CN110381986B - 用于血管外施予以治疗或预防凝血疾病的截短型冯维勒布兰德因子多肽 - Google Patents

用于血管外施予以治疗或预防凝血疾病的截短型冯维勒布兰德因子多肽 Download PDF

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Publication number
CN110381986B
CN110381986B CN201780069945.0A CN201780069945A CN110381986B CN 110381986 B CN110381986 B CN 110381986B CN 201780069945 A CN201780069945 A CN 201780069945A CN 110381986 B CN110381986 B CN 110381986B
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fviii
administered
recombinant polypeptide
cys
leu
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CN110381986A (zh
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S·佩斯特尔
E·拉凯
T·韦默
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CSL Behring Lengnau AG
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CSL Behring Recombinant Facility AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201780069945.0A 2016-11-11 2017-11-10 用于血管外施予以治疗或预防凝血疾病的截短型冯维勒布兰德因子多肽 Active CN110381986B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16198497 2016-11-11
EP16198497.6 2016-11-11
PCT/EP2017/078840 WO2018087271A1 (en) 2016-11-11 2017-11-10 Truncated von willebrand factor polypeptides for extravascular administration in the treatment or prophylaxis of a blood coagulation disorder

Publications (2)

Publication Number Publication Date
CN110381986A CN110381986A (zh) 2019-10-25
CN110381986B true CN110381986B (zh) 2023-08-18

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CN201780069945.0A Active CN110381986B (zh) 2016-11-11 2017-11-10 用于血管外施予以治疗或预防凝血疾病的截短型冯维勒布兰德因子多肽

Country Status (12)

Country Link
US (1) US11890327B2 (https=)
EP (1) EP3538134B1 (https=)
JP (1) JP2020504082A (https=)
KR (1) KR20190073576A (https=)
CN (1) CN110381986B (https=)
AU (1) AU2017358865A1 (https=)
CA (1) CA3043397A1 (https=)
DK (1) DK3538134T3 (https=)
ES (1) ES2908008T3 (https=)
SG (2) SG11201903954WA (https=)
TW (1) TW201828974A (https=)
WO (1) WO2018087271A1 (https=)

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IL319473A (en) 2016-12-02 2025-05-01 Bioverativ Therapeutics Inc Methods for treating hemophilic arthritis using chimeric blood clotting factors
BR112020022164A2 (pt) 2018-05-18 2021-02-02 Bioverativ Therapeutics Inc. métodos de tratamento de hemofilia a
CN114072420B (zh) * 2019-07-04 2024-06-11 康诺贝林伦瑙有限公司 用于增加凝血因子viii的体外稳定性的截短的血管性血友病因子(vwf)
JP7680442B2 (ja) 2019-11-11 2025-05-20 ツェー・エス・エル・ベーリング・レングナウ・アクチエンゲゼルシャフト 第ｖｉｉｉ因子に対する寛容を誘導するためのポリペプチド
KR102647642B1 (ko) * 2021-05-04 2024-03-15 (주)케어젠 혈액 응고 활성을 갖는 펩타이드와 이의 용도

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CN104411716A (zh) * 2012-04-24 2015-03-11 诺和诺德A/S（股份有限公司） 适用于治疗血友病的化合物
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CN104411323A (zh) * 2012-04-24 2015-03-11 诺和诺德A/S（股份有限公司） 适用于治疗血友病的药物组合物
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CA3043397A1 (en) 2018-05-17
JP2020504082A (ja) 2020-02-06
CN110381986A (zh) 2019-10-25
TW201828974A (zh) 2018-08-16
DK3538134T3 (da) 2022-02-07
WO2018087271A1 (en) 2018-05-17
EP3538134A1 (en) 2019-09-18
SG10201912768YA (en) 2020-02-27
KR20190073576A (ko) 2019-06-26
AU2017358865A1 (en) 2019-05-09
SG11201903954WA (en) 2019-05-30
EP3538134B1 (en) 2021-12-29
ES2908008T3 (es) 2022-04-27
US20210268071A1 (en) 2021-09-02
US11890327B2 (en) 2024-02-06

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