CN108888531A - A kind of spray - Google Patents
A kind of spray Download PDFInfo
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- CN108888531A CN108888531A CN201810891820.2A CN201810891820A CN108888531A CN 108888531 A CN108888531 A CN 108888531A CN 201810891820 A CN201810891820 A CN 201810891820A CN 108888531 A CN108888531 A CN 108888531A
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- spray
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- ceramide
- niacinamide
- hyaluronic acid
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- 0 C1CC*CC1 Chemical compound C1CC*CC1 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to a kind of sprays, including at least two in hyaluronic acid, niacinamide and ceramide, it further include aqueous phase solvent, the hyaluronic acid accounts for the 0.01-2% of spray gross weight, the niacinamide accounts for the 0.5-8% of spray gross weight, and the ceramide accounts for the 0.1-10% of spray gross weight.Spray of the invention, it is the cosmetic composition of whitening, moisturizing and anti-aging, and at least two in hyaluronic acid, niacinamide and ceramide are penetrated into deep skin with nanoscale or micron-sized subtle droplet, improve skin aging process, increase moisture content of skin, keeps skin elasticity.
Description
Technical field
The present invention relates to skin care item, cosmetic field more particularly to a kind of sprays.
Background technique
With physiological age increase and be chronically exposed to environmental stimuli environment, skin barrier is impaired, loses control of moisture
Loss, skin will appear aging, or even a variety of skin diseases is caused to occur.Pursuit to modern life quality, so that consumption
Person more focuses on skin care, it is desirable to which skin care item can have the function that whitening, moisturizing and anti-aging.
U.S.'s University of California teaches Peter M.Elias and initiates skin barrier " brick wall structure " theory, " brick wall "
Keratinocyte is represented, " mortar " then refers to lipid in horn cell gap (containing ceramide, fatty acid, cholesterol), " brick
Wall " and " mortar " make epidermis form firm structure, and the outer and iuntercellular flowing in the cell of limitation moisture makes skin remain important
Barrier function.The research of skin barrier has extensive effect, such as improves skin protection ability, avoids the invasion of detoxification object, is anti-
It controls dermatergosis and improves external preparation for skin medication effect.
Once sebum film and " brick wall structure " are destroyed, moisture of skin is easily lost.Ullrasonic spraying can pass through by
Corneocyte gap is permeated and enters skin corium, improves transfer efficiency of the drug in skin, and ullrasonic spraying formation can
The strong nanoparticle particle of penetrability, moisture more rapidly efficiently arrive at deep skin, reach moisturizing effects.But due to external environment
In the reason of stimulation or skin itself, skin itself cannot generate enough moisturizing factors, and very thin cortex loses control of water
The loss divided can make skin be in the presence of that drying is coarse in this way.
Ceramide structural formula is as follows：
Ceramide is also known as sphingolipid, is a kind of lipid in skin, plays in epidermal keratinocytes layer formation process
Important function, ceramide be the latest generation moisturizer developed in recent years.Studies have shown that with age, human body
Ceramide present in skin can be reduced gradually, lead to the skin abnormalities symptom such as dry skin and coarse skin type occur.Mind
Close with the structure of matter of keratoderma is constituted through amide, the water that can be penetrated into quickly in skin and cuticula combines, and is formed
A kind of reticular structure locks moisture, therefore skin supplement ceramide can restore rapidly moisturizing and barrier function.But individually make
With ceramide, there are problems that following two：On the one hand, free natural ceramide is Apoptosis courier, is excessively used
It can accelerate cell metabolism and removing.
Niacinamide structural formula is as follows：
Niacinamide is a kind of derivative of vitamin B3, is the biologically active form of niacin, sees a variety of animals and plants extensively
In.It is also confactor NADH (nicotinamide adenine dinucleotide) and NADPH (nicotinamide-adenine dinucleotide phosphate)
Important as precursors.They play the role of coenzyme in more than 40 kinds of biochemical reactions together with reduced-NAD H and NADPH, can also
Play the role of antioxidant.Niacinamide can accelerate collagen to synthesize, and repair impaired cuticula, while skin being promoted to update
And the horn cell containing melanin is promoted to fall off, so that the colour of skin that mitigation and prevention skin generate in early stage aging course is dim
Light, jaundice.
The structural formula of hyaluronic acid is as follows：
Hyaluronic acid is most types of cytoplasmic matrix in the mammalian body, keeps their stability and elasticity,
It is the substance that moisture retention is best in presently found nature, referred to as ideal natural moisturizing factor.The molecule of hyaluronic acid
Amount has differences in thousands of to millions of ranges according to the different absorptions of molecular weight, macromolecule and middle-molecular-weihydroxyethyl it is transparent
Matter acid can only rest on epidermis, cannot be introduced into deep skin, and moisture-keeping function is poor, and the hyaluronic acid of small-molecular-weight can penetrate into very
Skin, quickly can occur aquation with cell, keep the moisture of cell, further improve skin-nourishing metabolism, keep skin soft
It is tender, smooth, go wrinkle, increase elasticity, prevent aging.
It, can although application No. is 200980138471.6 Chinese patents to provide a kind of stable ceramide dispersion
To be effectively improved the Cutaneous permeation effect of ceramide, but more surfactant is added, influences its safety and stabilization
Property.Application No. is 20101014497.8 Chinese patents, select diguanosine tetraphosphate, niacinamide and hyaluronic acid combination, are used for
Improve moisture content of skin, increase elasticity and whitening, but the method smeared with simple Liquid, the delivering effect of main ingredient ingredient compared with
Difference is unfavorable for the absorption of skin.In addition, Chinese patent CN201510620456, CN201510620460, CN201610358625
A kind of wrinkle resistance, whitening toner, antianaphylactic hydrating smoothing toner, U.S. face smoothing toner are individually disclosed, is contained in these compositions
Hyaluronic acid, niacinamide and ceramide, but high-temperature digestion is all made of in preparation process, hyaluronic acid, niacinamide and nerve
Three kinds of ingredients of amide cause effective content to reduce to high temperature sensitive, in addition simple by the way of liquid applicator, skin effect
It is bad, and the increase in relation to substance may result in the raising of allergy rate.
Summary of the invention
In order to solve the above technical problems, being whitening, moisturizing and anti-aging the object of the present invention is to provide a kind of spray
Cosmetic composition, by least two in hyaluronic acid, niacinamide and ceramide with nanoscale or micron-sized subtle
Droplet penetrates into deep skin, improves skin aging process, increases moisture content of skin, keeps skin elasticity.
The present invention provides a kind of sprays also to wrap including at least two in hyaluronic acid, niacinamide and ceramide
Aqueous phase solvent is included, hyaluronic acid accounts for the 0.01-2% of spray gross weight, and niacinamide accounts for the 0.5-8% of spray gross weight, neural acyl
Amine accounts for the 0.1-10% of spray gross weight.
Preferably, on the basis of spray gross weight, spray is grouped as by each group of following mass percent：Hyaluronic acid
0.1-1%, niacinamide 1-3%, ceramide 5-8%, surplus are aqueous phase solvent.
Further, spray when in use, exists with drops, and the partial size of drop is 500nm-5 μm.
Further, aqueous phase solvent is the mixed liquor of water or second alcohol and water.
Further, in the mixed liquor of second alcohol and water, the mass fraction of ethyl alcohol is 5%.
Further, the molecular weight of hyaluronic acid is 3000-10000Da.
Further, ceramide is dihydrophytoceramide, class ceramide or synthesis ceramide, preferably synthetic mind
Through amide.
Further, it under conditions of guaranteeing to play effect, reduces niacinamide and does not tolerate probability, preferably niacinamide accounts for spray
The 3% of mist agent gross weight.
Further, the penetration-assisting agent for being also 3-10% containing mass percent in above-mentioned spray.
Further, penetration-assisting agent is one or more of glycerol, propylene glycol and butanediol.
Further, the preservative for being also 0.2-0.8% containing mass percent in above-mentioned spray.
Further, preservative is one in benzyl alcohol, imidazolidinyl urea, p-hydroxybenzoate and P-hydroxybenzoic acid
Kind is several.
" spray " in the present invention, means and each component is filled in special device, by manual pump when use
Pressure, high pressure gas, ultrasonic vibration or other methods release content object fog-like, for being directly sprayed onto the preparation of skin.
Preferably, spray uses ultrasonic nanodrop spray technology, simultaneously containing ceramide, niacinamide and thoroughly in spray
Bright matter acid, improves the state that skin barrier is damaged and has dry skin aging, enhances the moisturizing to skin and whitening function.One side
Ceramide cooperation niacinamide is used, the content of ceramide in cuticula is adjusted, further improves skin barrier function by face
Energy；On the other hand, ceramide can not lock skin deep layer moisture, and cooperation hyaluronic acid uses, and skin is helped to lock moisture.
Spray of the invention is used as surfactant, is that one kind has moistening skin, improves skin elasticity and brightens effect
The skin care item of fruit.
Spray of the invention in the preparation, under room temperature (20-30 DEG C), stirs evenly after each component is mixed, and makes each
Component is soluble in the aqueous phase solvent, is then filled into the container with spraying device.By the pressure of manual pump, high pressure gas when use
Body, ultrasonic vibration or other methods release content object fog-like.
According to the above aspect of the present invention, the present invention has at least the following advantages：
The present invention regard at least two in hyaluronic acid, niacinamide and ceramide as main ingredient, and spray is made, so that
Preparation penetrates into deep skin with nanoscale or micron-sized subtle droplet, improves skin aging process, and it is aqueous to increase skin
Amount keeps skin elasticity.
The transdermal ability of main ingredient can be improved in spray of the invention, improves skin barrier function, and can be used for promoting
It is metabolized into skin containing melanocyte, increases moisture content of skin, keep skin elasticity, nourishing and activation are risen to skin.
The above description is only an overview of the technical scheme of the present invention, in order to better understand the technical means of the present invention,
And can be implemented in accordance with the contents of the specification, with presently preferred embodiments of the present invention and cooperation, detailed description is as follows below.
Specific embodiment
With reference to embodiment, the embodiment of the present invention is furthur described in detail.Following embodiment is used for
Illustrate the present invention, but is not intended to limit the scope of the invention.
Embodiment 1
Present embodiments provide a kind of spray F1 used as surfactant, each component including following content：It is transparent
Matter acid 50mg, niacinamide 300mg, ceramide 500mg, pure water 10mL.Preparation method is as follows：
Hyaluronic acid, niacinamide and the ceramide for weighing recipe quantity respectively, are added pure water, and high-speed stirred keeps raw material abundant
Dissolution stands to get mixed liquor.Mixed liquor is filled in the container with ultrasonic spray apparatus to get spray.When use
By ultrasonic vibration, mixed liquor object fog-like is sprayed, ejection drop is nanosized liquid droplets.
In order to which as control, mixed liquor is filled in conventional bottle, as common surfactant, when use, is directly applied to skin
Skin surface.
Embodiment 2
Present embodiments provide a kind of spray F2, each component including following content：Hyaluronic acid 50mg, niacinamide
300mg, ceramide 500mg, glycerine water solution 10mL, wherein the mass fraction of glycerol is 10% in glycerine water solution.It is made
Preparation Method is as follows：
Hyaluronic acid, niacinamide and the ceramide for weighing recipe quantity respectively, are added glycerine water solution, and high-speed stirred makes original
Material sufficiently dissolution, stands to get mixed liquor.Mixed liquor is filled in the container with ultrasonic spray apparatus to get spray.
By ultrasonic vibration when use, mixed liquor object fog-like is sprayed, ejection drop is nanosized liquid droplets.
In order to which as control, mixed liquor is filled in conventional bottle, as common surfactant, when use, is directly applied to skin
Skin surface.
Embodiment 3
Present embodiments provide a kind of spray F3, each component including following content：Hyaluronic acid 50mg, niacinamide
300mg, pure water 10mL.Preparation method is as follows：
The hyaluronic acid and niacinamide for weighing recipe quantity respectively, are added pure water, high-speed stirred dissolves raw material sufficiently, quiet
It sets to get mixed liquor.Mixed liquor is filled in the container with ultrasonic spray apparatus to get spray.By super when use
Acoustic vibration sprays mixed liquor object fog-like, and ejection drop is nanosized liquid droplets.
In order to which as control, mixed liquor is filled in conventional bottle, as common surfactant, when use, is directly applied to skin
Skin surface.
Embodiment 4
Present embodiments provide a kind of spray F4, each component including following content：Hyaluronic acid 50mg, ceramide
500mg, pure water 10mL.Preparation method is as follows：
The hyaluronic acid and ceramide for weighing recipe quantity respectively, are added pure water, high-speed stirred dissolves raw material sufficiently, quiet
It sets to get mixed liquor.Mixed liquor is filled in the container with ultrasonic spray apparatus to get spray.By super when use
Acoustic vibration sprays mixed liquor object fog-like, and ejection drop is nanosized liquid droplets.
In order to which as control, mixed liquor is filled in conventional bottle, as common surfactant, when use, is directly applied to skin
Skin surface.
Embodiment 5
Present embodiments provide a kind of spray F5, each component including following content：Niacinamide 300mg, ceramide
500mg, pure water 10mL.Preparation method is as follows：
The niacinamide and ceramide for weighing recipe quantity respectively, are added pure water, high-speed stirred dissolves raw material sufficiently, quiet
It sets to get mixed liquor.Mixed liquor is filled in the container with ultrasonic spray apparatus to get spray.By super when use
Acoustic vibration sprays mixed liquor object fog-like, and ejection drop is nanosized liquid droplets.
In order to which as control, mixed liquor is filled in conventional bottle, as common surfactant, when use, is directly applied to skin
Skin surface.
Embodiment 6
Present embodiments provide a kind of spray F6, each component including following content：Hyaluronic acid 50mg, pure water
10mL.Preparation method is as follows：
The hyaluronic acid for weighing recipe quantity respectively, is added pure water, and high-speed stirred dissolves raw material sufficiently, stands to get mixed
Close liquid.Mixed liquor is filled in the container with ultrasonic spray apparatus to get spray.It, will by ultrasonic vibration when use
Mixed liquor object fog-like sprays, and ejection drop is nanosized liquid droplets.
In order to which as control, mixed liquor is filled in conventional bottle, as common surfactant, when use, is directly applied to skin
Skin surface.
Embodiment 7
Present embodiments provide a kind of spray F7, each component including following content：Niacinamide 300mg, pure water 10mL.
Preparation method is as follows：
The niacinamide for weighing recipe quantity respectively, is added pure water, and high-speed stirred dissolves raw material sufficiently, stands to get mixing
Liquid.Mixed liquor is filled in the container with ultrasonic spray apparatus to get spray.By ultrasonic vibration when use, will mix
It closes liquid object fog-like to spray, ejection drop is nanosized liquid droplets.
In order to which as control, mixed liquor is filled in conventional bottle, as common surfactant, when use, is directly applied to skin
Skin surface.
Embodiment 8
Present embodiments provide a kind of spray F8, each component including following content：Ceramide 500mg, pure water
10mL.Preparation method is as follows：
The ceramide for weighing recipe quantity respectively, is added pure water, and high-speed stirred dissolves raw material sufficiently, stands to get mixed
Close liquid.Mixed liquor is filled in the container with ultrasonic spray apparatus to get spray.It, will by ultrasonic vibration when use
Mixed liquor object fog-like sprays, and ejection drop is nanosized liquid droplets.
In order to which as control, mixed liquor is filled in conventional bottle, as common surfactant, when use, is directly applied to skin
Skin surface.
The spray for taking appropriate embodiment 1 to 8 to prepare places 0,3,7,14 under the conditions of 4 DEG C and room temperature (25 DEG C) respectively
Its appearance is observed after with 30 days, the results are shown in Table 1.
The different sprays of table 1 place the visual condition after different time at different temperatures
As can be found from Table 1, the F6 in embodiment 6 is in formation flocculent deposit in the 14th day, and as time increases, real
Flocculent deposit in example 6 is applied to increase, and embodiment 1-4 the 30th day it has also been found that flocculent deposit.This is because hyaluronic acid is high
Nutriment, perishable, in actual production or preservative, which can be added, in prevents flocculent deposit from generating.
80 20-28 years old users are tested, 3.0 × 3.0cm of Medial upper arm is selected2The skin of area, left arm are directly smeared
Comparison liquid in embodiment 1-8, right arm spray the spray of same quality in embodiment 1-8,10,30 and after sixty minutes,
Test sites measure moisture content of skin, are averaged, and measure effect such as table 2.
Table 2 uses different preparations moisture content of skin after different time
As can be found from Table 2, ullrasonic spraying is more preferable than direct smearing method effect, and as time increases, implements
Example 1 and 2 can significantly improve skin moisture content, it can be seen that, three's combination of hyaluronic acid, niacinamide and ceramide is better than
Combination of two or single component.
80 20-28 years old users are tested, 3.0 × 3.0cm of Medial upper arm is selected2The skin of area, left arm are directly smeared
Comparison liquid in embodiment 1-8, right arm sprays the spray of same quality in embodiment 1-8, after continuous use 1,2,4 and 8 week,
Improve in Test sites measurement skin elasticity, is averaged, measures effect such as table 3.
Table 3 uses different preparations skin elasticity improved values after different time
As can be found from Table 3, ullrasonic spraying is more preferable than direct smearing method effect, and as time increases, implements
Example 1 and 2 can significantly improve skin elasticity.
80 20-28 years old users are tested, 3.0 × 3.0cm of Medial upper arm is selected2The skin of area, left arm are directly smeared
Comparison liquid in embodiment 1-8, right arm sprays the spray of same quality in embodiment 1-8, after continuous use 1,2,4 and 8 week,
Dermal melanin reduction degree is measured in Test sites, is averaged, measures effect such as table 4.
Table 4 uses different preparations dermal melanin reduced value after different time
As can be found from Table 4, ullrasonic spraying is more preferable than direct smearing method effect, and as time increases, implements
Example 1 and 2 can substantially reduce dermal melanin.
Embodiment 9
A kind of spray is present embodiments provided, on the basis of gross weight, is grouped as by each group of following mass fraction：It is transparent
Matter acid 0.01%, niacinamide 1%, Cer EOS 0%, penetration-assisting agent 3%, preservative 0.2%, surplus are water.Wherein, penetration-assisting agent
For glycerol, preservative is benzyl alcohol.The molecular weight of hyaluronic acid is 3000Da.Preparation method is as follows：
Each component than water is weighed respectively, pure water is added, and high-speed stirred dissolves raw material sufficiently, stands to get mixed
Close liquid.Mixed liquor is filled in the container with ultrasonic spray apparatus to get spray.It, will by ultrasonic vibration when use
Mixed liquor object fog-like sprays, and ejection drop is nanosized liquid droplets.
Embodiment 10
A kind of spray is present embodiments provided, on the basis of gross weight, is grouped as by each group of following mass fraction：It is transparent
Matter acid 0.05%, niacinamide 8%, ceramide 7%, penetration-assisting agent 5%, preservative 0.8%, surplus are water.Wherein, penetration-assisting agent is
Propylene glycol, preservative are imidazolidinyl urea.The molecular weight of hyaluronic acid is 5000Da.Preparation method is the same as embodiment 9.
Embodiment 11
A kind of spray is present embodiments provided, on the basis of gross weight, is grouped as by each group of following mass fraction：It is transparent
Matter acid 1%, niacinamide 3%, Cer NP %, penetration-assisting agent 8%, preservative 0.5%, surplus are water.Wherein, penetration-assisting agent is fourth
Glycol, preservative are P-hydroxybenzoic acid.The molecular weight of hyaluronic acid is 8000Da.Preparation method is the same as embodiment 9.
Embodiment 12
A kind of spray is present embodiments provided, on the basis of gross weight, is grouped as by each group of following mass fraction：It is transparent
Matter acid 0.8%, niacinamide 5%, Cer EOS %, penetration-assisting agent 7%, preservative 0.5%, the ethanol water that surplus is 5%.
Wherein, penetration-assisting agent is butanediol, and preservative is P-hydroxybenzoic acid.The molecular weight of hyaluronic acid is 10000Da.
Embodiment 13
A kind of spray is present embodiments provided, on the basis of gross weight, is grouped as by each group of following mass fraction：It is transparent
Matter acid 0.8%, niacinamide 2%, ceramide 0.1%, penetration-assisting agent 10%, preservative 0.5%, the ethyl alcohol that surplus is 5% are water-soluble
Liquid.Wherein, penetration-assisting agent is butanediol, and preservative is p-hydroxybenzoate.
The above is only a preferred embodiment of the present invention, it is not intended to restrict the invention, it is noted that for this skill
For the those of ordinary skill in art field, without departing from the technical principles of the invention, can also make it is several improvement and
Modification, these improvements and modifications also should be regarded as protection scope of the present invention.
Claims (9)
1. a kind of spray, which is characterized in that including at least two in hyaluronic acid, niacinamide and ceramide, further include
Aqueous phase solvent, the hyaluronic acid account for the 0.01-2% of spray gross weight, and the niacinamide accounts for the 0.5-8% of spray gross weight,
The ceramide accounts for the 0.1-10% of spray gross weight.
2. spray according to claim 1, which is characterized in that on the basis of the gross weight of the spray, by following matter
The each group of amount percentage is grouped as：Hyaluronic acid 0.1-1%, niacinamide 1-3%, ceramide 5-8%, surplus are that water phase is molten
Agent.
3. spray according to claim 1, it is characterised in that：The spray when in use, exists with drops,
The partial size of the drop is 500nm-5 μm.
4. spray according to claim 1, it is characterised in that：The aqueous phase solvent is the mixing of water or second alcohol and water
Liquid.
5. spray according to claim 1, it is characterised in that：The molecular weight of the hyaluronic acid is 3000-
10000Da。
6. spray according to any one of claims 1-5, which is characterized in that also contain mass percent in spray
For the penetration-assisting agent of 3-10%.
7. spray according to claim 6, it is characterised in that：The penetration-assisting agent is in glycerol, propylene glycol and butanediol
One or more.
8. spray according to any one of claims 1-5, which is characterized in that also contain mass percent in spray
For the preservative of 0.2-0.8%.
9. spray according to claim 8, it is characterised in that：The preservative is benzyl alcohol, imidazolidinyl urea, to hydroxyl
One or more of yl benzoic acid ester and P-hydroxybenzoic acid.
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|---|---|---|---|
| CN201810891820.2A CN108888531A (en) | 2018-08-07 | 2018-08-07 | A kind of spray |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810891820.2A CN108888531A (en) | 2018-08-07 | 2018-08-07 | A kind of spray |
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| CN201810891820.2A Pending CN108888531A (en) | 2018-08-07 | 2018-08-07 | A kind of spray |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112263501A (en) * | 2020-11-17 | 2021-01-26 | 上海辉文生物技术股份有限公司 | Multifunctional repairing and anti-aging composition containing thiotaurine and application thereof |
| CN114081851A (en) * | 2021-11-01 | 2022-02-25 | 苏州纳美特生物科技有限公司 | Moisture-keeping spray |
| FR3117801A1 (en) * | 2020-12-22 | 2022-06-24 | L'oreal | COMPOSITION FOR LIGHTENING AND/OR BLEACHING KERATINOUS MATERIALS |
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| CN114081851A (en) * | 2021-11-01 | 2022-02-25 | 苏州纳美特生物科技有限公司 | Moisture-keeping spray |
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