CN104041819A - Ecological fermented arctium lappa product and preparation method - Google Patents
Ecological fermented arctium lappa product and preparation method Download PDFInfo
- Publication number
- CN104041819A CN104041819A CN201410295006.6A CN201410295006A CN104041819A CN 104041819 A CN104041819 A CN 104041819A CN 201410295006 A CN201410295006 A CN 201410295006A CN 104041819 A CN104041819 A CN 104041819A
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- burdock
- product
- ecological
- fermentation
- arctium lappa
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention provides an ecological fermented arctium lappa product which has the effects of lowering blood pressure and lowering blood fat, and belongs to the technical field of health foods. Particularly, the ecological fermented arctium lappa product provided by the invention is prepared from following raw materials in parts by weight: 200-600 parts of fermented arctium lappa, 100-400 parts of folium mori, 40-100 parts of astragalus membranaceus, 30-60 parts of salvia miltiorrhiza bunge, 20-80 parts of wild chrysanthemum flowers and 10-20 parts of momordica grosvenori. The ecological fermented arctium lappa product provided by the invention is simple and feasible in processing method, stable in quality, fresh in mouth feel and unique in flavor; the disadvantages of existing arctium lappa health tea that the mouth feel is thick and the bad flavor is great are avoided and the product is convenient for consumers to use. According to the ecological fermented arctium lappa product, all components can be mutually cooperated and have the mutual effects; the ecological fermented arctium lappa product has the effects of promoting blood circulation to remove meridian obstruction, promoting the circulation of qi and reducing phlegm, nourishing yin to lessen fire and clearing liver and improving vision; after being used for a long period, the ecological fermented arctium lappa product has the effects of enhancing the immunity of a human body, lowering the blood pressure and lowering the blood fat.
Description
Technical field
The invention belongs to health product technology field, relate to a kind of burdock product and deep processing thereof, specifically relate to a kind of ecological fermentation burdock product and preparation method.
Background technology
Burdock, is my ancient medicine-food two-purpose food vegetables, and Ming Dynasty's Li Shizhen (1518-1593 A.D.) claims its " cutting seedling ditch washes in a pan as vegetables; get root and boil, expose to the sun for dried meat, its beneficial people of cloud ", " the logical twelve regular channels, except the five internal organs bad odor " Mingyi Bielu " claims its " clothes are made light of one's life by commiting suicide resistance to old for a long time " in Compendium of Material Medica, to state it in detail.Burdock is worth high, rare special vegetables in Shu Duo section, radix bardanae contains polysaccharide and volatile oil, cellulose and amino acid, the amino acid content especially with special pharmacological effect is high, as the 25%-28% arginine that the asparatate with brain strengthening function accounts for total amino acid accounts for 18%-20%, and contain Ca, Mg, Fe, Mn, the macroelement of Zn needed by human and its polyphenols of trace element, have effect anticancer, anti-sudden change, thereby there is very high nutritive value and pharmacologically active more widely, be ideal natural health care.
Modern study shows that burdock plays an important role to health: burdock, containing a large amount of dietary fiber and mycins, can promote the growth of wriggling and the interior beneficial bacterium of large intestine of large intestine, can improve constipation so often eat, and it also has good curative effect to hemorrhoid and the carcinoma of the rectum; In radix bardanae, contain abundant water-soluble dietary fiber and synanthrin, can increase the excretion of cholesterol, stop the circulation of cholesterol at anus intestines, thereby reduce fatty absorption, reach the object of lowering blood-fat and reducing weight, and can absorb bile acid, increase the discharge of cholate and the excretion of cholesterol, therefore can prevent calculus; The fiber of radix bardanae has the effect that absorbs sodium, and excretes with ight soil, and sodium in body is reduced, and the protein in radix bardanae can make the pliable and tough of blood vessel change, sodium can be separated from cell, and excrete, and burdock is sweet to distend the blood vessels, and reaches antihypertensive effect; And radix bardanae can wind and heat dispersing, the effect of removing toxicity for detumescence, often eats the effect that can reach beauty treatment, and in addition, it also has the effect of tonifying kidney and strengthening yang.
At present, burdock deep processing, receives the favor of a lot of producers, and now existing multiple product emerges, and enjoys a good market both at home and abroad, however burdock as the exploitation of health products with given efficacy still in the starting stage.
Summary of the invention
The present invention is based on the studying for a long period of time and developing of burdock, a kind of ecological fermentation burdock product with the health-care efficacy such as step-down, reducing blood lipid and preparation method thereof is provided.
Ecological fermentation burdock product of the present invention, is prepared from by the raw material of following weight portion:
Fermentation burdock 200-600 mulberry leaf 100-400 Radix Astragali 40-100
Red sage root 30-60 mother chrysanthemum 20-80 Momordica grosvenori 10-20.
Preferably, ecological fermentation burdock product of the present invention, is prepared from by the raw material of following weight portion:
Fermentation burdock 200-400 mulberry leaf 120-200 Radix Astragali 40-80
Red sage root 30-60 mother chrysanthemum 30-60 Momordica grosvenori 10-20.
As further preferred, ecological fermentation burdock product of the present invention, is prepared from by the raw material of following weight portion:
Fermentation burdock 280 mulberry leaf 180 Radixs Astragali 48
The red sage root 36 mother chrysanthemum 36 Momordica grosvenoris 12.
Burdock, containing multivitamin and the mineral matter of the needed by human body such as synanthrin, cellulose, protein, calcium, phosphorus, iron, wherein carotene carotene content is higher 150 times than carrot, and the content of protein and calcium is first of tubers.Radix bardanae contains synanthrin and volatile oil, arctic acid, multiple polyphenol substance and aldehydes, and is rich in cellulose and amino acid.Burdock: bitter, pungent, cool.Clearing heat and detoxicating, dispelling wind relieve sore throat, detumescence.For anemopyretic cold, cough, sore-throat, sore furuncle poison, the ringworm of the foot, eczema.For anemopyretic cold, headache, sore-throat, mumps, rash goes out not saturating, and carbuncle furuncle sore can be hypoglycemic, hypotensive, blood fat, Cure for insomnia, improves the effects such as body immunity.
Mulberry leaf are the dry Lao Ye of moraceae plants mulberry.Mulberry-leaf extract DNJ and the root of kudzu vine extract flavonoids material is combined and forms a kind of novel substance-wash the clear sugar element of pancreas, is suitable for controlling the effects such as hypoglycemic, blood fat, anti-inflammatory.Mulberry leaf nature and flavor are sweet, bitter, cold.Return lung, Liver Channel.Dispelling wind and heat from the body, clearing away the lungheat and moisturizing, clears liver and improve vision.For anemopyretic cold, lung-heat type cough, dizziness headache, hot eyes is dim-sighted.
The Radix Astragali, sweet, temperature.Return lung, the spleen channel.Invigorating qi for strengthening superficies, diuresis holder poison, apocenosis, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, the sinking of qi of middle-jiao, rushes down prolapse of the anus for a long time, the uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy oedema, ulcer is difficult bursts, and burst and do not hold back for a long time, flaccidity of limbs due to deficiency of blood Huang, interior heat is quenched one's thirst; Chronic nephritis albuminuria, diabetes.
The red sage root, has another name called red ginseng, radix salviae miltiorrhizae, red etc.Hardship, is slightly cold.The thoughts of returning home, Liver Channel.Stasis-dispelling and pain-killing, activating blood to promote menstruation, relieving restlessness clears away heart-fire.For irregular menstruation, through closing dysmenorrhoea, a lump in the abdomen causing distension and pain, chest ventral spine pain, and hot numbness pain, sore swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Mother chrysanthemum, is the capitulum of feverfew mother chrysanthemum, HERBA CHRYSANTHEMI LAVANDULAEFOLII or lavandulaleaf dendranthema herb, bitter, pungent, is slightly cold.Return liver, the heart channel of Hang-Shaoyin.Clearing heat and detoxicating.Swollen for furunculosis carbuncle, red eye, swell pain, has a headache dizzy.Modern pharmacology confirms that it has step-down and antiviral, antibacterial action.
Momordica grosvenori is the dry fruit of cucurbitaceous plant Momordica grosvenori.Sweet, cool.Return lung, large intestine channel.Clearing heat and moistening lung, laxation defaecation.For lung-fire cough caused by dryness, pharyngalgia aphonia, the dry constipation of intestines.
Ecological fermentation burdock product of the present invention, related former material material is integration of drinking and medicinal herbs, therefore ecological fermentation burdock product of the present invention both can be prepared into ecological fermentation burdock preparation by conventional extraction and preparation technique, for example liquid oral formulation or oral dosage form, described oral dosage form is tablet, granule, capsule, soft capsule or pill.Also can be prepared into ecological fermentation burdock tea.
The present invention has supplied a kind of preparation method of above-mentioned ecological fermentation burdock preparation, comprises the following steps:
Step 1. selects diameter at the fresh and healthy burdock of 2-3 centimetre, and the crust of burdock is removed; Clean, with slicer section, slice thickness is 1.0-3.0mm; Or be cut into the fourth of 0.2-1cm × 0.2-1cm.
Step 2. is put in the sheet cutting or fourth in baking box, vacuum drying at 60-80 DEG C.
The burdock after drying is placed in container by step 3., adds dusty yeast according to the ratio of weight ratio 100:0.1-5, till adding water to be stirred to burdock no longer to absorb moisture, and under room temperature, sealed fermenting 15-30 days.
Step 4. is put in the burdock after fermentation in baking box and dries, and pulverizes 10 mesh sieves.
Step 5. was pulverized 10 mesh sieves by mulberry leaf, the Radix Astragali, the red sage root, mother chrysanthemum, Momordica grosvenori respectively.
Step 6., by weight portion of the present invention, takes above-mentioned 6 kinds of raw material, adds 95% alcohol reflux that above-mentioned 6 kinds of raw material 8-10 doubly measure to extract 2-3 time, each 2-3 hour, merge extract, reclaim ethanol, the clear cream that while being evaporated to 50-60 DEG C, relative density is 1.20-1.30; The clear cream of gained dry, pulverize, and technique is prepared into oral formulations routinely.
As preferably, the temperature in step 2 in baking box is 80 DEG C;
As preferably, in step 3, the ratio of burdock and dusty yeast is 100:2, sealed fermenting 20 days.
The present invention also provides a kind of preparation method of above-mentioned ecological fermentation burdock tea, comprises the following steps:
Step 1. selects diameter at the fresh and healthy burdock of 2-3 centimetre, and the crust of burdock is removed; Clean, with slicer section, slice thickness is 1.0-3.0mm; Or be cut into the fourth of 0.2-1cm × 0.2-1cm.
Step 2. is put in the sheet cutting or fourth in baking box, vacuum drying at 60-80 DEG C.
The burdock after drying is placed in container by step 3., adds dusty yeast according to the ratio of weight ratio 100:0.1-5, till adding water to be stirred to burdock no longer to absorb moisture, and under room temperature, sealed fermenting 15-30 days.
Step 4. is put in the burdock after fermentation in baking box and dries, and pulverizes 10 mesh sieves.
Step 5. was pulverized 10 mesh sieves by mulberry leaf, the Radix Astragali, the red sage root, mother chrysanthemum, Momordica grosvenori respectively.
Step 6. by weight portion of the present invention, takes above-mentioned 6 kinds of raw material and fully mixes, and is packaged into 5 grams every bag little packed with tea in bag wrapping paper; Be ecological fermentation burdock tea of the present invention.
As preferably, the temperature in step 2 in baking box is 70 DEG C;
As preferably, in step 3, the ratio of burdock and dusty yeast is 100:2, sealed fermenting 20 days.
Ecological fermentation burdock tea provided by the invention, one, processing method is simple, safe and reliable, and steady quality can at utmost retain the active component of burdock; Its two, clean taste, unique flavor, has avoided existing burdock tea health protection tea, mouthfeel is thick and heavy, the shortcoming that bad smell is large has facilitated consumer's use.
Ecological fermentation burdock product of the present invention confirms through pharmacology test: various components can be worked in coordination with mutually, interacts, and has promoting blood circulation and removing obstruction in channels, promoting the circulation of qi is reduced phlegm, nourishing Yin and falling fire, the effect of clearing liver and improving vision, long-term use can be played enhancing body immunity, reduces blood pressure, and reduces the effect of blood fat.
Detailed description of the invention
Below the invention will be further described for the description by detailed description of the invention, but this is not limitation of the present invention, those skilled in the art are according to basic thought of the present invention, can make various amendments or improvement, but only otherwise depart from basic thought of the present invention, all within the scope of the present invention.
The preparation of EXAMPLE l ecological fermentation burdock tea
Step 1. selects diameter at the fresh and healthy burdock of 2-3 centimetre, and the crust of burdock is removed; Clean, with slicer section, slice thickness is 2.0-3.0mm; Or be cut into the fourth of 0.2-0.5cm × 0.2-0.5cm.
Step 2. is put in the sheet cutting or fourth in baking box, vacuum drying at 70 DEG C.
The burdock after drying is placed in container by step 3., adds dusty yeast according to the ratio of weight ratio 100:2, till adding water to be stirred to burdock no longer to absorb moisture, and under room temperature, sealed fermenting 20 days.
Step 4. is put in the burdock after fermentation in baking box and dries, and pulverizes 10 mesh sieves;
Step 5. was pulverized 10 mesh sieves by mulberry leaf, the Radix Astragali, the red sage root, mother chrysanthemum, Momordica grosvenori respectively;
Step 6. takes respectively fermentation burdock 280 weight portions, mulberry leaf 180 weight portions, the Radix Astragali 48 weight portions, the red sage root 36 weight portions, mother chrysanthemum 36 weight portions, Momordica grosvenori 12 weight portions pulverized, 6 kinds of raw material of above-mentioned weight portion are fully mixed, be packaged into 5 grams every bag little packed with tea in bag wrapping paper; Be ecological fermentation burdock tea of the present invention.
The preparation of embodiment 2 ecological fermentation burdock teas
Step 1. selects diameter at the fresh and healthy burdock of 2-3 centimetre, and the crust of burdock is removed; Clean, with slicer section, slice thickness is 2.0-3.0mm; Or be cut into the fourth of 0.5-1.0cm × 0.5-1.0cm.
Step 2. is put in the sheet cutting or fourth in baking box, vacuum drying at 70 DEG C.
The burdock after drying is placed in container by step 3., adds dusty yeast according to the ratio of weight ratio 100:1, till adding water to be stirred to burdock no longer to absorb moisture, and under room temperature, sealed fermenting 30 days.
Step 4. is put in the burdock after fermentation in baking box and dries, and pulverizes 10 mesh sieves;
Step 5. was pulverized 10 mesh sieves by mulberry leaf, the Radix Astragali, the red sage root, mother chrysanthemum, Momordica grosvenori respectively;
Step 6. takes respectively fermentation burdock 600 weight portions, mulberry leaf 400 weight portions, the Radix Astragali 80 weight portions, the red sage root 40 weight portions, mother chrysanthemum 80 weight portions, Momordica grosvenori 20 weight portions pulverized, 6 kinds of raw material of above-mentioned weight portion are fully mixed, be packaged into 5 grams every bag little packed with tea in bag wrapping paper; Be ecological fermentation burdock tea of the present invention.
The preparation of embodiment 3 ecological fermentation burdock teas
Step 1. selects diameter at the fresh and healthy burdock of 2-3 centimetre, and the crust of burdock is removed; Clean, with slicer section, slice thickness is 1.0-2.0mm; Or be cut into the fourth of 0.2-0.4cm × 0.2-0.4cm.
Step 2. is put in the sheet cutting or fourth in baking box, vacuum drying at 60 DEG C.
The burdock after drying is placed in container by step 3., adds dusty yeast according to the ratio of weight ratio 100:0.5, till adding water to be stirred to burdock no longer to absorb moisture, and under room temperature, sealed fermenting 15 days.
Step 4. is put in the burdock after fermentation in baking box and dries, and pulverizes 10 mesh sieves;
Step 5. was pulverized 10 mesh sieves by mulberry leaf, the Radix Astragali, the red sage root, mother chrysanthemum, Momordica grosvenori respectively;
Step 6. takes respectively fermentation burdock 400 weight portions, mulberry leaf 200 weight portions, the Radix Astragali 60 weight portions, the red sage root 60 weight portions, mother chrysanthemum 60 weight portions, Momordica grosvenori 20 weight portions pulverized, 6 kinds of raw material of above-mentioned weight portion are fully mixed, be packaged into 5 grams every bag little packed with tea in bag wrapping paper; Be ecological fermentation burdock tea of the present invention.
The preparation of embodiment 4 ecological fermentation burdock teas
Step 1. selects diameter at the fresh and healthy burdock of 2-3 centimetre, and the crust of burdock is removed; Clean, with slicer section, slice thickness is 1.0-2.0mm; Or be cut into the fourth of 0.2-0.4cm × 0.2-0.4cm.
Step 2. is put in the sheet cutting or fourth in baking box, vacuum drying at 60 DEG C.
The burdock after drying is placed in container by step 3., adds dusty yeast according to the ratio of weight ratio 100:0.5, till adding water to be stirred to burdock no longer to absorb moisture, and under room temperature, sealed fermenting 15 days.
Step 4. is put in the burdock after fermentation in baking box and dries, and pulverizes 10 mesh sieves;
Step 5. was pulverized 10 mesh sieves by mulberry leaf, the Radix Astragali, the red sage root, mother chrysanthemum, Momordica grosvenori respectively;
Step 6. takes respectively fermentation burdock 200 weight portions, mulberry leaf 140 weight portions, the Radix Astragali 40 weight portions, the red sage root 30 weight portions, mother chrysanthemum 30 weight portions, Momordica grosvenori 10 weight portions pulverized, 6 kinds of raw material of above-mentioned weight portion are fully mixed, be packaged into 5 grams every bag little packed with tea in bag wrapping paper; Be ecological fermentation burdock tea of the present invention.
The preparation of embodiment 5 ecological fermentation burdock capsules
Step 1. selects diameter at the fresh and healthy burdock of 2-3 centimetre, and the crust of burdock is removed; Clean, with slicer section, slice thickness is 2.0-3.0mm; Or be cut into the fourth of 0.2-0.5cm × 0.2-0.5cm.
Step 2. is put in the sheet cutting or fourth in baking box, vacuum drying at 75 DEG C.
The burdock after drying is placed in container by step 3., adds dusty yeast according to the ratio of weight ratio 100:2, till adding water to be stirred to burdock no longer to absorb moisture, and under room temperature, sealed fermenting 20 days.
Step 4. is put in the burdock after fermentation in baking box and dries, and pulverizes 10 mesh sieves;
Step 5. was pulverized 10 mesh sieves by mulberry leaf, the Radix Astragali, the red sage root, mother chrysanthemum, Momordica grosvenori respectively;
Step 6. takes respectively fermentation burdock 280 weight portions, mulberry leaf 180 weight portions, the Radix Astragali 48 weight portions, the red sage root 36 weight portions, mother chrysanthemum 36 weight portions, Momordica grosvenori 12 weight portions pulverized, add 95% alcohol reflux of 10 times of amounts of above-mentioned 6 kinds of raw material to extract 2-3 time, each 2-3 hour, merge extract, reclaim ethanol, the clear cream that while being evaporated to 50-60 DEG C, relative density is 1.20-1.30; The clear cream of gained dry, pulverize, and adds the dolomol of 5% weight portion, after mixing, is loaded in capsule, obtains capsule of the present invention.
Comparative example 1
Step 1. selects diameter at the fresh and healthy burdock of 2-3 centimetre, and the crust of burdock is removed; Clean, with slicer section, slice thickness is 2.0-3.0mm; Or be cut into the fourth of 0.2-0.5cm × 0.2-0.5cm.
Step 2. is put in the sheet cutting or fourth in baking box, vacuum drying at 75 DEG C.
The burdock after drying is placed in container by step 3., adds dusty yeast according to the ratio of weight ratio 100:2, till adding water to be stirred to burdock no longer to absorb moisture, and under room temperature, sealed fermenting 20 days.
Step 4. is put in the burdock after fermentation in baking box and dries, and pulverizes 10 mesh sieves; Be packaged into 5 grams every bag little packed with tea in bag wrapping paper; Ecological fermentation burdock tea.
Pharmacology pharmacodynamic experiment
Ecological fermentation burdock tea of the present invention step-down, reducing blood lipid test:
One, ecological fermentation burdock tea of the present invention is to spontaneous hypertensive rat drop test
1 experiment material
1.1 animal used as test
48 of spontaneous hypertensive rats, male and female half and half, body weight 352g ± 28g.Be divided at random 4 groups, 12 every group, respectively organize relatively there was no significant difference (P > 0.05) of blood pressure, there is comparativity.
1.2 experiment products
Ecological fermentation burdock tea prepared by embodiment 1, brewed solution, every milliliter contained 1.8g.
Ecological fermentation burdock tea prepared by comparative example 1, brewed solution, every milliliter contained 2.0g.
Losartan Tablet, every contains Losartan Potassium 50mg, makes solution, every milliliter of pastille 6mg.
2 experimental techniques
2.1 groupings and processing
Western medicine group: every day 1 gavage, each 2ml, successive administration 4 weeks.Ecological fermentation burdock tea prepared by invention group: embodiment 1, every day 2 gavages, each 1ml, successive administration 4 weeks.Contrast groups: the solution that ecological fermentation burdock tea prepared by comparative example 1 is made, every day 2 gavages, each 1ml, successive administration 4 weeks.Control group: from the 1st week, give 2ml pure water gavage, every day 1 time, continuous 4 weeks.
2.2 assay method
SHR is put into 37 DEG C ± 1 DEG C electrothermostat before pressure measurement, heating is fully expanded rat tail artery, indirectly surveys the systolic pressure of rat tail artery with Conscious Rat blood pressure determination instrument, measures respectively before medication, after medication the blood pressure of 4 weeks.
2.3 statistical method
Data acquisition carries out statistical analysis with SPSS19.0 software, measurement data with
represent, before and after treatment, index relatively adopts t inspection; Enumeration data adopts X
2inspection.P < 0.05 represents that difference has statistical significance.
3 results
Each group rat blood pressure affects in table 1
The impact of the each group of table 1 rat blood pressure
| Group | Rat (n) | Before medication (mmHg) | After medication 4 weeks (mmHg) |
| Control group | 12 | 160.25±16.20 | 170.57±18.13 |
| Western medicine group | 12 | 160.88±14.00 | 145.61±9.22 &*@ |
| Invention group | 12 | 161.37±16.74 | 144.87±8.39 &*@ |
| Contrast groups | 12 | 161.01±18.91 | 168.40±11.35 |
Remarks: with control group comparison:
aMP.AMp.Ampp < 0.05, with before medication relatively:
*p < 0.05, and contrast groups comparison:
@p < 0.05.
Two, ecological fermentation burdock tea of the present invention is tested hyperlipidemia rats reducing blood lipid
1 materials and methods
1.1 animals used as test and feed
Healthy male SD is 60 of rats, body weight 200-250g.
Feed: cholesterol, sodium taurocholate, propylthiouracil, yolk powder, lard.
1.2 experiment products
Ecological fermentation burdock tea prepared by embodiment 1, brewed solution, every milliliter contained 1.8g.
Ecological fermentation burdock tea prepared by comparative example 1, brewed solution, every milliliter contained 2.0g.
Simvastatin sheet, makes solution, every milliliter of pastille 0.2mg.
2 experimental techniques
2.1 animal models and grouping
According to body weight sequence, be then divided at random 4 groups, hyperlipidemia model group, Simvastatin group, invention group, contrast groups, 15 every group.Application high lipid food is fed rat and is copied hyperlipemia model.Feed consist of 2% cholesterol, 0.3% sodium taurocholate, 7.5% lard, 0.2% propylthiouracil, 5% yolk powder, 85% basal feed, point early, middle and late 3 meal give respectively at regular time and quantity; Each group is all freely drunk water, and changes drinking-water and feed every day, keeps animal living environment to ventilate and sanitation and hygiene, continues 10 weeks.
2.2 medication
Adopt direct administration by gavage, in the gastric infusion that starts for the 5th week of modeling.
Hyperlipidemia model group (control group): gavage physiology salt, every day 2 gavages, each 1ml, successive administration 6 weeks.
Simvastatin group (Western medicine group): every day 1 gavage, each 2ml, successive administration 6 weeks.
Ecological fermentation burdock tea prepared by invention group: embodiment 1, every day 2 gavages, each 1ml, successive administration 4 weeks.
Contrast groups: the solution that ecological fermentation burdock tea prepared by comparative example 1 is made, every day 2 gavages, each 1ml, successive administration 6 weeks.
2.3 testing index
The 10th weekend, with after 10% chloraldurate intraperitoneal anesthesia, sterile working, opens abdominal cavity, inferior caval vein blood sampling, and 3500rpm, centrifugal 10min, extracts serum and detects serum TC, TG, LDL-C, HDL-C level with enzymic colorimetric.
2.4 statistical method
Data acquisition carries out statistical analysis with SPSS19.0 software, measurement data with
represent, before and after treatment, index relatively adopts t inspection; Enumeration data adopts X
2inspection.P < 0.05 represents that difference has statistical significance.
3 results
3.1 blood lipid level comparisons
The impact of each group of table 2 on hyperlipidemia rats TC, TG
| Group | Rat (n) | TC | TG |
| Control group | 12 | 21.24±8.24 | 0.86±0.22. |
| Western medicine group | 12 | 15.76±7.83 #* | 0.42±0.18 #* |
| Invention group | 12 | 13.07±6.19 #* | 0.40±0.14 #* |
| Contrast groups | 12 | 18.58±9.02 # | 0.75±0.13 |
Remarks: with the comparison of hyperlipidemia model group:
#p < 0.05; With contrast groups comparison:
*p < 0.05;
The impact of each group of table 3 on hyperlipidemia rats LDL-C, HDL-C
| Group | Rat (n) | LDL-C | HDL-C |
| Control group | 12 | 11.87±2.61 | 0.36±0.20 |
| Western medicine group | 12 | 8.08±2.22 #* | 1.82±0.39 #* |
| Invention group | 12 | 7.67±2.34 #* | 1.78±0.55 #* |
| Contrast groups | 12 | 11.04±2.44 | 0.42±0.18 |
Remarks: with the comparison of hyperlipidemia model group:
#p < 0.05; With contrast 1 group or contrast 2 groups of comparisons:
*p < 0.05
Experimental result prompting: invention group and Simvastatin group serum TC, TG, LDL-C content significantly reduce, HDL-C significantly raise (P < 0.05).Ecological fermentation burdock tea of the present invention has good step-down, effect for reducing blood fat.
Three, be clinical efficacy and the security of further investigating medicine of the present invention, select 100 routine hyperpietics to carry out clinical observation to the curative effect of medicine of the present invention.
100 routine cases are divided into two groups at random, treatment group 50 examples, control group 50 examples.Two groups of Genders, ill degree, through the equal not statistically significant of comparing difference (P > 0.05), have comparativity.All cases all, according to the diagnostic criteria of " new Chinese medicine clinical guidance principle ", is diagnosed as hypertension.
1. diagnostic criteria
Systolic pressure is more than or equal to 160mmHg (21.3kPa), diastolic pressure is more than or equal to 95mmHg (12.6kPa) for hypertension, when office hypertension, repeatedly Measure blood pressure, the mean value that has double diastolic blood pressure at least is at 90mmHg (12.0kPa) or just can be diagnosed as above hypertension.
2. methods for the treatment of
Treatment group gives ecological fermentation burdock tea prepared by the embodiment of the present invention 1, every bag 5g, drink-service after boiling water soaks, every day twice, each bag; Control group to specifications dosage gives FUFANG LIXUEPING PIAN treatment.Treat altogether for two groups and observe 30 days.
3. the standard of curative effect evaluation
Effective: 1. more than diastolic pressure decline 10mmHg (1.3kPa), and to reach normal range (NR); Though 2. diastolic pressure is not near normal, with decline 20mmHg2.7kPa) or more than; Must possess wherein 1;
Effective: 1. diastolic pressure declines not as good as 10mmHg (1.3kPa), but reaches normal range (NR); 2. diastolic pressure is treated front decline 10-19mmHg (1.3-2.5kPa), but does not reach normal range (NR); 3. systolic pressure is treated front decline 30mmHg (4kPa); Must possess wherein 1;
Invalid: not reach above standard.
After two groups of case treatments, curative effect comparative result is in table 4.
4. treatment results
Table 4. result for the treatment of
| Group | Number of cases | Effective n (%) | Effectively n (%) | Invalid n (%) | Total effective rate n (%) |
| Treatment group | 50 | 31(62) | 16(32) | 3(6) | 47(94.0) |
| Control group | 50 | 19(38) | 19(38) | 12(24) | 38(76) |
Experimental result shows, the antihypertensive effect for the treatment of group is better than control group, and P<0.05 has significant difference.
In experimentation, have slight depressive symptom drug withdrawal except control group has an example, all the other all patients have no any bad reaction simultaneously, and the light body for the treatment of group Most patients sensation body is strong.Ecological fermentation burdock tea of the present invention being described, having good hypotensive effect, be applicable to hyperpietic's long-term taking, is the daily treatment of hyperpietic and the desirable selection that keeps healthy.
The above, be only preferred embodiment of the present invention, is not the restriction of the present invention being made to other form, and the equivalence that any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as equivalent variations is implemented.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (10)
1. an ecological fermentation burdock product, is characterized in that, is prepared from by the raw material that contains following weight portion:
Fermentation burdock 200-600 mulberry leaf 100-400 Radix Astragali 40-100
Red sage root 30-60 mother chrysanthemum 20-80 Momordica grosvenori 10-20.
2. a kind of ecological fermentation burdock product according to claim 1, is characterized in that, is prepared from by the raw material that contains following weight portion:
Fermentation burdock 200-400 mulberry leaf 120-200 Radix Astragali 40-80
Red sage root 30-60 mother chrysanthemum 30-60 Momordica grosvenori 10-20.
3. according to a kind of ecological fermentation burdock product described in claim 1 and 2, it is characterized in that, be prepared from by the raw material that contains following weight portion:
Fermentation burdock 280 mulberry leaf 180 Radixs Astragali 48
The red sage root 36 mother chrysanthemum 36 Momordica grosvenoris 12.
4. according to a kind of ecological fermentation burdock product described in claim 1-3, it is characterized in that, described ecological fermentation burdock product is oral formulations.
5. a kind of ecological fermentation burdock product according to claim 4, is characterized in that, described oral formulations is preferably oral solid formulation; Described oral solid formulation is medicinal tea, tablet, granule, capsule, soft capsule or pill.
6. a preparation method for the oral formulations of ecological fermentation burdock product according to claim 4, is characterized in that, comprises the following steps:
Step 1. selects diameter at the fresh and healthy burdock of 2-3 centimetre, and the crust of burdock is removed; Clean, with slicer section, slice thickness is 1.0-3.0mm; Or be cut into the fourth of 0.2-1cm × 0.2-1cm;
Step 2. is put in the sheet cutting or fourth in baking box, vacuum drying at 60-80 DEG C;
The burdock after drying is placed in container by step 3., adds dusty yeast according to the ratio of weight ratio 100:0.1-5, till adding water to be stirred to burdock no longer to absorb moisture, and under room temperature, sealed fermenting 15-30 days;
Step 4. is put in the burdock after fermentation in baking box and dries, and pulverizes 10 mesh sieves;
Step 5. was pulverized 10 mesh sieves by mulberry leaf, the Radix Astragali, the red sage root, mother chrysanthemum, Momordica grosvenori respectively;
Step 6., by weight portion of the present invention, takes above-mentioned 6 kinds of raw material, adds 95% alcohol reflux that above-mentioned 6 kinds of raw material 8-10 doubly measure to extract 2-3 time, each 2-3 hour, merge extract, reclaim ethanol, the clear cream that while being evaporated to 50-60 DEG C, relative density is 1.20-1.30; The clear cream of gained dry, pulverize, and technique is prepared into oral formulations routinely.
7. preparation method according to claim 6, is characterized in that, in step 2, oven temperature is 80 DEG C; In step 3, the ratio of burdock and dusty yeast is 100:2, and the sealed fermenting time is 20 days.
8. a preparation method for the medicinal tea of ecological fermentation burdock product as claimed in claim 5, is characterized in that, comprises the following steps:
Step 1. selects diameter at the fresh and healthy burdock of 2-3 centimetre, and the crust of burdock is removed; Clean, with slicer section, slice thickness is 1.0-3.0mm; Or be cut into the fourth of 0.2-1cm × 0.2-1cm;
Step 2. is put in the sheet cutting or fourth in baking box, vacuum drying at 60-80 DEG C;
The burdock after drying is placed in container by step 3., adds dusty yeast according to the ratio of weight ratio 100:0.1-5, till adding water to be stirred to burdock no longer to absorb moisture, and under room temperature, sealed fermenting 15-30 days;
Step 4. is put in the burdock after fermentation in baking box and dries, and pulverizes 10 mesh sieves;
Step 5. was pulverized 10 mesh sieves by mulberry leaf, the Radix Astragali, the red sage root, mother chrysanthemum, Momordica grosvenori respectively;
Step 6. by weight portion of the present invention, takes above-mentioned 6 kinds of raw material and fully mixes, and is packaged into 5 grams every bag little packed with tea in bag wrapping paper; Be ecological fermentation burdock tea of the present invention.
9. preparation method according to claim 7, is characterized in that, in step 2, oven temperature is 70 DEG C, and in step 3, the ratio of burdock and dusty yeast is 100:2, and the sealed fermenting time is 20 days.
10. according to a kind of ecological fermentation burdock product described in claim 1-8, in the purposes of step-down, reduction lipid aspects.
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| CN107518330A (en) * | 2016-06-22 | 2017-12-29 | 李道明 | A kind of fermentation process of burdock food |
| CN110915966A (en) * | 2019-12-24 | 2020-03-27 | 徐州工程学院 | Composite burdock tea |
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