CN110404042A - A kind of compound oral liquid and preparation method thereof with fat reducing and weight reducing function - Google Patents
A kind of compound oral liquid and preparation method thereof with fat reducing and weight reducing function Download PDFInfo
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- CN110404042A CN110404042A CN201910801163.2A CN201910801163A CN110404042A CN 110404042 A CN110404042 A CN 110404042A CN 201910801163 A CN201910801163 A CN 201910801163A CN 110404042 A CN110404042 A CN 110404042A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 50
- 239000007788 liquid Substances 0.000 title claims abstract description 35
- 150000001875 compounds Chemical class 0.000 title claims abstract description 16
- 239000002994 raw material Substances 0.000 claims abstract description 26
- 244000037364 Cinnamomum aromaticum Species 0.000 claims abstract description 16
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 claims abstract description 16
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims abstract description 16
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims abstract description 16
- 235000009685 Crataegus X maligna Nutrition 0.000 claims abstract description 16
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims abstract description 16
- 235000009486 Crataegus bullatus Nutrition 0.000 claims abstract description 16
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims abstract description 16
- 235000009682 Crataegus limnophila Nutrition 0.000 claims abstract description 16
- 235000004423 Crataegus monogyna Nutrition 0.000 claims abstract description 16
- 235000002313 Crataegus paludosa Nutrition 0.000 claims abstract description 16
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims abstract description 16
- 235000000340 Solanum pseudocapsicum Nutrition 0.000 claims abstract description 16
- 240000004482 Withania somnifera Species 0.000 claims abstract description 16
- 235000001978 Withania somnifera Nutrition 0.000 claims abstract description 16
- 244000185386 Thladiantha grosvenorii Species 0.000 claims abstract description 14
- 235000011171 Thladiantha grosvenorii Nutrition 0.000 claims abstract description 14
- 239000000463 material Substances 0.000 claims abstract description 9
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- 235000006886 Zingiber officinale Nutrition 0.000 claims abstract description 8
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- 239000000284 extract Substances 0.000 claims description 42
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- 238000003756 stirring Methods 0.000 claims description 36
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- 235000013305 food Nutrition 0.000 claims description 19
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- 238000011049 filling Methods 0.000 claims description 15
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- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 14
- 238000009928 pasteurization Methods 0.000 claims description 14
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- 206010020772 Hypertension Diseases 0.000 description 1
- 238000009098 adjuvant therapy Methods 0.000 description 1
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- KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 description 1
- 229960003964 deoxycholic acid Drugs 0.000 description 1
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 description 1
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- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
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- 230000005976 liver dysfunction Effects 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
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- 238000004519 manufacturing process Methods 0.000 description 1
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- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
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Classifications
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
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- Medical Informatics (AREA)
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- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
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- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention proposes a kind of compound oral liquids with fat reducing and weight reducing function, are prepared by weight by following raw material: 10-20 parts of hawthorn, 15-25 parts of Siraitia grosvenorii, 10-15 parts of cassia seed, 10-20 parts of wintercherry, 5-10 parts of ginger, 2-7 parts of fructus lycii, 10-15 parts of radix cyathulae, Radix Ophiopogonis 5-15 part, 20-25 parts of Ilex Latifolia Thunb, 10-20 parts of Radix Glycyrrhizae.Composition of the invention be integration of drinking and medicinal herbs material combination form, have the characteristics that it is pure natural, green safe, take composition of the invention be not necessarily to specially diet, without any side effects and sense of discomfort, convenient, medicine source is easy to get extensively, cheap；Preparation process is simple, easy to operate, is suitble to industrial production.
Description
Technical field
The present invention relates to diet products technical fields, and in particular to a kind of compound oral liquid with fat reducing and weight reducing function and
Preparation method.
Background technique
Fat and hyperlipidemia number is constantly soaring at present, and clinically the side effect and rebound of slimming medicine cause curative effect non-
Often undesirable, blood lipid-lowering medicine long-term use similarly has side effect to liver kidney.This patent uses the natural former material of dual-purpose of drug and food
Material safely and effectively lose weight through scientific formula process exploitation one kind, antihyperlipidemic product.This patent is consulting lot of documents and test base
On plinth, four kinds of raw materials are screened from ten kinds of medicine and food raw materials, are kept product efficacy best by formula and process optimization, are changed simultaneously
Sentimental official and mouthfeel are minimized cost.The inexpensive abundant, simple production process of this product raw material, positioning crowd are mainly obesity
With hyperlipidemia.Meanwhile this product also has adjuvant treatment effect to diabetes and hypertensive patient.
Summary of the invention
The present invention provides a kind of compound oral liquid and preparation method thereof with fat reducing and weight reducing function, it is intended that mentioning
Have pure natural, green safe for a kind of compound oral liquid with fat reducing and weight reducing function by selecting integration of drinking and medicinal herbs raw material
Feature takes composition of the invention without specially dieting, and without any side effects and sense of discomfort, convenient, medicine source is easy extensively
, it is cheap；Preparation process is simple, easy to operate, is suitble to industrial production.
The present invention provides a kind of compound oral liquid with fat reducing and weight reducing function, is prepared from the following materials: hawthorn, sieve
Chinese fruit, cassia seed, wintercherry, ginger, fructus lycii, radix cyathulae, Radix Ophiopogonis, Ilex Latifolia Thunb, Radix Glycyrrhizae.
As further improvement of the invention, it is prepared by weight by following raw material: 10-20 parts of hawthorn, Siraitia grosvenorii
15-25 parts, 10-15 parts of cassia seed, 10-20 parts of wintercherry, 5-10 parts of ginger, 2-7 parts of fructus lycii, 10-15 parts of radix cyathulae, Radix Ophiopogonis 5-
15 parts, 20-25 parts of Ilex Latifolia Thunb, 10-20 parts of Radix Glycyrrhizae.
As further improvement of the invention, it is prepared from the following materials: hawthorn, Siraitia grosvenorii, cassia seed, wintercherry.
As further improvement of the invention, it is prepared from the following materials: hawthorn, Siraitia grosvenorii, cassia seed, wintercherry.
The present invention further protects a kind of preparation method of above-mentioned compound oral liquid with fat reducing and weight reducing function, by raw material
Medicine extracts after weighing and obtains Chinese medical extract, mixes in proportion with sterile water, and food emulsifying agent, food stabilizer and food is added
Xylitol, sodium citrate, potassium sorbate are added after stirring and emulsifying and stirs evenly, stands, filtering, sterilizing and filling are for antioxidant
.
As further improvement of the invention, bulk pharmaceutical chemicals are cleaned, is dry, are crushed, soaks in water, is warming up to boiling, are decocted
It after boiling 5-10h, being cooled to room temperature, filters, filter residue is added in ethanol solution, after decompression low temperature reflux extracts 3-5h, filtering, reject
Filter residue merges filtrate twice, is concentrated under reduced pressure, and spray drying obtains Chinese medical extract.
As further improvement of the invention, the mass ratio of the bulk pharmaceutical chemicals and water is 1:(5-15)；The ethanol solution
Mass fraction be 75wt%, the mass ratio of the filter residue and ethanol solution is 1:(5-10).
As further improvement of the invention, the emulsifying process is to stir 10-15min with 10000-15000r/min.
As further improvement of the invention, the sterilizing uses pasteurization.
The present invention further protects a kind of compound oral liquid of above-mentioned fat reducing and weight reducing function.
Theory of traditional Chinese medical science thinks, fat too fat to move external cause is caused to have eating and drinking without temperance, and delicious food savoury is hurt, internal cause then by spleen, liver,
The dirty dysfunction of kidney three, deficiency-weakness of spleen-QI, transmitting and distributing the fluids dereliction of duty, so as to cause retention of water-damp in the body, polywater is at drink, phlegm caused by coagulation of excessive fluid；Kidney department
Two just, deficiency of kidney-QI, cannot in time excrete foul smell；Liver dysfunction, functional activity of QI being not smooth make foul smell phlegm wet more stop up resistance body
It is interior, cause fat too fat to move.So delicious food savoury should be avoided and imperial outer, adjustment spleen, Liver and kidney function in prevention and treatment obesity, remove dampness by means of aromatics,
Qi-regulating helps fortune, dissolving phlegmization drink and in pacifying.
Modern medical theory is thought: obesity is that the adipose tissue of body increases, and leads to the ratio of body weight shared by adipose tissue
The increase of example.Principle of losing weight is to reach negative energy balance, promotes the decomposition of fat.Controlling Energy intaking is prevention and obesity controlling
Basic measures, it is main to control three nutritious elements fat, carbohydrate, the intake of protein and conversion in vivo, improvement
Achieve the purpose that correction metabolism is unbalance in energy supply in body.
The invention has the following beneficial effects:
The present invention from the Chinese medicine of the Weight-reducing and lipid-lowering of 10 taste integration of drinking and medicinal herbs further screening obtained 4 kinds have obvious lipid-loweringing,
The Chinese medicine of the effect of weight-reducing compounds, and obtains oral solution bulk pharmaceutical chemicals, effect is obvious, and raw material sources are wide；
The present invention extracts the water-soluble active ingredient in bulk pharmaceutical chemicals using decocting, extracts raw material using ethanol solution low temperature reflux
Alcohol-soluble active constituent in medicine, part alcohol-soluble active constituent is not soluble in water, when finally preparing oral solution, using food
Grade emulsifier, obtains homogeneous composition, and stabilizer is added and stablizes, obtained after potassium sorbate anti-corrosion long shelf-life, delicate mouthfeel,
The uniform oral solution of solution；
The present invention sterilizes to oral solution using pasteurization, mixed raw material is heated to 68-70 DEG C, and keep this temperature
Rapid cooling is to 4-5 DEG C after 30min.Because the killing point of general bacterium be 68 DEG C of temperature with time 30min hereinafter,
It is cooled down suddenly after this heating, hot and cold variation sharply can also promote the death of bacterium, while keep active in oral solution
Ingredient by high temperature, does not improve the Weight-reducing and lipid-lowering effect of oral solution；
Composition of the invention is that integration of drinking and medicinal herbs material combination forms, and has the characteristics that pure natural, green safe, takes the present invention
Composition without specially dieting, without any side effects and sense of discomfort, convenient, medicine source is easy to get extensively, cheap；Preparation
Simple process, it is easy to operate, it is suitble to industrial production.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
Some embodiments of invention without any creative labor, may be used also for those of ordinary skill in the art
To obtain other drawings based on these drawings.
Fig. 1 is the influence experimental result comparison diagram in test case 1 of the present invention to obesity mice body fat；
Fig. 2 is fat-reducing effect clinical test results comparison diagram in test case 2 of the present invention.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
Embodiment 1
Raw material forms (parts by weight): 10 parts of hawthorn, 15 parts of Siraitia grosvenorii, 10 parts of cassia seed, 10 parts of wintercherry, 5 parts of ginger, fructus lycii 2
Part, 10 parts of radix cyathulae, 5 parts of Radix Ophiopogonis, 20 parts of Ilex Latifolia Thunb, 10 parts of Radix Glycyrrhizae.
Preparation method:
S1. the preparation of Chinese medical extract: bulk pharmaceutical chemicals are cleaned in proportion, is dry, are crushed, are soaked in water by solid-to-liquid ratio 1:5, are risen
Temperature after decocting 5h, is cooled to room temperature to boiling, and is filtered, and filter residue is added in 75wt% ethanol solution, solid-to-liquid ratio 1:5, is depressurized low
After warm refluxing extraction 3h, filtering, reject filter residue merges filtrate twice, and being concentrated under reduced pressure into density is 1.2g/cm3, spray drying,
Obtain Chinese medical extract；
S2. the preparation of oral solution: extracting after bulk pharmaceutical chemicals are weighed and obtain Chinese medical extract, mixed in the ratio and sterile water of 1:10
It is even, food emulsifying agent, food stabilizer and food antioxidant, stirring and emulsifying is added, emulsifying process is to stir with 10000r/min
10min is mixed, xylitol, sodium citrate, potassium sorbate is added and stirs evenly, stands, filtering, pasteurization, 68 DEG C of sterilizing 30min
Be cooled to 4 DEG C in 10s afterwards, it is filling to obtain the final product.
Embodiment 2
Raw material forms (parts by weight): 20 parts of hawthorn, 25 parts of Siraitia grosvenorii, 15 parts of cassia seed, 20 parts of wintercherry, 10 parts of ginger, fructus lycii 7
Part, 15 parts of radix cyathulae, 15 parts of Radix Ophiopogonis, 25 parts of Ilex Latifolia Thunb, 20 parts of Radix Glycyrrhizae.
Preparation method:
S1. the preparation of Chinese medical extract: bulk pharmaceutical chemicals are cleaned in proportion, is dry, are crushed, are soaked in water by solid-to-liquid ratio 1:15, are risen
Temperature after decocting 10h, is cooled to room temperature to boiling, and is filtered, and filter residue is added in 75wt% ethanol solution, solid-to-liquid ratio 1:10, is depressurized low
After warm refluxing extraction 5h, filtering, reject filter residue merges filtrate twice, and being concentrated under reduced pressure into density is 1.5g/cm3, spray drying,
Obtain Chinese medical extract；
S2. the preparation of oral solution: extracting after bulk pharmaceutical chemicals are weighed and obtain Chinese medical extract, mixed in the ratio and sterile water of 1:10
It is even, food emulsifying agent, food stabilizer and food antioxidant, stirring and emulsifying is added, emulsifying process is to stir with 15000r/min
15min is mixed, xylitol, sodium citrate, potassium sorbate is added and stirs evenly, stands, filtering, pasteurization, 70 DEG C of sterilizing 30min
Be cooled to 5 DEG C in 10s afterwards, it is filling to obtain the final product.
Embodiment 3
Raw material forms (parts by weight): 15 parts of hawthorn, 20 parts of Siraitia grosvenorii, 12 parts of cassia seed, 15 parts of wintercherry, 7 parts of ginger, fructus lycii 5
Part, 11 parts of radix cyathulae, 10 parts of Radix Ophiopogonis, 22 parts of Ilex Latifolia Thunb, 15 parts of Radix Glycyrrhizae.
Preparation method:
S1. the preparation of Chinese medical extract: bulk pharmaceutical chemicals are cleaned in proportion, is dry, are crushed, are soaked in water by solid-to-liquid ratio 1:10, are risen
Temperature after decocting 7h, is cooled to room temperature to boiling, and is filtered, and filter residue is added in 75wt% ethanol solution, solid-to-liquid ratio 1:7, depressurizes low temperature
After refluxing extraction 4h, filtering, reject filter residue merges filtrate twice, and being concentrated under reduced pressure into density is 1.35g/cm3, it is spray-dried, obtains
To Chinese medical extract；
S2. the preparation of oral solution: extracting after bulk pharmaceutical chemicals are weighed and obtain Chinese medical extract, mixed in the ratio and sterile water of 1:10
It is even, food emulsifying agent, food stabilizer and food antioxidant, stirring and emulsifying is added, emulsifying process is to stir with 12500r/min
13min is mixed, xylitol, sodium citrate, potassium sorbate is added and stirs evenly, stands, filtering, pasteurization, 69 DEG C of sterilizing 30min
Be cooled to 4 DEG C in 10s afterwards, it is filling to obtain the final product.
Embodiment 4
Raw material forms (parts by weight): 10-20 parts of hawthorn, 15-25 parts of Siraitia grosvenorii, 10-15 parts of cassia seed, 10-20 parts of wintercherry.
Preparation method:
S1. the preparation of Chinese medical extract: bulk pharmaceutical chemicals are cleaned in proportion, is dry, are crushed, are soaked in water by solid-to-liquid ratio 1:10, are risen
Temperature after decocting 7h, is cooled to room temperature to boiling, and is filtered, and filter residue is added in 75wt% ethanol solution, solid-to-liquid ratio 1:7, depressurizes low temperature
After refluxing extraction 4h, filtering, reject filter residue merges filtrate twice, and being concentrated under reduced pressure into density is 1.42g/cm3, it is spray-dried, obtains
To Chinese medical extract；
S2. the preparation of oral solution: extracting after bulk pharmaceutical chemicals are weighed and obtain Chinese medical extract, mixed in the ratio and sterile water of 1:10
It is even, food emulsifying agent, food stabilizer and food antioxidant, stirring and emulsifying is added, emulsifying process is to stir with 12500r/min
13min is mixed, xylitol, sodium citrate, potassium sorbate is added and stirs evenly, stands, filtering, pasteurization, 69 DEG C of sterilizing 30min
Be cooled to 4 DEG C in 10s afterwards, it is filling to obtain the final product.
Embodiment 5
Raw material forms (parts by weight): 20 parts of hawthorn, 25 parts of Siraitia grosvenorii, 15 parts of cassia seed, 20 parts of wintercherry.
Preparation method:
S1. the preparation of Chinese medical extract: bulk pharmaceutical chemicals are cleaned in proportion, is dry, are crushed, are soaked in water by solid-to-liquid ratio 1:10, are risen
Temperature after decocting 7h, is cooled to room temperature to boiling, and is filtered, and filter residue is added in 75wt% ethanol solution, solid-to-liquid ratio 1:7, depressurizes low temperature
After refluxing extraction 4h, filtering, reject filter residue merges filtrate twice, and being concentrated under reduced pressure into density is 1.39g/cm3, it is spray-dried, obtains
To Chinese medical extract；
S2. the preparation of oral solution: extracting after bulk pharmaceutical chemicals are weighed and obtain Chinese medical extract, mixed in the ratio and sterile water of 1:10
It is even, food emulsifying agent, food stabilizer and food antioxidant, stirring and emulsifying is added, emulsifying process is to stir with 12500r/min
13min is mixed, xylitol, sodium citrate, potassium sorbate is added and stirs evenly, stands, filtering, pasteurization, 69 DEG C of sterilizing 30min
Be cooled to 4 DEG C in 10s afterwards, it is filling to obtain the final product.
Comparative example 1
Raw material forms (parts by weight): 5 parts of hawthorn, 30 parts of Siraitia grosvenorii, 5 parts of cassia seed, 40 parts of wintercherry.
Preparation method:
S1. the preparation of Chinese medical extract: bulk pharmaceutical chemicals are cleaned in proportion, is dry, are crushed, are soaked in water by solid-to-liquid ratio 1:10, are risen
Temperature after decocting 7h, is cooled to room temperature to boiling, and is filtered, and filter residue is added in 75wt% ethanol solution, solid-to-liquid ratio 1:7, depressurizes low temperature
After refluxing extraction 4h, filtering, reject filter residue merges filtrate twice, and being concentrated under reduced pressure into density is 1.39g/cm3, it is spray-dried, obtains
To Chinese medical extract；
S2. the preparation of oral solution: extracting after bulk pharmaceutical chemicals are weighed and obtain Chinese medical extract, mixed in the ratio and sterile water of 1:10
It is even, food emulsifying agent, food stabilizer and food antioxidant, stirring and emulsifying is added, emulsifying process is to stir with 12500r/min
13min is mixed, xylitol, sodium citrate, potassium sorbate is added and stirs evenly, stands, filtering, pasteurization, 69 DEG C of sterilizing 30min
Be cooled to 4 DEG C in 10s afterwards, it is filling to obtain the final product.
Comparative example 2
Raw material forms (parts by weight): 80 parts of hawthorn.
Preparation method:
S1. the preparation of Chinese medical extract: bulk pharmaceutical chemicals are cleaned in proportion, is dry, are crushed, are soaked in water by solid-to-liquid ratio 1:10, are risen
Temperature after decocting 7h, is cooled to room temperature to boiling, and is filtered, and filter residue is added in 75wt% ethanol solution, solid-to-liquid ratio 1:7, depressurizes low temperature
After refluxing extraction 4h, filtering, reject filter residue merges filtrate twice, and being concentrated under reduced pressure into density is 1.39g/cm3, it is spray-dried, obtains
To Chinese medical extract；
S2. the preparation of oral solution: extracting after bulk pharmaceutical chemicals are weighed and obtain Chinese medical extract, mixed in the ratio and sterile water of 1:10
It is even, food emulsifying agent, food stabilizer and food antioxidant, stirring and emulsifying is added, emulsifying process is to stir with 12500r/min
13min is mixed, xylitol, sodium citrate, potassium sorbate is added and stirs evenly, stands, filtering, pasteurization, 69 DEG C of sterilizing 30min
Be cooled to 4 DEG C in 10s afterwards, it is filling to obtain the final product.
Comparative example 3
Raw material forms (parts by weight): 80 parts of Siraitia grosvenorii.
Preparation method:
S1. the preparation of Chinese medical extract: bulk pharmaceutical chemicals are cleaned in proportion, is dry, are crushed, are soaked in water by solid-to-liquid ratio 1:10, are risen
Temperature after decocting 7h, is cooled to room temperature to boiling, and is filtered, and filter residue is added in 75wt% ethanol solution, solid-to-liquid ratio 1:7, depressurizes low temperature
After refluxing extraction 4h, filtering, reject filter residue merges filtrate twice, and being concentrated under reduced pressure into density is 1.39g/cm3, it is spray-dried, obtains
To Chinese medical extract；
S2. the preparation of oral solution: extracting after bulk pharmaceutical chemicals are weighed and obtain Chinese medical extract, mixed in the ratio and sterile water of 1:10
It is even, food emulsifying agent, food stabilizer and food antioxidant, stirring and emulsifying is added, emulsifying process is to stir with 12500r/min
13min is mixed, xylitol, sodium citrate, potassium sorbate is added and stirs evenly, stands, filtering, pasteurization, 69 DEG C of sterilizing 30min
Be cooled to 4 DEG C in 10s afterwards, it is filling to obtain the final product.
Comparative example 4
Raw material forms (parts by weight): 80 parts of cassia seed.
Preparation method:
S1. the preparation of Chinese medical extract: bulk pharmaceutical chemicals are cleaned in proportion, is dry, are crushed, are soaked in water by solid-to-liquid ratio 1:10, are risen
Temperature after decocting 7h, is cooled to room temperature to boiling, and is filtered, and filter residue is added in 75wt% ethanol solution, solid-to-liquid ratio 1:7, depressurizes low temperature
After refluxing extraction 4h, filtering, reject filter residue merges filtrate twice, and being concentrated under reduced pressure into density is 1.39g/cm3, it is spray-dried, obtains
To Chinese medical extract；
S2. the preparation of oral solution: extracting after bulk pharmaceutical chemicals are weighed and obtain Chinese medical extract, mixed in the ratio and sterile water of 1:10
It is even, food emulsifying agent, food stabilizer and food antioxidant, stirring and emulsifying is added, emulsifying process is to stir with 12500r/min
13min is mixed, xylitol, sodium citrate, potassium sorbate is added and stirs evenly, stands, filtering, pasteurization, 69 DEG C of sterilizing 30min
Be cooled to 4 DEG C in 10s afterwards, it is filling to obtain the final product.
Comparative example 5
Raw material forms (parts by weight): 80 parts of wintercherry.
Preparation method:
S1. the preparation of Chinese medical extract: bulk pharmaceutical chemicals are cleaned in proportion, is dry, are crushed, are soaked in water by solid-to-liquid ratio 1:10, are risen
Temperature after decocting 7h, is cooled to room temperature to boiling, and is filtered, and filter residue is added in 75wt% ethanol solution, solid-to-liquid ratio 1:7, depressurizes low temperature
After refluxing extraction 4h, filtering, reject filter residue merges filtrate twice, and being concentrated under reduced pressure into density is 1.39g/cm3, it is spray-dried, obtains
To Chinese medical extract；
S2. the preparation of oral solution: extracting after bulk pharmaceutical chemicals are weighed and obtain Chinese medical extract, mixed in the ratio and sterile water of 1:10
It is even, food emulsifying agent, food stabilizer and food antioxidant, stirring and emulsifying is added, emulsifying process is to stir with 12500r/min
13min is mixed, xylitol, sodium citrate, potassium sorbate is added and stirs evenly, stands, filtering, pasteurization, 69 DEG C of sterilizing 30min
Be cooled to 4 DEG C in 10s afterwards, it is filling to obtain the final product.
Influence experiment of the test case 1 to obesity mice body fat
50 mouse are taken, half male and half female, weight 18-22g, be randomly divided into 12 groups: blank control group, obese model group are real
Apply 1 group of example, 2 groups of embodiment, 3 groups of embodiment, 4 groups of embodiment, 5 groups of embodiment, 1 group of comparative example, 2 groups of comparative example, comparative example 3
Group, 4 groups of comparative example and 5 groups of comparative example.In addition to blank control group is to basal feed, remaining each group takes fat feed, described
Fat feed is that milk powder 10g, lard 10g, cholesterol 1.5g, deoxycholic acid are added in every 100g basal feed
0.3g, it is other for basic feed.Daily stomach-filling 1 time, continuous gavage 42d, claims 1 weight every 7d, after last stomach-filling
For 24 hours, mouse is put to death, stomach fat is taken to claim weight in wet base, calculate fat index.Experimental result is shown in Fig. 1.
By Fig. 1 result it is found that after 42d stomach-filling, compared with blank group and model group, embodiment 4-5 group is to fat small
Mouse fat index, which increases, extremely significant reduction effect (P < 0.01)；Embodiment 1-3 group can significantly reduce obesity mice fat and refer to
Number (P < 0.05).Comparative example 1-5 only has fat-reducing effect slightly, and effect is unobvious.
2 fat-reducing effect clinical test of test case
The weight-reducing oral liquor and commercially available similar weight-reducing oral liquor for taking the present embodiment 1-5 and comparative example 1-5 preparation, to 180
Test-meal experimental study of the mature age in 20-55 years old (average age 35 years old) subject's 60 day time of progress.
Subject's condition: simple obesity crowd, adult human male, women, BMI >=30, abdomen skinfold > 30mm, waistline >
101cm, weight are above standard weight 20%.Standard weight (kg)=[height (cm) -100] × 0.9.
Subject excludes: (1) merge intentionally, liver, the serious diseases such as kidney and hemopoietic system, mental patient.(2) in a short time
Article related with tested function is taken, the judgement person to result is influenced.
Test method: subject takes weight-reducing oral liquor and the city of 1-5 of the embodiment of the present invention and comparative example 1-5 preparation
Weight-reducing oral liquor is sold, is continuously taken 60 days, each taking 1 bottle, 3 times a day, is taken before the meal or in meal every time.Blank group is taken
Measure water.
Efficiency index detection: weight, height, waistline (navel week), hip circumference, thigh circumference, fatty percentage of liveweight percentage, and count
It calculates constitutional index (BMI).
Test result:
Subject takes the oral solution of 1-5 of the embodiment of the present invention and comparative example 1-5 and the preparation of commercially available similar weight-reducing oral liquor, and 60
It body shape index test result is shown in Fig. 2.Annotation: capitalization is the P < 0.01 compared with blank group；Lowercase is
Compared with blank group, P < 0.05.
Fig. 2 show embodiment 1-5 preparation oral solution when subject takes 60 days, weight, height, waistline, hip circumference,
Thigh circumference, abdomen stratum corneum lipids, fatty percentage of liveweight percentage, compared to the blank group compared with efficacy measures (except height index) are equal
There is conspicuousness reduction, there is significant difference (P < 0.01)；Compared with Example 5, proportion is different for bulk pharmaceutical chemicals in comparative example 1, does not have
Play good fat-reducing effect；Comparative example 2-5 is to prepare oral solution using bulk pharmaceutical chemicals individual in embodiment 5 progress equivalent,
Fat-reducing effect only slightly, effect are unobvious, it is seen then that bulk pharmaceutical chemicals combination is prepared oral solution, can obviously play weight-reducing drop
The effect of rouge, each group bulk pharmaceutical chemicals play the role of synergy.
Compared with prior art, the present invention is further screened from the Chinese medicine of the Weight-reducing and lipid-lowering of 10 taste integration of drinking and medicinal herbs
Have the effect of the Chinese medicine compounding of obvious lipid-loweringing, weight-reducing to 4 kinds, obtain oral solution bulk pharmaceutical chemicals, effect is obvious, and raw material comes
Source is wide；
The present invention extracts the water-soluble active ingredient in bulk pharmaceutical chemicals using decocting, extracts raw material using ethanol solution low temperature reflux
Alcohol-soluble active constituent in medicine, part alcohol-soluble active constituent is not soluble in water, when finally preparing oral solution, using food
Grade emulsifier, obtains homogeneous composition, and stabilizer is added and stablizes, obtained after potassium sorbate anti-corrosion long shelf-life, delicate mouthfeel,
The uniform oral solution of solution；
The present invention sterilizes to oral solution using pasteurization, mixed raw material is heated to 68-70 DEG C, and keep this temperature
Rapid cooling is to 4-5 DEG C after 30min.Because the killing point of general bacterium be 68 DEG C of temperature with time 30min hereinafter,
It is cooled down suddenly after this heating, hot and cold variation sharply can also promote the death of bacterium, while keep active in oral solution
Ingredient by high temperature, does not improve the Weight-reducing and lipid-lowering effect of oral solution；
Composition of the invention is that integration of drinking and medicinal herbs material combination forms, and has the characteristics that pure natural, green safe, takes the present invention
Composition without specially dieting, without any side effects and sense of discomfort, convenient, medicine source is easy to get extensively, cheap；Preparation
Simple process, it is easy to operate, it is suitble to industrial production.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Within mind and principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of compound oral liquid with fat reducing and weight reducing function, which is characterized in that be prepared from the following materials: hawthorn, sieve
Chinese fruit, cassia seed, wintercherry, ginger, fructus lycii, radix cyathulae, Radix Ophiopogonis, Ilex Latifolia Thunb, Radix Glycyrrhizae.
2. a kind of compound oral liquid with fat reducing and weight reducing function according to claim 1, which is characterized in that by following raw material
It is prepared by weight: 10-20 parts of hawthorn, 15-25 parts of Siraitia grosvenorii, 10-15 parts of cassia seed, 10-20 parts of wintercherry, ginger 5-10
Part, 2-7 parts of fructus lycii, 10-15 parts of radix cyathulae, Radix Ophiopogonis 5-15 part, 20-25 parts of Ilex Latifolia Thunb, 10-20 parts of Radix Glycyrrhizae.
3. a kind of compound oral liquid with fat reducing and weight reducing function according to claim 1, which is characterized in that by following raw material
It is prepared: hawthorn, Siraitia grosvenorii, cassia seed, wintercherry.
4. a kind of compound oral liquid with fat reducing and weight reducing function according to claim 1, which is characterized in that by following raw material
It is prepared by weight: 10-20 parts of hawthorn, 15-25 parts of Siraitia grosvenorii, 10-15 parts of cassia seed, 10-20 parts of wintercherry.
5. a kind of preparation side of the compound oral liquid as described in any one of claim 1-4 claim with fat reducing and weight reducing function
Method, which is characterized in that extracted after weighing bulk pharmaceutical chemicals and obtain Chinese medical extract, mixed in proportion with sterile water, food cream is added
Xylitol, sodium citrate, potassium sorbate are added after stirring and emulsifying and stirs evenly for agent, food stabilizer and food antioxidant,
It stands, filtering, sterilizing and filling to obtain the final product.
6. preparation method according to claim 5, which is characterized in that the preparation method of the Chinese medical extract include: by
Bulk pharmaceutical chemicals are cleaned, are dry, crushing, and soak in water, and are warming up to boiling, after decocting 5-10h, are cooled to room temperature, and filter, and filter residue is added
In ethanol solution, after decompression low temperature reflux extracts 3-5h, filtering, reject filter residue merges filtrate twice, is concentrated under reduced pressure, spraying dry
It is dry, obtain Chinese medical extract.
7. preparation method according to claim 6, which is characterized in that the mass ratio of the bulk pharmaceutical chemicals and water is 1:(5-
15)；The mass fraction of the ethanol solution is 75wt%, and the mass ratio of the filter residue and ethanol solution is 1:(5-10).
8. preparation method according to claim 5, which is characterized in that the emulsifying process is with 10000-15000r/min
Stir 10-15min.
9. preparation method according to claim 5, which is characterized in that the sterilizing uses pasteurization.
10. a kind of compound oral liquid of the fat reducing and weight reducing function as described in any one of claim 1-9 claim.
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| CN111358876A (en) * | 2020-05-03 | 2020-07-03 | 深圳简体美健康信息咨询有限公司 | Pure natural composition with lipid-lowering and weight-losing functions and preparation method thereof |
| CN112791103A (en) * | 2020-12-31 | 2021-05-14 | 四平华科生物技术有限责任公司 | Deer blood product and preparation method thereof |
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| CN111358876A (en) * | 2020-05-03 | 2020-07-03 | 深圳简体美健康信息咨询有限公司 | Pure natural composition with lipid-lowering and weight-losing functions and preparation method thereof |
| CN112791103A (en) * | 2020-12-31 | 2021-05-14 | 四平华科生物技术有限责任公司 | Deer blood product and preparation method thereof |
| CN112791103B (en) * | 2020-12-31 | 2024-04-19 | 四平华科生物技术有限责任公司 | Deer blood product and preparation method thereof |
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Effective date of registration: 20211129 Address after: 517000 longtanwan Industrial Park (plant 2), Lanba village, Yuannan Town, Yuancheng District, Heyuan City, Guangdong Province Patentee after: Guangdong Jinzheng Food Co.,Ltd. Address before: 316000 plot C2-10, Xiaohui Industrial Zone, Putuo Zhanmao, Putuo marine science and Technology Industrial Park, Zhoushan City, Zhejiang Province Patentee before: Zhejiang Ocean University |