CN110327419A - 一种降血糖中药组合物及其制备方法 - Google Patents
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Abstract
一种降血糖中药组合物，包括天花粉，地黄，白术，茯苓，山药，山栀子，车前草，山茱萸，五味子，知母。一种能降血糖的中药组合物的制备方法，具体包括如下步骤：1、称取原料：称取天花粉，地黄，白术，茯苓，山药，山栀子，车前草，山茱萸，五味子，知母。2、煎煮：取一口砂锅，砂锅中加入水，将步骤1中所称原料加入砂锅中一起煎煮，将滤液滤出。3、再次煎煮：将步骤2中的滤渣加水煎煮，将滤液滤出。4、将步骤2和步骤3所煎滤液兑到一起。本发明的有益效果为：疗效好，无毒副作用，血糖不易反弹，从而既能缓解患者经济上的长期服药的负担，又能解除身心长期服药所带来的副作用和创伤，适于广泛推广应用。
Description
技术领域
本发明属于中药技术领域，尤其涉及一种降血糖中药组合物及其制备方法。
背景技术
糖尿病患者目前普遍所使用的控制血糖的方法是服用降糖药(以西药为主)和注射胰岛素，常用的降糖类西药有双胍类，喹酮类，促泌剂等。常见的副作用是双胍类会腹胀，其他各有各的不良反应，常见的有过敏，肝肾负担，低血糖等。注射胰岛素最直接的副作用就是在剂量不当的情况下出现低血糖，其次是胰岛素具有纳水潴留作用，会产生水肿；再者长期注射胰岛素对人体本身皮肤也会产生创伤，多数人肚脐周围产生硬块，久久不易消除，这也大大降低了患者的生活质量。
“消渴症”根据病机不同，可细分为“上消、中消和下消”。糖尿病与中医“消渴症”在病机和证型上比较相似，因此中医治疗糖尿病可以参照“消渴症”能取得较好的临床效果。
发明内容
针对上述现有技术中存在的问题，本发明的目的是通过中医中药来控制人体内血糖含量，使之处于正常的范围之内，通过一段时间的调理逐步减少降糖西药和胰岛素的用量。本发明利用传统中医治病理论并使用中药通过调理脾胃肝肾功能，调节体内消化系统的新陈代谢，从而控制血液中的含糖量，使之能够达到很好的降糖控糖作用。本发明对上消、中消和下消等不同病机的“消渴症”均有很好的降糖作用，是一种能够满足“三消”的中药降糖组方。
为了实现上述目的，本发明采用如下技术方案：
一种降血糖中药组合物，包括天花粉，地黄，白术，茯苓，山药，山栀子，车前草，山茱萸，五味子，知母。
进一步的，各成分重量比为：天花粉：地黄：白术：茯苓：山药：山栀子：车前草：山茱萸：五味子：知母＝18-22：18-22：18-22：10-14：10-14：10-14：13-17：10-14：10-14：8-12：8-12：13-17。
进一步的，各成分重量比为：天花粉：地黄：白术：茯苓：山药：山栀子：车前草：山茱萸：五味子：知母＝20：20：20：12：12：12：15：12：12：10：10：15。
本发明的另一个目的是提供一种降血糖中药组合物的制备方法，具体包括如下步骤：
1、称取原料：称取天花粉，地黄，白术，茯苓，山药，山栀子，车前草，山茱萸，五味子，知母。
2、煎煮：将步骤1中所称原料加水一起煎煮，将滤液滤出。
3、再次煎煮：将步骤2中的滤渣加水煎煮，将滤液滤出。
4、将步骤2和步骤3所煎滤液兑到一起。
进一步的，步骤1中所称取各原料的重量为天花粉20克，地黄20克，白术12克，茯苓12克，山药12克，山栀子12克，车前草12克，山茱萸10克，五味子10克，知母15克。
进一步的，步骤2中所加水量为三碗(900ml)，煎煮至一碗水(300ml)。
进一步的，步骤3中所加水量为两碗(600ml)，煎煮至一碗水(300ml)。
本发明的有益效果为：疗效好，无毒副作用，血糖不易反弹，从而既能缓解患者经济上的长期服药的负担，又能解除身心长期服药所带来的副作用和创伤，适于广泛推广应用。
具体实施方式
为了便于理解，下面结合实施例，对本发明技术方案作进一步具体描述：
一种降血糖中药组合物，由下述原料制成：天花粉20克，地黄20克，白术12克，茯苓12克，山药12克，山栀子12克，车前草12克，山茱萸10克，五味子10克，知母15克。
一种降血糖中药组合物的制备方法，具体包括如下步骤：
1、称取原料：天花粉20克，地黄20克，白术12克，茯苓12克，山药12克，山栀子12克，车前草12克，山茱萸10克，五味子10克，知母15克。
2、煎煮：取一口砂锅，砂锅中加入三碗水(900ml)，将步骤1中所称各成分加入砂锅中一起煎煮，三碗水煎成一碗(300ml)，将滤液滤出。
3、再次煎煮：将步骤2中的滤渣加两碗水(600ml)煎成一碗(300ml)，将滤液滤出。
4、将步骤2和步骤3所煎滤液兑到一起，煎好的药液应注意保鲜，防止酸腐变质。
服用方法：将步骤4中所制得的药液分早晚两次服用。
急性毒性试验：取小鼠80只，体重22-25克，对80只小鼠平均分成两组，对其中一组小鼠灌胃药液，另一组为对照组，对给药的半数致死量(LD50)进行了试验测定，但未测到LD50，因此进行了最大耐受量试验。结果：以最大给药量100g/kg灌胃，相当于成人临床拟日用剂量的50倍，七日内小鼠无一死亡，处死小鼠解剖观察各脏器未发现毒性反应，给药组与对照组小鼠无任何差异。
六个月长期毒性试验：取大鼠80只，体重180～220g，对80只大鼠平均分成四组，对第一组大鼠以80g/kg剂量连续灌胃给药180天，对第二组大鼠以40g/kg剂量连续灌胃给药180天，对第三组大鼠以20g/kg剂量连续灌胃给药180天，第四组为对照组。按人用(75kg为标准)剂量2.2g/kg/天计算，80g/kg、40g/kg、20g/kg，为人用有效剂量的40倍、20倍和10倍；连续灌胃给药180天，观察对大鼠各项生理、生化指标的影响。实验结果表明：不同剂量给大鼠连续口服180天，对大鼠的进食量和体重增长无影响。对肝肾功能未发现明显毒性作用。对血常规、血生化、尿液生化及骨髓片等均未见明显影响，各组间与对照组比较无明显差异。
临床论证：
为了验证本发明药物组合物的效果，门诊处随机抽取300例糖尿病患者，有早期患者，有中期患者，还有晚期患者，年龄在25～72岁之间，平均年龄50.2岁，其中男性患者165例，女性患者135例。随机分为治疗组和对照组，其中治疗组男性患者90例，女性患者70例，平均年龄51岁，对照组男性患者75例，女性患者65例，平均年龄49岁，两组性别、年龄、病程等比较，差异均无显著性意义(P＞0.05)，具有可比性。
治疗方法：对照组常规给药。治疗组以本发明制备的药液，口服一次250ml，一日两次，合计七天。
患者服药前需要根据辨证情况调整本配方中每种药品剂量。统计数据显示，服用7天内血糖下降者约为110人，服用7天后血糖下降减少胰岛素注射或者减少服用降糖西药者占80人，服用四周内停止胰岛素注射和停服降糖西药者约占130人，效果不明显者约60人。降糖总体有效率在80％以上，这些降糖有效者停掉胰岛素和降糖西药后，通过饮食控制和适当运动保持血糖在正常水平的约占95％，有5％的人偶尔出现血糖波动。
Claims (7)
1.一种降血糖中药组合物，其特征在于：包括天花粉，地黄，白术，茯苓，山药，山栀子，车前草，山茱萸，五味子，知母。
2.根据权利要求1所述的降血糖中药组合物，其特征在于：各成分重量比为：天花粉：地黄：白术：茯苓：山药：山栀子：车前草：山茱萸：五味子：知母＝18-22：18-22：18-22：10-14：10-14：10-14：13-17：10-14：10-14：8-12：8-12：13-17。
3.根据权利要求2所述的降血糖中药组合物，其特征在于：各成分重量比为：天花粉，地黄，白术，茯苓，山药，山栀子，车前草，山茱萸，五味子，知母＝20：20：20：12：12：12：15：12：12：10：10：15。
4.根据权利要求1所述的降血糖中药组合物的制备方法，其特征在于：具体包括如下步骤：
(1)称取原料：称取天花粉，地黄，白术，茯苓，山药，山栀子，车前草，山茱萸，五味子，知母。
(2)煎煮：取一口砂锅，砂锅中加入水，将步骤1中所称原料加入砂锅中一起煎煮，将滤液滤出。
(3)再次煎煮：将步骤2中的滤渣加水煎煮，将滤液滤出。
(4)将步骤2和步骤3所煎滤液兑到一起。
5.根据权利要求4所述的降血糖中药组合物的制备方法，其特征在于：步骤1中所称取各原料的重量为天花粉20克，地黄20克，白术12克，茯苓12克，山药12克，山栀子12克，车前草12克，山茱萸10克，五味子10克，知母15克。
6.根据权利要求5所述的降血糖中药组合物的制备方法，其特征在于：步骤2中所加水量为三碗(900ml)，煎煮至一碗水(300ml)。
7.根据权利要求6所述的降血糖中药组合物的制备方法，其特征在于：步骤3中所加水量为两碗(600ml)，煎煮至一碗水(300ml)。
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