CN110314105A - A kind of hair-loss preventing and hair-restoring class Essence and preparation method thereof - Google Patents
A kind of hair-loss preventing and hair-restoring class Essence and preparation method thereof Download PDFInfo
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- CN110314105A CN110314105A CN201910538140.7A CN201910538140A CN110314105A CN 110314105 A CN110314105 A CN 110314105A CN 201910538140 A CN201910538140 A CN 201910538140A CN 110314105 A CN110314105 A CN 110314105A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
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Abstract
The present invention provides a kind of hair-loss preventing and hair-restoring class Essence, including water phase material and alcohol phase material, and water phase material includes: 30-70 parts of water, 0.001-3 parts of pH adjusting agent according to mass parts；The pH adjusting agent is lactic acid, lactobionic acid or acetic acid etc.；Alcohol phase material includes: 10-50 parts of ethyl alcohol according to mass parts, 0.001-3 parts of dihydro (nerve) sphingol；The preparation method of above-mentioned hair-loss preventing and hair-restoring class Essence, comprising the following steps: the preparation of water phase material: lactic acid is dissolved in water at normal temperature, makes the pH of its aqueous solution to 4-7；The preparation of alcohol phase material: dihydro (nerve) sphingol being dissolved in ethyl alcohol, the ethanol solution of dihydro (nerve) sphingol is made, adds essence, after mixing evenly up to alcohol phase material；Alcohol phase material is added gradually in water phase material again, is stirred evenly, clear transparent solutions are obtained.Hair-loss preventing and hair-restoring class Essence of the invention has certain solubility, good transparency and stability.
Description
Technical field
The invention belongs to hair-washing hair-care technical fields, specifically, being related to a kind of hair-loss preventing and hair-restoring class Essence.
Background technique
Hair-loss preventing and hair-restoring class Essence is to nourish as a kind of resident hair-loss preventing and hair-restoring the effect of property product, main demand
Scalp, hair-loss preventing and hair-restoring etc..The active constituent of hair-loss preventing and hair-restoring class product addition is relatively simple on the market at present: component polypeptides, life
Ginger extracts active constituent, cacumen biotae extracts active constituent etc..
For example, Chinese invention patent application: having effects that composition, cosmetics, Essence and the essence of educating hair and Anti-hair loss
The preparation method of magnificent liquid, application number: 201810101504.0, publication number: 108578269A；Have in the invention and educates hair and prevent
The composition of alopecia effect includes that the raw material of following mass fraction is made: 0.001-10 parts of -1 copper of tripeptides, biotin 0.01-5
Part, 0.01-10 parts of niacinamide, 0.01-20 parts of panthenol and solvent composition.
For another example, Chinese invention patent application: a kind of yellow ginger oil-control anticreep development hair scalp Essence and preparation method thereof,
Application number: 201810317289.8, publication number: 108295011A；The invention discloses a kind of yellow ginger oil-control anticreep development hair scalp
Essence and preparation method thereof is grouped as by the group of following mass percents: 15% Cacumen Platycladi extract and ginger-root extract
Mixed liquor, 1.5% polysorbate -20,3% dihydroxymethyl glycolylurea, 0.2% essence, 0.1% panthenol and 0.05% Radix Glycyrrhizae
Sour dipotassium, surplus are deionized water.
In order to further expand the active constituent of hair-loss preventing and hair-restoring class product addition, the present invention provides a kind of using dihydro (mind
Through) sphingol does the hair-loss preventing and hair-restoring class Essence of active constituent.Dihydro (nerve) sphingol is a kind of intracorporal glycolipid, is
The main component of cell membrane can send out life cycle by the activity of inhibition 5α-reductase, balancing head, strengthen hair and improvement
Scalp health reaches prevention and solves the problems, such as alopecia.But the solubility of dihydro (nerve) sphingol in water is very low, and
It is easily become cloudy after dissolution.It is difficult and molten that the present invention solves the dissolution of dihydro (nerve) sphingol using a kind of new technical method
The problem of liquid stability difference.
Summary of the invention
The present invention in view of the deficienciess of the prior art, provide a kind of hair-loss preventing and hair-restoring class Essence, using new activity at
Point --- dihydro (nerve) sphingol, and solve after dihydro (nerve) sphingol dissolves difficulty and dissolved in aqueous phase system easily
Become cloudy the problem of i.e. stability difference.
The technical scheme to solve the above technical problems is that
A kind of hair-loss preventing and hair-restoring class Essence, including water phase material and alcohol phase material, in which:
The water phase material includes: 30-70 parts of water, 0.001-3 parts of pH adjusting agent according to mass parts；The pH adjusting agent
It can be one of lactic acid, lactobionic acid, acid acid more stronger than lactic acid or a variety of, acid acid more stronger than lactic acid, such as second
Acid, hydrochloric acid, sulfuric acid, phosphoric acid etc..
The alcohol phase material includes: 10-50 parts of ethyl alcohol according to mass parts, 0.001-3 parts of dihydro (nerve) sphingol, fragrant
It is 0.01-2 parts smart.
The present invention is further arranged to, and the mass parts of dihydro (nerve) sphingol are 0.001-1 parts.Preferably, institute
Dihydro (nerve) sphingol is stated using dihydro (nerve) sphingol of Ying Chuan company, Germany.
The present invention is further arranged to, and the mass parts of the ethyl alcohol are 15-45 parts.
The present invention is further arranged to, and the mass parts of the lactic acid are 0.02-2 parts.
Another technical solution that the present invention solves above-mentioned technical problem is as follows: the system of above-mentioned hair-loss preventing and hair-restoring class Essence
Preparation Method, comprising:
The preparation of water phase material: pH adjusting agent is dissolved in water at normal temperature, makes the pH of its aqueous solution to 4-7；
The preparation of alcohol phase material: dihydro (nerve) sphingol is dissolved in ethyl alcohol, dihydro (nerve) sphingol is made
Ethanol solution adds essence, after mixing evenly up to alcohol phase material；
Alcohol phase material is added gradually in water phase material again, is stirred evenly, clear transparent solutions are obtained.
Hair-loss preventing and hair-restoring class Essence quality of the invention is transparent, property is stable and product is mild.Ensured by following approach
German Ying Chuan company dihydro (nerve) sphingol, which is added in hair-loss preventing and hair-restoring class Essence (aqueous phase system), has certain dissolution
Degree, good transparency and stability:
(1) addition ethanol in proper amount is used as the solvent of dihydro (nerve) sphingol, promotes its system that is soluble in the aqueous phase, by grinding
Study carefully and grope, the final optimum addition range for determining ethyl alcohol is 15-45 parts, i.e., it is good to may insure that formula has in the range
Volatility and use feeling.Moreover, the ethyl alcohol of appropriate amount can play the role of inhibiting microorganism in system, without
It needs additionally to add preservative again:
(2) lactic acid adjusts aqueous phase system to reasonable pH to 4-7, which is dihydro (nerve) sphingol in water phase body
It is the optimum PH range of dissolution.Meanwhile with the zone of reasonableness that is reduced to of pH, the irritation of formula is also being gradually decreased.
The active constituent for focusing on addition with the entirely different hair-loss preventing and hair-restoring of market product of the invention, i.e. dihydro (mind
Through) sphingol is as both effectiveness ingredient, because dihydro (nerve) sphingol is easy after dissolving difficulty in aqueous phase system and dissolving
Become cloudy that i.e. stability is poor, so hardly consistent with the requirement of hair-loss preventing and hair-restoring class Essence.The kind that the present invention passes through preferred acid
Class and dosage adjust the pH to 4-7 of water phase, this pH range can ensure that dihydro (nerve) sphingol has good solubility,
So that final products have excellent transparency and stability；The resident product is kept by the dosage range of preferred alcohol
While suitable volatile, also there is good feel, hair sense and skin sense.
Detailed description of the invention
Fig. 1 is the efficiency chart that different types of acid reduces pH.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that the described embodiment is only a part of the embodiment of the present invention, instead of all the embodiments.Based on this
Embodiment in invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
Embodiment 1
A kind of hair-loss preventing and hair-restoring class Essence, including water phase material and alcohol phase material, in which:
Water phase material includes: 30 parts of water, 0.001 part of lactic acid according to mass parts；
Alcohol phase material includes: 20 parts of ethyl alcohol according to mass parts, 0.5 part of sphingol of dihydro (nerve) of German Ying Chuan company,
1 part of essence.
The preparation method of above-mentioned hair-loss preventing and hair-restoring class Essence, comprising the following steps:
The preparation of water phase material: being dissolved in water for lactic acid at normal temperature, makes the pH of its aqueous solution to close to 7；
The preparation of alcohol phase material: dihydro (nerve) sphingol is dissolved in ethyl alcohol, dihydro (nerve) sphingol is made
Ethanol solution adds essence, after mixing evenly up to alcohol phase material；
Alcohol phase material is added gradually in water phase material again, is stirred evenly, clear transparent solutions are obtained.
Embodiment 2
A kind of hair-loss preventing and hair-restoring class Essence, including water phase material and alcohol phase material, in which:
Water phase material includes: 70 parts of water, 3 parts of lactic acid according to mass parts；
Alcohol phase material includes: 30 parts of ethyl alcohol according to mass parts, 2 parts of sphingol of dihydro (nerve) of German Ying Chuan company, fragrant
0.01 part of essence.
The preparation method of above-mentioned hair-loss preventing and hair-restoring class Essence, comprising the following steps:
The preparation of water phase material: being dissolved in water for lactic acid at normal temperature, makes the pH of its aqueous solution to close to 4；
The preparation of alcohol phase material: dihydro (nerve) sphingol is dissolved in ethyl alcohol, dihydro (nerve) sphingol is made
Ethanol solution adds essence, after mixing evenly up to alcohol phase material；
Alcohol phase material is added gradually in water phase material again, is stirred evenly, clear transparent solutions are obtained.
Embodiment 3
A kind of hair-loss preventing and hair-restoring class Essence, including water phase material and alcohol phase material, in which:
Water phase material includes: 60 parts of water, 0.02 part of dilute sulfuric acid according to mass parts；
Alcohol phase material includes: 50 parts of ethyl alcohol according to mass parts, 3 parts of sphingol of dihydro (nerve) of German Ying Chuan company, fragrant
2 parts of essence.
The preparation method of above-mentioned hair-loss preventing and hair-restoring class Essence, comprising the following steps:
The preparation of water phase material: being dissolved in water for dilute sulfuric acid at normal temperature, makes the pH of its aqueous solution to close to 5；
The preparation of alcohol phase material: dihydro (nerve) sphingol is dissolved in ethyl alcohol, dihydro (nerve) sphingol is made
Ethanol solution adds essence, after mixing evenly up to alcohol phase material；
Alcohol phase material is added gradually in water phase material again, is stirred evenly, clear transparent solutions are obtained.
Embodiment 4
A kind of hair-loss preventing and hair-restoring class Essence, including water phase material and alcohol phase material, in which:
Water phase material includes: 45 parts of water, 0.03 part of dilute hydrochloric acid according to mass parts；
Alcohol phase material includes: 10 parts of ethyl alcohol according to mass parts, dihydro (nerve) sphingol 0.001 of German Ying Chuan company
Part, 0.6 part of essence.
The preparation method of above-mentioned hair-loss preventing and hair-restoring class Essence, comprising the following steps:
The preparation of water phase material: being dissolved in water for dilute hydrochloric acid at normal temperature, makes the pH of its aqueous solution to close to 5；
The preparation of alcohol phase material: dihydro (nerve) sphingol is dissolved in ethyl alcohol, dihydro (nerve) sphingol is made
Ethanol solution adds essence, after mixing evenly up to alcohol phase material；
Alcohol phase material is added gradually in water phase material again, is stirred evenly, clear transparent solutions are obtained.
Embodiment 5
A kind of hair-loss preventing and hair-restoring class Essence, including water phase material and alcohol phase material, in which:
Water phase material includes: 50 parts of water, 3 parts of lactobionic acid according to mass parts；
Alcohol phase material includes: 45 parts of ethyl alcohol according to mass parts, 1 part of sphingol of dihydro (nerve) of German Ying Chuan company, fragrant
0.6 part of essence.
The preparation method of above-mentioned hair-loss preventing and hair-restoring class Essence, comprising the following steps:
The preparation of water phase material: being dissolved in water for lactobionic acid at normal temperature, makes the pH of its aqueous solution to close to 4；
The preparation of alcohol phase material: dihydro (nerve) sphingol is dissolved in ethyl alcohol, dihydro (nerve) sphingol is made
Ethanol solution adds essence, after mixing evenly up to alcohol phase material；
Alcohol phase material is added gradually in water phase material again, is stirred evenly, clear transparent solutions are obtained.
Embodiment 6
A kind of hair-loss preventing and hair-restoring class Essence, including water phase material and alcohol phase material, in which:
Water phase material includes: 50 parts of water, 2 parts of acetic acid according to mass parts；
Alcohol phase material includes: 35 parts of ethyl alcohol according to mass parts, 1.5 parts of sphingol of dihydro (nerve) of German Ying Chuan company,
0.6 part of essence.
The preparation method of above-mentioned hair-loss preventing and hair-restoring class Essence, comprising the following steps:
The preparation of water phase material: acetic acid is dissolved in water at normal temperature, makes the pH of its aqueous solution to 6.5；
The preparation of alcohol phase material: dihydro (nerve) sphingol is dissolved in ethyl alcohol, dihydro (nerve) sphingol is made
Ethanol solution adds essence, after mixing evenly up to alcohol phase material；
Alcohol phase material is added gradually in water phase material again, is stirred evenly, clear transparent solutions are obtained.
Comparative test:
The present invention is used as the solvent of dihydro (nerve) sphingol by addition ethanol in proper amount, promotes its system that is soluble in the aqueous phase,
The ethyl alcohol of appropriate amount can play the role of inhibiting microorganism in system, without additionally adding preservative again.Further
Ground adjusts aqueous phase system to reasonable pH to 4-7, so that dihydro (nerve) sphingol is molten in aqueous phase system by adding lactic acid
Solution is best, while irritation is also gradually decreasing.
In research process of the present invention, the influence to different types of acid to the final transparency of system has carried out research pair
Than as shown in table 1.
Influence of the different acid of table 1. to system transparency
| Used acid | Adjust pH to 6 or so, the transparency of system |
| Lactic acid | Clear |
| Citric acid | White Flocculus floats on liquid level |
| Lactobionic acid | Clear |
| Acetic acid | Clear |
| DL-malic acid | White Flocculus floats on liquid level |
| DL- mandelic acid | White Flocculus floats on liquid level |
By experimental exploring, attempts different types of acid and be used as pH adjusting agent, the experimental results showed that, lactic acid, lactobionic acid are equal
It can be used as the pH adjusting agent of this system, and citric acid, DL-malic acid, DL- mandelic acid etc. then cannot.Analyze original therein
Reason, it is believed that many acid acid for being higher than lactic acid are used equally for this system.Therefore, and by taking acetic acid as an example tested, demonstrate with
Upper idea.The experimental results showed that acetic acid can be not only used for doing the pH adjusting agent of system, system clear, Er Qiexiang are kept
There is better efficiency in terms of reducing pH for lactic acid and lactobionic acid.
Fig. 1 is the efficiency chart that different types of acid reduces pH, as known to Fig. 1 data, it is considered that, acid stronger acid
The efficiency for reducing pH is higher, so, acetic acid, hydrochloric acid, sulfuric acid, phosphoric acid etc. can be employed as the pH adjusting agent of this system.So this
System uses but is not limited to lactic acid or lactobionic acid as pH regulator.But consider other problems, for example strong acid has deep-etching
Property, acetic acid slightly have penetrating odor etc., so, lactic acid is the optimal selection of the pH of regulation system.After above-mentioned lactic acid determines,
According further to overall reaction system, by experimental study, the preferably additive amount of lactic acid is 0.02-2 parts.
The finally obtained hair-loss preventing and hair-restoring class Essence of the present invention has certain solubility, good transparency and stabilization
Property, and product is mild.
For the ethyl alcohol dosage in system, it is believed that ethyl alcohol dosage is too low, will affect the volatility of product and salubrious
Sense, if dosage is excessively high, it is likely that so that product is stimulated scalp, so, the dosage of final ethyl alcohol is preferably at 15-45 parts.
Using the system containing 45 parts of ethyl alcohol as experimental system, by a series of experimental study, to dihydro (nerve) sphingol
Solubility exploration is carried out, experimental result is as shown in table 2.
Dissolution experiment of table 2. dihydro (nerve) sphingol in the system of 45 parts of ethanol contents
It is learnt by experimental phenomena, when ethyl alcohol dosage is 45 parts, the optimal dissolution range of dihydro (nerve) sphingol is
0.001-1.0 parts.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all in spirit of the invention and
Within principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (8)
1. a kind of hair-loss preventing and hair-restoring class Essence, which is characterized in that including water phase material and alcohol phase material, in which:
The water phase material includes: 30-70 parts of water, 0.001-3 parts of pH adjusting agent according to mass parts；
The alcohol phase material includes: 10-50 parts of ethyl alcohol according to mass parts, 0.001-3 parts of dihydro (nerve) sphingol.
2. hair-loss preventing and hair-restoring class Essence according to claim 1, which is characterized in that the matter of dihydro (nerve) sphingol
Measuring part is 0.001-1 parts.
3. hair-loss preventing and hair-restoring class Essence according to claim 2, which is characterized in that dihydro (nerve) sphingol uses
Dihydro (nerve) sphingol of German Ying Chuan company.
4. hair-loss preventing and hair-restoring class Essence according to claim 1, which is characterized in that the mass parts of the ethyl alcohol are 15-45
Part.
5. hair-loss preventing and hair-restoring class Essence according to claim 1, which is characterized in that the pH adjusting agent is lactic acid, lactose
One of acid, acid acid more stronger than lactic acid are a variety of.
6. hair-loss preventing and hair-restoring class Essence according to claim 5, which is characterized in that the mass parts of the lactic acid are 0.02-2
Part.
7. hair-loss preventing and hair-restoring class Essence according to claim 1, which is characterized in that according to mass parts further include essence
0.01-2 parts.
8. a kind of preparation method of the described in any item hair-loss preventing and hair-restoring class Essences of claim 1-7 characterized by comprising
The preparation of water phase material: pH adjusting agent is dissolved in water at normal temperature, makes the pH of its aqueous solution to 4-7；
The preparation of alcohol phase material: dihydro (nerve) sphingol is dissolved in ethyl alcohol, the ethyl alcohol of dihydro (nerve) sphingol is made
Solution adds essence, after mixing evenly up to alcohol phase material；
Alcohol phase material is added gradually in water phase material again, is stirred evenly, clear transparent solutions are obtained.
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| CN201910538140.7A CN110314105A (en) | 2019-06-20 | 2019-06-20 | A kind of hair-loss preventing and hair-restoring class Essence and preparation method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104666102A (en) * | 2015-03-20 | 2015-06-03 | 江苏隆力奇生物科技股份有限公司 | Dihydro-sphingosine nanocapsule emulsion as well as preparation method and application thereof |
| CN106166118A (en) * | 2016-07-28 | 2016-11-30 | 王玉艳 | A kind of Anti-hair loss, germinal preparation |
| CN109431895A (en) * | 2018-11-23 | 2019-03-08 | 肇庆迪彩日化科技有限公司 | A kind of scalp care compositions of Anti-hair loss and its preparation method and application |
-
2019
- 2019-06-20 CN CN201910538140.7A patent/CN110314105A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104666102A (en) * | 2015-03-20 | 2015-06-03 | 江苏隆力奇生物科技股份有限公司 | Dihydro-sphingosine nanocapsule emulsion as well as preparation method and application thereof |
| CN106166118A (en) * | 2016-07-28 | 2016-11-30 | 王玉艳 | A kind of Anti-hair loss, germinal preparation |
| CN109431895A (en) * | 2018-11-23 | 2019-03-08 | 肇庆迪彩日化科技有限公司 | A kind of scalp care compositions of Anti-hair loss and its preparation method and application |
Non-Patent Citations (1)
| Title |
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Application publication date: 20191011 |