CN110368409A - A kind of Radix Angelicae Sinensis prepared slices of Chinese crude drugs and preparation method thereof - Google Patents
A kind of Radix Angelicae Sinensis prepared slices of Chinese crude drugs and preparation method thereof Download PDFInfo
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
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- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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Abstract
The present invention relates to prepared slices of Chinese crude drugs technical fields, and in particular to a kind of Radix Angelicae Sinensis prepared slices of Chinese crude drugs and preparation method thereof.The preparation method includes the following steps: A, sorting, cleaning；B, profit leaching；C, it is sliced, steams；D, vacuum freeze drying, crushing；E, it embeds；F, drying, tabletting.Preparation method process of the invention is simple, it operates easily controllable, high production efficiency, it is at low cost, by using the processing mode of embedding, active functional component in Radix Angelicae Sinensis is effectively protected, moisture content≤4.5%, Ligustilide content is 57.83-58.64%, ferulaic acid content is 0.061-0.073%, and the Radix Angelicae Sinensis prepared slices of Chinese crude drugs obtained can be made easy to dissolve, it is easy to be digested, it absorbs, dissolution rate is 97.25-98.88%, and bacteria can be prevented from growing, aflatoxin B1 content is 1.6-2.3 μ g/kg, shelf-life is longer, quality is stablized, it can be used for large-scale industrial production.
Description
Technical field
The present invention relates to prepared slices of Chinese crude drugs technical fields, and in particular to a kind of Radix Angelicae Sinensis prepared slices of Chinese crude drugs and preparation method thereof.
Background technique
It is sweet in flavor, pungent when being classified as umbelliferae, it is warm-natured, return liver, the heart, the spleen channel, there is replenishing and activating blood, menstruction regulating and pain relieving, profit
Intestines defaecation, anticancer, immune, anti-ageing anti-effect of waiting for a long time.
And it is a big characteristic of Chinese traditional treatment that medicine materical crude slice, which is used as medicine, is that Chinese medicine is passed through the processes such as screening, cutting, processing, system
At the finished product of certain specification.But in current processing and treating method, the modes such as immersion are often used to the cleaning of Chinese medicine, are made
The surface for obtaining Chinese medicine is easy to steep rotten mouldy and internal sufficiently softening yet, so that prepared slices of Chinese crude drugs bacterium easy to breed；Meanwhile
Angelica sinensis moisture content after processing is high, is easy moldy metamorphism, and the shelf-life is shorter, and water-soluble poor, is difficult to uniformly water-soluble
Dissolution, it is difficult to be absorbed by the body.
Summary of the invention
In order to overcome shortcoming and defect existing in the prior art, the purpose of the present invention is to provide a kind of Radix Angelicae Sinensis Chinese medicine drinks
The preparation method of piece, the preparation method process is simple, operates easily controllable, high production efficiency, at low cost, by using embedding
The active functional component in Radix Angelicae Sinensis is effectively protected in processing mode, and the Radix Angelicae Sinensis prepared slices of Chinese crude drugs obtained can be made to be easy to molten
Solution, is easy to be digested, absorb, and bacteria can be prevented from growing, and the shelf-life is longer, and quality is stablized, and can be used for large-scale industrial production.
Another object of the present invention is to provide a kind of Radix Angelicae Sinensis prepared slices of Chinese crude drugs, and the prepared slices of Chinese crude drugs active ingredients are higher,
Water content is low, and bacteria can be prevented from growing, and the shelf-life is longer, and water-soluble higher, easy to dissolve, and is easy to by human consumption, absorbs.
The purpose of the invention is achieved by the following technical solution: a kind of preparation method of the Radix Angelicae Sinensis prepared slices of Chinese crude drugs, including as follows
Step:
A, sorting, cleaning: choosing the medicinal part of Radix Angelicae Sinensis, impregnates 40-60min with pure water, pulls out, blot surface moisture, then
It is placed in the ethanol solution that mass fraction is 50-65% and impregnates 8-10min, pull out, rinse well, dry, obtain Radix Angelicae Sinensis spice；
B, profit leaching: the Radix Angelicae Sinensis spice after step A drying is soaked in pure water, and room temperature profit leaching is depressurized in vacuum, and repressurization is normal
Gentle leaching；
C, it is sliced, steams: the Radix Angelicae Sinensis spice after step B profit leaching sufficiently being sliced, obtains Radix Angelicae Sinensis sheet material, and utilize and steam liquid
To Radix Angelicae Sinensis sheet material water proof high pressure steaming；
D, vacuum freeze drying, crushing: the Radix Angelicae Sinensis sheet material after step C high pressure steaming is subjected to vacuum freeze drying, drying finishes
After crushed, be made Radix Angelicae Sinensis particle；
E, it embeds: Radix Angelicae Sinensis particle made from step D is placed in embedding liquid, stir 40-60min at being 35-40 DEG C in temperature, make
Obtain embedded particles；
F, drying, tabletting: embedded particles made from step E are successively carried out to microwave drying treatment and oven drying processing, finally
Tabletting is carried out, the Radix Angelicae Sinensis prepared slices of Chinese crude drugs, vacuum packaging is made.
The preparation method process of the Radix Angelicae Sinensis prepared slices of Chinese crude drugs of the present invention is simple, operates easily controllable, high production efficiency, at low cost,
By using the processing mode of embedding, the active functional component in Radix Angelicae Sinensis is effectively protected, and Radix Angelicae Sinensis obtained can be made
The prepared slices of Chinese crude drugs are easy to dissolve, are easy to be digested, absorb, and bacteria can be prevented from growing, and the shelf-life is longer, and quality is stablized, and can be used for big
Bulk industrial production.
Preferably, in the step A, the temperature of drying is 40-55 DEG C, time 30-35min.In step A of the present invention,
Using impurity, the dust etc. on pure water cleaning Radix Angelicae Sinensis surface, after blotting surface moisture, Radix Angelicae Sinensis surface is carried out using ethanol solution
Sterilization processing, avoids bacterium easy to breed in later period long-time soaking process, moldy metamorphism, and the matter of strict control ethanol solution
Score is measured, it is ideal to the bactericidal effect on Radix Angelicae Sinensis surface, and precipitation of the effective component in high concentration alcoholic solution in Radix Angelicae Sinensis is avoided, it protects
Demonstrate,prove the quality of Radix Angelicae Sinensis；And the temperature of subsequent strict control drying can make alcohol component volatilize by the way of low temperature drying, and
It avoids the excessively high volatile oil component caused in Radix Angelicae Sinensis of temperature from being destroyed, or even volatilizees, loses, guarantee the quality of Radix Angelicae Sinensis.
Preferably, in the step B, the vacuum degree of the decompression room temperature profit leaching is -0.05~-0.075Mpa, and decompression is normal
The time of gentle leaching is 60-90min, and the pressure of the pressurization room temperature profit leaching is 1.5-4.0Mpa, the time of pressurization room temperature profit leaching
For 50-70min.
Tradition generallys use Dipping method, wet cloth dampening, spray dampening and softens to Radix Angelicae Sinensis, is to utilize to work as
Return the active absorption to moisture, absorbing water naturally reaches softening degree；Wherein in Dipping method, Radix Angelicae Sinensis contacts appearance with water for a long time
Easily there is the phenomenon of bellding, general sugar, lead to the loss of effective component, influences the quality of angelica sinensis, and Radix Angelicae Sinensis and water are for a long time
Contact is easy so that moisture two causes epidermis leaching rotten and internal not soften too long in Radix Angelicae Sinensis superficial residence；And wet cloth dampening is being inhaled
While receiving moisture, the effective components such as part volatile oil in Radix Angelicae Sinensis can be received by wet cloth back suction, also result in the loss of ingredient, shadow
Radix Angelicae Sinensis quality is rung, and softens low efficiency, needs constantly to keep the skin wet to wet cloth, while wet cloth bacterium easy to breed and mould
Bacterium is easy to cause Radix Angelicae Sinensis moldy metamorphism during long-time is contacted with Radix Angelicae Sinensis；And it sprays dampening and although avoids Radix Angelicae Sinensis
It in a large amount of water Long Term Contacts, but needs repeatedly, constantly to spray, process is many and diverse, and efficiency is lower.
And step B of the present invention by using vacuumize, depressurize room temperature profit leaching mode so that Radix Angelicae Sinensis to moisture actively inhale
It receives, recycles the mode of pressurization room temperature profit leaching, moisture is pressed into Radix Angelicae Sinensis tissue, realize the Passive intake of Radix Angelicae Sinensis, decompression is normal
Gentle leaching is combined with pressurization room temperature profit leaching mode, is improved Radix Angelicae Sinensis to the absorption efficiency of moisture, is shortened softening duration, improves
Soften efficiency, and reduce contact duration of the Radix Angelicae Sinensis with water, reduces the loss amount of effective component, and avoid mildew phenomena.And lead to
Time and pressure that strict control moistens leaching twice are crossed, Radix Angelicae Sinensis can be made to fully absorb moisture, so that Radix Angelicae Sinensis surface and internal component are soft
Change, is easy to carry out subsequent slicing process, and can guarantee the thickness uniformity of subsequent slice.
Preferably, it in the step C, is sliced to chamfer, with a thickness of 2-3mm；It is described steam liquid be by ginger juice, yellow rice wine and
Pure water is the mixture that form of 5-10:3-8:20-30 with weight ratio, and the pressure of the high pressure steaming is 2-3Mpa, and the time is
15-20min。
In step C of the present invention, by the way of beveling, and the slice thickness of strict control beveling, the tissue of Radix Angelicae Sinensis can be made
Lines is obvious, it is subsequent steam process and steam liquid easily enter in the tissue of Radix Angelicae Sinensis, Radix Angelicae Sinensis absorption steams that liquid is fast, and raising steams effect
Rate；And the ginger juice and yellow rice wine that certain content is used in liquid are steamed, and warm-natured, cold extermination, replenishing and activating blood, by way of steaming, and
Strict control steaming time and, so that Radix Angelicae Sinensis absorbs a certain amount of ginger juice and yellow rice wine, compounding can improve the temperature of angelica sinensis
Performance is mended, and ginger juice and yellow rice wine are soluble easily in water, the subsequent dissolubility of angelica sinensis in water obtained can be promoted, and used high
Press the mode that steams, and strict control its pressure, can by steam in liquid at being partially pressed into Radix Angelicae Sinensis Tabellae material, raising steams efficiency,
Reduction steams duration, and avoiding steaming for a long time causes the effective component in Radix Angelicae Sinensis to volatilize, lose.
Preferably, in the step D, the vacuum degree of vacuum freeze drying is -0.02~-0.07Mpa, temperature is -10~-
30 DEG C, drying time 3-6h, water content≤3% of vacuum freeze drying to Radix Angelicae Sinensis sheet material；Smashed Radix Angelicae Sinensis grain diameter is
40-160 mesh.
In step D of the present invention, in the way of vacuum freeze drying, and by the dry vacuum degree of strict control, temperature and
Time can make Radix Angelicae Sinensis sheet material sufficiently dry at low temperature, the drying mode of high temperature is avoided to make waving in Radix Angelicae Sinensis, ginger and yellow rice wine
Component damages are sent out, effect ingredient in Radix Angelicae Sinensis is effectively protected, the content of effective component in raising angelica sinensis, and
Under conditions of low temperature, the moisture inside Radix Angelicae Sinensis forms the ice crystal of fine uniform, and ice crystal distils under conditions of vacuum, realizes water
Point removal, while to form multiple tiny holes inside Radix Angelicae Sinensis, internal structure is loose so that in medicine materical crude slice Radix Angelicae Sinensis it is effective at
Point it is easy to dissolve out, while loose structure can improve subsequent crushing effect, it is smaller to make to crush Radix Angelicae Sinensis particle mesh number obtained, just
In subsequent embedding treatment and compressing tablet process.
Preferably, in the step E, the mixing mass ratio of the Radix Angelicae Sinensis particle and embedding liquid is 3:5-8.Step of the present invention
It, can be to working as by carrying out embedding treatment, and the mixing mass ratio of strict control Radix Angelicae Sinensis particle and embedding liquid to Radix Angelicae Sinensis particle in E
Return particle effectively, adequately protect, reduces the volatilization, loss of the effective components such as volatile oil in Radix Angelicae Sinensis particle, improve Radix Angelicae Sinensis
The Storage period of particle, and the surface wall material high water solubility embedded can improve the water solubility of angelica sinensis obtained；If embedding liquid
Dosage is very few, then lower to the embedding effect of Radix Angelicae Sinensis particle, and embedding not exclusively, if the dosage of embedding liquid is excessive, makes subsequent
It is difficult to drying in drying process completely, improves dry duration and energy consumption, while making materials cost and process cost higher.
Preferably, in the step F, the drying power of the microwave drying is 45-65kW, drying time 6-20min,
Dry water content≤6.5% to Radix Angelicae Sinensis particle；The drying temperature of the oven drying is 40-50 DEG C, drying time 20-
25min；The pressure of the tabletting is 4-6 atmospheric pressure, and the tabletting time is 8-16s.
In step F of the present invention, by carrying out microwave drying to the Radix Angelicae Sinensis particle after embedding, drying efficiency is high, drying time
It is short, and microwave disinfection disinfection treatment can be carried out to the Radix Angelicae Sinensis particle before tabletting, packaging, duration of guaranteeing the quality is improved, and at microwave drying
After reason, the intermolecular activity of Radix Angelicae Sinensis particle recycles the heated-air drying of baking oven at this time, it is dry to improve baking oven still in active state
Dry efficiency shortens the time of oven drying, and drying temperature is low, in such a way that microwave drying and oven drying combine,
The volatile oil isoreactivity functional component in Radix Angelicae Sinensis can be made to be protected, avoid leading to Radix Angelicae Sinensis in the environment of crossing high temperature for a long time
Volatilization, the loss of effective component；After dried, tabletting is finally carried out, then the Radix Angelicae Sinensis prepared slices of Chinese crude drugs are made, then use vacuum packaging,
The Radix Angelicae Sinensis prepared slices of Chinese crude drugs can be protected, avoid being influenced to lead to moldy metamorphism by oxygen, heat, moisture etc. in exposure air.
Preferably, every part of embedding liquid is made by following steps:
S1: weighing 3-8 parts of β-cyclodextrins, 1-1.5 parts of lecithin and 6-12 portions of aloe gravy, is added to 50-60 parts of quality point
Number is in the ethanol solution of 65-70%, and return stirring 2-4h at being 55-58 DEG C in temperature, filtering obtains filtrate A and filter residue A；
S2: 65-80 parts of pure water are added in the filter residue A obtained to step S1, and return stirring 3-4h at being 60-63 DEG C in temperature is obtained
To liquor B and filter residue B；
S3: filtrate A that step S1 is obtained and the liquor B for obtaining step S2 are mixed, and obtain embedding liquid.
Above-mentioned steps preparation embedding liquid of the present invention, it is easy to operate, it is good to the covered effect of Radix Angelicae Sinensis particle, wherein by adopting
Use β-cyclodextrin, lecithin and aloe gravy as cladding ingredient, there are a three-dimensional cylinders for β-cyclodextrin molecular structure
The lesser Radix Angelicae Sinensis particle of mesh number and the lecithin for being enclosed with Radix Angelicae Sinensis particle can be incorporated among cavity by shape chirality hydrophobic cavity,
The inclusion structure for forming surface relative hydropathic, internal relative hydrophobic has preferable protective effect to Radix Angelicae Sinensis particle, while can mention
The hydrophily of high Radix Angelicae Sinensis particle, promotes it to be scattered in aqueous solution；And the lecithin used can be affine with cell, with tissue phase
Hold, and the non-toxic and non-immunogenicity in human body, and there is certain targeting and slow release, on the other hand, relative hydrophobic
Radix Angelicae Sinensis particle by the duplicature on lecithin surface, wrapped up by lecithin, reduce the volatilization of Radix Angelicae Sinensis particle active principle, and ovum
The surface of phosphatide also relative hydrophobic is then embedded in β-cyclodextrin hydrophobic cavity, double-deck protection is carried out to Radix Angelicae Sinensis particle,
Improve the protection stability to Radix Angelicae Sinensis particle；And the aloe gravy used contains aloe polysaccharide ingredient, is on the one hand adjustable Radix Angelicae Sinensis
The flavor of particle increases sweet taste mouthfeel, and the surface color of Radix Angelicae Sinensis particle can on the other hand stablized, is not easy to be oxidized, brown stain, mention
Protectiveness of the height to Radix Angelicae Sinensis particle, triplicity embed Radix Angelicae Sinensis particle, can make the Radix Angelicae Sinensis prepared slices of Chinese crude drugs shelf-life obtained
It is long, it is not easy mildew and brown stain.
And β-cyclodextrin, lecithin and aloe gravy three are dissolved in the ethanol solution of certain mass score, and
Carry out reflow treatment, on the one hand can improve above-mentioned three embedding liquid solvent in solubility so that lecithin it is easy to dissolve and
In water, on the other hand the aloe polysaccharide in aloe gravy can be extracted, and the alcohol component used is subsequent dried
Cheng Zhongneng is removed, and is not impacted to angelica sinensis；Thereafter it recycles water to carry out reflow treatment to filter residue A, β-cyclisation can be pasted
Essence and aloe polysaccharide dissolution, then when mix with filtrate A, what is obtained embeds liquid to the embedding effect of Radix Angelicae Sinensis particle.
It preferably, further include that sweet system is carried out to smashed Radix Angelicae Sinensis particle, the honey is made specific before the step E
Step are as follows: Radix Angelicae Sinensis particle made from step D is added into reconciliation honey, ultrasonic agitation carries out microwave drying after stirring, remove broken
Bits.
Preferably, the Radix Angelicae Sinensis particle and the sweet mixing mass ratio that reconciles are 8-10:3；The supersonic frequency of the ultrasonic agitation
Rate is 15000-18000Hz, ultrasonic time 12-16min；The power of the microwave drying is 50-60kW, time 22-
26min。
The present invention can improve the mouthfeel of Radix Angelicae Sinensis particle, and pass through control Radix Angelicae Sinensis particle by the way that the sweet system of honey progress that reconciles is added
With the mixed proportion of reconciliation honey, the water solubility of reconciliation honey raising Radix Angelicae Sinensis particle can be utilized；Specifically, using the side of ultrasonic agitation
Formula, and the frequency of strict control ultrasonic treatment and time, the honey that can will reconcile are embedded in after vacuum freeze drying with numerous tiny
In the Radix Angelicae Sinensis particle of hole, the uniform Combination of reconciliation honey and Radix Angelicae Sinensis particle is improved, finally by the mode of microwave drying to mixed
Closing has the Radix Angelicae Sinensis particle of reconciliation honey to be dried, and improves the dry and comfortable degree of Radix Angelicae Sinensis particle, reduces water content, makes it easy to carry out subsequent
Embedding treatment, and be easy to appear after microwave drying reconciliation honey crystallization be precipitated the phenomenon that, then need the crystal that will be precipitated remove, raising
Subsequent embedding effect.
Preferably, every part of reconciliation honey includes 2-3 parts of complex enzymes and 30-40 parts of honey, the complex enzyme are by fiber
Plain enzyme, papain are with the mixture that weight ratio is that 6-8:3 is formed.
In reconciliation honey of the invention, by addition cellulase and papain, slugging can be played the role of, so that
Radix Angelicae Sinensis particle is convenient for being digested, absorbing；Wherein, the cellulase activity of use is high, can improve Radix Angelicae Sinensis particle and disappear people is intracorporal
Change degree promotes being absorbed for Radix Angelicae Sinensis effective active composition；The papain of use activity with higher, and it is water-soluble
Height, thermal stability are good, lower to its activity influence in subsequent drying process, can improve the water solubility of Radix Angelicae Sinensis particle.
Another object of the present invention is achieved through the following technical solutions: a kind of Radix Angelicae Sinensis prepared slices of Chinese crude drugs, the Radix Angelicae Sinensis Chinese medicine drink
Piece is made by above-mentioned Radix Angelicae Sinensis prepared slices of Chinese crude drugs preparation method, and moisture content≤4.5% of the Radix Angelicae Sinensis prepared slices of Chinese crude drugs, Ligustilide contains
Amount is 57.83-58.64%, and the content of ferulic acid is 0.061-0.073%, and the content of aflatoxin B1 is 1.6-2.3 μ g/kg,
Dissolution rate is 97.25-98.88%.
Prepared slices of Chinese crude drugs active ingredients produced by the present invention are higher, and water content is low, and bacteria can be prevented from growing, the shelf-life compared with
It is long and water-soluble higher, it is easy to dissolve, and be easy to by human consumption, absorb.
The beneficial effects of the present invention are: Radix Angelicae Sinensis prepared slices of Chinese crude drugs preparation method process of the invention is simple, and operation is easy to control
System, high production efficiency is at low cost, by using the processing mode of embedding, carries out to the active functional component in Radix Angelicae Sinensis effective
Protection, and the Radix Angelicae Sinensis prepared slices of Chinese crude drugs obtained can be made easy to dissolve, is easy to be digested, absorb, and bacteria can be prevented from growing, the shelf-life compared with
Long, quality is stablized, and can be used for large-scale industrial production.
Radix Angelicae Sinensis prepared slices of Chinese crude drugs active ingredients produced by the present invention are higher, and water content is low, and bacteria can be prevented from growing, the shelf-life
It is longer and water-soluble higher, it is easy to dissolve, and be easy to by human consumption, absorb, have replenishing and activating blood, menstruction regulating and pain relieving, ease constipation logical
Just, anticancer, immune, anti-ageing anti-effect of waiting for a long time.
Specific embodiment
For the ease of the understanding of those skilled in the art, below with reference to embodiment, the present invention is further illustrated, real
The content that the mode of applying refers to not is limitation of the invention.
Embodiment 1
A kind of preparation method of the Radix Angelicae Sinensis prepared slices of Chinese crude drugs, includes the following steps:
A, sorting, cleaning: choosing the medicinal part of Radix Angelicae Sinensis, impregnates 40min with pure water, pulls out, blot surface moisture, then be placed in
10min is impregnated in the ethanol solution that mass fraction is 50%, pulls out, rinse well, dries, obtains Radix Angelicae Sinensis spice；
B, profit leaching: the Radix Angelicae Sinensis spice after step A drying is soaked in pure water, and room temperature profit leaching is depressurized in vacuum, and repressurization is normal
Gentle leaching；
C, it is sliced, steams: the Radix Angelicae Sinensis spice after step B profit leaching sufficiently being sliced, obtains Radix Angelicae Sinensis sheet material, and utilize and steam liquid
To Radix Angelicae Sinensis sheet material water proof high pressure steaming；
D, vacuum freeze drying, crushing: the Radix Angelicae Sinensis sheet material after step C high pressure steaming is subjected to vacuum freeze drying, drying finishes
After crushed, be made Radix Angelicae Sinensis particle；
E, it embeds: Radix Angelicae Sinensis particle made from step D is placed in embedding liquid, stir 60min at being 35 DEG C in temperature, embedding is made
Particle；
F, drying, tabletting: embedded particles made from step E are successively carried out to microwave drying treatment and oven drying processing, finally
Tabletting is carried out, the Radix Angelicae Sinensis prepared slices of Chinese crude drugs, vacuum packaging is made.
In the step A, the temperature of drying is 40 DEG C, time 35min；In the step B, the decompression room temperature profit leaching
Vacuum degree be -0.05Mpa, decompression room temperature profit leaching time be 90min, it is described pressurization room temperature profit leaching pressure be 1.5Mpa,
The time that the room temperature that pressurizes moistens leaching is 70min.
In the step C, be sliced for beveling, with a thickness of 2mm, it is described steam liquid be by ginger juice, yellow rice wine and pure water with
Weight ratio is the mixture of 5:3:20 composition, and the pressure of the high pressure steaming is 2Mpa, time 20min.
In the step D, the vacuum degree of vacuum freeze drying is -0.02Mpa, and temperature is -30 DEG C, drying time 3h,
Vacuum freeze drying to Radix Angelicae Sinensis sheet material water content≤3%；Smashed Radix Angelicae Sinensis grain diameter is 40 mesh.
In the step E, the mixing mass ratio of the Radix Angelicae Sinensis particle and embedding liquid is 3:5, and every part of embedding liquid is by such as
Lower step is made:
S1: weighing 3 parts of β-cyclodextrins, 1 part of lecithin and 6 portions of aloe gravy, and the ethyl alcohol for being 70% to 50 parts of mass fractions is added
In solution, return stirring 4h at being 55 DEG C in temperature, filtering obtains filtrate A and filter residue A；
S2: the filter residue A that obtains to step S1 is added 65 parts of pure water, return stirring 4h at being 60 DEG C in temperature, obtain liquor B and
Filter residue B；
S3: filtrate A that step S1 is obtained and the liquor B for obtaining step S2 are mixed, and obtain embedding liquid.
It further include that sweet system is carried out to smashed Radix Angelicae Sinensis particle before the step E, the specific steps of the honey system are as follows:
Radix Angelicae Sinensis particle made from step D is added into reconciliation honey, ultrasonic agitation carries out microwave drying after stirring, remove clast.
The Radix Angelicae Sinensis particle and the sweet mixing mass ratio that reconciles are 8:3；The supersonic frequency of the ultrasonic agitation is
15000Hz, ultrasonic time 16min；The power of the microwave drying is 50kW, time 26min.
Every part of reconciliation honey includes 2 parts of complex enzymes and 40 parts of honey, and the complex enzyme is by cellulase, Papain
Enzyme is with the mixture that weight ratio is that 6:3 is formed.
In the step F, the drying power of the microwave drying is 45kW, drying time 20min, drying to Radix Angelicae Sinensis
Water content≤6.5% of grain；The drying temperature of the oven drying is 40 DEG C, drying time 25min；The pressure of the tabletting
For 4 atmospheric pressure, the tabletting time is 8s.
Embodiment 2
A kind of preparation method of the Radix Angelicae Sinensis prepared slices of Chinese crude drugs, includes the following steps:
A, sorting, cleaning: choosing the medicinal part of Radix Angelicae Sinensis, impregnates 45min with pure water, pulls out, blot surface moisture, then be placed in
9.5min is impregnated in the ethanol solution that mass fraction is 53%, pulls out, rinse well, dries, obtains Radix Angelicae Sinensis spice；
B, profit leaching: the Radix Angelicae Sinensis spice after step A drying is soaked in pure water, and room temperature profit leaching is depressurized in vacuum, and repressurization is normal
Gentle leaching；
C, it is sliced, steams: the Radix Angelicae Sinensis spice after step B profit leaching sufficiently being sliced, obtains Radix Angelicae Sinensis sheet material, and utilize and steam liquid
To Radix Angelicae Sinensis sheet material water proof high pressure steaming；
D, vacuum freeze drying, crushing: the Radix Angelicae Sinensis sheet material after step C high pressure steaming is subjected to vacuum freeze drying, drying finishes
After crushed, be made Radix Angelicae Sinensis particle；
E, it embeds: Radix Angelicae Sinensis particle made from step D is placed in embedding liquid, stir 55min at being 36 DEG C in temperature, embedding is made
Particle；
F, drying, tabletting: embedded particles made from step E are successively carried out to microwave drying treatment and oven drying processing, finally
Tabletting is carried out, the Radix Angelicae Sinensis prepared slices of Chinese crude drugs, vacuum packaging is made.
In the step A, the temperature of drying is 43 DEG C, time 33min；In the step B, the decompression room temperature profit leaching
Vacuum degree be -0.055Mpa, decompression room temperature profit leaching time be 82min, it is described pressurization room temperature profit leaching pressure be 2.5Mpa,
The time that the room temperature that pressurizes moistens leaching is 65min.
In the step C, it is sliced to chamfer, with a thickness of 2.2mm, the liquid that steams is by ginger juice, yellow rice wine and pure water
It is the mixture that 6:5:22 is formed with weight ratio, the pressure of the high pressure steaming is 2.2Mpa, time 18min.
In the step D, the vacuum degree of vacuum freeze drying is -0.03Mpa, and temperature is -25 DEG C, drying time 4h,
Vacuum freeze drying to Radix Angelicae Sinensis sheet material water content≤3%；Smashed Radix Angelicae Sinensis grain diameter is 70 mesh.
In the step E, the mixing mass ratio of the Radix Angelicae Sinensis particle and embedding liquid is 3:6, and every part of embedding liquid is by such as
Lower step is made:
S1: weighing 4 parts of β-cyclodextrins, 1.2 parts of lecithin and 8 portions of aloe gravy, and the second for being 69% to 52 parts of mass fractions is added
In alcoholic solution, return stirring 3.5h at being 56 DEG C in temperature, filtering obtains filtrate A and filter residue A；
S2: 68 parts of pure water are added in the filter residue A obtained to step S1, and return stirring 3.8h at being 61 DEG C in temperature obtains liquor B
With filter residue B；
S3: filtrate A that step S1 is obtained and the liquor B for obtaining step S2 are mixed, and obtain embedding liquid.
It further include that sweet system is carried out to smashed Radix Angelicae Sinensis particle before the step E, the specific steps of the honey system are as follows:
Radix Angelicae Sinensis particle made from step D is added into reconciliation honey, ultrasonic agitation carries out microwave drying after stirring, remove clast.
The Radix Angelicae Sinensis particle and the sweet mixing mass ratio that reconciles are 8.5:3；The supersonic frequency of the ultrasonic agitation is
16000Hz, ultrasonic time 15min；The power of the microwave drying is 52kW, time 25min.
Every part of reconciliation honey includes 2.2 parts of complex enzymes and 38 parts of honey, and the complex enzyme is by cellulase, pawpaw egg
White enzyme is with the mixture that weight ratio is that 6.5:3 is formed.
In the step F, the drying power of the microwave drying is 50kW, drying time 16min, drying to Radix Angelicae Sinensis
Water content≤6.5% of grain；The drying temperature of the oven drying is 42 DEG C, drying time 23min；The pressure of the tabletting
For 4.5 atmospheric pressure, the tabletting time is 10s.
Embodiment 3
A kind of preparation method of the Radix Angelicae Sinensis prepared slices of Chinese crude drugs, includes the following steps:
A, sorting, cleaning: choosing the medicinal part of Radix Angelicae Sinensis, impregnates 50min with pure water, pulls out, blot surface moisture, then be placed in
9min is impregnated in the ethanol solution that mass fraction is 58%, pulls out, rinse well, dries, obtains Radix Angelicae Sinensis spice；
B, profit leaching: the Radix Angelicae Sinensis spice after step A drying is soaked in pure water, and room temperature profit leaching is depressurized in vacuum, and repressurization is normal
Gentle leaching；
C, it is sliced, steams: the Radix Angelicae Sinensis spice after step B profit leaching sufficiently being sliced, obtains Radix Angelicae Sinensis sheet material, and utilize and steam liquid
To Radix Angelicae Sinensis sheet material water proof high pressure steaming；
D, vacuum freeze drying, crushing: the Radix Angelicae Sinensis sheet material after step C high pressure steaming is subjected to vacuum freeze drying, drying finishes
After crushed, be made Radix Angelicae Sinensis particle；
E, it embeds: Radix Angelicae Sinensis particle made from step D is placed in embedding liquid, stir 50min at being 38 DEG C in temperature, embedding is made
Particle；
F, drying, tabletting: embedded particles made from step E are successively carried out to microwave drying treatment and oven drying processing, finally
Tabletting is carried out, the Radix Angelicae Sinensis prepared slices of Chinese crude drugs, vacuum packaging is made.
In the step A, the temperature of drying is 48 DEG C, time 32min；In the step B, the decompression room temperature profit leaching
Vacuum degree be -0.060Mpa, decompression room temperature profit leaching time be 75min, it is described pressurization room temperature profit leaching pressure be 3.0Mpa,
The time that the room temperature that pressurizes moistens leaching is 60min.
In the step C, it is sliced to chamfer, with a thickness of 2.5mm, the liquid that steams is by ginger juice, yellow rice wine and pure water
It is the mixture that 8:6:25 is formed with weight ratio, the pressure of the high pressure steaming is 2.5Mpa, time 17min.
In the step D, the vacuum degree of vacuum freeze drying is -0.05Mpa, and temperature is -20 DEG C, and drying time is
4.5h, water content≤3% of vacuum freeze drying to Radix Angelicae Sinensis sheet material；Smashed Radix Angelicae Sinensis grain diameter is 100 mesh.
In the step E, the Radix Angelicae Sinensis particle and embedding liquid mixing mass ratio be 3:6.5, every part of embedding liquid by
Following steps are made:
S1: weighing 5 parts of β-cyclodextrins, 1.3 parts of lecithin and 9 portions of aloe gravy, and the second for being 68% to 55 parts of mass fractions is added
In alcoholic solution, return stirring 3h at being 56.5 DEG C in temperature, filtering obtains filtrate A and filter residue A；
S2: 72 parts of pure water are added in the filter residue A obtained to step S1, and return stirring 3.5h at being 62 DEG C in temperature obtains liquor B
With filter residue B；
S3: filtrate A that step S1 is obtained and the liquor B for obtaining step S2 are mixed, and obtain embedding liquid.
It further include that sweet system is carried out to smashed Radix Angelicae Sinensis particle before the step E, the specific steps of the honey system are as follows:
Radix Angelicae Sinensis particle made from step D is added into reconciliation honey, ultrasonic agitation carries out microwave drying after stirring, remove clast.
The Radix Angelicae Sinensis particle and the sweet mixing mass ratio that reconciles are 9:3；The supersonic frequency of the ultrasonic agitation is
16500Hz, ultrasonic time 14min；The power of the microwave drying is 55kW, time 24min.
Every part of reconciliation honey includes 2.5 parts of complex enzymes and 35 parts of honey, and the complex enzyme is by cellulase, pawpaw egg
White enzyme is with the mixture that weight ratio is that 7:3 is formed.
In the step F, the drying power of the microwave drying is 55kW, drying time 13min, drying to Radix Angelicae Sinensis
Water content≤6.5% of grain；The drying temperature of the oven drying is 45 DEG C, drying time 22min；The pressure of the tabletting
For 5 atmospheric pressure, the tabletting time is 12s.
Embodiment 4
A kind of preparation method of the Radix Angelicae Sinensis prepared slices of Chinese crude drugs, includes the following steps:
A, sorting, cleaning: choosing the medicinal part of Radix Angelicae Sinensis, impregnates 55min with pure water, pulls out, blot surface moisture, then be placed in
8.5min is impregnated in the ethanol solution that mass fraction is 62%, pulls out, rinse well, dries, obtains Radix Angelicae Sinensis spice；
B, profit leaching: the Radix Angelicae Sinensis spice after step A drying is soaked in pure water, and room temperature profit leaching is depressurized in vacuum, and repressurization is normal
Gentle leaching；
C, it is sliced, steams: the Radix Angelicae Sinensis spice after step B profit leaching sufficiently being sliced, obtains Radix Angelicae Sinensis sheet material, and utilize and steam liquid
To Radix Angelicae Sinensis sheet material water proof high pressure steaming；
D, vacuum freeze drying, crushing: the Radix Angelicae Sinensis sheet material after step C high pressure steaming is subjected to vacuum freeze drying, drying finishes
After crushed, be made Radix Angelicae Sinensis particle；
E, it embeds: Radix Angelicae Sinensis particle made from step D is placed in embedding liquid, stir 45min at being 39 DEG C in temperature, embedding is made
Particle；
F, drying, tabletting: embedded particles made from step E are successively carried out to microwave drying treatment and oven drying processing, finally
Tabletting is carried out, the Radix Angelicae Sinensis prepared slices of Chinese crude drugs, vacuum packaging is made.
In the step A, the temperature of drying is 52 DEG C, time 31min；In the step B, the decompression room temperature profit leaching
Vacuum degree be -0.065Mpa, decompression room temperature profit leaching time be 68min, it is described pressurization room temperature profit leaching pressure be 3.5Mpa,
The time that the room temperature that pressurizes moistens leaching is 55min.
In the step C, it is sliced to chamfer, with a thickness of 2.8mm, the liquid that steams is by ginger juice, yellow rice wine and pure water
It is the mixture that 9:7:28 is formed with weight ratio, the pressure of the high pressure steaming is 2.8Mpa, time 16min.
In the step D, the vacuum degree of vacuum freeze drying is -0.06Mpa, and temperature is -15 DEG C, drying time 5h,
Vacuum freeze drying to Radix Angelicae Sinensis sheet material water content≤3%；Smashed Radix Angelicae Sinensis grain diameter is 130 mesh.
In the step E, the mixing mass ratio of the Radix Angelicae Sinensis particle and embedding liquid is 3:7, and every part of embedding liquid is by such as
Lower step is made:
S1: weighing 6 parts of β-cyclodextrins, 1.4 parts of lecithin and 11 portions of aloe gravy, and being added to 58 parts of mass fractions is 66%
In ethanol solution, return stirring 2.5h at being 57 DEG C in temperature, filtering obtains filtrate A and filter residue A；
S2: 76 parts of pure water are added in the filter residue A obtained to step S1, and return stirring 3.2h at being 62 DEG C in temperature obtains liquor B
With filter residue B；
S3: filtrate A that step S1 is obtained and the liquor B for obtaining step S2 are mixed, and obtain embedding liquid.
It further include that sweet system is carried out to smashed Radix Angelicae Sinensis particle before the step E, the specific steps of the honey system are as follows:
Radix Angelicae Sinensis particle made from step D is added into reconciliation honey, ultrasonic agitation carries out microwave drying after stirring, remove clast.
The Radix Angelicae Sinensis particle and the sweet mixing mass ratio that reconciles are 9.5:3；The supersonic frequency of the ultrasonic agitation is
17000Hz, ultrasonic time 13min；The power of the microwave drying is 58kW, time 23min.
Every part of reconciliation honey includes 2.8 parts of complex enzymes and 32 parts of honey, and the complex enzyme is by cellulase, pawpaw egg
White enzyme is with the mixture that weight ratio is that 7.5:3 is formed.
In the step F, the drying power of the microwave drying is 60kW, drying time 10min, drying to Radix Angelicae Sinensis
Water content≤6.5% of grain；The drying temperature of the oven drying is 48 DEG C, drying time 21min；The pressure of the tabletting
For 5.5 atmospheric pressure, the tabletting time is 14s.
Embodiment 5
A kind of preparation method of the Radix Angelicae Sinensis prepared slices of Chinese crude drugs, includes the following steps:
A, sorting, cleaning: choosing the medicinal part of Radix Angelicae Sinensis, impregnates 60min with pure water, pulls out, blot surface moisture, then be placed in
8min is impregnated in the ethanol solution that mass fraction is 65%, pulls out, rinse well, dries, obtains Radix Angelicae Sinensis spice；
B, profit leaching: the Radix Angelicae Sinensis spice after step A drying is soaked in pure water, and room temperature profit leaching is depressurized in vacuum, and repressurization is normal
Gentle leaching；
C, it is sliced, steams: the Radix Angelicae Sinensis spice after step B profit leaching sufficiently being sliced, obtains Radix Angelicae Sinensis sheet material, and utilize and steam liquid
To Radix Angelicae Sinensis sheet material water proof high pressure steaming；
D, vacuum freeze drying, crushing: the Radix Angelicae Sinensis sheet material after step C high pressure steaming is subjected to vacuum freeze drying, drying finishes
After crushed, be made Radix Angelicae Sinensis particle；
E, it embeds: Radix Angelicae Sinensis particle made from step D is placed in embedding liquid, stir 40min at being 40 DEG C in temperature, embedding is made
Particle；
F, drying, tabletting: embedded particles made from step E are successively carried out to microwave drying treatment and oven drying processing, finally
Tabletting is carried out, the Radix Angelicae Sinensis prepared slices of Chinese crude drugs, vacuum packaging is made.
In the step A, the temperature of drying is 55 DEG C, time 30min；In the step B, the decompression room temperature profit leaching
Vacuum degree be -0.075Mpa, decompression room temperature profit leaching time be 60min, it is described pressurization room temperature profit leaching pressure be 4.0Mpa,
The time that the room temperature that pressurizes moistens leaching is 50min.
In the step C, be sliced for beveling, with a thickness of 3mm, it is described steam liquid be by ginger juice, yellow rice wine and pure water with
Weight ratio is the mixture of 10:8:30 composition, and the pressure of the high pressure steaming is 3Mpa, time 15min.
In the step D, the vacuum degree of vacuum freeze drying is -0.07Mpa, and temperature is -10 DEG C, drying time 6h,
Vacuum freeze drying to Radix Angelicae Sinensis sheet material water content≤3%；Smashed Radix Angelicae Sinensis grain diameter is 160 mesh.
In the step E, the mixing mass ratio of the Radix Angelicae Sinensis particle and embedding liquid is 3:8, and every part of embedding liquid is by such as
Lower step is made:
S1: weighing 8 parts of β-cyclodextrins, 1.5 parts of lecithin and 12 portions of aloe gravy, and being added to 60 parts of mass fractions is 65%
In ethanol solution, return stirring 2h at being 58 DEG C in temperature, filtering obtains filtrate A and filter residue A；
S2: the filter residue A that obtains to step S1 is added 80 parts of pure water, return stirring 3h at being 63 DEG C in temperature, obtain liquor B and
Filter residue B；
S3: filtrate A that step S1 is obtained and the liquor B for obtaining step S2 are mixed, and obtain embedding liquid.
It further include that sweet system is carried out to smashed Radix Angelicae Sinensis particle before the step E, the specific steps of the honey system are as follows:
Radix Angelicae Sinensis particle made from step D is added into reconciliation honey, ultrasonic agitation carries out microwave drying after stirring, remove clast.
The Radix Angelicae Sinensis particle and the sweet mixing mass ratio that reconciles are 10:3；The supersonic frequency of the ultrasonic agitation is
18000Hz, ultrasonic time 12min；The power of the microwave drying is 60kW, time 22min.
Every part of reconciliation honey includes 3 parts of complex enzymes and 30 parts of honey, and the complex enzyme is by cellulase, Papain
Enzyme is with the mixture that weight ratio is that 8:3 is formed.
In the step F, the drying power of the microwave drying is 65kW, drying time 6min, drying to Radix Angelicae Sinensis
Water content≤6.5% of grain；The drying temperature of the oven drying is 50 DEG C, drying time 20min；The pressure of the tabletting
For 6 atmospheric pressure, the tabletting time is 16s.
Comparative example 1
This comparative example and the difference of above-described embodiment 3 are:
In the drying process of the step D, specific steps are as follows: by the Radix Angelicae Sinensis sheet material after step C high pressure steaming temperature be 48 DEG C
Under conditions of oven drying 7h, crushed after dry, Radix Angelicae Sinensis particle be made.
Comparative example 2
This comparative example and the difference of above-described embodiment 3 are:
A kind of preparation method of the Radix Angelicae Sinensis prepared slices of Chinese crude drugs, includes the following steps:
A, sorting, cleaning: choosing the medicinal part of Radix Angelicae Sinensis, impregnates 50min with pure water, pulls out, blot surface moisture, then be placed in
9min is impregnated in the ethanol solution that mass fraction is 58%, pulls out, rinse well, dries, obtains Radix Angelicae Sinensis spice；
B, profit leaching: the Radix Angelicae Sinensis spice after step A drying is soaked in pure water, and room temperature profit leaching is depressurized in vacuum, and repressurization is normal
Gentle leaching；
C, it is sliced, steams: the Radix Angelicae Sinensis spice after step B profit leaching sufficiently being sliced, obtains Radix Angelicae Sinensis sheet material, and utilize and steam liquid
To Radix Angelicae Sinensis sheet material water proof high pressure steaming；
D, vacuum freeze drying, crushing: the Radix Angelicae Sinensis sheet material after step C high pressure steaming is subjected to vacuum freeze drying, drying finishes
After crushed, be made Radix Angelicae Sinensis particle；
F, tabletting: carrying out tabletting for Radix Angelicae Sinensis particle made from step D, and the Radix Angelicae Sinensis prepared slices of Chinese crude drugs, vacuum packaging is made.
Comparative example 3
This comparative example and the difference of above-described embodiment 3 are:
In the step E, every part of embedding liquid is made by following steps:
S1: weighing 5 parts of β-cyclodextrins and 9 portions of aloe gravy, is added in the ethanol solution for being 68% to 55 parts of mass fractions,
Temperature is return stirring 3h at 56.5 DEG C, and filtering obtains filtrate A and filter residue A；
S2: 72 parts of pure water are added in the filter residue A obtained to step S1, and return stirring 3.5h at being 62 DEG C in temperature obtains liquor B
With filter residue B；
S3: filtrate A that step S1 is obtained and the liquor B for obtaining step S2 are mixed, and obtain embedding liquid.
Comparative example 4
This comparative example and the difference of above-described embodiment 3 are:
In the drying process of the step F, specific steps are as follows: the condition for being 45 DEG C in temperature by embedded particles made from step E
Under, then oven drying 22min carries out tabletting, the Radix Angelicae Sinensis prepared slices of Chinese crude drugs, vacuum packaging is made.
Comparative example 5
This comparative example and the difference of above-described embodiment 3 are:
It is only honey in the reconciliation honey, does not add complex enzyme.
The Radix Angelicae Sinensis prepared slices of Chinese crude drugs made from above-described embodiment 1-5 and comparative example 1-5 are subjected to water content, volatile oil (in rhizoma ligustici
Ester) test such as content, ferulaic acid content, aflatoxin B1 content, dissolution rate, shown in test result is as follows:
Wherein, the measurement of the water content is surveyed according to standard as defined in four general rules 0832 of " Chinese Pharmacopoeia " version in 2015
Examination, the measurement of volatile oil (Ligustilide) content is according to standard as defined in four general rules 2204 of " Chinese Pharmacopoeia " version in 2015
It is tested, the measurement of the ferulaic acid content is carried out according to standard as defined in four general rules 0512 of " Chinese Pharmacopoeia " version in 2015
Test, the measurement of the aflatoxin B1 content according to standard as defined in four general rules 2351 of " Chinese Pharmacopoeia " version in 2015 into
Row test, the measurement of the dissolution rate are tested according to standard as defined in four general rules 0931 of " Chinese Pharmacopoeia " version in 2015.
By above-mentioned data it is found that can effectively be protected to the active functional component in Radix Angelicae Sinensis by means of the present invention
Shield, Radix Angelicae Sinensis prepared slices of Chinese crude drugs moisture content≤4.5% obtained, Ligustilide content are 57.83-58.64%, and ferulaic acid content is
0.061-0.073%, and by the processing mode of honey system and embedding, can make the Radix Angelicae Sinensis prepared slices of Chinese crude drugs obtained easy to dissolve, be easy to by
Digestion absorbs, dissolution rate 97.25-98.88%, and bacteria can be prevented from growing, and aflatoxin B1 content is 1.6-2.3 μ g/kg,
Shelf-life is longer, and quality is stablized, and can be used for large-scale industrial production.
Wherein, in the drying process of 1 step D of comparative example using conventional oven drying mode, the prepared slices of Chinese crude drugs obtained with
Embodiment 3 is compared, and water content obviously rises, and Ligustilide content, ferulaic acid content are substantially reduced, and aflatoxin B1 content has
Increased, dissolution rate is also decreased obviously, and illustrates that conventional oven drying mode will cause effective component to Radix Angelicae Sinensis after profit leaching and wave
Hair and loss, reduce quality, and drying efficiency and effect are lower, so that water content is higher, mould easy to breed；Further relate to this
Invention can make Radix Angelicae Sinensis sheet material sufficiently dry at low temperature, avoid the drying side of high temperature by using the mode of vacuum freeze drying
Formula loses the volatile ingredient in Radix Angelicae Sinensis, and effect ingredient in Radix Angelicae Sinensis is effectively protected, and improving has in angelica sinensis
The content of ingredient is imitated, and under conditions of low temperature, the moisture inside Radix Angelicae Sinensis forms the ice crystal of fine uniform, and in the condition of vacuum
Lower ice crystal distillation, realizes the removal of moisture, while to form multiple tiny holes inside Radix Angelicae Sinensis, and internal structure is loose, so that
The effective component of Radix Angelicae Sinensis is easy to dissolve out in medicine materical crude slice.
To Radix Angelicae Sinensis particle without embedding treatment in the preparation process of comparative example 2, after vacuum freeze drying, crushing directly
Tabletting is carried out, compared with Example 3, Ligustilide content, ferulaic acid content are substantially reduced the prepared slices of Chinese crude drugs obtained, aspergillus flavus poison
Plain B1 content obviously increases, and water solubility also declines, and illustrates the present invention by carrying out embedding treatment, and strict control to Radix Angelicae Sinensis particle
The mixing mass ratio of Radix Angelicae Sinensis particle and embedding liquid can carry out effective, adequately protection to Radix Angelicae Sinensis particle, reduce ligusticumic in Radix Angelicae Sinensis particle
Volatilization, the loss of the effective components such as this lactone, improve the Storage period of Radix Angelicae Sinensis particle, and the surface wall material high water solubility embedded, energy
Improve the water solubility of angelica sinensis obtained.
Lecithin is not used in the embedding liquid of comparative example 3, compared with Example 3, Ligustilide contains the prepared slices of Chinese crude drugs obtained
Amount, ferulaic acid content reduce, and aflatoxin B1 content increases, and water solubility also declines, and illustrate the present invention by using β-cyclisation
As cladding ingredient, the Radix Angelicae Sinensis particle of relative hydrophobic passes through the duplicature on lecithin surface, quilt for dextrin, lecithin and aloe gravy
Lecithin package, reduces the volatilization of Radix Angelicae Sinensis particle active principle, and the surface of lecithin also relative hydrophobic, then is embedded in β-ring
The hydrophobic cavity for changing dextrin carries out double-deck protection to Radix Angelicae Sinensis particle, improves the protection stability to Radix Angelicae Sinensis particle, reduces effective
The volatilization and loss of ingredient, and the dissolution rate of Radix Angelicae Sinensis particle is improved, it is easy to be absorbed.
In the step F of comparative example 4, microwave drying is not used to the particle after embedding, only with oven drying, it is obtained in
Compared with Example 3, water content obviously rises medicine medicine materical crude slice, and Ligustilide content, ferulaic acid content reduce, and aflatoxin B1 contains
Amount decreases, and water solubility also declines, and it is dry using microwave drying and baking oven to the Radix Angelicae Sinensis particle after embedding to illustrate that the present invention passes through
The dry mode combined can make the Ligustilide isoreactivity functional component in Radix Angelicae Sinensis be protected, after microwave drying treatment, when
Return the intermolecular activity of particle still in active state, recycles the heated-air drying of baking oven at this time, the effect of oven drying can be improved
Rate shortens the time of oven drying, and drying temperature is low, avoids leading to Radix Angelicae Sinensis effective component in the environment of crossing high temperature for a long time
Volatilization, loss.
In the sweet system processing of comparative example 5, reconcile and add complex enzyme in honey, the prepared slices of Chinese crude drugs obtained compared with Example 3,
Dissolution rate significantly reduces, and illustrates that the present invention by addition cellulase and papain, can play the role of slugging, improves
The dissolution situation of Radix Angelicae Sinensis particle, and be easy to be digested, absorb.
Above-described embodiment is the preferable implementation of the present invention, and in addition to this, the present invention can be realized with other way,
Do not depart under the premise of present inventive concept it is any obviously replace it is within the scope of the present invention.
Claims (10)
1. a kind of preparation method of the Radix Angelicae Sinensis prepared slices of Chinese crude drugs, characterized by the following steps:
A, sorting, cleaning: choosing the medicinal part of Radix Angelicae Sinensis, impregnates 40-60min with pure water, pulls out, blot surface moisture, then
It is placed in the ethanol solution that mass fraction is 50-65% and impregnates 8-10min, pull out, rinse well, dry, obtain Radix Angelicae Sinensis spice；
B, profit leaching: the Radix Angelicae Sinensis spice after step A drying is soaked in pure water, and room temperature profit leaching is depressurized in vacuum, and repressurization is normal
Gentle leaching；
C, it is sliced, steams: the Radix Angelicae Sinensis spice after step B profit leaching sufficiently being sliced, obtains Radix Angelicae Sinensis sheet material, and utilize and steam liquid
To Radix Angelicae Sinensis sheet material water proof high pressure steaming；
D, vacuum freeze drying, crushing: the Radix Angelicae Sinensis sheet material after step C high pressure steaming is subjected to vacuum freeze drying, drying finishes
After crushed, be made Radix Angelicae Sinensis particle；
E, it embeds: Radix Angelicae Sinensis particle made from step D is placed in embedding liquid, stir 40-60min at being 35-40 DEG C in temperature, make
Obtain embedded particles；
F, drying, tabletting: embedded particles made from step E are successively carried out to microwave drying treatment and oven drying processing, finally
Tabletting is carried out, the Radix Angelicae Sinensis prepared slices of Chinese crude drugs, vacuum packaging is made.
2. a kind of preparation method of Radix Angelicae Sinensis prepared slices of Chinese crude drugs according to claim 1, it is characterised in that: in the step A, dry
Dry temperature is 40-55 DEG C, time 30-35min；In the step B, the vacuum degree of the decompression room temperature profit leaching is -0.05
The time of~-0.075Mpa, decompression room temperature profit leaching are 60-90min, and the pressure of the pressurization room temperature profit leaching is 1.5-4.0Mpa,
The time that the room temperature that pressurizes moistens leaching is 50-70min.
3. a kind of preparation method of Radix Angelicae Sinensis prepared slices of Chinese crude drugs according to claim 1, it is characterised in that: in the step C, cut
Piece is beveling, and with a thickness of 2-3mm, the liquid that steams is with weight ratio by ginger juice, yellow rice wine and pure water for 5-10:3-8:20-
The mixture of 30 compositions, the pressure of the high pressure steaming are 2-3Mpa, time 15-20min.
4. a kind of preparation method of Radix Angelicae Sinensis prepared slices of Chinese crude drugs according to claim 1, it is characterised in that: in the step D, very
The vacuum degree of vacuum freecing-dry is -0.02~-0.07Mpa, and temperature is -10~-30 DEG C, drying time 3-6h, vacuum refrigeration
Dry water content≤3% to Radix Angelicae Sinensis sheet material；Smashed Radix Angelicae Sinensis grain diameter is 40-160 mesh.
5. a kind of preparation method of Radix Angelicae Sinensis prepared slices of Chinese crude drugs according to claim 1, it is characterised in that: in the step E, institute
Stating Radix Angelicae Sinensis particle and embedding the mixing mass ratio of liquid is 3:5-8, and every part of embedding liquid is made by following steps:
S1: weighing 3-8 parts of β-cyclodextrins, 1-1.5 parts of lecithin and 6-12 portions of aloe gravy, is added to 50-60 parts of quality point
Number is in the ethanol solution of 65-70%, and return stirring 2-4h at being 55-58 DEG C in temperature, filtering obtains filtrate A and filter residue A；
S2: 65-80 parts of pure water are added in the filter residue A obtained to step S1, and return stirring 3-4h at being 60-63 DEG C in temperature is obtained
To liquor B and filter residue B；
S3: filtrate A that step S1 is obtained and the liquor B for obtaining step S2 are mixed, and obtain embedding liquid.
6. a kind of preparation method of Radix Angelicae Sinensis prepared slices of Chinese crude drugs according to claim 1, it is characterised in that: before the step E,
It further include that sweet system is carried out to smashed Radix Angelicae Sinensis particle, the specific steps of the honey system are as follows: add Radix Angelicae Sinensis particle made from step D
Enter into reconciliation honey, ultrasonic agitation carries out microwave drying after stirring, remove clast.
7. a kind of preparation method of Radix Angelicae Sinensis prepared slices of Chinese crude drugs according to claim 6, it is characterised in that: the Radix Angelicae Sinensis particle with
The sweet mixing mass ratio that reconciles is 8-10:3；The supersonic frequency of the ultrasonic agitation is 15000-18000Hz, and ultrasonic time is
12-16min；The power of the microwave drying is 50-60kW, time 22-26min.
8. a kind of preparation method of Radix Angelicae Sinensis prepared slices of Chinese crude drugs according to claim 6, it is characterised in that: every part of reconciliation honey
Including 2-3 parts of complex enzymes and 30-40 parts of honey, the complex enzyme is with weight ratio by cellulase, papain for 6-8:3
The mixture of composition.
9. a kind of preparation method of Radix Angelicae Sinensis prepared slices of Chinese crude drugs according to claim 1, it is characterised in that: in the step F, institute
The drying power for stating microwave drying is 45-65kW, drying time 6-20min, the dry water content to Radix Angelicae Sinensis particle≤
6.5%；The drying temperature of the oven drying is 40-50 DEG C, drying time 20-25min；The pressure of the tabletting is 4-6
A atmospheric pressure, tabletting time are 8-16s.
10. a kind of Radix Angelicae Sinensis prepared slices of Chinese crude drugs, it is characterised in that: the Radix Angelicae Sinensis prepared slices of Chinese crude drugs are described in any item by claim 1-9
Radix Angelicae Sinensis prepared slices of Chinese crude drugs preparation method is made, moisture content≤4.5% of the Radix Angelicae Sinensis prepared slices of Chinese crude drugs, and Ligustilide content is 57.83-
58.64%, the content of ferulic acid is 0.061-0.073%, and the content of aflatoxin B1 is 1.6-2.3 μ g/kg, and dissolution rate is
97.25-98.88%。
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110522826A (en) * | 2019-08-28 | 2019-12-03 | 广东元德中药饮片有限公司 | A kind of west safflower prepared slices of Chinese crude drugs and preparation method thereof |
| CN111249315A (en) * | 2020-03-11 | 2020-06-09 | 上海养和堂中药饮片有限公司 | Preparation process of traditional Chinese medicine decoction pieces |
| CN113456498A (en) * | 2021-06-30 | 2021-10-01 | 安徽正和堂中药饮片有限公司 | Chinese herbal pieces based on angelica sinensis and processing method thereof |
| CN113476488A (en) * | 2021-07-01 | 2021-10-08 | 安徽正和堂中药饮片有限公司 | Chinese angelica root Chinese herbal pieces and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108245540A (en) * | 2018-04-04 | 2018-07-06 | 安徽颐生堂中药饮片有限公司 | A kind of preparation method of angelica sinensis |
| CN108785521A (en) * | 2018-05-11 | 2018-11-13 | 桐城市天泰农业种植专业合作社 | A kind of sealwort essence piece and its processing method |
-
2019
- 2019-07-31 CN CN201910702086.5A patent/CN110368409A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108245540A (en) * | 2018-04-04 | 2018-07-06 | 安徽颐生堂中药饮片有限公司 | A kind of preparation method of angelica sinensis |
| CN108785521A (en) * | 2018-05-11 | 2018-11-13 | 桐城市天泰农业种植专业合作社 | A kind of sealwort essence piece and its processing method |
Non-Patent Citations (1)
| Title |
|---|
| 宋丽雅等: "《化妆品植物功效添加剂的研究与开发》", 30 September 2011, 中国轻工业出版社 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110522826A (en) * | 2019-08-28 | 2019-12-03 | 广东元德中药饮片有限公司 | A kind of west safflower prepared slices of Chinese crude drugs and preparation method thereof |
| CN111249315A (en) * | 2020-03-11 | 2020-06-09 | 上海养和堂中药饮片有限公司 | Preparation process of traditional Chinese medicine decoction pieces |
| CN113456498A (en) * | 2021-06-30 | 2021-10-01 | 安徽正和堂中药饮片有限公司 | Chinese herbal pieces based on angelica sinensis and processing method thereof |
| CN113476488A (en) * | 2021-07-01 | 2021-10-08 | 安徽正和堂中药饮片有限公司 | Chinese angelica root Chinese herbal pieces and preparation method thereof |
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Application publication date: 20191025 |