CN110404002A - A kind of essential oil for treating sleep disturbance and preparation method thereof and purposes - Google Patents
A kind of essential oil for treating sleep disturbance and preparation method thereof and purposes Download PDFInfo
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Abstract
The invention discloses a kind of essential oil for treating sleep disturbance and preparation method thereof and purposes, it is characterized in that, the essential oil is 290~310 parts of the monimopetalum chinense prepared with the raw material of following mass fraction, 140~160 parts, 140~160 parts of long column Camellia nitidissima of 200~360 part, thread agalloch eaglewood of Hyssopus officinalis.Essential oil raw material of the invention obtains simply, and preparation method is convenient.Clinical test results confirm: essential oil treatment sleep disturbance effect of the invention has good effect, is easy to be received by the majority of consumers, has a good application prospect and market prospects.
Description
Technical field
It is especially a kind of with treatment sleep disturbance effect the present invention relates to a kind of essential oil and preparation method thereof and purposes
Essential oil used for cosmetic and preparation method thereof and purposes.
Background technique
It is shown according to World Health Organization's data survey, the whole world has 27% people to have sleep disturbance, BEIJING CHAO-YANG HOSPITAL's sleep
" the 2018 Chinese Investigation on sleep quality report " of breathing center publication altogether investigates 100,000 people, and respondent covers the whole nation
All provinces.Investigation result shows, 16% surveyee there are less than 6 hours of Nighttime sleep, show as 24 points with
It just goes to bed, and gets up before 6 points afterwards；There is 83.81% surveyee to be often subject to sleeping problems puzzlement, wherein entering
It sleeps difficulty and accounts for 25.83%, shallow sleeper has 26.49%, and sleep insufficiency or insomnia are maximum latent at Chinese common people's health
Lie prostrate one of killer.Sleeping problems crowd's bring of substantial amounts is huge sleep industrial market.According to incompletely statistics, 2015
Year, China was related to improvement sleep product industry to segment market being 211,400,000,000, and by 2018, China integrally slept market (comprising getting into bed
Tool, household etc.) capacity is more than 1,000,000,000,000 yuan.Aromatotherapy is a kind of back to nature therapy for having long history, is combined
Art and treatment dual function, it is comprehensive to consider Human Physiology and demand in the abyss of the mind.Essential oil molecule is small, is approximately human body
The 1/500 of cell, essential oil molecule can act on human body by way of sucking, and in air-breathing, essential oil is brought into nasal cavity highest
Point, about 6s can reach brain olfactory area, trigger the release of chemical substance in nervous system, generate calm relaxation or stimulation mentions
Vibration effect.4~12h of essential oil molecule is excreted by the excretas such as sweat, urine and expiration, generally will not be as most chemical drugs
Object is such, and residual is in vivo.Result of study shows that some aromatic essential oils have sedation to nervous system, such as sweet tea wild marjoram
Essential oil, German Chamomile essential oil and Lavender.Familiar Lavender also has significant function in terms of relieving mental strain and helping sleep
Effect.To insomniac caused by melancholy or anxiety, bathed using evening with Lavender, or in handkerchief or pillow cover before sleeping
The mode of the upper a little Lavenders of drop, can effectively improve sleep.In conclusion the significant novel therapeutic sleep of development effectiveness
The essential oil product of obstacle has a vast market.
Summary of the invention
Place that purpose of the invention is to overcome the shortcomings in the prior art provides novel the having of one kind and treats sleep
Obstructive action essential oil and its preparation process.
The essential oil with treatment sleep disturbance effect of the present invention, is with monimopetalum chinense, Hyssopus officinalis, silk agalloch eaglewood, long column
Camellia nitidissima is raw material preparation, and the weight percentage of any component is no more than the 30% of total amount.
The essential oil for treating sleep disturbance is prepared with the raw material of following mass fraction: 290~310 parts of monimopetalum chinense, mind are fragrant
Careless 200~260 part, thread agalloch eaglewood grass 140~160,140~160 parts of long column Camellia nitidissima,.
Preferably, the essential oil with skin moisture-keeping effect, is to be prepared with the raw material of following parts by weight: monimopetalum chinense
300 parts, 150 parts, 150 parts of long column Camellia nitidissima of 250 part, thread agalloch eaglewood of Hyssopus officinalis.
In order to solve the above-mentioned technical problem, the present invention also provides the methods for preparing above-mentioned essential oil.
The method provided by the invention for preparing above-mentioned essential oil the following steps are included:
(1) ultra high pressure treatment: by 290~310 parts of monimopetalum chinense, 200~260 part, thread agalloch eaglewood grass 140~160 of Hyssopus officinalis, length
140~160 parts of column Camellia nitidissima, be uniformly mixed, place it is dry in an oven crush for 24 hours, cross 40 meshes, be subsequently placed in vacuum packet
Vacuum sealing in pack, then vacuum bag is placed in the extra-high tension unit of the vast Bioisystech Co., Ltd of Tyson, Tianjin China, it is arranged
Pressure 300MPa, dwell time 10min carry out ultra high pressure treatment；
(2) it extracts: plant composition described in step (1) is placed in Nantong Oil Co., Ltd, Huaxing SFE130-
50-02C type supercritical fluid extraction equipment, as shown in Figure 1, setting CO2 flow 24L/h, the pressure of separator 1 is 8MPa, temperature
Degree is 30 DEG C, and the pressure of separator 2 is 6MPa, and temperature is 25 DEG C, and the pressure of separator 1 is 4.5MPa, and temperature is 15 DEG C, is obtained
Medicinal extract；
(3) molecular distillation isolates and purifies: the resulting medicinal extract of supercritical extract described in step (2) is dissolved in 10 times of volumes
In 50 DEG C of dehydrated alcohols, it is filtered by 1 μm of strainer again after cooling to remove most of wax, then in 70 DEG C of conditions
Under, ethyl alcohol concentrate is obtained using vacuum distillation, ethyl alcohol concentrate is then placed in German UIC-Gmb H company KDL5 type knifing
In formula molecular distillation apparatus, fixed feed rate is set as 1mL/min, knifing rotating speed 150r/min, vapo(u)rizing temperature is 80 DEG C
It is 100Pa with distillation pressure, cryosurface temperature is 5 DEG C, and the second alcohol and water in concentrate is completely removed.Ethyl alcohol will finally be removed
Be fitted into bottle for material with the concentrate of water, set separating technology parameter: as 1mL/min, knifing rotating speed is fixed feed rate
350r/min, vapo(u)rizing temperature are 120 DEG C, vacuum degree 3.0Pa, and cryosurface temperature is 5 DEG C, obtain purification essential oil.
Fig. 1 SFE130-50-02C type supercritical fluid extraction equipment schematic diagram
In China, aromatotherapy is also known as champignon therapy, i.e., pressure of being releived using plants essential oil and enhancement health
A kind of naturopathy.Usually used essential oil can be one kind, be also possible to several essential oils and mix, to improve
Curative effect.Conventional 2~5 monosodium glutamate oil constitute formula, according to the characteristic and chemical property of various different essential oils, make after combined allotment
At finished product.There are many kinds of the modes of essential oil treatment, including the methods of fumigation, shower, massage, scraping, sucking, oral, passes through people
The smell of body, the sense of taste, feeling function absorb the hormone of plant via skin, digestive system and respiratory system, adjust human body
The systems such as central nervous system, blood circulation, endocrine make body and mind restore to coordinate, eliminate the feelings such as melancholy, anxiety, unhappiness, indignation
The feeling of thread and fatigue.Root of the present invention from a large amount of natural plant essential oils, is selected it is documented that with many experiments screening
Monimopetalum chinense, Hyssopus officinalis, silk agalloch eaglewood, long column Camellia nitidissima are raw material, have prepared described having and have treated sleep disturbance effect
Essential oil, wherein the monimopetalum chinense selects Celastraceae (Celastraceae) monimopetalum chinense to belong to Monimopetalum Rehd. single
The dry flower of platymiscium monimopetalum chinense Monimopetalum chinense Rehd.；Hyssopus officinalis selects Labiatae Hyssopus officinalis platymiscium
The drying herb of hard point Hyssopus officinalis Hyssopus cuspidatus Boriss.；It is Thymelaeceae eaglewood that silk agalloch eaglewood, which is selected,
Silk agalloch eaglewood A. filarial (Oken) Merr. contains the core material of resin；Long column Camellia nitidissima selects Theaceae Camellia long column golden flower
The drying blade of tea (Camellia. nitidissma var.Longistyla).All bulk pharmaceutical chemicals are through Guangdong Provincial TCM Hospital Yuan
The small red director pharmacist of traditional Chinese medicine identifies Ji Yuan, while quality meets using standard, and sample voucher, which is stored in Guangzhou blueness haze biotechnology, to be had
Limit company sample room.
Root it is documented that:
Monimopetalum chinense is that Celastraceae (Celastraceae) monimopetalum chinense belongs to Monimopetalum Rehd. single platymiscium valve forever
The dry flower of rattan Monimopetalum chinense Rehd., monimopetalum chinense category Celastraceae, monimopetalum chinense kind, with general Celastraceae
For blade to raw difference, it is single allagophyllous, very rare, researching value with higher.Monimopetalum chinense is distinctive state, China
Family's rare imminent extinction protected plants of second level.Tai Renchang has found the plant in Anhui south Qimen County in nineteen twenty-six for the first time, intends entitled " Qi at that time
Rattan ", because its petal is harbored in fruit without withering and falling, therefore middle name is called always monimopetalum chinense.Monimopetalum chinense rare numbers, are only grown in
Anhui Jiangxi borders on area, and is in Disjunct distribution.Its leaf is papery, and spring and summer is green, and autumn switchs to brownish red, and winter becomes dark red
Color.In the next spring, blade is again gradually green by red turn, carries out photosynthesis, falls to long become a useful person of young leaves.Petal is in cochlear, light green color, companion
With ovary development to fruit maturation, do not wither and fall still.
Hyssopus officinalis is the drying of point Hyssopus officinalis Hyssopus cuspidatus Boriss. firmly of Labiatae Hyssopus officinalis platymiscium
Herb, Hyssopus officinalis introduce China's cultivation in nineteen ninety-five originating from Europe.Hyssopus officinalis alias hyssop, hyssop, spray, tender tip
Salad, condiment can be made or extract aromatic oil and be used as sweet wine fragrance, flower is for ornamental.Hyssopus officinalis complete stool, which is used as medicine, sweating removing toxic substances,
The effect of anti-inflammatory detumescence, preventing phlegm from forming and stopping coughing.
Silk agalloch eaglewood is the core material that Thymelaeceae eaglewood silk agalloch eaglewood A.filarial (Oken) Merr. contains resin, is sunk
Perfume (or spice) is the natural mixture matter collectively constituted by xylem organization and its secretion that tree species are formed during the growth process.Agalloch eaglewood is
China's rare Chinese medicine and conventional fragrant qi-regulating drug, have continued to use thousands of years in traditional Chinese medicine, Tibetanmedicine and Ayurvedic medicine,
Have effects that " promoting qi circulation and relieving pain, warming middle energizer to arrest vomiting, gas of receiving are relievingd asthma ".Modern pharmacology drug efficacy study shows agalloch eaglewood in tranquilizing and allaying excitement, tune
Section gastrointestinal function, antibacterial, anti-inflammatory, antitumor etc. all have extensive medical value, make in prescription a more than 160
With.Agalloch eaglewood integrates the value of medicinal, fragrance, religion culture and collection etc., deep to be pursued by people, occupies " heavy Tan Long
First of the big name perfume of musk deer " four, good reputations such as " gold in medicine " " king in perfume " " diamonds in plant " are enjoyed.
Long column Camellia nitidissima is Theaceae Camellia long column Camellia nitidissima (Camellia.nitidissma
Var.Longistyla drying blade).Long column Camellia nitidissima is the distinctive plant resources in Guangxi Zhuang Autonomous Region, wherein containing rich
Rich polysaccharide, flavonoids, tea polyphenols, saponin(e isoreactivity chemical component and a variety of pairs of human bodies have important health-care effect germanium,
Selenium, molybdenum, vanadium, manganese, zinc and a great number of elements potassium, calcium, magnesium etc.；Also contain lysine, threonine, glutamic acid, serine, asparagus fern ammonia
The amino acid such as acid.Long column Camellia nitidissima not only has high ornamental value, but also has certain nutritive and medicinal value, quilt
It is described as " national treasure mind tea ".Clinical experimental study proves that long column golden camellia tea has enhancing immunity of organisms, enhancing myocardial contraction
Power, enhancing blood vessel elasticity promote liver metabolism, anti-aging, inhibit tumour, reduce serum cholesterol, reduce blood pressure, human activin
The effects of various biological enzyme, balance body various functions.
Currently, both at home and abroad there is not yet by monimopetalum chinense, Hyssopus officinalis, silk agalloch eaglewood, long column Camellia nitidissima composition be used for treat sleep
The relevant report of dormancy obstacle.In conclusion being looked into the beneficial effects of the present invention are the cause of disease and pathomechanism according to sleep disturbance
A large amount of monographs and document have been read, a variety of natural plants are successively screened, has filtered out the essential oil that can effectively treat sleep disturbance finally.
Essential oil raw material of the invention obtains simply, and preparation method is convenient.Clinical test results confirm: essential oil fragrant of the invention,
It, which treats sleep disturbance effect, has good effect, is easy to be received by the majority of consumers, has a good application prospect and city
Field prospect.
Detailed description, art technology are done to technical solution of the present invention in foregoing invention content of the present invention part
Personnel are according to the i.e. repeatable present invention of above content and obtain technical effect of the present invention.Below by specific embodiment
The content of present invention is further explained, so that those skilled in the art are more clearly understood that the present invention, not to the present invention
Limitation, any equivalent replacement or it is known change belong to the scope of the present invention.
Specific embodiment
Embodiment 1
300 grams of monimopetalum chinense, 250 150 grams, 150 grams of long column Camellia nitidissima of gram, thread agalloch eaglewood grass of Hyssopus officinalis are uniformly mixed, placed
It is dry in an oven to crush for 24 hours, 40 meshes are crossed, are subsequently placed in vacuum sealing in vacuum packaging bag, then vacuum bag is placed in Tianjin
In the extra-high tension unit of the magnificent vast Bioisystech Co., Ltd of Tyson, setting pressure 300MPa, dwell time 10min carry out super-pressure
Processing；Plant composition noted earlier is placed in Nantong Oil Co., Ltd, Huaxing SFE130-50-02C type shooting flow
Body extraction equipment, as shown in Figure 1, setting CO2 flow 24L/h, the pressure of separator 1 is 8MPa, and temperature is 30 DEG C, separator 2
Pressure be 6MPa, temperature is 25 DEG C, and the pressure of separator 1 is 4.5MPa, and temperature is 15 DEG C, obtains medicinal extract；It then will be described
The resulting medicinal extract of supercritical extract is dissolved in 50 DEG C of dehydrated alcohols of 10 times of volumes, is carried out again by 1 μm of strainer after cooling
Filter then under the conditions of 70 DEG C, obtains ethyl alcohol concentrate using vacuum distillation, then ethyl alcohol is concentrated to remove most of wax
Liquid is placed in German UIC-Gmb H company KDL5 type wiped film molecular distillation device, sets fixed feed rate as 1mL/min,
Knifing rotating speed is 150r/min, and vapo(u)rizing temperature is 80 DEG C and distillation pressure is 100Pa, and cryosurface temperature is 5 DEG C, will be in concentrate
Second alcohol and water completely remove.Finally the concentrate for removing second alcohol and water is fitted into bottle for material, sets separating technology parameter: Gu
Determining feed rate is 1mL/min, and knifing rotating speed 350r/min, vapo(u)rizing temperature is 120 DEG C, and vacuum degree is 3.0 Pa, cryosurface
Temperature is 5 DEG C, obtains purification essential oil.Finally at room temperature, gained essential oil is stored in brown seal glass bottle, room temperature is kept away
Light storage.
Embodiment 2
By the essential oil obtained of embodiment 1, it is used to prepare the champignon liquid for the treatment of sleep disturbance, the weight percent of component is such as
Under:
Production technology: all components are stirred evenly at 30 DEG C.
Matrix components used in present pre-ferred embodiments are as described above, matrix components used in the present embodiment can be by this
The effect of essential oil of invention, performs to most preferably.But the common matrix that can be applied to cosmetics of other producer's productions can also be used for this
Invention, as long as dosage meets national cosmetic additive amount standard, will not influence effect of the present invention, therefore do not arrange one by one
It lifts.Emulsifying equipment used in the present invention is the FV-30L FISCO of Shanghai Frock Fluid Machinery Manufacture Co., Ltd.'s production
Vacuum homogeneous emulsifying machine has the functions such as homogeneous, stirring and temperature control.The homogenized milk for cosmetics preparation of other producer's productions
Changing equipment can be used for the present invention, as long as being operated in strict accordance with technological parameter of the present invention, can reach this hair
The bright effect.
Embodiment 3
This research is by observing the influence of essential oil of the invention to sleep disturbance, in human body level verification essential oil of the invention
The curative effect of sleep disturbance is treated, material used in experiment is champignon liquid prepared by embodiment 2.
1. materials and methods
1.1 sleep disturbance patient's general information observe case be 2 months in Mays, 2019 in 2017 Guangzhou Zi Hetang good fortune and
Medical sleep disturbance patient 60 of traditional chinese medical science clinic, wherein male 28, women 32, the age 30.3~8.4 (31.24 ±
6.76) year.Before experiment starts, all patients sign informed consent form.Using random card envelope, in strict accordance with card serial number
Regulation grouping and treatment.Treatment group and control group be divided into the patient for meeting the standard of being included in, every group each 30.30 trouble for the treatment of group
Male 16 in person, women 14, average age be (40.86 ± 6.33) year, average course of disease be (5.68 ± 1.23) year, control
Group 30 patients in male 14, women 18, average age be (40.12 ± 6.95) year, average course of disease be (5.24 ±
1.57) year, the gender of 2 groups of patients, age, the course of disease, Pittsburgh Sleep Quality Index scale (Pittsburgh sleep
Quality index, PSQD scoring is compared, and comparing difference is not statistically significant (P > 0.05) between no significant difference,
It is comparable.Two groups of patients respectively carry out a sleep laboratory before and after clinical test, and place is selected at clean, noiseless
Clinic's sleep consulting room carries out, space 15m2, temperature setting is 26 DEG C, sound insulation, good every light effect.Patient closes before testing
All electronic equipments such as mobile phone, PDA, sleep is whole to be influenced, without the external world without electronic interferences.Menstrual period does not check.Patient cannot
In the state starved or satiated excessively.Two groups of patient compliances are good, and no adverse events occur, and research process is without falling off.
1.2 diagnostic criteria are referring to " Chinese Spirit obstacle diagnosis and classification standard ", almost with insomnia for unique symptom, packet
It includes: 1) having difficulty in going to sleep, sleep not depth, dreaminess, early awakening, or be not easy to sleep again after waking up, sense of discomfort, tired or daytime sleepiness after waking up
Deng；2) there is the tendency of insomnia and extremely concern insomnia result；3) apparent worries are caused to sleep quantity, the discontented of quality
Or social function is impaired；4) at least occur 3 times weekly, and at least 1 month；It 5) is not any physical disease or spirit barrier
Hinder a part of symptom.
1.3 are included in standard 1) there is insomnia classical symptom, it is per week at least to break out 3 times, and continue 1 month or more；2) it accords with
Close insomnia diagnostic criteria；3) age 18~50 years old, male or female；4) voluntarily receive treatment.
1.4 exclusion criterias 1) it is all to stable class drug addicts；2) it is tight that liver, kidney, tumour and hemopoietic system etc. are associated with
Weight primary disease person；3) mental patient；4) gestation, breast feeding women；5) it is unable to complier；6) it takes and has an impact to research
Other drugs.
The champignon liquid that 1.5 treatment method treatment groups use is provided by Guangzhou Qing Lan Biotechnology Co., Ltd, application method
The liquid storage of K401 fumigating machine (Guangzhou Arnold's Ma Environmental Protection Technology Co., Ltd) is added for the champignon liquid that treatment group prepares embodiment 2
In bottle, 1h opens fumigating machine before patient's sleep, sets 15 watts of power, and long-pressing is sprayed key and starts by spraying, and periodically 3 hours, 1
Times/day.Then only pure water is added in the liquid storage bottle of K401 fumigating machine for control group, other same treatment groups of condition, two groups of treatments
Curative effect is observed after 60 days, carries out therapeutic evaluation, and record adverse reaction.
1.6 parameters for observation on effect and standards of grading: curative effect is evaluated referring to " new Chinese medicine guideline of clinical investigations ".It is clinical
Recovery from illness: sleeping time restores normal or Nighttime sleep in 6h or more, wakes up rear energetic；Effective: sleep is clearly better, and sleeps
Sleep time increase 3h or more, and Depth of sleep increases, and the state of mind is obviously improved earlier above after waking up；Effective: symptom mitigates, sleeping time
Increase earlier above, less than 3h；Invalid: insomnia is not improved or aggravates after treatment.Meanwhile sleep quality is evaluated according to PSQI, it should
By 9 self-appraisals and 5, he comments item design to questionnaire, and 7 factors are made of 18 entries, and range is at 0~21 point, PSQI
Total score >=8 point are represented there are sleep disordered, and the higher expression sleep quality of score is poorer.Effective percentage is to fully recover plus effective added with effect
Meter.
2. result
After treatment 60 days, the sleep disturbance for the treatment of group patient is obviously improved, and total effective rate 83.33%, control group always has
Efficiency only has 30.00%, and treatment group's total effective rate is apparently higher than control group (P < 0.01), and see Table 1 for details.
12 groups of Clinical efficacy comparison N (p/%) of table
Note: compared with treatment group, * P < 0.05, * * P < 0.01.
PSQI scoring is compared before two groups of patients treat, no significant difference (P > 0.05).Treatment group PSQI scoring ratio
It decreased significantly before treatment, otherness is statistically significant (P < 0.01) compared with before treatment.Treatment group's various functions index
Compared with the control group, difference is statistically significant (P < 0.01) for situation of change, is shown in Table 2.
2 two groups of patient PSQI scorings of table are compared
Note: compared with before treatment, * P < 0.05, * * P < 0.01；Compared with the control group, Δ P < 0.05, Δ Δ P <
0.01。
Adverse reaction does not occur before and after treatment for product safety assessment, and no 1 patient falls off.Entire research process is not sent out
It is raw to close Adverse Event with the champignon liquid phase containing essential oil of the present invention.
In conclusion the sleep disturbance cause of disease is complicated, the course of disease is very long, lacks effective treatment means at present.This result of study
It has been shown that, essential oil of the invention can significantly improve the sleep quality of sleep disturbance patient, highly-safe, have very high clinical application
Value, is worthy of popularization.
Present invention is not limited to the embodiments described above, without departing from the essence of the present invention, this field skill
Any deformation, improvement, the replacement that art personnel are contemplated that each fall within the scope of the present invention.
Claims (4)
1. the essential oil for treating sleep disturbance, it is characterised in that: be using monimopetalum chinense, Hyssopus officinalis, silk agalloch eaglewood, long column Camellia nitidissima as raw material
Preparation, and the weight percentage of any component is no more than the 30% of total amount.
2. the essential oil for the treatment of sleep disturbance according to claim 1, which is characterized in that be with the raw material of following mass fraction
Preparation: 290~310 parts of monimopetalum chinense, 200~260 part, thread agalloch eaglewood grass 140~160 of Hyssopus officinalis, long column Camellia nitidissima 140~160
Part.
3. the essential oil for the treatment of sleep disturbance according to claim 2, which is characterized in that be with the raw material of following mass fraction
Preparation: 300 parts of monimopetalum chinense, 150 parts, 150 parts of long column Camellia nitidissima of 250 part, thread agalloch eaglewood of Hyssopus officinalis.
4. application according to claims 1 to 3, which is characterized in that the preparation method of the essential oil, including walk as follows
It is rapid:
(1) ultra high pressure treatment: by 290~310 parts of monimopetalum chinense, 200~260 part, thread agalloch eaglewood grass 140~160 of Hyssopus officinalis, long column gold
140~160 parts of jasmine tea are uniformly mixed, and place drying in an oven for 24 hours, crush, cross 40 meshes, be subsequently placed in vacuum packaging bag
Vacuum sealing, then vacuum bag is placed in the extra-high tension unit of the vast Bioisystech Co., Ltd of Tyson, Tianjin China, pressure is set
300MPa, dwell time 10min carry out ultra high pressure treatment；
(2) it extracts: plant composition described in step (1) is placed in Nantong Oil Co., Ltd, Huaxing SFE130-50-
02C type supercritical fluid extraction equipment, as shown in Figure 1, setting CO2 flow 24L/h, the pressure of separator 1 is 8MPa, and temperature is
30 DEG C, the pressure of separator 2 is 6MPa, and temperature is 25 DEG C, and the pressure of separator 1 is 4.5MPa, and temperature is 15 DEG C, is soaked
Cream；
(3) molecular distillation isolates and purifies: the resulting medicinal extract of supercritical extract described in step (2) is dissolved in 50 DEG C of 10 times of volumes
In dehydrated alcohol, it is filtered by 1 μm of strainer again after cooling to remove most of wax, then under the conditions of 70 DEG C, is adopted
Ethyl alcohol concentrate is obtained with vacuum distillation, ethyl alcohol concentrate is then placed in German UIC-Gmb H company KDL5 type scraped film type point
In sub- distilling apparatus, fixed feed rate is set as 1mL/min, knifing rotating speed 150r/min, vapo(u)rizing temperature is 80 DEG C and steams
Evaporating pressure is 100Pa, and cryosurface temperature is 5 DEG C, and the second alcohol and water in concentrate is completely removed.Second alcohol and water will finally be removed
Concentrate be fitted into bottle for material, set separating technology parameter: fixed feed rate is 1mL/min, knifing rotating speed 350r/
Min, vapo(u)rizing temperature are 120 DEG C, vacuum degree 3.0Pa, and cryosurface temperature is 5 DEG C, obtain purification essential oil.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111000939A (en) * | 2019-11-07 | 2020-04-14 | 广州青岚生物科技有限公司 | Essential oil for treating depression and preparation method and application thereof |
| CN111423937A (en) * | 2020-05-19 | 2020-07-17 | 广州市天然芳香科学技术研究院有限公司 | Aquilaria agallocha fireless aromatherapy liquid and preparation method and application thereof |
-
2019
- 2019-07-15 CN CN201910664702.2A patent/CN110404002A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111000939A (en) * | 2019-11-07 | 2020-04-14 | 广州青岚生物科技有限公司 | Essential oil for treating depression and preparation method and application thereof |
| CN111423937A (en) * | 2020-05-19 | 2020-07-17 | 广州市天然芳香科学技术研究院有限公司 | Aquilaria agallocha fireless aromatherapy liquid and preparation method and application thereof |
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