CN110352198B - Cd133结合剂及其用途 - Google Patents

Cd133结合剂及其用途 Download PDF

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Publication number
CN110352198B
CN110352198B CN201780078237.3A CN201780078237A CN110352198B CN 110352198 B CN110352198 B CN 110352198B CN 201780078237 A CN201780078237 A CN 201780078237A CN 110352198 B CN110352198 B CN 110352198B
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antibody
gly
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leu
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CN110352198A (zh
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J·莫法特
J·亚当斯
G·潘
S·西德胡
R·威廉姆斯
X·张
S·辛格
C·维纳戈帕尔
P·沃拉
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McMaster University
University of Toronto
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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CN201780078237.3A 2016-10-19 2017-10-19 Cd133结合剂及其用途 Active CN110352198B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662410162P 2016-10-19 2016-10-19
US62/410,162 2016-10-19
US201762472209P 2017-03-16 2017-03-16
US62/472,209 2017-03-16
PCT/CA2017/051245 WO2018072025A1 (en) 2016-10-19 2017-10-19 Cd133-binding agents and uses thereof

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CN110352198A CN110352198A (zh) 2019-10-18
CN110352198B true CN110352198B (zh) 2024-03-26

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US (2) US11220551B2 (enExample)
EP (1) EP3529279A4 (enExample)
JP (1) JP7231158B2 (enExample)
CN (1) CN110352198B (enExample)
WO (1) WO2018072025A1 (enExample)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201908784TA (en) * 2017-03-27 2019-10-30 Hoffmann La Roche Improved antigen binding receptor formats
CN110526987A (zh) * 2018-05-25 2019-12-03 深圳宾德生物技术有限公司 靶向cd133的嵌合抗原受体、嵌合抗原受体t细胞及其制备方法和应用
CN109735500B (zh) * 2019-01-25 2023-05-16 苏州茂行生物科技有限公司 一种分泌型靶向cd133的car-t细胞及其制备方法和应用
KR102503349B1 (ko) 2019-05-14 2023-02-23 프로벤션 바이오, 인코포레이티드 제1형 당뇨병을 예방하기 위한 방법 및 조성물
GB2599814A (en) 2019-05-31 2022-04-13 Univ Johns Hopkins Bispecific binding agents
JP2022534513A (ja) * 2019-05-31 2022-08-01 ザ・ジョンズ・ホプキンス・ユニバーシティー がん細胞遊走を阻害するためのＩＬ－６Ｒα／ＩＬ－８Ｒ二重特異性結合剤
CN113912697B (zh) * 2019-07-24 2023-05-30 暨南大学 靶向cd133的结合蛋白与应用
US12006366B2 (en) 2020-06-11 2024-06-11 Provention Bio, Inc. Methods and compositions for preventing type 1 diabetes
CN111529690B (zh) * 2020-06-17 2023-03-31 中国科学院昆明动物研究所 人cd133蛋白1-108肽段的新用途
CN114057875B (zh) * 2020-07-31 2023-05-05 北京市神经外科研究所 抗cd133的单链抗体及其在制备治疗肿瘤的药物中的用途
TW202229546A (zh) * 2020-09-27 2022-08-01 美商建南德克公司 高通量多參數免疫細胞接合物篩選測定
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
AU2021392032A1 (en) 2020-12-03 2023-06-22 Century Therapeutics, Inc. Genetically engineered cells and uses thereof
EP4263600A1 (en) 2020-12-18 2023-10-25 Century Therapeutics, Inc. Chimeric antigen receptor systems with adaptable receptor specificity
JP2024500189A (ja) 2020-12-21 2024-01-04 アロジーン セラピューティクス，インコーポレイテッド プロテアーゼ活性化ｃｄ４５ゲートｃａｒ
KR20230142470A (ko) 2021-01-29 2023-10-11 알로젠 테라퓨틱스 인코포레이티드 동종이계 세포 산물의 T 세포 인식을 완화하기 위한TAP2, NLRC5, β2m, TRAC, RFX5, RFXAP, 및 RFXANK 중 하나 이상의 녹다운 또는 녹아웃
EP4347654A1 (en) * 2021-06-04 2024-04-10 Amgen Research (Munich) GmbH T cell engager molecules and uses thereof
CN114213537B (zh) * 2021-12-24 2022-06-14 北京市神经外科研究所 Cd133抗体、嵌合抗原受体及其应用
CN114316050B (zh) * 2021-12-24 2022-11-11 北京市神经外科研究所 Cd133抗体、嵌合抗原受体及其应用
EP4463135A2 (en) 2022-01-10 2024-11-20 Sana Biotechnology, Inc. Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
US20240042030A1 (en) 2022-07-29 2024-02-08 Allogene Therapeutics, Inc. Engineered cells with reduced gene expression to mitigate immune cell recognition
EP4572772A1 (en) 2022-08-17 2025-06-25 Capstan Therapeutics, Inc. Conditioning for in vivo immune cell engineering
EP4602174A1 (en) 2022-10-13 2025-08-20 Sana Biotechnology, Inc. Viral particles targeting hematopoietic stem cells
EP4627096A1 (en) 2022-12-02 2025-10-08 Sana Biotechnology, Inc. Lipid particles with cofusogens and methods of producing and using the same
WO2024220597A2 (en) 2023-04-18 2024-10-24 Sana Biotechnology, Inc. Digital droplet based assay for detecting replication competent lentiviral vector
AU2024274792A1 (en) 2023-05-23 2025-10-23 Sana Biotechnology, Inc. Tandem fusogens and related lipid particles
US12311033B2 (en) 2023-05-31 2025-05-27 Capstan Therapeutics, Inc. Lipid nanoparticle formulations and compositions
WO2025056957A1 (en) * 2023-09-15 2025-03-20 Jimenez Mendoza, Dimas Peptide based medicines for treating cancer
WO2025076113A1 (en) 2023-10-05 2025-04-10 Capstan Therapeutics, Inc. Ionizable cationic lipids with conserved spacing and lipid nanoparticles
US20250127728A1 (en) 2023-10-05 2025-04-24 Capstan Therapeutics, Inc. Constrained Ionizable Cationic Lipids and Lipid Nanoparticles
WO2025096560A1 (en) 2023-10-30 2025-05-08 Allogene Therapeutics, Inc. Engineered cells
WO2025184529A1 (en) 2024-03-01 2025-09-04 Sana Biotechnology, Inc. Viral particles with fusogen display and related compositions and methods
WO2025217454A2 (en) 2024-04-11 2025-10-16 Capstan Therapeutics, Inc. Ionizable cationic lipids and lipid nanoparticles
WO2025217452A1 (en) 2024-04-11 2025-10-16 Capstan Therapeutics, Inc. Constrained ionizable cationic lipids and lipid nanoparticles
CN118108849B (zh) * 2024-04-28 2024-06-25 苏州睿瀛生物技术有限公司 一种抗cd33的纳米抗体制备方法和抗体的荧光标记流式应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2769989A1 (en) * 2013-02-21 2014-08-27 Universitätsklinikum Freiburg Recombinant bispecific antibody that binds to the CD133 antigen on tumor cells and to the human CD3 T cell receptor
WO2016154623A2 (en) * 2015-03-26 2016-09-29 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Anti-cd133 monoclonal antibodies and related compositions and methods

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2065397A1 (en) * 2007-11-20 2009-06-03 Miltenyi Biotech GmbH. Method for the separation of cells
CA2962157A1 (en) * 2016-10-19 2018-04-19 The Governing Council Of The University Of Toronto Cd133-binding agents and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2769989A1 (en) * 2013-02-21 2014-08-27 Universitätsklinikum Freiburg Recombinant bispecific antibody that binds to the CD133 antigen on tumor cells and to the human CD3 T cell receptor
WO2016154623A2 (en) * 2015-03-26 2016-09-29 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Anti-cd133 monoclonal antibodies and related compositions and methods

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Generation of Anti-CD133 Human Synthetic Antibodies as Tools for Exploring CD133 Function;Rashida Williams;《http://tspace.library.utoronto.ca/handle/1807/43333》;20131211;第6-8、35-36页，图9-11、13-14 *
Preclinical validation of a novel CD133/CD3 bispecic T-cell engager (BiTE) antibody to target patient-derived glioblastoma cells;Parvez Vora等;《Cancer Res》;20160430;第76卷;摘要部分 *
Rashida Williams.Generation of Anti-CD133 Human Synthetic Antibodies as Tools for Exploring CD133 Function.《http://tspace.library.utoronto.ca/handle/1807/43333》.2013,第6-8、35-36页，图9-11、13-14. *
The efficacy of CD133 BiTEs and CAR-T cells in preclinical model of recurrent glioblastoma;Parvez Vora等;《Cancer Immunol》;20160930;第4卷;摘要部分 *

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CN110352198A (zh) 2019-10-18
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