CN110327265A - Scalp care composition and preparation method and application thereof - Google Patents
Scalp care composition and preparation method and application thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
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- A—HUMAN NECESSITIES
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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Abstract
The invention provides a scalp care composition which comprises a hyaluronic acid compound, dipotassium glycyrrhizinate, a chamomile extract and gellan gum. The scalp care composition plays a synergistic role in moisturizing and resisting allergy through the combination of the hyaluronic acid compound, the dipotassium glycyrrhizinate and the chamomile extract, and improves the barrier function of skin. The scalp care composition has the physical form of semisolid and proper viscosity, so that the scalp care composition has enough residence time on the skin, effective components are fully absorbed by the skin, and the problems that the traditional scalp care product has strong sticky feeling and the penetration and absorption of functional components are influenced by a rheological agent are solved. Therefore, the scalp care composition provided by the invention has good moisture retention and anti-allergy effects, is beneficial to absorption and good in use feeling, can be applied to washing-free scalp care spray, and has a wide application prospect.
Description
Technical field
The invention belongs to household chemicals technical fields, and in particular to a kind of scalp care compositions and preparation method thereof and
Using.
Background technique
Scalp is very important a part in skin, similar with facial skin structure, blood vessel and sebum rich in
Gland, the balance of ecological environment are the basic of hair healthy growth.The sweat gland of scalp, smegma are vigorous, but due to hair
Barrier be difficult to thoroughly clean, Yi Yinqi microbial reproduction；The sebum of scalp is irradiated with ultraviolet radiation equal environmental stimulus, is easy hair
Raw peroxidization, causes scalp light inflammation to react；And the capacity of self-regulation of scalp can with the increase at age and by
Step decline.Therefore, scalp care is can not be ignored the problem of.
Currently, scalp care product in the market is based on shampoo.The primary efficacy of shampoo is cleaning hair and head
Skin, but shampoo while cleaning scalp, can inevitably clean has protective sebum on scalp, makes scalp barrier function
It is destroyed.In addition, grease conditioner would generally be added in shampoo, it is tight to reduce dry scalp, but grease conditioner
It can be rinsed when having one's hair wash bath, short in the residence time of scalp, effect is general, can not alleviate the tight shape of dry scalp
State, and it is easy to appear drying property dandruff.When cation opsonizing agent addition is excessive in shampoo, also can correct belt stimulate,
Cause itching of the scalp, scalp tender subject also can be increasingly severe.Therefore, the scalp care for carrying out profession, keeps scalp completely clear
It is refreshing, scalp tender subject is solved, is had great importance.
CN108553382A discloses the application of a kind of scalp nursing solution and its scalp care compositions and they, the head
Skin care composition includes shrubby sophora extract, Notogineng Extract, Folium Artemisiae Argyi extract, common cnidium fruit P.E, windproof root extract, side
CedarLeaves extract, purslane extract, asparagus juice, propylene glycol, niacinamide, dipotassium glycyrrhizinate and vitamin B6；The scalp shield
Managing liquid includes the scalp care compositions and preservative, essence and water.The scalp care compositions and scalp nursing solution
Anti-dandruff, antipruritic, oil-control and anticreep effect are preferable, and mild, safe, non-stimulated to human body, environmentally friendly.
CN106232099A discloses a kind of scalp care compositions, in the scalp care compositions comprising about 0.05~
5% anti-dandruff active, about 0.1~25% one or more organic solvents, about 1~99% volatile vehicle,
Wherein anti-dandruff active is imidazoles (such as Climbazole), thiazole, triazole and its mixture, organic solvent be polyalcohol,
Alcohols and its mixture with aromatic functional groups, volatile vehicle are the mixture of water or water and organic solvent.The head
Skin care composition has good anti-dandruff effect, and increases its antimycotic efficiency.
CN107412109A discloses a kind of Shu Min type scalp nursing solution, removes in the Shu Min type scalp nursing solution and contains head
The acceptable group of skin conditioning liquid also includes 0.05~12% Rhizoma Zingiberis zerumbet rhizome extract, 0.1~15% scalp Shu Min tune exceptionally
Manage the denatured ethyl alcohol of agent and 5~30%；Wherein, scalp Shu Min conditioner is PEG-8 caprylic/capric glyceride, pentanediol moisturizing
The mixture of agent and peppermint oil.The scalp nursing solution can effectively refreshing root of hair, pleasant scalp reduce dandruff, scalp itch only
And the generation of the symptoms such as raw pimple of scalp.
However in existing scalp care product, residence time of the rinse-off products on scalp is short, functionality therein
Ingredient can not effectively play its effect.In leave product, the glutinous soapy feeling of scalp care Essence is strong, does not only result in user's
Use feeling is poor, and will affect absorption of the scalp to effective component；What rheological agent can improve product sticks greasy problem, but simultaneously
Infiltration and scalp absorption to effective component of the effective component on scalp can be weakened.Therefore, scalp care in the prior art
The addition type and additive amount of the moisturizer of product, scalp care agent and rheological agent can all influence scalp care effect.
Based on this, develop a kind of moisturizing antiallergic effect it is good, conducive to absorbing and the good scalp care compositions of use feeling, be
The research emphasis of this field.
Summary of the invention
In view of the deficiencies of the prior art, the purpose of the present invention is to provide a kind of scalp care compositions and preparation method thereof
And application, it include that hyalomitome acid compounds, dipotassium glycyrrhizinate, camomile extract and knot are cold in the scalp care compositions
Glue, the mutual coordinated between hyalomitome acid compounds, dipotassium glycyrrhizinate and camomile extract three make the scalp
Care composition has effects that excellent moisturizing antiallergic, and gellan gum assigns the semisolid physics shape of scalp care compositions
State is conducive to absorption of the scalp to effective component, and improves the use feeling of user.
To achieve this purpose, the present invention adopts the following technical scheme:
In a first aspect, the present invention provides a kind of scalp care compositions, the scalp care compositions include hyaluronic acid
Class compound, dipotassium glycyrrhizinate, camomile extract and gellan gum.
Hyaluronic acid is a kind of acid mucopolysaccharide, is shown in body with its unique molecular structure and physicochemical property more
The important physiological function of kind, especially has special water retention, the water of 100 times of its own weight can be absorbed, be to send out at present
The best substance of moisture retention in existing nature, referred to as ideal " natural moisturizing factor ".Hyaluronic acid is distributed widely in people
A large amount of hyaluronic acids are wherein also contained at each position of body in skin, it can improve skin-nourishing metabolism, make skin wet, increase
Elasticity prevents aging, is good skin penetration enhancer again while moisturizing.
Dipotassium glycyrrhizinate is the derivative of the glycyrrhizin (glycyrrhizic acid) of Radix Glycyrrhizae root and stem, can be used as skin conditioning agent
Use, have the function of it is antibacterial, move back redness, antiphlogistic healing, removing toxic substances, antiallergic, anti-irritant and oil-control, suitable anaphylaxis skin can
Sensitivity inflammation phenomenon when effectively prevention skin is stimulated, inflammation caused by counterglow have anti-inflammatory sedation, are commonly used for resisting
In allergy and reparation cosmetics.
In camomile extract contain flavones, saponin(e, polysaccharide, volatile oil isoreactivity ingredient, main function be Lavender Extract,
Sensibility, detumescence anti-inflammatory are soothed the skin, thin fine vascular is received, reduces chemical substance or the excessively high wound to skin of essential oil concentration
Evil can make skin generate protection, and sensitivity skin is suitble to use.
It is mentioned in scalp care compositions provided by the invention comprising hyalomitome acid compounds, dipotassium glycyrrhizinate and chamomile
Object is taken, wherein hyalomitome acids compound penetration is extremely strong, is able to enter dermal layer of the skin, promotes the moisture preserving energy of skin corium
Power, dipotassium glycyrrhizinate and camomile extract all have functions of detumescence, relieving inflammation, soothe the skin the effect of sensibility, Lavender Extract, three
Combination can play synergistic function, facilitate enhance skin to effective component profound level absorb, keep effective component complete
The reparation of sensitivity damaged skin in pairs, and skin barrier function is promoted, moisture is lost in reduction skin, and then promotes skin
Self-protection ability reduces sensitivity.
It further include gellan gum in scalp care compositions of the present invention, gellan gum is the polysaccharide of natural botanical source,
The semisolid physical aspect of scalp care compositions of the present invention and suitable viscosity are imparted as thickener, makes the head
Skin care composition has enough residence times on the skin, fully absorbs effective component by skin, to solve biography
The active material residence time is short, the problem of can not being effectively absorbed by the skin in system scalp care product.
Scalp care compositions provided by the invention are extracted by hyalomitome acid compounds, dipotassium glycyrrhizinate and chamomile
The mutual coordinated of three kinds of effective components of object makes it have excellent moisturizing antiallergic effect, promotes skin barrier function；And
Suitable viscosity is made it have by gellan gum, makes effective component by skin in the residence time of scalp by improving effective component
It fully absorbs, solves the problems, such as that traditional scalp care product sticks that soapy feeling is strong, rheological agent influences both effectiveness ingredient osmotic absorption.
Preferably, the scalp care compositions include following ingredient according to mass percentage:
In scalp care compositions provided by the invention, the content of each component should be in the range of above-mentioned restriction, if effectively
The content of ingredient hyalomitome acid compounds, dipotassium glycyrrhizinate and camomile extract be lower than the framework of the present definition, then without
Method effectively plays the effect of moisturizing antiallergic；If the content of effective component, which is higher than, limits range, the absorption burden of skin will increase,
And it may cause toxic side effect.The content of gellan gum limits range lower than the present invention, then can not effectively thicken, can not make the head
There is skin care composition semisolid form the viscosity of scalp care compositions can be made excessive if its too high levels, unfavorable
In its on the skin evenly dispersed.
In the present invention, the mass percentages of the hyalomitome acid compounds can for 0.02%, 0.04%,
0.06%, 0.08%, 0.1%, 0.13%, 0.15%, 0.18%, 0.2%, 0.23%, 0.25%, 0.28%, 0.3%,
0.33%, the specific point value between 0.35%, 0.38%, 0.4%, 0.45% or 0.48% and above-mentioned point value, as space is limited
And for concise consideration, specific point value that range described in the present invention no longer exclusive list includes.
The mass percentage of the dipotassium glycyrrhizinate can for 0.02%, 0.04%, 0.06%, 0.08%, 0.1%,
0.13%, 0.15%, 0.18%, 0.2%, 0.23%, 0.25%, 0.28%, 0.3%, 0.33%, 0.35%, 0.38%,
0.4%, the specific point value between 0.45% or 0.48% and above-mentioned point value, as space is limited and for concise consideration, this hair
The specific point value that range described in bright no longer exclusive list includes.
The mass percentage of the camomile extract can for 0.02%, 0.05%, 0.08%, 0.1%,
0.15%, 0.2%, 0.3%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.5%, 2.0%, 2.5%,
3.0%, the specific point value between 3.5%, 4.0% or 4.5% and above-mentioned point value, as space is limited and for concise consideration,
The specific point value that range described in the present invention no longer exclusive list includes.
The mass percentage of the gellan gum can for 0.06%, 0.08%, 0.1%, 0.13%, 0.15%,
0.18%, 0.2%, 0.25%, 0.3%, 0.35%, 0.4%, 0.45%, 0.5%, 0.6%, 0.7%, 0.8% or 0.9%,
And the specific point value between above-mentioned point value, as space is limited and for concise consideration, model described in the present invention no longer exclusive list
Enclose including specific point value.
Preferably, hyalomitome acid compounds are hyaluronic acid and/or Sodium Hyaluronate.
Preferably, the molecular weight of the Sodium Hyaluronate be less than 10000Da, such as 9500Da, 9000Da, 8800Da,
8500Da、8300Da、8000Da、7800Da、7500Da、7300Da、7000Da、6800Da、6500Da、6300Da、6000Da、
5800Da, 5500Da, 5300Da, 5000Da, 4800Da, 4500Da, 4300Da or 4000Da etc..
In scalp care compositions provided by the invention, hyalomitome acid compounds preferably clear matter acid sodium is described transparent
Matter acid sodium is small-molecular-weight Sodium Hyaluronate, and molecular weight is lower than 10000Da.It is transparent in scalp care compositions of the present invention
Matter acid sodium has extremely strong permeability, can penetrate into skin corium, promote the moisturizing storage capacity of skin corium, has mild dilation capillary
Blood vessel, the effect for increasing blood circulation, improving intermediate supersession, skin-nourishing being promoted to absorb, and skin can be promoted to effective component
Absorption, thus in the profound maintenance and moisturizing for realizing sensitive skin.
Preferably, the scalp care compositions include following ingredient according to mass percentage:
Preferably, the scalp care compositions further include hydrolysed corn starch.
It preferably, is the quality percentage of the hydrolysed corn starch in terms of 100% by the quality of the scalp care compositions
Content be 0.01~1.0%, such as 0.02%, 0.05%, 0.08%, 0.1%, 0.15%, 0.2%, 0.25%, 0.3%,
0.35%, 0.4%, 0.45%, 0.5%, 0.6%, 0.7%, 0.8% or 0.9% etc., further preferably 0.1~0.4%.
It further include hydrolysed corn starch in scalp care compositions provided by the invention, hydrolysed corn starch is a kind of natural
Moisturizer and skin conditioning agent, hair moist, hair follicle health, root of hair can be kept firm, while there is certain antipruritic function
Effect.
Preferably, the scalp care compositions further include small molecule polyol.
Preferably, the small molecule polyol in hexylene glycol, propylene glycol, glycerol or butanediol any one or extremely
Few two kinds of combination.
It preferably, is the quality percentage of the small molecule polyol in terms of 100% by the quality of the scalp care compositions
Content be 0.1~1.0%, such as 0.13%, 0.15%, 0.2%, 0.25%, 0.3%, 0.35%, 0.4%, 0.45%,
0.5%, 0.6%, 0.7%, 0.8% or 0.9% etc., further preferably 0.5%.
Further include small molecule polyol in scalp care compositions provided by the invention, the small molecule polyol be containing
The polyalcohol of 2~10 C atoms.Multiple hydroxyls in small molecule polyol can have moisturizing function with water by Hydrogenbond
Effect, can improve the moisture preserving function of skin with hyalomitome acid compounds collective effect.
Preferably, the scalp care compositions further include magnesium sulfate.
It preferably, is in terms of 100% by the quality of the scalp care compositions, the mass percentage of the magnesium sulfate is
0.05~1.0%, for example, 0.06%, 0.08%, 0.1%, 0.15%, 0.2%, 0.25%, 0.3%, 0.35%, 0.4%,
0.45%, 0.5%, 0.6%, 0.7%, 0.8% or 0.9% etc., further preferably 0.5%.
It further include magnesium sulfate in scalp care compositions provided by the invention.Gellan gum is that one kind from fermentation is water-soluble
Property polysaccharide material, molecular structure be the straight chain with rhamnose, glucose and glucose repeat units, the gellan gum pair of low acyl group
Ion is more sensitive, and ion concentration is higher, and hydration time is longer, and the intensity of gel can also enhance as ion concentration increases,
When reaching certain value, the intensity of gel can be reduced.Bivalent ions gel strength can be higher than monovalent ion, the gel bullet of formation
Property increase, be not easily broken, facilitate scalp care compositions of the present invention and form semisolid physical aspect.
Preferably, the scalp care compositions further include ethyl alcohol.
It preferably, is in terms of 100% by the quality of the scalp care compositions, the mass percentage of the ethyl alcohol is
0.1~5.0%, for example, 0.13%, 0.15%, 0.2%, 0.25%, 0.3%, 0.35%, 0.4%, 0.45%, 0.5%,
0.7%, 0.9%, 1.0%, 1.5%, 2.0%, 2.5%, 3.0%, 3.5%, 4.0% or 4.5% etc., further preferably
0.5%.
It further include ethyl alcohol in scalp care compositions provided by the invention, on the one hand ethyl alcohol is used as penetrating agent to facilitate scalp
Each component in care composition can be preferably deep into scalp, on the other hand have cleaning and biocidal efficacies, can be with
Inhibit the fat secretion on skin and restrains pore.
Preferably, the scalp care compositions include following ingredient according to mass percentage:
On the other hand, the present invention provides a kind of preparation method of scalp care compositions as described above, the preparation side
Method the following steps are included:
(1) gellan gum, hyalomitome acid compounds, dipotassium glycyrrhizinate and water are mixed, stirring obtains mixed liquor I；
(2) mixed liquor I that step (1) obtains is mixed with camomile extract, obtains the scalp care compositions.
Preferably, the temperature of step (1) described stirring be 70~80 DEG C, such as 71 DEG C, 72 DEG C, 73 DEG C, 74 DEG C, 75 DEG C,
76 DEG C, 77 DEG C, 78 DEG C or 79 DEG C etc., further preferably 75 DEG C.
Preferably, step (2) the mixed temperature be 40~60 DEG C, such as 41 DEG C, 43 DEG C, 45 DEG C, 47 DEG C, 49 DEG C,
50 DEG C, 52 DEG C, 54 DEG C, 56 DEG C, 58 DEG C or 59 DEG C etc., further preferably 50 DEG C.
Preferably, the preparation method specifically includes the following steps:
(1) gellan gum, hyalomitome acid compounds, dipotassium glycyrrhizinate and water are mixed, 70~80 DEG C are stirred and keep the temperature 20
~40min (such as 21min, 23min, 25min, 27min, 30min, 32min, 35min, 37min or 39min etc.), is mixed
Close liquid I；
(2) mixed liquor I that step (1) obtains is cooled to 40~60 DEG C, with camomile extract, hydrolysed corn starch,
Ethyl alcohol and small molecule polyol mixing, add magnesium sulfate solution, mix, and discharging obtains the scalp care compositions.
The preparation method of scalp care compositions of the present invention is divided into two steps, higher temperature of the first step at 70~80 DEG C
Lower progress facilitates gellan gum, hyalomitome acid compounds and dipotassium glycyrrhizinate and dissolves dispersion in water completely；Second step is 40
It is carried out under the conditions of~60 DEG C, the other components such as camomile extract should be made sufficiently to dissolve, disperse, and to avoid chamomile from mentioning
Take active constituent in object deactivation at high temperature.
On the other hand, the present invention is provided during a kind of disposable scalp care is spraying, and the disposable scalp care is spraying comprising such as
The upper scalp care compositions.
Compared with the existing technology, the invention has the following advantages:
The present invention provides a kind of comprising hyalomitome acid compounds, dipotassium glycyrrhizinate, camomile extract and gellan gum
Scalp care compositions, wherein hyalomitome acids compound penetration is extremely strong, is able to enter dermal layer of the skin, promotes skin corium
Moisture preserving ability, dipotassium glycyrrhizinate and camomile extract all have functions of detumescence, relieving inflammation, soothe the skin sensibility, Lavender Extract
The combination of effect, three can play synergistic function, so that the percutaneous rate of scattering and disappearing of moisture of skin is reached 8~12%, histamine
Inhibiting rate reaches 45% or more, promotes the moisture preserving ability and antiallergy anti-inflammatory ability of skin, repairs sensitive skin, in turn
Promote the barrier function of skin.Scalp care compositions of the present invention have semisolid physical aspect and suitable viscosity,
Making the scalp care compositions on the skin has enough residence times, fully absorbs effective component by skin, solves
Traditional scalp care product sticks the problem that soapy feeling is strong, rheological agent influences both effectiveness ingredient osmotic absorption.Therefore, of the present invention
Scalp care compositions moisturizing antiallergic effect is good, be conducive to absorb and use feeling is good, can be applied to disposable scalp care it is spraying in,
It has broad application prospects.
Specific embodiment
The technical scheme of the invention is further explained by means of specific implementation.Those skilled in the art should be bright
, the described embodiments are merely helpful in understanding the present invention, should not be regarded as a specific limitation of the invention.
The material used in following embodiment of the present invention includes:
Sodium Hyaluronate, molecular weight 6000Da, purchased from the prosperous Fu Ruida of China；Dipotassium glycyrrhizinate is purchased from the general plant in Gansu；Ocean is sweet
Chrysanthemum extract is avenged purchased from Guangzhou Austria；Gellan gum is purchased from the Leix A Ze；Hexylene glycol is fragrant purchased from moral；Hydrolysed corn starch is purchased from Shanghai
Purple nation；Magnesium sulfate and ethyl alcohol are purchased from traditional Chinese medicines reagent.
KU812 cell comes from the bright cell bank in upper Haikang；The related reagent of test organization amine release concentration is tried purchased from Aladdin
Agent.
Examples 1 to 4
A kind of scalp care compositions, concrete component is as shown in table 1, and the unit of each component content is parts by weight:
Table 1
The preparation method is as follows:
(1) at room temperature that gellan gum, Sodium Hyaluronate, dipotassium glycyrrhizinate is soluble in water, stirring is warming up to 75 DEG C, in the temperature
Degree is lower to keep the temperature 30min, obtains mixed liquor I；
(2) mixed liquor I that step (1) obtains is cooled to 50 DEG C, then with camomile extract, hydrolysed corn starch,
Ethyl alcohol, hexylene glycol and water mixing, stir evenly；Magnesium sulfate solution is added, mixes, makes 100 parts by weight of raw material total amount；It takes advantage of
Heat discharging, obtains the scalp care compositions.
Embodiment 5
The present embodiment provides a kind of scalp care compositions, concrete component is as follows:
The preparation method is as follows:
(1) at room temperature that gellan gum, Sodium Hyaluronate, dipotassium glycyrrhizinate is soluble in water, stirring is warming up to 75 DEG C, in the temperature
Degree is lower to keep the temperature 30min, obtains mixed liquor I；
(2) mixed liquor I that step (1) obtains is cooled to 50 DEG C, is then mixed with camomile extract and water, makes raw material
Total amount is 100 parts by weight, stirs evenly, discharges while hot, obtains the scalp care compositions.
Comparative example 1
This comparative example the difference from embodiment 1 is that, do not add Sodium Hyaluronate and dipotassium glycyrrhizinate.
Comparative example 2
This comparative example the difference from embodiment 1 is that, do not add Sodium Hyaluronate.
Comparative example 3
This comparative example the difference from embodiment 1 is that, do not add dipotassium glycyrrhizinate.
Comparative example 4
This comparative example the difference from embodiment 1 is that, do not add camomile extract.
Performance test:
(1) the percutaneous rate of scattering and disappearing of moisture of skin ((transepidermal water loss, TEWL):
It is measured using the moisture of skin tester Tewameter TM300 that scatters and disappears, using measuring probe in skin surface
Metastable test subenvironment is formed, the water vapor pressure ladder of temperature-humidity sensor measurement skin (about within 1cm) is passed through
Degree directly measures the amount of moisture of epidermis evaporation.Moisture of skin windage reflected within test period, Experimental Area moisture loss
Change with time rule, can be used for the water lock performance of characterization test sample, value is smaller, and moisture loss is fewer, shows skin
Barrier function it is better；Otherwise it is weaker.
The scalp care compositions provided based on above method testing example 1~5, comparative example 1~4 pass through moisture of skin
The influence of skin rate of scattering and disappearing.It is 20~40 years old volunteer as subjects using 20 ages, men and women is fifty-fifty；It is selected on volunteer's scalp
Taking diameter is the round trial zone of 3cm, uniformly smears Examples 1 to 5, the scalp care compositions that comparative example 1~4 provides, point
Do not test the region smear before, smear 1h after, smear 2h after the percutaneous rate of scattering and disappearing of moisture of skin (%), obtained test data is such as
Shown in table 2.
Table 2
| TEWL before smearing | TEWL after smearing 1h | TEWL after smearing 2h | |
| Embodiment 1 | 14.5% | 11.3% | 11.9% |
| Embodiment 2 | 14.7% | 10.8% | 11.7% |
| Embodiment 3 | 14.6% | 9.2% | 10.8% |
| Embodiment 4 | 14.9% | 8.1% | 9.4% |
| Embodiment 5 | 15.3% | 8.3% | 9.8% |
| Comparative example 1 | 14.3% | 13.5% | 14.9% |
| Comparative example 2 | 14.4% | 12.6% | 13.8% |
| Comparative example 3 | 14.5% | 11.5% | 12.7% |
| Comparative example 4 | 14.6% | 10.9% | 12.1% |
It is available from the data of table 2, after smearing the scalp care compositions 1h that the embodiment of the present invention 1~5 provides, skin
The percutaneous rate of scattering and disappearing of moisture decreased significantly, and declines degree and be greater than comparative example 1~4, wherein smearing scalp care described in embodiment 4
Skin TEWL is minimum after composition 1h, up to 8.1%.Smear Examples 1 to 5 provide scalp care compositions 2h after, TEWL compared with
Slightly rise when 1h, but still be significantly less than the TEWL before smearing, is also significantly less than and smears the scalp care of comparative example 1~4
TEWL after composition.This show the embodiment of the present invention 1~5 provide scalp care compositions in, Sodium Hyaluronate, glycyrrhizic acid
The mutual cooperation of three kinds of components of dipotassium and camomile extract could reduce the percutaneous rate of scattering and disappearing of moisture of skin, and it is good lasting to realize
Moistening effect；Three has the function of synergy, and indispensable, does not add Sodium Hyaluronate, sweet in comparative example 1~4
Any one of oxalic acid dipotassium and camomile extract or two kinds of scalp care compositions can not all have moisture-keeping efficacy, smear
It is no different before TEWL and smearing after 2h, does not have moisture-keeping efficacy substantially.Therefore, lead in scalp care compositions provided by the invention
The mutual collaboration for crossing Sodium Hyaluronate, dipotassium glycyrrhizinate and camomile extract can promote the moisture preserving ability of skin, drop
Moisture is lost in low skin, repairs skin barrier function, so that the self-protection ability of skin is promoted to a certain extent, drop
Low sensitivity.
(2) histamine inhibiting rate:
Histamine is a kind of active amine compound, is to be widely present in the intracorporal biogenic amine of animals and plants, by histidine decarboxylation
It is formed, is usually stored in the mast cell of tissue.In vivo, histamine is important one of chemical mediator, when body by
When certain stimulation causes antigen-antibody reaction, causes the cell membrane penetration of mast cell to sexually revise, release histamine, in turn
Pathologic, physiologic effect is generated with Histamine receptors.In allergy and inflammatory reaction, the histamine that is discharged after mast cell degranulation
Isoreactivity medium can directly participate in allergic reaction, therefore histamine releasing concentration is to evaluate the important finger of allergy and inflammatory reaction
Mark.
KU812 cell and mast cell have high similarity, and activation leads to cell degranulation, it is proinflammatory to release histamine
Cell factor, histamine proinflammatory cytokine vasoactive, smooth muscle, connective tissue and muccus gland, can expand or tie up
Hold inflammatory reaction.By inducing KU812 cell tissue amine releasing theory, for evaluating scalp care compositions pair of the present invention
The influence of histamine releasing.
Specific experiment process is as follows: cell count is 1.0 × 105A/hole, it is mixed with the culture medium that 1mL contains 10% serum
It is outstanding to be inoculated in orifice plate, for 24 hours after adherent growth, discards culture medium and 1mL tyrode (Tyrode liquid) balance 10min is added.Often
50 μ L C48/80 (10 μ g/mL) stimulation is added in hole, and blank control group is arranged, 50 μ L Tyrode liquid are added.Respectively at 0,15,
30,45,60min termination reaction.Terminating method is to be centrifuged 10min under 0~4 DEG C of low temperature with 2000r/min, takes supernatant standby
With.KU812 is directly spare with plate centrifuge same rotational speed centrifuging and taking supernatant.It weighs histamine standard items 10mg and is placed in 100mL
In volumetric flask, constant volume is dissolved with methanol, as stock solution.Respectively it is accurate draw stock solution 0.5,1.5,2.5,3.5,4.5,
5.5mL is in 10mL volumetric flask, with methanol dilution constant volume.Assay of histamine levels is measured using Liquid Chromatography/Mass Spectrometry (LC-MS), by peak face
Product integral carries out linear regression calculating to concentration, and obtaining calibration curve equation is Y=2.735X+28.476, R2=0.9997, show
Histamine sample volume and peak area when concentration is between 5.0~55.0ng/mL are in good linear relationship.Using LC-MS
Method (LC-MS) replaces original Enzyme-linked Immunosorbent Assay (ELISA) method, improves specificity and sensitivity.
The histamine for the scalp care compositions that testing example 1~5, comparative example 1~4 provide according to the method described above inhibits
Rate, test data are as shown in table 3.
Table 3
| Histamine inhibiting rate/% | |
| Embodiment 1 | 45.53 |
| Embodiment 2 | 46.37 |
| Embodiment 3 | 45.89 |
| Embodiment 4 | 45.76 |
| Embodiment 5 | 44.85 |
| Comparative example 1 | 29.89 |
| Comparative example 2 | 28.78 |
| Comparative example 3 | 28.97 |
| Comparative example 4 | 31.23 |
| Blank control group | 22.36% |
It is available from the data of table 3, suppression of the scalp care compositions that the embodiment of the present invention 1~5 provides to histamine
Rate processed reaches 45% or more, is significantly higher than in comparative example 1~4 scalp care compositions to the inhibiting rate of histamine.This shows
In the scalp care compositions that the embodiment of the present invention 1~5 provides, Sodium Hyaluronate, dipotassium glycyrrhizinate and camomile extract three
The mutual cooperation of kind component could effectively inhibit the release of histamine, realize good antiallergic effect；There is three collaboration to increase
The effect of effect, and it is indispensable, it is not added in Sodium Hyaluronate, dipotassium glycyrrhizinate and camomile extract in comparative example 1~4
Any one or two kinds of scalp care compositions all can not efficiently inhibit histamine releasing.Therefore, hyaluronic acid in the present invention
The histamine that the mutual collaboration of sodium, dipotassium glycyrrhizinate and camomile extract can promote the scalp care compositions inhibits
Rate, by inhibit histamine releasing realize antiallergy, anti-inflammatory the effect of, the self-protection ability of skin is promoted with this, reduce
Sensitivity.
The Applicant declares that the present invention is explained by the above embodiments scalp care compositions provided by the invention and its system
Preparation Method and application, but the present invention is not limited to the above embodiments, that is, does not mean that the present invention must rely on above-described embodiment
It could implement.It should be clear to those skilled in the art, any improvement in the present invention, to each raw material of product of the present invention
Equivalence replacement and addition, the selection of concrete mode of auxiliary element etc., all fall within protection scope of the present invention and the open scope
Within.
Claims (10)
1. a kind of scalp care compositions, which is characterized in that the scalp care compositions include hyalomitome acid compounds, sweet
Oxalic acid dipotassium, camomile extract and gellan gum.
2. scalp care compositions according to claim 1, which is characterized in that the scalp care compositions are according to quality
Percentage composition includes following ingredient:
3. scalp care compositions according to claim 1 or 2, which is characterized in that hyalomitome acid compounds are transparent
Matter acid and/or Sodium Hyaluronate；
Preferably, the molecular weight of the Sodium Hyaluronate is less than 10000Da.
4. described in any item scalp care compositions according to claim 1~3, which is characterized in that the scalp care combination
Object includes following ingredient according to mass percentage:
5. scalp care compositions according to any one of claims 1 to 4, which is characterized in that the scalp care combination
Object further includes hydrolysed corn starch；
It preferably, is the mass percentage of the hydrolysed corn starch in terms of 100% by the quality of the scalp care compositions
It is 0.01~1.0%, further preferably 0.1~0.4%.
6. described in any item scalp care compositions according to claim 1~5, which is characterized in that the scalp care combination
Object further includes small molecule polyol；
Preferably, the small molecule polyol in hexylene glycol, propylene glycol, glycerol or butanediol any one or at least two
The combination of kind；
It preferably, is the mass percentage of the small molecule polyol in terms of 100% by the quality of the scalp care compositions
It is 0.1~1.0%, further preferably 0.5%；
Preferably, the scalp care compositions further include magnesium sulfate；
It preferably, is in terms of 100% by the quality of the scalp care compositions, the mass percentage of the magnesium sulfate is 0.05
~1.0%, further preferably 0.5%；
Preferably, the scalp care compositions further include ethyl alcohol；
Preferably, by the quality of the scalp care compositions it is in terms of 100% that the mass percentage of the ethyl alcohol is 0.1~
5.0%, further preferably 0.5%.
7. described in any item scalp care compositions according to claim 1~6, which is characterized in that the scalp care combination
Object includes following ingredient according to mass percentage:
8. a kind of preparation method of scalp care compositions as described in any one of claims 1 to 7, which is characterized in that described
Preparation method the following steps are included:
(1) gellan gum, hyalomitome acid compounds, dipotassium glycyrrhizinate and water are mixed, stirring obtains mixed liquor I；
(2) mixed liquor I that step (1) obtains is mixed with camomile extract, obtains the scalp care compositions.
9. preparation method according to claim 8, which is characterized in that the temperature of step (1) described stirring is 70~80 DEG C,
Preferably 75 DEG C；
Preferably, step (2) the mixed temperature is 40~60 DEG C, further preferably 50 DEG C；
Preferably, the preparation method specifically includes the following steps:
(1) gellan gum, hyalomitome acid compounds, dipotassium glycyrrhizinate and water are mixed, 70~80 DEG C stir and keep the temperature 20~
40min obtains mixed liquor I；
(2) mixed liquor I that step (1) obtains is cooled to 40~60 DEG C, with camomile extract, hydrolysed corn starch, ethyl alcohol
It is mixed with small molecule polyol, adds magnesium sulfate solution, mixed, discharging obtains the scalp care compositions.
10. a kind of disposable scalp care is spraying, which is characterized in that comprising such as claim 1 during the disposable scalp care is spraying
~7 described in any item scalp care compositions.
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| CN112656709A (en) * | 2021-01-06 | 2021-04-16 | 华熙生物科技股份有限公司 | Skin care compositions and uses thereof |
| CN113398037A (en) * | 2021-07-23 | 2021-09-17 | 广州澳乐健康产业有限公司 | Wash-free mousse capable of improving hair refreshing feeling and fluffy feeling |
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Address after: 510663 No.15, Kelin Road, Guangzhou Science City, Guangzhou high tech Industrial Development Zone, Guangdong Province Applicant after: Guangzhou Huanya cosmetics technology Co.,Ltd. Address before: 510663 No.15, Kelin Road, Guangzhou Science City, Guangzhou high tech Industrial Development Zone, Guangdong Province Applicant before: GUANGZHOU HUANYA COSMETICS TECHNOLOGY Co.,Ltd. |
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Application publication date: 20191015 |