of above-mentioned processing and all the other raw materials are sent into pulverizer and are ground into smalls, sieve.
The Chinese medicine preparation of described treatment myocardial ischemia, the used sieve that sieves can be 90～100 orders.
The Chinese medicine preparation of described treatment myocardial ischemia, the time of pulverizing in pulverizer can be 10～20 minutes.
The preparation of the powder of described Chinese medicine preparation further comprises the step that adopts ultraviolet radiation to carry out disinfection to mixed smalls.
Compared with prior art, advantage of the present invention is: compatibility of the present invention is rationally evident in efficacy, instant effect, clinical trial certificate effective percentage height; It is safe in utilization that the present invention treats the Chinese medicine preparation of myocardial ischemia, and avirulence through anxious malicious experimental verification, has no side effect, and is applicable to the patient of different body constitution, can take for a long time; The Chinese medicine preparation that the present invention treats myocardial ischemia has no drug resistance, and is careful for Chinese medicine preparation and selection, do not have dependent ingredient is arranged, so patient takes for a long time also and can not produce dependency.
The specific embodiment
Motherland's medical science is thought: obstruction of qi in the chest and cardialgia can be because of internal injury caused by excess of seven emotions, improper diet and overtiredness, exopathogen holds, the positive deficiency of vital energy decline wait thereby.Heart governing blood and vessels, blood vessels are obstructed, however pained soldier sends out; Damaged by excess of seven emotions, qi depression to blood stasis then, the channels of the heart is obstructed and send out; The exopathogen visitor is in the blood vessels of the heart, and spasm of collateral is obstructed, however soldier's pain; Weakened body resistance unable handsome blood and going, the blood clots absorbing stagnates, and also can cause pained.Disorder of QI movement, then chest stops up and feels oppressed, and it is unfavorable to breathe; Heart master god, heart arteries and veins is not smooth, and irritability is so see severe palpitation.Although cause the reason difference of the thoracic obstruction, to stop in the blood stasis, the stagnation of QI is not all right, and venation is become estranged, and is the common pathology link of obstruction of qi in the chest and cardialgia.Say as " element ask arteries and veins want precise and tiny opinion ": " the arteries and veins person, the house of blood also, hesitant pulse indicating precordial pain ".Thereby, blood-activating and qi-promoting, the coronary circulation-promoting pain-relieving method is widely used in the treatment of the thoracic obstruction.
The present invention treats the Chinese medicine preparation of myocardial ischemia, and the effect of each herbal medicine is:
The Cortex Eucommiae: control the spinal column ache, a little less than the limbs flaccidity, seminal emission, spermatorrhea is had loose bowels just before dawn, asthenia, dribbling urination, uncontrolled urination is itched.Wang Haogu: " Liver Channel edema caused by disorder of QI." " Thunder God is concocted the property of medicine and is separated ": " go into kidney channel." " book on Chinese herbal medicine is through separating ": " the lunar lung meridian of starting with." the Radix Achyranthis Bidentatae invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.Be used for soreness of waist and knee joint, muscles and bones is unable, amenorrhea lump in the abdomen, dizziness due to hyperactivity of liver-YANG.
Rhizoma Et Radix Notopterygii: expelling cold and relieving exterior syndrome, wind-damp dispelling, pain relieving.Xin Wen, gas is male and loose, and the power of delivering is strong, and the heresy of main loose Taiyang channel ailment said due to cold or exposure and cold-damp has that cold expelling dispels the wind, the merit of removing dampness to relieve pain, and so kindly control the wind-cold damp pathogen dragon and show, fever with aversion to cold, the flesh table is lossless, stiffness of the nape, limb aching pain person have a headache.
Radix Puerariae: induce sweat and bring down a fever, promote the production of body fluid, rash, yang invigorating antidiarrheal.Be used for fever caused by exogenous pathogens headache, hypertension neck pain, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, have loose bowels.Compendium of Material Medica is carried: Radix Puerariae, cool in nature, gas is put down, sweet in the mouth, tool heat clearing away, pathogenic fire reducing, all effects of toxin expelling.Modern medicine study shows: the isoflavonoid puerarin in the Radix Puerariae has certain curative effect to hypertension, hyperlipidemia, hyperglycemia and cardiovascular and cerebrovascular disease.
Radix Salviae Miltiorrhizae: Radix Salviae Miltiorrhizae can promote reparation and the regeneration organized, Radix Salviae Miltiorrhizae can promote fibroblast differentiation, collagen fiber to form more obvious; Granulation forms comparative maturity.Local congestion alleviates, blood circulation improves, and healing time shortens.The inhibition hyperplasia has inhibitory action to the fibroblast of hyperplasia.
Radix Angelicae Sinensis: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Rhizoma Curcumae removing blood stasis promoting the circulation of QI to relieve pain, warm concerted effort is bigger, can treat amenorrhea due to stagnation of blood stomachache, abdominal mass, gather, removing food stagnancy eliminating stagnation, the pain relieving of circulation of qi promoting removing food stagnancy, removing blood stasis, promoting the circulation of QI to relieve pain.
Rhizoma Gastrodiae: suppressing the hyperactive liver to relieve the wind syndrome relieving convulsion.It is dizzy to be used to have a headache, numb limbs and tense tendons, hands and feet caused by paralysis, infantile convulsion, epilepsy clonus, tetanus.
Radix Astragali tonifying Qi and lifting yang, holder skin ulcer granulation promoting; Be used for the replenishing vital QI with drugs of warm nature taste and granulation promoting is used for insufficiency of vital energy and blood, skin infection caves in, and bursts for a long time and does not hold back; Invigorating the spleen and benefiting QI, and the adjusting body's immunological function is arranged.
Rhizoma Polygoni Cuspidati, little hardship are slightly cold.Return liver, gallbladder, lung meridian.Expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.Be used for arthralgia, jaundice due to damp-heat, amenorrhea, lump in the abdomen, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus, cough with copious phlegm." book on Chinese herbal medicine is stated ": the curing mainly of Rhizoma Polygoni Cuspidati, its promoting the circulation of blood like with the Radix Carpesii class, its treat wind like with the Semen Vaccariae class, the former worthies calls its expelling summer-heat poison more, is former in to remove stagnation of pathogenic heat from blood biochemistry then, the blood of the moon wind dirty and the sufficient the moon of fainting is dirty so hands is fainted, it is controlled as rousing and answers small wooden raft also.Side's book is same as the flavor of all heat clearing away in order to treat the convulsion patient, for cutting ear, so demonstrate,proves use also bright in him with its function, what? side's book is in order to control pouring, and promptly Dan Xi treats the injured pouring of old man's QI and blood, also thinks key medicine, uses in tonic.Call the person of diminishing of empty people's clothes, parallel with tonic, it so that.
Herba Centellae hardship, suffering, cold.Return the liver,spleen,kidney warp.Clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.Be used for jaundice due to damp-heat, heatstroke diarrhoea, sand Stranguria stranguria with blood, carbuncle sore tumefacting virus, injury from falling down.
The Rhizoma Chuanxiong suffering, temperature.Return liver, gallbladder, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping.Control air-cooled headache and revolve dizzyly, the hypochondriac pain abdomen is painful, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.Be used for menoxenia, amenorrhea dysmenorrhea, abdominal mass stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia." not Lu ": ＂ removes in the brain cold moving, and urticaria goes on the face, the order lacrimation, profuse nasal discharge and spittle, before we notice it as liquor-saturated, all cold gas, the hard pain of trusted subordinate, attacked by pestiferous factors, the soldier is anxious to swell and ache, side of body wind pain, warming middle-JIAO endogenous cold.＂ " property of medicine opinion ": ＂ controls waist foot weakness, hemiplegia, and main afterbirth does not go out, and controls cold type of pain in the abdomen.＂ " Japan hanako materia medica ": ＂ controls a wind cutting, all gas, and all strains, all blood are mended five kinds of over strain, and strengthening bone and muscle is transferred many arteries and veins, and broken crux stagnated blood is supported fresh blood, puts on flesh, and serious epistaxis is spitted blood and hematuria, hemorrhoid complicated by anal fistula, brain carbuncle carbuncle on the back, the scrofula wart is superfluous, skin ulcer scabies, and evacuation of pus repercussive blood.＂
Poria is sweet, flat, light, the function of have promoting diuresis to eliminate damp pathogen, spleen invigorating, calming the nerves.And can promote the immunologic function of human body; Ether or ethanol extraction can make isolated frog heart shrink reinforcement, to tame rabbit blood glucose rising are then reduced.The Poria decoct has sedation to mice.
The Cortex Cinnamomi extremely hot in nature, acrid in the mouth, sweet.It is supporing yang to mend fire, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.Be used for sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness vomiting and diarrhoea, amenorrhea, dysmenorrhea, warming the meridian and promoting blood circulation.Supplement to the Herbal: Jun osmanthus, male osmanthus, Cortex Cinnamomi, gone up trichroismly, and be both a thing.By Guilin, Gui Ling, because of running after fame in osmanthus, the present give birth to, not from this prefecture.From sea, border on the south the mountain range, cassia tree is arranged to the greatest extent, only willow, Xiangzhou are maximum.Flavor is promptly hot strong, the thick again heavily fortified point of skin, and thick person must be tender, and Bao Zhebi is old.With Lao Bao person is of the same colour, is of the same colour with thick tender person, tender promptly hot fragrant, the tube volume again of holding concurrently; Always must be lightly seasoned, natural plate is thin.Plate approaches the person, promptly male osmanthus also, name is here with the eldest child; Tube volume person, promptly Jun osmanthus also, with tender and easy volume.Ancient prescription has an osmanthus, and word is like the Jun word, descendant's mistake and book it, practise and become social custom, pass as for book, also multiple because of following.Cortex Cinnamomi promptly is to eliminate first mistake on the skin, get its near in, the Xin Eryou flavor.
Rhizoma Atractylodis Macrocephalae hardship, sweet, salty, cold has the function of heat clearing away, detoxifcation, yin nourishing.The Rhizoma Atractylodis Macrocephalae has invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect.Be used for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement." medicine origin " record: " the dry and middle QI invigorating of dehumidifying benefit, warming middle-JIAO removes the taste being attacked by dampness, removes gastric heat, and strong taste advance diet, quench the thirst, and are antiabortive.”
The Fructus Forsythiae hardship is slightly cold.Return lung, the heart, small intestine meridian.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Be used for carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease is from the beginning of, warm joining the army, the hyperpyrexia excessive thirst, coma is sent out speckle, the pyretic stranguria urine retention.The medicinal part of Fructus Forsythiae mainly is a fruit.Its shell, i.e. " sticking up " in " antelope sticks up detoxifying pills ".Contain forsythol, coumarin, oleanolic acid, Saponin, Citrin etc.Have effects such as heat clearing away, detoxifcation, eliminating stagnation evacuation of pus.Cure mainly warm, skin infection, scrofula, erysipelas, class's rash, influenza.
The Radix Rehmanniae Preparata sweet in the mouth, slightly warm in nature.Return liver, kidney channel.Has the YIN nourishing of enriching blood effect.Be used for blood deficiency and yellow complexion, dizzy, palpitation and insomnia, menoxenia, diseases such as metrorrhagia.Can be used for deficiency of kidney yin hectic fever hectic fever due to YIN-deficiency, night sweat, pass out semen, quench one's thirst etc.; The vital essence replenishing and marrow benifiting effect is used for the Liver and kidney essence and blood and loses empty soreness of the waist and knees, vertigo and tinnitus, early whitening of beard and hair etc.
Radix Polygoni Multiflori hardship, sweet, puckery, temperature.Return liver, the heart, kidney channel.Detoxifcation, eliminating carbuncle, loosening bowel to relieve constipation.Be used for the scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation; Hyperlipidemia.Modern medicine study shows that Radix Polygoni Multiflori has the function of enhance immunity.The Aged Mice spleen that Radix Polygoni Multiflori causes meticortelone and cyclophosphamide, the thymus inhibition changes that obvious antagonism is arranged, and the phagocytic rate of splenic macrophage and phagocytic index are obviously improved.The Radix Polygoni Multiflori ethanol extract of feeding can obviously improve the injury repairing ability of senile rat periphery lymphocyte DNA.Mouse gavaging Radix Polygoni Multiflori Preparata 6g/kg, successive administration 7 days can obviously improve the phagocytic activity of peritoneal macrophage, and the phagocytic index that meticortelone is caused descends, and tangible antagonism is arranged.Radix Polygoni Multiflori decocting ethanol extract all has potentiation to mouse T lymphocyte and bone-marrow-derived lymphocyte immunologic function, and the former effect is more remarkable.Radix Polygoni Multiflori extract 25-100mg/kg, lumbar injection, successive administration 3 days can significantly improve normal mouse by inductive thymus of ConA and splenic T lymphproliferation response; Subcutaneous injection 5-100g/kg, continuous 3 days, can obviously increase normal mouse spleen antibody forming cell number, the most remarkable with the effect of 50g/kg group.
Colla Corii Asini is sweet, and is flat." herbal classic ": the ＂ sweet in the mouth is flat.＂ " not Lu ": the ＂ tepor, nontoxic.＂ " medicine origin ": ＂ " curing mainly secret formula " cloud, property is flat, and is lightly seasoned.＂ goes into lung, liver, kidney channel.Nourishing YIN and supplementing blood, antiabortive.Control blood deficiency, cough due to consumptive disease is spitted blood, and epistaxis, has blood in stool menoxenia, metrorrhagia, vaginal bleeding during pregnancy." herbal classic ": collapse the extremely voluminous symptoms like malaria of labor, waist stomachache, painful limbs, woman's hematochezia in the ＂ master trusted subordinate.Antiabortive.Obey QI invigorating for a long time.＂ " not Lu ": ＂ husband lower abdominal pain, asthenia weakness and emaciation, cloudy QI-insufficiency, foot acid unable to stand for a long time, nourishing the liver gas.＂ " property of medicine opinion ": the hard muscles and bones of ＂ master, QI invigorating dysentery relieving.＂ " a thousand pieces of gold dietetic therapy ": ＂ controls strong wind.＂
Radix Glycyrrhizae is sweet, and is flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.The Radix Glycyrrhizae nature and flavor are sweet, and are flat.The popular feeling, lung, spleen, stomach warp.Being used as medicine can eliminating fire and detoxication, the lung moistening expelling phlegm for arresting cough, and QI invigorating invigorating middle warmer, relieving spasm to stop pain, the mitigation property of medicine are used for the treatment of deficiency of heart-QI, severe palpitation, irregularly intermittent and regularly intermittent pulse, weakness of the spleen and stomach, insufficiency of vital energy and blood, lassitude, and disease such as the anxious pain of spasm in the abdomen.The property of medicine of Radix Glycyrrhizae relaxes, and can rise, can fall, and can be used with various kinds of drug such as tonic, cathartic, cold medicine, warm medicine, the medicine of a cold natures, and the effect of the mediation property of medicine is arranged.Western modern medicine haircut is existing, and the Radix Glycyrrhizae agent has the function of antiinflammatory and the reflection of resistance attitude, therefore in doctor trained in Western medicine clinically mainly as demulcent.Relieving cough eliminates the phlegm, treatment pharyngalgia laryngitis; Radix Glycyrrhizae or enoxolone have the effect of desoxycortone class, and chronic adrenocortical hypofunction is had good efficacy; Glycyrrhiza preparation can promote stomach mucus to form and secretion, prolongs the epithelial cell life-span, and anti-inflammatory activity is arranged, and is usually used in the treatment of chronic ulcer and duodenal ulcer; The flavone of Radix Glycyrrhizae has antiinflammatory, spasmolytic and antiacid effect.
Myocardial ischemia disease is mainly in the middle-aged and elderly people more than 40 years old, comes to one's autumn, and healthy energy degradation, and all medicines of blood-activating and qi-promoting, property is opened broken more, easily hinders healthy energy, and the product that Gu Zuo sets upright with supplementing QI and nourishing YIN both can have been set upright with eliminating evil, again can be eliminating evil and just do not hinder, be that benefit is clear mutually.The thoracic obstruction of qi depression to blood stasis is that the blood stasis stagnation of QI is handed over mutually for suffering from.The handsome blood of gas is capable, and the stagnation of QI is blood stasis then; Blood stasis checks, functional activity of QI being not smooth.Blood stasis stagnation of QI numbness resistance heart arteries and veins, QI and blood is obstructed, so yet soldier's pain.At above-mentioned pathogenesis, our major function is a promoting flow of QI and blood.Circulation of qi promoting is laid equal stress on invigorating blood circulation, and compatibility is rigorous, eliminating evil with set upright and execute, play the merit of regulating the flow of QI to dissipate blood stasis, benefiting vital QI and blood, function of spleen and stomach regulating altogether.
The Chinese medicine preparation that the present invention treats myocardial ischemia prepares the medicine of powder preparation formulation according to following method:
With described raw material water brush, wash clean, pull out and dry;
Radix Angelicae Sinensis, Rhizoma Chuanxiong, Poria, Cortex Cinnamomi, Radix Rehmanniae Preparata are put into the little fire of marmite respectively fried 5～10 minutes, respectively it was pulverized 10 minutes with pulverizer, treat that it becomes smalls, 100 mesh sieve sieve;
The Cortex Eucommiae after will drying, Rhizoma Et Radix Notopterygii, Radix Puerariae, Radix Salviae Miltiorrhizae, Rhizoma Gastrodiae, Fructus Forsythiae, Radix Polygoni Multiflori, Colla Corii Asini are sent into respectively and are cut into flakelet in the microtome, again raw material and all the other raw materials of above-mentioned processing are sent into pulverizer pulverizing 20 minutes, treat that it becomes smalls, 90 orders sieve, smalls after sieving adopts ultraviolet radiation to carry out disinfection, and subpackage is stand-by.
Pharmacodynamic experiment:
This medicine is to the protective effect of mice hypoxia-bearing capability: 120 of test mices; male; every group is further divided at random under normal pressure, normal pressure+ISO and three kinds of conditions of low pressure and tests after the administration of animal last, and the result has obvious enhancing mice hypoxia-bearing capability with showing this medicine treatment 8 days.
Influence to rat heart muscle ischemia due to the pituitrin: zoopery shows, the experiment of blood pressure, heart rate and electrocardiogram positive rate before and after the ischemia is shown that this medicine can obviously resist the myocardial ischemia symptom that pituitrin causes.Change for the serum lactic dehydrogenase isozyme that has pituitrin to cause shows that cardiac muscle is had significant protective effect.
Influence to rat blood serum T-CHOL and platelet aggregation and adhesion function: zoopery shows can significantly reduce serum and liver cholesterol level, can significantly improve hematoblastic gathering and adhesion function.
Influence to the mice stress ability: 64 rat random packet treatments are after 6 days, and except that normal group, all the other each groups cause the blood stasis animal model, survey whole blood contrast viscosity behind the drug treatment next day, plasma viscosity, the packed cell volume percentage rate, erythrocyte is built up indexs such as index.The result shows this medicine to the high shear rate of blood stasis rat, and low shear rate, RBC are built up the exponential sum plasma viscosity and compared the effect of having clear improvement.
To rat heart function and hemodynamic influence: can obviously increase CO, the CI of normal rat, low dose of this medicine LVSP that still can raise, with 35 minutes significantly.Other cardiac functions and hemodynamic index there is not obvious influence.
Influence to ischemic myocardium function, metabolism and form:
1, this medicine is to ischemia rat heart function and hemodynamic influence: experimental results show that, MI (myocardial infarction) group back 35 minutes in infraction, mean arterial pressure in the time of 50 minutes, Lvsp ,-dp/atmax, CO, CI etc. all significantly reduce, and this medicine can make the mean arterial pressure behind the MI, LVSP ,+increase such as dp/dtmax, CO, CI, the most remarkable with small dose group.
2, to the influence of acute ischemia cardiac muscle metamorphosis: from the microscopy result as seen, each infraction and infraction intervention group all have kitchen range high aspiration flesh infarction; The MI group is 9/10 example, and small dose group is 2/8 example, and heavy dose of group is 5/11 example, and positive controls is 6/11 example, illustrates that Chinese medicine preparation of the present invention has the effect that alleviates myocardial necrosis.
Model case 1: the Ms Zhang, 48 years old, ill 5 years, sensation of oppression over the chest with shortness of breath, the chest pain insomnia, dizzy cardiopalmus, weak, the dark greasy fur of tongue, deep-thready pulse.Use following prescription:
Cortex Eucommiae 10g, Rhizoma Et Radix Notopterygii 10g, Radix Puerariae 10g, Radix Salviae Miltiorrhizae 10g, Radix Angelicae Sinensis 10g, Rhizoma Gastrodiae 10g, Radix Astragali 10g, Rhizoma Polygoni Cuspidati 10g, Herba Centellae 10g, Rhizoma Chuanxiong 10g, Poria 10g, Cortex Cinnamomi 10g, Rhizoma Atractylodis Macrocephalae 10g, Fructus Forsythiae 10g, Radix Rehmanniae Preparata 10g, Radix Polygoni Multiflori 10g, Colla Corii Asini 10g, Radix Glycyrrhizae 10g.
Obviously alleviate through 35 doses of symptoms of clothes Chinese medicine decoction of the present invention, so far not recurrence.
Model case 2: Mrs Wang, 53 years old, patient's readme felt that the pit of the stomach is stuffy in recent months, heart beating is jumped terribly sometimes, left breast twinge, pain is drawn the back sometimes, the dark stringy and thready pulse of tongue, card belongs to stagnation of heart-blood.Use following prescription:
Cortex Eucommiae 10g, Rhizoma Et Radix Notopterygii 10g, Radix Puerariae 10g, Radix Salviae Miltiorrhizae 10g, Radix Angelicae Sinensis 10g, Rhizoma Gastrodiae 10g, Radix Astragali 10g, Rhizoma Polygoni Cuspidati 10g, Herba Centellae 10g, Rhizoma Chuanxiong 15g, Poria 15g, Cortex Cinnamomi 15g, Rhizoma Atractylodis Macrocephalae 15g, Fructus Forsythiae 15g, Radix Rehmanniae Preparata 15g, Radix Polygoni Multiflori 15g, Colla Corii Asini 15g, Radix Glycyrrhizae 15g.
Adopt oral medicinal herb decoction of the present invention, clothes are 20 doses earlier, and symptom is clearly better, and obeys 20 doses then again, and symptoms such as the stuffy and left breast twinge in the pit of the stomach disappear substantially.Visit after 6 months, do not see recurrence.
Model case 3, Mr. Zhao, 63 years old, before 3 years the beginning ill, disease is a coronary heart disease, asthma chest distress, old property pain reflexes to the back sometimes, extreme cold of the limbs feels run-down, repeatedly repeatedly the outbreak.Use following prescription:
Cortex Eucommiae 15g, Rhizoma Et Radix Notopterygii 15g, Radix Puerariae 15g, Radix Salviae Miltiorrhizae 15g, Radix Angelicae Sinensis 15g, Rhizoma Gastrodiae 15g, Radix Astragali 15g, Rhizoma Polygoni Cuspidati 15g, Herba Centellae 15g, Rhizoma Chuanxiong 10g, Poria 10g, Cortex Cinnamomi 10g, Rhizoma Atractylodis Macrocephalae 10g, Fructus Forsythiae 10g, Radix Rehmanniae Preparata 10g, Radix Polygoni Multiflori 10g, Colla Corii Asini 10g, Radix Glycyrrhizae 10g.
Obviously alleviate through clothes Chinese medicine decoction of the present invention 40 doses of symptoms, after take Chinese powder medicine of the present invention January again, consolidate curative effect, not recurrence in 4 years so far.
Model case 4: cold man, 61 years old, patient's angina pectoris medical history 2 years, show effect frequently 3～5 times weekly nearly January, each lasting about 5～6 minutes, moving then chest pain, cardiopalmus, chest distress, dysphoria with smothery sensation is restless, can alleviate from clothes " FUFANG DANSHEN DIWAN ", then need buccal " nitroglycerine tablets " in the time of bitterly very.Clinical diagnosis is an angina pectoris, belongs to heart arteries and veins stagnant heat card.Use following prescription:
Cortex Eucommiae 10g, Rhizoma Et Radix Notopterygii 10g, Radix Puerariae 10g, Radix Salviae Miltiorrhizae 10g, Radix Angelicae Sinensis 15g, Rhizoma Gastrodiae 15g, Radix Astragali 15g, Rhizoma Polygoni Cuspidati 15g, Herba Centellae 15g, Rhizoma Chuanxiong 15g, Poria 10g, Cortex Cinnamomi 10g, Rhizoma Atractylodis Macrocephalae 10g, Fructus Forsythiae 10g, Radix Rehmanniae Preparata 10g, Radix Polygoni Multiflori 10g, Colla Corii Asini 10g, Radix Glycyrrhizae 10g.
Through 40 doses of clothes Chinese powder medicines of the present invention, treatment back check electrocardiogram V4-6ST section is recovered, and the T ripple is comparatively uprightly smooth, does not occur untoward reaction in the therapeutic process.
More than each example formulations be the state of an illness and the health of inventor according to different patients, the representative formula of utilization, through the preparation, infusion becomes powder, or pill, or decoction, general 2 doses of clothes 3 days, one after each meal, one month is a course of treatment, through 90 routine coronary heart disease (comprising angina pectoris, myocardial infarction) patient observation on probation, all obtain satisfied effect 2-4 the course of treatment, clinical observation on the therapeutic effect, effective percentage reaches 88.9%, does not have recurrence substantially through visiting.
Claims (10)
1, a kind of Chinese medicine preparation for the treatment of myocardial ischemia, it is characterized in that the ratio of weight and number of various compositions is: 10～20 parts of the Cortexs Eucommiae, 10～20 parts of Rhizoma Et Radix Notopterygiis, 10～20 parts of Radix Puerariaes, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts in Rhizoma Gastrodiae, 10～20 parts of the Radixs Astragali, 10～20 parts of Rhizoma Polygoni Cuspidati, 10～20 parts of Herba Centellaes, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts in Poria, 10～20 parts of Cortex Cinnamomis, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Fructus Forsythiaes, 10～20 parts in Radix Rehmanniae Preparata, 10～20 parts of Radix Polygoni Multiflori, 10～20 parts in Colla Corii Asini, 10～20 parts in Radix Glycyrrhizae.
2, according to the Chinese medicine preparation of the described treatment myocardial ischemia of claim 1, it is characterized in that the ratio of weight and number of various compositions is: 10～15 parts of the Cortexs Eucommiae, 10～15 parts of Rhizoma Et Radix Notopterygiis, 10～15 parts of Radix Puerariaes, 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts in Rhizoma Gastrodiae, 10～15 parts of the Radixs Astragali, 10～15 parts of Rhizoma Polygoni Cuspidati, 10～15 parts of Herba Centellaes, 15～20 parts of Rhizoma Chuanxiongs, 15～20 parts in Poria, 15～20 parts of Cortex Cinnamomis, 15～20 parts of the Rhizoma Atractylodis Macrocephalaes, 15～20 parts of Fructus Forsythiaes, 15～20 parts in Radix Rehmanniae Preparata, 15～20 parts of Radix Polygoni Multiflori, 15～20 parts in Colla Corii Asini, 15～20 parts in Radix Glycyrrhizae.
3, according to the Chinese medicine preparation of the described treatment myocardial ischemia of claim 1, it is characterized in that the ratio of weight and number of various compositions is: 15～20 parts of the Cortexs Eucommiae, 15～20 parts of Rhizoma Et Radix Notopterygiis, 15～20 parts of Radix Puerariaes, 15～20 parts of Radix Salviae Miltiorrhizaes, 15～20 parts of Radix Angelicae Sinensis, 15～20 parts in Rhizoma Gastrodiae, 15～20 parts of the Radixs Astragali, 15～20 parts of Rhizoma Polygoni Cuspidati, 15～20 parts of Herba Centellaes, 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts in Poria, 10～15 parts of Cortex Cinnamomis, 10～15 parts of the Rhizoma Atractylodis Macrocephalaes, 10～15 parts of Fructus Forsythiaes, 10～15 parts in Radix Rehmanniae Preparata, 10～15 parts of Radix Polygoni Multiflori, 10～15 parts in Colla Corii Asini, 10～15 parts in Radix Glycyrrhizae.
4, according to the Chinese medicine preparation of the described treatment myocardial ischemia of claim 1, it is characterized in that the ratio of weight and number of various compositions is: 10～15 parts of the Cortexs Eucommiae, 10～15 parts of Rhizoma Et Radix Notopterygiis, 10～15 parts of Radix Puerariaes, 10～15 parts of Radix Salviae Miltiorrhizaes, 15～20 parts of Radix Angelicae Sinensis, 15～20 parts in Rhizoma Gastrodiae, 15～20 parts of the Radixs Astragali, 15～20 parts of Rhizoma Polygoni Cuspidati, 15～20 parts of Herba Centellaes, 15～20 parts of Rhizoma Chuanxiongs, 10～20 parts in Poria, 10～20 parts of Cortex Cinnamomis, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Fructus Forsythiaes, 10～15 parts in Radix Rehmanniae Preparata, 10～15 parts of Radix Polygoni Multiflori, 10～15 parts in Colla Corii Asini, 10～15 parts in Radix Glycyrrhizae.
According to the Chinese medicine preparation of each described treatment myocardial ischemia in the claim 1～4, it is characterized in that 5, the administering mode of described Chinese medicine preparation is oral.
According to the Chinese medicine preparation of each described treatment myocardial ischemia in the claim 1～4, it is characterized in that 6, described Chinese medicine preparation dosage form is decoction, powder, honey refining pill, hydration pill, tablet, capsule, oral liquid, granule or syrup.
According to the Chinese medicine preparation of each described treatment myocardial ischemia in the claim 1～4, it is characterized in that 7, the preparation of the powder of described Chinese medicine preparation may further comprise the steps:
With described raw material water brush, wash clean, pull out and dry;
Radix Angelicae Sinensis, Rhizoma Chuanxiong, Poria, Cortex Cinnamomi, Radix Rehmanniae Preparata are put into the little fire of marmite respectively fried 5～10 minutes, respectively it is ground into smalls, sieve with pulverizer;
The Cortex Eucommiae after will drying, Rhizoma Et Radix Notopterygii, Radix Puerariae, Radix Salviae Miltiorrhizae, Rhizoma Gastrodiae, Fructus Forsythiae, Radix Polygoni Multiflori, Colla Corii Asini are sent into respectively and are cut into flakelet in the microtome, again the raw material of above-mentioned processing and all the other raw materials are sent into pulverizer and are ground into smalls, sieve.
According to the Chinese medicine preparation of the described treatment myocardial ischemia of claim 7, it is characterized in that 8, the used sieve that sieves is 90～100 orders.
According to the Chinese medicine preparation of the described treatment myocardial ischemia of claim 7, it is characterized in that 9, the time of pulverizing is 10～20 minutes in pulverizer.
According to the Chinese medicine preparation of the described treatment myocardial ischemia of claim 7, it is characterized in that 10, the preparation of the powder of described Chinese medicine preparation further comprises the step that adopts ultraviolet radiation to carry out disinfection to mixed smalls.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103212044A (en) * | 2013-04-08 | 2013-07-24 | 姜玉芝 | Traditional Chinese medicine composition for treating cardiovascular diseases |
| CN103330911A (en) * | 2012-03-31 | 2013-10-02 | 李浩成 | Chinese medicine powder for treating coronary heart disease and preparation method thereof |
| CN103385967A (en) * | 2013-07-19 | 2013-11-13 | 苏州市天灵中药饮片有限公司 | Fleece-flower root-containing traditional Chinese medicine preparation and preparation method thereof |
| CN104288709A (en) * | 2014-11-11 | 2015-01-21 | 邵明涛 | Chinese patent medicinal preparation for treating angina pectoris |
| CN104306901A (en) * | 2014-11-11 | 2015-01-28 | 邵明涛 | Method for preparing traditional Chinese medicine preparation for angina pectoris |
| EP3701961A4 (en) * | 2017-10-27 | 2021-07-21 | National Institute for Korean Medicine Development | Antithrombotic composition containing polygonum cuspidatum sieb. et zucc. and cinnamomum cassia blume |
-
2008
- 2008-12-03 CN CN2008101798634A patent/CN101417086B/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103330911A (en) * | 2012-03-31 | 2013-10-02 | 李浩成 | Chinese medicine powder for treating coronary heart disease and preparation method thereof |
| CN103330911B (en) * | 2012-03-31 | 2014-12-17 | 韩笑峰 | Chinese medicine powder for treating coronary heart disease and preparation method thereof |
| CN103212044A (en) * | 2013-04-08 | 2013-07-24 | 姜玉芝 | Traditional Chinese medicine composition for treating cardiovascular diseases |
| CN103212044B (en) * | 2013-04-08 | 2015-04-01 | 周丽英 | Traditional Chinese medicine composition for treating cardiovascular diseases |
| CN103385967A (en) * | 2013-07-19 | 2013-11-13 | 苏州市天灵中药饮片有限公司 | Fleece-flower root-containing traditional Chinese medicine preparation and preparation method thereof |
| CN104288709A (en) * | 2014-11-11 | 2015-01-21 | 邵明涛 | Chinese patent medicinal preparation for treating angina pectoris |
| CN104306901A (en) * | 2014-11-11 | 2015-01-28 | 邵明涛 | Method for preparing traditional Chinese medicine preparation for angina pectoris |
| EP3701961A4 (en) * | 2017-10-27 | 2021-07-21 | National Institute for Korean Medicine Development | Antithrombotic composition containing polygonum cuspidatum sieb. et zucc. and cinnamomum cassia blume |
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| CN101417086B (en) | 2011-03-09 |
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