CN110404042B - Compound oral liquid with weight-losing and lipid-lowering functions and preparation method thereof - Google Patents
Compound oral liquid with weight-losing and lipid-lowering functions and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention provides a compound oral liquid with weight-losing and lipid-lowering functions, which is prepared from the following raw materials in parts by weight: 10-20 parts of hawthorn, 15-25 parts of momordica grosvenori, 10-15 parts of cassia seed, 10-20 parts of winter cherry, 5-10 parts of ginger, 2-7 parts of wolfberry fruit, 10-15 parts of medicinal cyathula root, 5-15 parts of dwarf lilyturf root, 20-25 parts of broadleaf holly leaf and 10-20 parts of liquorice. The composition is prepared by combining medicinal and edible raw materials, has the characteristics of pure nature, greenness and safety, does not need special diet when being taken, does not have any side effect or discomfort, is convenient to eat, has wide and easily-obtained medicinal sources and is low in price; the preparation process is simple, the operation is convenient, and the method is suitable for industrial production.
Description
Technical Field
The invention relates to the technical field of weight-losing products, in particular to a compound oral liquid with weight-losing and lipid-lowering functions and a preparation method thereof.
Background
At present, the number of people suffering from obesity and hyperlipidemia is rising continuously, but the curative effect caused by the side effect and rebound of the clinical weight-reducing medicine is not ideal, and the long-term administration of the blood fat-reducing medicine also has the side effect on liver and kidney. The patent adopts natural raw materials with dual purposes of medicine and food and develops a safe and effective weight-losing and lipid-lowering product through a scientific formula process. On the basis of looking up a large number of literatures and experiments, four raw materials are screened from ten medicinal and edible raw materials, the product has the best efficacy by optimizing the formula and the process, and meanwhile, the sense and the taste are improved, and the cost is reduced as much as possible. The product has the advantages of cheap and rich raw materials, simple production process and capability of positioning people mainly obesity with hyperlipidemia. Meanwhile, the product also has auxiliary treatment effect on patients with diabetes and hypertension.
Disclosure of Invention
The invention provides a compound oral liquid with weight-losing and lipid-lowering functions and a preparation method thereof, and aims to provide the compound oral liquid with the weight-losing and lipid-lowering functions, which has the characteristics of pure nature, greenness and safety by selecting medicinal and edible raw materials; the preparation process is simple, the operation is convenient, and the method is suitable for industrial production.
The invention provides a compound oral liquid with weight-losing and lipid-lowering functions, which is prepared from the following raw materials: hawthorn fruit, momordica grosvenori, cassia seed, sour pulp, ginger, medlar, medicinal cyathula root, dwarf lilyturf tuber, broadleaf holly leaf and liquorice.
As a further improvement of the invention, the health-care food is prepared from the following raw materials in parts by weight: 10-20 parts of hawthorn, 15-25 parts of momordica grosvenori, 10-15 parts of cassia seed, 10-20 parts of winter cherry, 5-10 parts of ginger, 2-7 parts of wolfberry fruit, 10-15 parts of medicinal cyathula root, 5-15 parts of dwarf lilyturf root, 20-25 parts of broadleaf holly leaf and 10-20 parts of liquorice.
As a further improvement of the invention, the medicine is prepared from the following raw materials: hawthorn fruit, momordica grosvenori, cassia seed and sour pulp.
As a further improvement of the invention, the medicine is prepared from the following raw materials: hawthorn fruit, momordica grosvenori, cassia seed and sour pulp.
The invention further provides a preparation method of the compound oral liquid with the functions of losing weight and reducing fat, which comprises the steps of weighing the raw material medicines, extracting to obtain a traditional Chinese medicine extract, uniformly mixing the traditional Chinese medicine extract with sterile water according to a proportion, adding a food emulsifier, a food stabilizer and a food antioxidant, stirring and emulsifying, adding xylitol, sodium citrate and potassium sorbate, uniformly stirring, standing, filtering, sterilizing and filling to obtain the compound oral liquid.
The further improvement of the invention comprises the steps of cleaning, drying and crushing the raw material medicines, soaking in water, heating to boil, decocting for 5-10h, cooling to room temperature, filtering, adding filter residues into an ethanol solution, carrying out reflux extraction at low temperature under reduced pressure for 3-5h, filtering, removing the filter residues, combining the two filtrates, concentrating under reduced pressure, and carrying out spray drying to obtain the traditional Chinese medicine extract.
As a further improvement of the invention, the mass ratio of the bulk drugs to water is 1: (5-15); the mass fraction of the ethanol solution is 75wt%, and the mass ratio of the filter residue to the ethanol solution is 1: (5-10).
As a further improvement of the invention, the emulsification process is stirring at 10000-15000r/min for 10-15 min.
As a further improvement of the invention, the sterilization is pasteurization.
The invention further protects the compound oral liquid with the functions of losing weight and lowering lipid.
The theory of the traditional Chinese medicine considers that the external cause of obesity and overstaffed is damaged by improper diet and fat, sweet and thick taste, and the internal cause is dysfunction of spleen, liver and kidney, spleen qi is weak, and water retention and transformation are lost, so that water-dampness internal stagnation is caused, water is collected into water, and the water is condensed into phlegm; kidney qi is deficient, so turbid qi cannot be discharged out of the body in time; liver qi fails to regulate qi flow, so turbid qi, phlegm and dampness are more obstructed in the body, and obesity and swelling are caused. Therefore, the prevention and treatment of obesity should avoid the fatness, sweetness and thick taste to protect the body from the outside, regulate the functions of spleen, liver and kidney, eliminate dampness by fragrance, regulate qi and promote movement, and eliminate phlegm and drink for internal use.
Modern medical theory holds that: obesity is an increase in the adipose tissue of the body, resulting in an increase in the proportion of adipose tissue to the body weight. The principle of weight loss is to achieve negative energy balance and promote the decomposition of fat. Controlling energy intake is a basic measure for preventing and controlling obesity, mainly controls the intake of three nutrients, namely fat, carbohydrate and protein and the transformation in vivo, improves the internal energy supply of the organism and achieves the aim of correcting the imbalance of substance metabolism.
The invention has the following beneficial effects:
the invention further screens and obtains 4 Chinese medicinal material combinations with obvious fat-reducing and fat-reducing effects from 10 Chinese medicinal materials with homology of medicine and food, and the oral liquid raw material medicine is obtained, has obvious effect and wide raw material source;
according to the invention, water is decocted to extract water-soluble active ingredients in the raw material medicines, an ethanol solution is adopted to reflux and extract alcohol-soluble active ingredients in the raw material medicines at low temperature, part of the alcohol-soluble active ingredients are insoluble in water, a food-grade emulsifier is adopted to emulsify when the oral liquid is finally prepared, a homogeneous component is obtained, a stabilizer is added for stabilization, and the oral liquid with long shelf life, delicate taste and uniform solution is obtained after potassium sorbate is preserved;
the invention adopts pasteurization to sterilize oral liquid, heats the mixed raw materials to 68-70 ℃, and rapidly cools the mixed raw materials to 4-5 ℃ after keeping the temperature for 30 min. Because the common bacterial dead points are all at the temperature of 68 ℃ and the time of below 30min, the bacteria can be killed by sudden cooling and sharp changes of heat and cold after heating, and simultaneously the active ingredients in the oral liquid are kept from being damaged by high temperature, so that the weight-losing and lipid-lowering effects of the oral liquid are improved;
the composition is prepared by combining medicinal and edible raw materials, has the characteristics of pure nature, greenness and safety, does not need special diet when being taken, does not have any side effect or discomfort, is convenient to eat, has wide and easily-obtained medicinal sources and is low in price; the preparation process is simple, the operation is convenient, and the method is suitable for industrial production.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.
FIG. 1 is a graph showing a comparison of the results of experiments on the effect of fat in obese mice in test example 1 of the present invention;
FIG. 2 is a comparison of the results of the clinical trial of the effect of weight loss in test example 2 of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The raw materials comprise the following components in parts by weight: 10 parts of hawthorn, 15 parts of momordica grosvenori, 10 parts of cassia seed, 10 parts of winter cherry, 5 parts of ginger, 2 parts of medlar, 10 parts of medicinal cyathula root, 5 parts of dwarf lilyturf tuber, 20 parts of broadleaf holly leaf and 10 parts of liquorice.
The preparation method comprises the following steps:
s1, preparation of the traditional Chinese medicine extract: cleaning raw materials, drying, pulverizing, soaking in water at a solid-to-liquid ratio of 1:5, heating to boil, decocting for 5 hr, cooling to room temperature, filtering, adding the residue into 75wt% ethanol solution at a solid-to-liquid ratio of 1:5, reflux extracting under reduced pressure at low temperature for 3 hr, filtering, removing the residue, mixing the filtrates, and concentrating under reduced pressure to density of 1.2g/cm3Spray drying to obtain Chinese medicinal extract;
s2 preparation of oral liquid: weighing the raw materials, extracting to obtain traditional Chinese medicine extract, mixing with sterile water at a ratio of 1:10, adding food emulsifier, food stabilizer and food antioxidant, stirring and emulsifying, wherein the emulsifying process comprises stirring at 10000r/min for 10min, adding xylitol, sodium citrate and potassium sorbate, stirring, standing, filtering, pasteurizing, sterilizing at 68 deg.C for 30min, cooling to 4 deg.C within 10s, and bottling.
Example 2
The raw materials comprise the following components in parts by weight: 20 parts of hawthorn, 25 parts of momordica grosvenori, 15 parts of cassia seed, 20 parts of winter cherry, 10 parts of ginger, 7 parts of medlar, 15 parts of medicinal cyathula root, 15 parts of dwarf lilyturf tuber, 25 parts of broadleaf holly leaf and 20 parts of liquorice.
The preparation method comprises the following steps:
s1, preparation of the traditional Chinese medicine extract: cleaning raw materials, drying, pulverizing, soaking in water at a solid-to-liquid ratio of 1:15, heating to boil, decocting for 10 hr, cooling to room temperature, filtering, adding the residue into 75wt% ethanol solution at a solid-to-liquid ratio of 1:10, reflux extracting under reduced pressure at low temperature for 5 hr, filtering, removing the residue, mixing the filtrates, and concentrating under reduced pressure to density of 1.5g/cm3Spray drying to obtain Chinese medicinal extract;
s2 preparation of oral liquid: weighing the raw materials, extracting to obtain traditional Chinese medicine extract, mixing with sterile water at a ratio of 1:10, adding food emulsifier, food stabilizer and food antioxidant, stirring and emulsifying, wherein the emulsifying process comprises stirring at 15000r/min for 15min, adding xylitol, sodium citrate and potassium sorbate, stirring, standing, filtering, pasteurizing, sterilizing at 70 deg.C for 30min, cooling to 5 deg.C within 10s, and bottling.
Example 3
The raw materials comprise the following components in parts by weight: 15 parts of hawthorn, 20 parts of momordica grosvenori, 12 parts of cassia seed, 15 parts of winter cherry, 7 parts of ginger, 5 parts of medlar, 11 parts of medicinal cyathula root, 10 parts of dwarf lilyturf tuber, 22 parts of broadleaf holly leaf and 15 parts of liquorice.
The preparation method comprises the following steps:
s1, preparation of the traditional Chinese medicine extract: cleaning raw materials, drying, pulverizing, soaking in water at a solid-to-liquid ratio of 1:10, heating to boil, decocting for 7 hr, cooling to room temperature, filtering, adding the residue into 75wt% ethanol solution at a solid-to-liquid ratio of 1:7, reflux extracting under reduced pressure at low temperature for 4 hr, filtering, removing the residue, mixing the filtrates, and concentrating under reduced pressure to density of 1.35g/cm3Spray drying to obtain Chinese medicinal extract;
s2 preparation of oral liquid: weighing the raw materials, extracting to obtain traditional Chinese medicine extract, mixing with sterile water at a ratio of 1:10, adding food emulsifier, food stabilizer and food antioxidant, stirring and emulsifying, wherein the emulsifying process comprises stirring at 12500r/min for 13min, adding xylitol, sodium citrate and potassium sorbate, stirring, standing, filtering, pasteurizing, sterilizing at 69 deg.C for 30min, cooling to 4 deg.C within 10s, and bottling.
Example 4
The raw materials comprise the following components in parts by weight: 10-20 parts of hawthorn, 15-25 parts of momordica grosvenori, 10-15 parts of cassia seed and 10-20 parts of winter cherry.
The preparation method comprises the following steps:
s1, preparation of the traditional Chinese medicine extract: cleaning raw materials, drying, pulverizing, soaking in water at a solid-to-liquid ratio of 1:10, heating to boil, decocting for 7 hr, cooling to room temperature, filtering, adding the residue into 75wt% ethanol solution at a solid-to-liquid ratio of 1:7, reflux extracting under reduced pressure at low temperature for 4 hr, filtering, removing the residue, mixing the filtrates, and concentrating under reduced pressure to density of 1.42g/cm3Spray drying to obtain Chinese medicinal extract;
s2 preparation of oral liquid: weighing the raw materials, extracting to obtain traditional Chinese medicine extract, mixing with sterile water at a ratio of 1:10, adding food emulsifier, food stabilizer and food antioxidant, stirring and emulsifying, wherein the emulsifying process comprises stirring at 12500r/min for 13min, adding xylitol, sodium citrate and potassium sorbate, stirring, standing, filtering, pasteurizing, sterilizing at 69 deg.C for 30min, cooling to 4 deg.C within 10s, and bottling.
Example 5
The raw materials comprise the following components in parts by weight: 20 parts of hawthorn, 25 parts of momordica grosvenori, 15 parts of cassia seed and 20 parts of winter cherry.
The preparation method comprises the following steps:
s1, preparation of the traditional Chinese medicine extract: cleaning raw materials, drying, pulverizing, soaking in water at a solid-to-liquid ratio of 1:10, heating to boil, decocting for 7 hr, cooling to room temperature, filtering, adding the residue into 75wt% ethanol solution at a solid-to-liquid ratio of 1:7, reflux extracting under reduced pressure at low temperature for 4 hr, filtering, removing the residue, mixing the filtrates, and concentrating under reduced pressure to density of 1.39g/cm3Spray drying to obtain Chinese medicinal extract;
s2 preparation of oral liquid: weighing the raw materials, extracting to obtain traditional Chinese medicine extract, mixing with sterile water at a ratio of 1:10, adding food emulsifier, food stabilizer and food antioxidant, stirring and emulsifying, wherein the emulsifying process comprises stirring at 12500r/min for 13min, adding xylitol, sodium citrate and potassium sorbate, stirring, standing, filtering, pasteurizing, sterilizing at 69 deg.C for 30min, cooling to 4 deg.C within 10s, and bottling.
Comparative example 1
The raw materials comprise the following components in parts by weight: 5 parts of hawthorn, 30 parts of momordica grosvenori, 5 parts of cassia seed and 40 parts of winter cherry.
The preparation method comprises the following steps:
s1, preparation of the traditional Chinese medicine extract: cleaning raw materials, drying, pulverizing, soaking in water at a solid-to-liquid ratio of 1:10, heating to boil, decocting for 7 hr, cooling to room temperature, filtering, adding the residue into 75wt% ethanol solution at a solid-to-liquid ratio of 1:7, reflux extracting under reduced pressure at low temperature for 4 hr, filtering, removing the residue, mixing the filtrates, and concentrating under reduced pressure to density of 1.39g/cm3Spray drying to obtain Chinese medicinal extract;
s2 preparation of oral liquid: weighing the raw materials, extracting to obtain traditional Chinese medicine extract, mixing with sterile water at a ratio of 1:10, adding food emulsifier, food stabilizer and food antioxidant, stirring and emulsifying, wherein the emulsifying process comprises stirring at 12500r/min for 13min, adding xylitol, sodium citrate and potassium sorbate, stirring, standing, filtering, pasteurizing, sterilizing at 69 deg.C for 30min, cooling to 4 deg.C within 10s, and bottling.
Comparative example 2
The raw materials comprise the following components in parts by weight: 80 parts of hawthorn.
The preparation method comprises the following steps:
s1, preparation of the traditional Chinese medicine extract: cleaning raw materials, drying, pulverizing, soaking in water at a solid-to-liquid ratio of 1:10, heating to boil, decocting for 7 hr, cooling to room temperature, filtering, adding the residue into 75wt% ethanol solution at a solid-to-liquid ratio of 1:7, reflux extracting under reduced pressure at low temperature for 4 hr, filtering, removing the residue, mixing the filtrates, and concentrating under reduced pressure to density of 1.39g/cm3Spray drying to obtain Chinese medicinal extract;
s2 preparation of oral liquid: weighing the raw materials, extracting to obtain traditional Chinese medicine extract, mixing with sterile water at a ratio of 1:10, adding food emulsifier, food stabilizer and food antioxidant, stirring and emulsifying, wherein the emulsifying process comprises stirring at 12500r/min for 13min, adding xylitol, sodium citrate and potassium sorbate, stirring, standing, filtering, pasteurizing, sterilizing at 69 deg.C for 30min, cooling to 4 deg.C within 10s, and bottling.
Comparative example 3
The raw materials comprise the following components in parts by weight: 80 parts of momordica grosvenori.
The preparation method comprises the following steps:
s1, preparation of the traditional Chinese medicine extract: cleaning raw materials, drying, pulverizing, soaking in water at a solid-to-liquid ratio of 1:10, heating to boil, decocting for 7 hr, cooling to room temperature, filtering, adding the residue into 75wt% ethanol solution at a solid-to-liquid ratio of 1:7, reflux extracting under reduced pressure at low temperature for 4 hr, filtering, removing the residue, mixing the filtrates, and concentrating under reduced pressure to density of 1.39g/cm3Spray drying to obtain Chinese medicinal extract;
s2 preparation of oral liquid: weighing the raw materials, extracting to obtain traditional Chinese medicine extract, mixing with sterile water at a ratio of 1:10, adding food emulsifier, food stabilizer and food antioxidant, stirring and emulsifying, wherein the emulsifying process comprises stirring at 12500r/min for 13min, adding xylitol, sodium citrate and potassium sorbate, stirring, standing, filtering, pasteurizing, sterilizing at 69 deg.C for 30min, cooling to 4 deg.C within 10s, and bottling.
Comparative example 4
The raw materials comprise the following components in parts by weight: 80 parts of cassia seed.
The preparation method comprises the following steps:
s1, preparation of the traditional Chinese medicine extract: cleaning raw materials, drying, pulverizing, soaking in water at a solid-to-liquid ratio of 1:10, heating to boil, decocting for 7 hr, cooling to room temperature, filtering, adding the residue into 75wt% ethanol solution at a solid-to-liquid ratio of 1:7, reflux extracting under reduced pressure at low temperature for 4 hr, filtering, removing the residue, mixing the filtrates, and concentrating under reduced pressure to density of 1.39g/cm3Spray drying to obtain Chinese medicinal extract;
s2 preparation of oral liquid: weighing the raw materials, extracting to obtain traditional Chinese medicine extract, mixing with sterile water at a ratio of 1:10, adding food emulsifier, food stabilizer and food antioxidant, stirring and emulsifying, wherein the emulsifying process comprises stirring at 12500r/min for 13min, adding xylitol, sodium citrate and potassium sorbate, stirring, standing, filtering, pasteurizing, sterilizing at 69 deg.C for 30min, cooling to 4 deg.C within 10s, and bottling.
Comparative example 5
The raw materials comprise the following components in parts by weight: 80 parts of wintercherry.
The preparation method comprises the following steps:
s1, preparation of the traditional Chinese medicine extract: cleaning raw materials, drying, pulverizing, soaking in water at a solid-to-liquid ratio of 1:10, heating to boil, decocting for 7 hr, cooling to room temperature, filtering, adding the residue into 75wt% ethanol solution at a solid-to-liquid ratio of 1:7, reflux extracting under reduced pressure at low temperature for 4 hr, filtering, removing the residue, mixing the filtrates, and concentrating under reduced pressure to density of 1.39g/cm3Spray drying to obtain Chinese medicinal extract;
s2 preparation of oral liquid: weighing the raw materials, extracting to obtain traditional Chinese medicine extract, mixing with sterile water at a ratio of 1:10, adding food emulsifier, food stabilizer and food antioxidant, stirring and emulsifying, wherein the emulsifying process comprises stirring at 12500r/min for 13min, adding xylitol, sodium citrate and potassium sorbate, stirring, standing, filtering, pasteurizing, sterilizing at 69 deg.C for 30min, cooling to 4 deg.C within 10s, and bottling.
Test example 1 Effect on fat in obese mice
Taking 50 mice, each half of the male and the female, weighing 18-22g, randomly dividing into 12 groups: a blank control group, an obesity model group, an example 1 group, an example 2 group, an example 3 group, an example 4 group, an example 5 group, a comparative example 1 group, a comparative example 2 group, a comparative example 3 group, a comparative example 4 group, and a comparative example 5 group. Except for the blank control group, the rest groups all take the obesity feed, wherein the obesity feed is prepared by adding 10g of milk powder, 10g of lard oil, 1.5g of cholesterol and 0.3g of deoxycholic acid into every 100g of the basic feed, and the rest groups are the basic feed. Gavage is carried out for 1 time every day, gavage is carried out for 42 days continuously, the weight is weighed for 1 time every 7 days, the mice are sacrificed 24 hours after the last gavage, abdominal fat is taken and weighed as wet weight, and the fat index is calculated. The results of the experiment are shown in FIG. 1.
As can be seen from the results in FIG. 1, after the 42d intragastric administration, the groups of examples 4 to 5 have a very significant reduction effect on the increase of fat index of obese mice (P < 0.01) compared with the blank group and the model group; examples 1-3 groups significantly reduced the fat index (P < 0.05) in obese mice. Comparative examples 1 to 5 had only slight weight loss effect and the effect was not significant.
Test example 2 clinical test for weight-reducing effect
A study of a feeding trial was conducted on 180 subjects aged 20 to 55 years (average age: 35 years) in 180 adults by taking the weight-reducing oral liquids prepared in examples 1 to 5 and comparative examples 1 to 5 and the commercially available similar weight-reducing oral liquids for 60 days. Subject conditions: the BMI of the simple obese people, adult male and female, is more than or equal to 30, the thickness of abdominal skin folds is more than 30mm, the waist circumference is more than 101cm, and the weight exceeds the standard weight by 20 percent. Standard body weight (kg) ═ body height (cm) -100 × 0.9.
Subject exclusion: (1) patients with serious diseases of heart, liver, kidney and hemopoietic system, and psychosis are complicated. (2) Taking articles related to the tested function in a short time affects the judgment of the result.
The test method comprises the following steps: the subjects took the weight-reducing oral liquids prepared in examples 1 to 5 of the present invention and comparative examples 1 to 5, and the commercially available weight-reducing oral liquids, continuously for 60 days, 1 bottle per time, 3 times a day, and before or during each meal. The blank group was dosed with equal amount of water.
And (3) detecting an efficacy index: weight, height, waist circumference (periumbilical), hip circumference, thigh circumference, percent fat on weight, and Body Mass Index (BMI) calculated.
And (3) test results:
the results of the physical form index test of 60 days after the subjects took the oral liquid prepared by the invention examples 1-5 and the comparative examples 1-5 and the similar commercial weight-reducing oral liquid are shown in figure 2. Note that: capital letters are compared to the blank, P is less than 0.01; lower case letters are compared to the blank, P < 0.05.
FIG. 2 shows that the oral liquids prepared in examples 1 to 5 have significantly reduced efficacy indexes (except height index) and significantly different (P < 0.01) compared with the blank group, such as weight, height, waist circumference, hip circumference, thigh circumference, abdominal sebum thickness, and percentage of fat in the weight, when the subject takes the oral liquid for 60 days; compared with the traditional Chinese medicine in example 5, the traditional Chinese medicine in the comparative example 1 has different mixture ratio and does not have good weight-losing effect; comparative examples 2 to 5 show that the oral liquid prepared from the single raw material medicines in example 5 in the same amount has a slight weight-reducing effect and an unobvious effect, and thus the oral liquid prepared from the raw material medicines can obviously play a role in reducing weight and fat, and each group of raw material medicines has a synergistic effect.
Compared with the prior art, the invention further screens and obtains 4 Chinese medicinal material combinations with obvious fat-reducing and fat-reducing effects from 10 Chinese medicinal materials with homology of medicine and food, and the oral liquid raw material medicine is obtained, has obvious effect and wide raw material source;
according to the invention, water is decocted to extract water-soluble active ingredients in the raw material medicines, an ethanol solution is adopted to reflux and extract alcohol-soluble active ingredients in the raw material medicines at low temperature, part of the alcohol-soluble active ingredients are insoluble in water, a food-grade emulsifier is adopted to emulsify when the oral liquid is finally prepared, a homogeneous component is obtained, a stabilizer is added for stabilization, and the oral liquid with long shelf life, delicate taste and uniform solution is obtained after potassium sorbate is preserved;
the invention adopts pasteurization to sterilize oral liquid, heats the mixed raw materials to 68-70 ℃, and rapidly cools the mixed raw materials to 4-5 ℃ after keeping the temperature for 30 min. Because the common bacterial dead points are all at the temperature of 68 ℃ and the time of below 30min, the bacteria can be killed by sudden cooling and sharp changes of heat and cold after heating, and simultaneously the active ingredients in the oral liquid are kept from being damaged by high temperature, so that the weight-losing and lipid-lowering effects of the oral liquid are improved;
the composition is prepared by combining medicinal and edible raw materials, has the characteristics of pure nature, greenness and safety, does not need special diet when being taken, does not have any side effect or discomfort, is convenient to eat, has wide and easily-obtained medicinal sources and is low in price; the preparation process is simple, the operation is convenient, and the method is suitable for industrial production.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (7)
1. The compound oral liquid with the functions of losing weight and reducing fat is characterized by being prepared from the following raw materials: 10-20 parts of hawthorn, 15-25 parts of momordica grosvenori, 10-15 parts of cassia seed, 10-20 parts of wintercherry, 5-10 parts of ginger, 2-7 parts of wolfberry fruit, 10-15 parts of medicinal cyathula root, 5-15 parts of dwarf lilyturf tuber, 20-25 parts of broadleaf holly leaf and 10-20 parts of liquorice;
the preparation method of the compound oral liquid with the functions of losing weight and reducing fat comprises the following steps:
weighing the raw materials, extracting to obtain traditional Chinese medicine extract, mixing with sterile water at a certain proportion, adding food emulsifier, food stabilizer and food antioxidant, stirring for emulsification, adding xylitol, sodium citrate and potassium sorbate, stirring, standing, filtering, sterilizing, and packaging.
2. The compound oral liquid with the functions of losing weight and reducing fat as claimed in claim 1, which is prepared from the following raw materials: according to the weight parts, 10 parts of hawthorn, 15 parts of momordica grosvenori, 10 parts of cassia seed, 10 parts of sour pulp, 5 parts of ginger, 2 parts of wolfberry fruit, 10 parts of medicinal cyathula root, 5 parts of dwarf lilyturf tuber, 20 parts of broadleaf holly leaf and 10 parts of liquorice.
3. The compound oral liquid with the functions of losing weight and reducing fat is characterized by being prepared from the following raw materials in parts by weight: 10-20 parts of hawthorn, 15-25 parts of momordica grosvenori, 10-15 parts of cassia seed and 10-20 parts of winter cherry.
4. The compound oral liquid with the functions of losing weight and reducing fat as claimed in claim 1, wherein the preparation method of the traditional Chinese medicine extract comprises the following steps: cleaning raw materials, drying, pulverizing, soaking in water, heating to boil, decocting for 5-10 hr, cooling to room temperature, filtering, adding the residue into ethanol solution, reflux extracting under reduced pressure at low temperature for 3-5 hr, filtering, removing residue, mixing the filtrates, concentrating under reduced pressure, and spray drying to obtain Chinese medicinal extract.
5. The compound oral liquid with the functions of losing weight and reducing fat according to claim 4, wherein the mass ratio of the raw material medicines to water is 1: (5-15); the mass fraction of the ethanol solution is 75wt%, and the mass ratio of the filter residue to the ethanol solution is 1: (5-10).
6. The compound oral liquid with the functions of losing weight and reducing fat as claimed in claim 1, wherein the emulsification process is stirring at 10000-15000r/min for 10-15 min.
7. The compound oral liquid with weight-losing and lipid-lowering functions as claimed in claim 1, wherein pasteurization is adopted for sterilization.
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Effective date of registration: 20211129 Address after: 517000 longtanwan Industrial Park (plant 2), Lanba village, Yuannan Town, Yuancheng District, Heyuan City, Guangdong Province Patentee after: Guangdong Jinzheng Food Co.,Ltd. Address before: 316000 plot C2-10, Xiaohui Industrial Zone, Putuo Zhanmao, Putuo marine science and Technology Industrial Park, Zhoushan City, Zhejiang Province Patentee before: Zhejiang Ocean University |