CN104666102A - Dihydro-sphingosine nanocapsule emulsion as well as preparation method and application thereof - Google Patents
Dihydro-sphingosine nanocapsule emulsion as well as preparation method and application thereof Download PDFInfo
- Publication number
- CN104666102A CN104666102A CN201510123538.6A CN201510123538A CN104666102A CN 104666102 A CN104666102 A CN 104666102A CN 201510123538 A CN201510123538 A CN 201510123538A CN 104666102 A CN104666102 A CN 104666102A
- Authority
- CN
- China
- Prior art keywords
- dihydrosphingosine
- nanocapsule
- nanocapsule emulsion
- emulsion
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Cosmetics (AREA)
Abstract
The invention discloses a dihydro-sphingosine nanocapsule emulsion as well as a preparation method and application thereof. The preparation method of the dihydro-sphingosine nanocapsule emulsion comprises the following steps: mixing dihydro-sphingosine, caprylin/caprin and water uniformly, regulating the pH of the mixture to 5-7 by using a pH regulator, and treating by using a high-pressure homogenizer to obtain the dihydro-sphingosine nanocapsule emulsion which is milky white in appearance, has an average particle size of less than 200nm and can be used for preparing cosmetics. The dihydro-sphingosine nanocapsule emulsion has the characteristics of good stability, water dispersibility and biocompatibility, is safe to use, is easy and convincement to prepare and can be matched with a required skin care preparation optionally. The dihydro-sphingosine can penetrate into hair follicles deeply to fully prevent the loss of hair.
Description
Technical field
The present invention relates to technical field of cosmetic preparation, particularly relating to a kind of take dihydrosphingosine as nanocapsule emulsion of active component and its preparation method and application.
Background technology
Alopecia is a kind of phenomenon of alopecia, and the hair normally come off is all the hair being in catagen and resting stage, is constantly in dynamic equilibrium, therefore can maintains the hair of normal quantity owing to entering catagen with the hair newly entering trophophase.Pathologic alopecia refers to hair exception or excessive coming off, and wherein androgenic alopecia is one main, also known as seborrheic alopecia; claimed male pattern alopecia in the past; its sick with heredity, androgen, seborrhea be relevant, symptom be scalp portion fat secretion too much, hair has greasy feeling.
The generation of androgenetic alopecia (Androgenetic alopecia is called for short AGA) is main relevant with inherited genetic factors and androgen.The development of this disease is often with the androgen of normal level, and the quality of heredity can make hair follicle increase androgenic sensitivity.Human body hair follicle is the target organ to Androgen-sensitive, and its growth has periodically, usually experiences trophophase, catagen and resting stage three phases.The androgen of human secretory is mainly testosterone, testosterone changes dihydrotestosterone under the effect of 5α-reductase, androgen receptor again in scalp portion hair follicle target cell is combined, suppress the growth promoter of hair papilla, the growth metabolism of interference hair follicle cell, make hair enter resting stage in advance, thus cause AGA.Androgen is the key factor affecting hair follicle development, and androgen changes has substantial connection with the reason of seborrheic alopecia.In males, important androgen is after a kind of reductase transforms, then be positioned at intrafollicular receptors bind, can there is the reaction of complexity, make that the trophophase of hair follicle shortens, hair follicle diameter diminishes, and then cause alopecia.
Dihydrosphingosine is a kind of glycolipid in body, is cell membrane main component, can by suppressing 5α-reductase active, and balancing head sends out life cycle, strengthens hair and improves scalp health, reaches the problem that prevention solves alopecia.But dihydrosphingosine, owing to being slightly soluble in water, soluble in polarity oils and fats, mainly through dissolve with ethanol solution in commercial application process, limits the extensive use of product.
Along with nanotechnology is in the extensive use of cosmetic field, adopt the cosmetics of nanotechnology development, unique distinction is that carrying out special handling to the composition of most effect in cosmetics becomes nano level micro-structure, and penetrate to the skin deep layer smoothly, better plays the effects such as skin protection.
Summary of the invention
The technical problem that the present invention mainly solves is to provide a kind of dihydrosphingosine nanocapsule emulsion and its preparation method and application, it has, and stability is high, the feature such as water dispersible and biocompatibility, effect of dihydrosphingosine active ingredient can be given full play to, to reach effect anti-loss for a long time.
For solving the problems of the technologies described above, the technical scheme that the present invention adopts is: provide a kind of dihydrosphingosine nanocapsule emulsion, with parts by weight, the component comprised is: dihydrosphingosine 0.1 ~ 5 part, caprylic/capric glyceride 1 ~ 20 part, 75 ~ 99 parts, water, pH adjusting agent, and wherein the amount of pH adjusting agent is regulate the pH value of described dihydrosphingosine nanocapsule emulsion to be 5 ~ 7.
In a preferred embodiment of the present invention, with parts by weight, the component that described dihydrosphingosine nanocapsule emulsion comprises is: dihydrosphingosine 0.2 ~ 4 part, caprylic/capric glyceride 2 ~ 18 parts, 80 ~ 95 parts, water, pH adjusting agent, and wherein the amount of pH adjusting agent is regulate the pH value of described dihydrosphingosine nanocapsule emulsion to be 5 ~ 7.
In a preferred embodiment of the present invention, the mean diameter of described dihydrosphingosine nanocapsule emulsion is less than 200nm.
In a preferred embodiment of the present invention, described pH adjusting agent is hydrochloric acid, sulphuric acid or lactic acid.
A kind of preparation method of dihydrosphingosine nanocapsule emulsion is provided, comprising step is: the component mixing taking claim 1-4 arbitrary dihydrosphingosine nanocapsule emulsion, and make pH value be 5 ~ 7 with pH adjusting agent adjustment, then high pressure homogenize process obtains dihydrosphingosine nanocapsule emulsion.
In a preferred embodiment of the present invention, preparation method comprises step and is: dihydrosphingosine and caprylic/capric glyceride stir and make homogeneous mixed liquor by (1) at 50 DEG C ~ 80 DEG C; (2) in homogeneous mixed liquor, add 75 ~ 99g water, and be 5-7 by pH adjusting agent by pH regulator; (3) through high pressure homogenizer process, high pressure homogenize pressure is 500 bar ~ 1500bar, and cycle-index is 4 times ~ 8 times, and the particle diameter obtaining a kind of milky white shape is less than the dihydrosphingosine nanocapsule emulsion of 200nm.
There is provided a kind of application of dihydrosphingosine nanocapsule emulsion, by described dihydrosphingosine nanocapsule emulsion applications in preparation cosmetic product.
The invention has the beneficial effects as follows: dihydrosphingosine nanocapsule emulsion of the present invention and its preparation method and application, preparation method, without the need to using organic solvent and the solubilizing agent of ethanol class, greatly improves the safety that product uses; Constant product quality, has good water solublity, makes the preparation of the product containing dihydrosphingosine convenient, simple, can with any interworking of required skin care item preparation; Because this dihydrosphingosine nanocapsule emulsion particle diameter is little, be easy to dihydrosphingosine to infiltrate into scalp hair follicles deep layer, give full play to the anticreep effect of dihydrosphingosine.
Detailed description of the invention
Be clearly and completely described to the technical scheme in the embodiment of the present invention below, obviously, described embodiment is only a part of embodiment of the present invention, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making other embodiments all obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment one:
There is provided a kind of dihydrosphingosine nanocapsule emulsion, the component comprised is: dihydrosphingosine, caprylic/capric glyceride, water and pH adjusting agent.
Concrete preparation method is: 0.1g dihydrosphingosine and 1g caprylic/capric glyceride are made homogeneous mixed liquor under stirring condition at 60 DEG C of temperature, then in mixed liquor, 98.9g water is added, stir and form milky white liquid, hydrochloric acid solution adjust ph is 5, finally by this milky white liquid by high pressure homogenizer process, high pressure homogenize pressure is 500 bar, and cycle-index is 8 times, dihydrosphingosine nanocapsule emulsion can be obtained, measure its grain through laser particle analyzer and be about 172nm.
Embodiment two:
There is provided a kind of preparation method of dihydrosphingosine nanocapsule emulsion, comprising step is:
5g dihydrosphingosine and 20g caprylic/capric glyceride are made homogeneous mixed liquor under stirring condition at 80 DEG C of temperature, then in mixed liquor, 75g water is added, stir and form milky white liquid, sulfuric acid solution adjust ph is 6, finally by this milky white liquid by high pressure homogenizer process, high pressure homogenize pressure is 1000 bar, and cycle-index is 4 times, dihydrosphingosine nanocapsule emulsion can be obtained, measure its grain through laser particle analyzer and be about 108nm.
Embodiment two:
There is provided a kind of preparation method of dihydrosphingosine nanocapsule emulsion, comprising step is:
2.5g dihydrosphingosine and 10g caprylic/capric glyceride are made homogeneous mixed liquor under stirring condition by embodiment 3 at 70 DEG C of temperature, then in mixed liquor, 87.5g water is added, stir and form milky white liquid, lactic acid solution adjust ph is 7, finally by this milky white liquid by high pressure homogenizer process, high pressure homogenize pressure is 1500 bar, and cycle-index is 4 times, dihydrosphingosine nanocapsule emulsion can be obtained, measure its grain through laser particle analyzer and be about 79nm.
Embodiment two:
There is provided a kind of preparation method of dihydrosphingosine nanocapsule emulsion, comprising step is:
2g dihydrosphingosine and 10g caprylic/capric glyceride are made homogeneous mixed liquor under stirring condition by embodiment 4 at 70 DEG C of temperature, then in mixed liquor, 88g water is added, stir and form milky white liquid, hydrochloric acid solution adjust ph is 6.4, finally by this milky white liquid by high pressure homogenizer process, high pressure homogenize pressure is 900 bar, and cycle-index is 6 times, dihydrosphingosine nanocapsule emulsion can be obtained, measure its grain through laser particle analyzer and be about 124nm.
The foregoing is only embodiments of the invention; not thereby the scope of the claims of the present invention is limited; every utilize description of the present invention to do equivalent structure or equivalent flow process conversion; or be directly or indirectly used in other relevant technical field, be all in like manner included in scope of patent protection of the present invention.
Claims (7)
1. a dihydrosphingosine nanocapsule emulsion, it is characterized in that, with parts by weight, the component comprised is: dihydrosphingosine 0.1 ~ 5 part, caprylic/capric glyceride 1 ~ 20 part, 75 ~ 99 parts, water, pH adjusting agent, and wherein the amount of pH adjusting agent is regulate the pH value of described dihydrosphingosine nanocapsule emulsion to be 5 ~ 7.
2. dihydrosphingosine nanocapsule emulsion according to claim 1, it is characterized in that, with parts by weight, the component comprised is: dihydrosphingosine 0.2 ~ 4 part, caprylic/capric glyceride 2 ~ 18 parts, 80 ~ 95 parts, water, pH adjusting agent, and wherein the amount of pH adjusting agent is regulate the pH value of described dihydrosphingosine nanocapsule emulsion to be 5 ~ 7.
3. dihydrosphingosine nanocapsule emulsion according to claim 1 and 2, is characterized in that, the mean diameter of described dihydrosphingosine nanocapsule emulsion is less than 200nm.
4. dihydrosphingosine nanocapsule emulsion according to claim 1 and 2, is characterized in that, described pH adjusting agent is hydrochloric acid, sulphuric acid or lactic acid.
5. the preparation method of dihydrosphingosine nanocapsule emulsion according to claim 1, it is characterized in that, comprising step is: the component mixing taking claim 1-4 arbitrary dihydrosphingosine nanocapsule emulsion, and make pH value be 5 ~ 7 with pH adjusting agent adjustment, then high pressure homogenize process obtains dihydrosphingosine nanocapsule emulsion.
6. the preparation method of dihydrosphingosine nanocapsule emulsion according to claim 5, is characterized in that, comprises step and is: dihydrosphingosine and caprylic/capric glyceride stir and make homogeneous mixed liquor by (1) at 50 DEG C ~ 80 DEG C; (2) in homogeneous mixed liquor, add 75 ~ 99g water, and be 5-7 by pH adjusting agent by pH regulator; (3) through high pressure homogenizer process, high pressure homogenize pressure is 500 bar ~ 1500bar, and cycle-index is 4 times ~ 8 times, and the particle diameter obtaining a kind of milky white shape is less than the dihydrosphingosine nanocapsule emulsion of 200nm.
7. the application of dihydrosphingosine nanocapsule emulsion according to claim 1, is characterized in that, by described dihydrosphingosine nanocapsule emulsion applications in preparation cosmetic product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510123538.6A CN104666102A (en) | 2015-03-20 | 2015-03-20 | Dihydro-sphingosine nanocapsule emulsion as well as preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510123538.6A CN104666102A (en) | 2015-03-20 | 2015-03-20 | Dihydro-sphingosine nanocapsule emulsion as well as preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104666102A true CN104666102A (en) | 2015-06-03 |
Family
ID=53302057
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510123538.6A Pending CN104666102A (en) | 2015-03-20 | 2015-03-20 | Dihydro-sphingosine nanocapsule emulsion as well as preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104666102A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110314105A (en) * | 2019-06-20 | 2019-10-11 | 上海绿瑞生物科技有限公司 | A kind of hair-loss preventing and hair-restoring class Essence and preparation method thereof |
| CN113350219A (en) * | 2021-06-28 | 2021-09-07 | 广州大唐化妆品有限公司 | Hair loss preventing and hair fixing composition, shampoo containing hair loss preventing and hair fixing composition and preparation method of shampoo |
| CN115737492A (en) * | 2022-08-08 | 2023-03-07 | 上海若梵生物科技有限公司 | Anti-hair loss hair-fixing product and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0585924A (en) * | 1991-09-26 | 1993-04-06 | Kao Corp | External preparation of skin |
| CN101214197A (en) * | 2007-12-28 | 2008-07-09 | 清华大学 | Cozymase Q10 nano microcapsule emulsions and preparation and application thereof |
| CN102164664A (en) * | 2008-09-30 | 2011-08-24 | 富士胶片株式会社 | Ceramide dispersion and method for producing same |
| CN103690391A (en) * | 2013-12-27 | 2014-04-02 | 苏州纳康生物科技有限公司 | Ceramide nanoemulsion and preparation method thereof |
-
2015
- 2015-03-20 CN CN201510123538.6A patent/CN104666102A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0585924A (en) * | 1991-09-26 | 1993-04-06 | Kao Corp | External preparation of skin |
| CN101214197A (en) * | 2007-12-28 | 2008-07-09 | 清华大学 | Cozymase Q10 nano microcapsule emulsions and preparation and application thereof |
| CN102164664A (en) * | 2008-09-30 | 2011-08-24 | 富士胶片株式会社 | Ceramide dispersion and method for producing same |
| CN103690391A (en) * | 2013-12-27 | 2014-04-02 | 苏州纳康生物科技有限公司 | Ceramide nanoemulsion and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110314105A (en) * | 2019-06-20 | 2019-10-11 | 上海绿瑞生物科技有限公司 | A kind of hair-loss preventing and hair-restoring class Essence and preparation method thereof |
| CN113350219A (en) * | 2021-06-28 | 2021-09-07 | 广州大唐化妆品有限公司 | Hair loss preventing and hair fixing composition, shampoo containing hair loss preventing and hair fixing composition and preparation method of shampoo |
| CN115737492A (en) * | 2022-08-08 | 2023-03-07 | 上海若梵生物科技有限公司 | Anti-hair loss hair-fixing product and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US8465763B2 (en) | 3-hydroxychlormadinone acetate for the topical treatment of androgen-dependent skin diseases | |
| JP6553845B2 (en) | Skin / hair lightening composition | |
| JP6405099B2 (en) | Cosmetic composition | |
| KR102494289B1 (en) | Active mixtures | |
| BR102015005868B1 (en) | titanium dioxide coated to reduce the bleaching effect on the skin | |
| CN104666102A (en) | Dihydro-sphingosine nanocapsule emulsion as well as preparation method and application thereof | |
| TR201810389T4 (en) | Polymeric finasteride and minoxidil nanoparticles, the method for preparing them, aqueous suspension containing them, the pharmaceutical composition and their use. | |
| US10456344B2 (en) | Hair composition | |
| CN110215416A (en) | A kind of camellia oil oleogel lotion and preparation method thereof | |
| JP6129557B2 (en) | Use of 2,3-dihydroxypropyl dodecanoate for the treatment of seborrhea | |
| Shatalebi et al. | Preparation and evaluation of minoxidil foamable emu oil emulsion | |
| CN102065839A (en) | Gel composition comprising minoxidil | |
| CN107530273A (en) | Composition containing Valerian root P.E | |
| HUE027440T2 (en) | C-19 steroids for specific therapeutic uses | |
| Zhang et al. | A multifunctional cholesterol-free liposomal platform based on protopanaxadiol for alopecia therapy | |
| CN105163711A (en) | Emulsion based hair cosmetic | |
| JP4681132B2 (en) | Nitric oxide synthase production promoter and cosmetic or pharmaceutical composition | |
| CN108888531A (en) | A kind of spray | |
| CN114469808B (en) | Preparation method of antioxidant nanoemulsion containing yeast peptide and application of antioxidant nanoemulsion in cosmetics | |
| JP6522278B2 (en) | Hair composition | |
| CN105979925A (en) | Composition for promoting hair growth or preventing hair loss | |
| Hussein et al. | Assessment of the efficacy of topical antiandrogen; spironolactone in patients with androgenetic alopecia by dermoscopy | |
| JP2010120879A (en) | Skin care preparation for external use and manufacturing method of the same | |
| CN106265142A (en) | A kind of emulsified salt type skin-cleaning articles and preparation method thereof | |
| JP4455682B2 (en) | Testosterone 5α-reductase inhibitor |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150603 |