CN113350219A

CN113350219A - Hair loss preventing and hair fixing composition, shampoo containing hair loss preventing and hair fixing composition and preparation method of shampoo

Info

Publication number: CN113350219A
Application number: CN202110722244.0A
Authority: CN
Inventors: 李涛; 丁淑兰; 张福佳; 林华朝; 王钊; 朱俊成; 余圣明; 罗君锋
Original assignee: Guangzhou Datang Cosmetics Co ltd
Current assignee: Guangzhou Datang Cosmetics Co ltd
Priority date: 2021-06-28
Filing date: 2021-06-28
Publication date: 2021-09-07

Abstract

The invention discloses an anti-hair loss and hair-fixing composition, a shampoo containing the same and a preparation method of the shampoo, wherein the anti-hair loss and hair-fixing composition comprises the following components: sphinganine, panthenol, nicotinamide, acetyl tetrapeptide-3, adenosine; the preparation method comprises the following steps: (1) dissolving sphinganine in ethanol or polyalcohol, mixing, heating, and stirring to dissolve uniformly to obtain mixture A; (2) and sequentially adding the mixture A, panthenol, nicotinamide, acetyl tetrapeptide-3 and adenosine into deionized water, and uniformly stirring and dissolving to obtain a finished product. The shampoo containing the hair loss preventing and hair strengthening composition is prepared by using the hair loss preventing and hair strengthening composition as a main active ingredient and matching with other ingredients. The action mechanisms of various components in the composition aim at alopecia, the components are combined together to have a synergistic effect, and the shampoo containing the composition has good anti-hair loss and hair-strengthening effects and is safe to use.

Description

Hair loss preventing and hair fixing composition, shampoo containing hair loss preventing and hair fixing composition and preparation method of shampoo

Technical Field

The invention relates to the technical field of hair loss prevention and hair solidification, in particular to a hair loss prevention and hair solidification composition, a shampoo containing the hair loss prevention and hair solidification composition and a preparation method of the shampoo.

Background

The hair follicle growth cycle of the human scalp is asynchronous, with approximately 15% to 20% of the follicles in the resting phase, only 1% in the catagen phase, and the remainder in the anagen phase. The growth period generally lasts for 3-7 years, at the moment, the hair follicles go deep into the scalp, and the hairs are in an active growth state; in the catagen stage of 3-4 weeks, the hair follicle is atrophied, the outer root sheath begins to cornify, the hair papilla is gradually reduced, the number of cells is reduced, and the hair stops growing; when the outer root sheath is completely cornified, the hair is separated from the papilla and falls off; after a rest period of 3-4 months, the hair follicles become active again, and new, healthy scalp begins to grow, and the cycle is repeated continuously. When the hair loss amount is about the same as the new hair amount, the hair density is basically unchanged, namely the normal physiological hair loss is obtained; however, if the hair growth cycle is unbalanced, the amount of hair loss exceeds the amount of new hair, or the hair growth rate is very slow, which leads to thinning of hair, i.e. pathological hair loss.

The types of pathological alopecia that are common at present are: seborrheic alopecia, seasonal alopecia, neurogenic alopecia, and also other types of alopecia such as: alopecia caused by aging alopecia, hair loss due to permanent wave, hair loss due to external environment infection, and immunity decrease (decrease in insulin growth factor 1 and prostaglandin D2).

Seborrheic alopecia, also known as androgenic alopecia, is a genetically determined and androgen-influenced alopecia disease, usually accompanied by a problem of excessive scalp lipid secretion. Statistically, 95% of patients with alopecia belong to seborrheic alopecia. Regarding the mechanism of seborrheic alopecia, it was discovered that hair follicle stem cells can secrete some cell factors or growth factors inhibiting hair growth, the abnormal secretion of these factors is derived from the fact that the metabolite Dihydrotestosterone (DHT) of Testosterone (Testosterone, T) catalyzed by 5 α reductase activity, both T and DHT can bind to androgen receptor, the obtained complex is transferred from cytoplasm to nucleus and binds to specific gene site, and the transcription and translation of protein are affected, so as to produce a series of cell factors or growth factors causing abnormal hair growth to attack hair follicle, resulting in the miniaturization of hair follicle and finally the inhibition of hair growth. Therefore, seborrheic alopecia can be effectively prevented and alleviated by inhibiting the activity of 5 α reductase.

Seasonal alopecia occurs mainly in autumn and winter, and dry and cold air causes skin temperature to decrease and pores to converge. The microfilament blood vessels of the scalp show an inactive state, and because the microfilament blood vessel network directly conveys nutrition to hair roots, the hair roots are influenced by the nutrition to generate nutrient metabolic disturbance, and the nutrient supply at the hair root parts is insufficient to generate the after-loss of hair dryness nutrition, thereby causing the phenomenon of alopecia.

Alopecia areata or Cicatricial Alopecia (CA) is a group of Alopecia diseases centered on hair follicles and characterized by destructive and permanent inflammation.

Alopecia is determined by multiple factors such as hair follicle stem cells, sebaceous glands, pileus and the like, so that the alopecia is difficult to be effectively inhibited by unreasonable single functional components or component matching.

For alopecia, it is common to use minoxidil, finasteride, and doxicarb, however, these drugs have large side effects on human body, such as domiphen or allergic dermatitis easily appeared in minoxidil, and finasteride is easily damaged in sexual function. Therefore, the scalp health of the mild and moderate alopecia patients can be nursed by reasonably selecting the anti-alopecia and hair-nourishing series nursing products, and the alopecia can be prevented.

In the washing and nursing product, because some chemically synthesized components have side effects, in the prior art, the anti-hair loss product mostly uses one or more Chinese herbal medicine extract combinations as anti-hair loss effective components, however, the Chinese herbal medicine extract components are complex, the extraction process is complicated, components except the required effective components and even unknown components are inevitably mixed in the extraction process, and the potential hazards exist in the aspects of scalp health and even human health after long-term use. For example, the number of reports of the problem of medicinal liver injury (DILI) caused by polygonum multiflorum and the formulated preparation containing polygonum multiflorum has increased, and liver injury may be caused by a short-time large dose or a small dose for a long time.

At present, the highest rate of various alopecia types is androgenetic alopecia, the alopecia type belongs to gene determination, no radical treatment technology exists at present, hair washing and caring products generally avoid damage to hair follicles caused by the combination of excessive dihydrotestosterone and androgen receptors through continuously inhibiting 5 alpha reductase, so the technology is easy to repeat after being stopped, and the traditional Chinese medicine plant extract is not the best choice for long-time use. Thus, there is a need in the market for a product that is safe, effective, and suitable for long-term use.

Disclosure of Invention

Aiming at the defects of the prior art, the invention provides a product with good anti-hair-loss and hair-fixing effects and safe use.

In order to solve the technical problems, the invention adopts the technical scheme that the anti-hair loss and hair-fixing composition comprises the following components in percentage by mass: sphinganine: panthenol: nicotinamide: acetyl tetrapeptide-3: adenosine is 0.001-10.0: 0.001-10.0: 0.001-10.0: 0.001-10.0: 0.001 to 10.0; the preparation method comprises the following steps:

(1) dissolving sphinganine in ethanol or polyalcohol, mixing, heating, stirring to dissolve uniformly to obtain mixture A, and cooling to 40 deg.C;

preferably, the polyol is a mixture of one or more of pentanediol, 1,3 propanediol, 1,3 butanediol. Further preferred is pentanediol.

Preferably, in the mixture A, the mass ratio of the sphinganine to the ethanol or the polyol is 1:5 to 20.

Preferably, the heating temperature is 60-80 ℃, and the stirring speed is 80-200 rpm/min; further, the stirring speed is 150 rpm/min; the stirring time is 5min to 20min, and further, the stirring time is 10 min.

(2) And sequentially adding the mixture A, panthenol, nicotinamide, acetyl tetrapeptide-3 and adenosine into deionized water, and uniformly stirring and dissolving to obtain a finished product.

Preferably, the mass ratio of the mixture A, the panthenol, the nicotinamide, the acetyl tetrapeptide-3, the adenosine and the deionized water is 1: 2-5.

Preferably, the temperature during stirring is set to be 25-45 ℃, further, the stirring temperature is 40 ℃, and the stirring speed is 50-180 rpm/min; further, the stirring speed is 100 rpm/min; the stirring time is 5min to 10min, and further, the stirring time is 5 min.

The anti-hair loss and hair-fixing composition can be used for preparing hair care products with the functions of preventing hair loss and fixing hair, wherein the hair care products comprise shampoo, hair conditioner and scalp care solution.

The invention solves another technical problem by providing a shampoo containing the anti-hair loss and hair-fixing composition, which comprises the following components in parts by mass:

0.01-0.5 part of acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer; 60-80 parts of purified water; 0.05-1 part of allantoin; 5-20 parts of sodium laureth sulfate; 0.5-3 parts of palm kernel oil amide DEA; 1-5 parts of sodium lauryl sulfate; 0.05-1 part of zinc chloride; 0.1-0.8 part of cocamide methyl MEA; 0.1-0.5 part of piroctone olamine salt; 0.01-0.5 part of triethanolamine; 100.01-1 parts of polyquaternium; 0.05-0.5 part of guar gum hydroxypropyl trimethyl ammonium chloride; 0.1 to 0.5 portion of zinc pyrithione; 0.1-0.8 part of sodium polynaphthalenesulfonate; 0.5-5 parts of sodium lauroyl sarcosinate; 0.1-5 parts of sodium lauroyl glutamate; 0.1-1 part of lauryl diethylene diamino glycine; 0.5-2 parts of cocoyl hydroxyethyl imidazoline; 0.1-1 part of PPG-3 new base ether; 0.1-1 part of C12-13 alcohol lactate; 0.1-1.5 parts of polydimethylsiloxane; laureth-230.05-0.2 portion; 0.1-1 part of sodium laureth sulfate; 0.1-2 parts of dimethiconol; 0.1-1 part of dodecyl benzene sulfonic acid TEA salt; 0.1-3 parts of lauramidopropyl hydroxysulfobetaine; 70.5-3 parts of polyquaternium; 0.0001 to 0.5 portion of sodium chloride; 0.4-1 part of phenoxyethanol; 0.05-0.5 part of ethylhexyl glycerol; 0.01-0.5 part of citric acid; 0.01-10 parts of hair loss preventing and hair fixing composition.

The invention solves another technical problem by providing a preparation method of the shampoo, which comprises the following steps:

(1) dispersing polyquaternium-10 and sodium chloride uniformly by using purified water to obtain a first mixture for later use;

(2) dispersing triethanolamine with purified water uniformly to obtain a second mixture for later use;

(3) dispersing zinc pyrithione and sodium polynaphthalene sulfonate uniformly by using purified water to obtain a third mixture for later use;

(4) dispersing guar gum hydroxypropyl trimethyl ammonium chloride with purified water uniformly to obtain a fourth mixture for later use;

(5) putting the acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer into a main pot, homogenizing and dissolving the acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer uniformly by using purified water until no particles exist, and heating to 78-82 ℃;

(6) sequentially adding allantoin, sodium laureth sulfate, palm kernel oil amide DEA, sodium laureth sulfate, zinc chloride, coconut oil amide methyl MEA and piroctone olamine ethanol ammonium salt into a main pot, keeping the temperature at 78-82 ℃, and stirring and dissolving uniformly;

(7) adding the second mixture into the pot, uniformly stirring, then adding the first mixture, uniformly stirring, then adding the third mixture, uniformly stirring, then adding the fourth mixture, keeping the temperature at 80-85 ℃, stirring for about 30 minutes, uniformly stirring, and then cooling to 50 ℃;

(8) dispersing sodium lauroyl sarcosinate, sodium lauroyl glutamate, lauryl diethylene diaminoglycine, cocoyl hydroxyethyl imidazoline, PPG-3 neo-yl ether, C12-13 alcohol lactate, polydimethylsiloxane, laureth-23, sodium laureth sulfate, dimethiconol, dodecyl benzene sulfonate (TEA) salt, lauramidopropyl hydroxysulfobetaine, polyquaternium-7, sodium chloride, phenoxyethanol, ethylhexyl glycerol and citric acid to be free of particles by using purified water, filtering, adding into a main pot, and stirring until the mixture is uniform and free of particles or clusters;

(9) cooling to 45 deg.C, dissolving the composition with purified water, adding into the main pot, stirring, taking out, and inspecting.

Sphinganine is a glycolipid in vivo, is a main component of cell membrane, and can inhibit 5 alpha reductase, reduce secretion of abnormal growth factor in stem cells of dermal hair papilla and bulge, thereby regulating normal growth factor and cytokine, and balancing hair growth cycle.

Panthenol is a precursor of vitamin B5, and vitamin B5 is a natural component of hair. Panthenol can promote healthy growth of hair by enhancing expression of keratin-related proteins.

Nicotinamide, also called vitamin B3, is a vitamin necessary for human body, and can promote blood circulation of hair bulb, reduce inflammation, rebuild keratin, ensure keratinization process in hair follicle, and finally make hair become strong and tough;

adenosine is an important component of Adenosine Triphosphate (ATP) in human cells and can up-regulate the expression of genes encoding growth factors in dermal papilla cells, such as FGF-7, VEGF, TGF- β, stimulate local angiogenesis, dilate blood vessels, increase blood circulation, ensure nutrient supply, and reduce alopecia.

The acetyl tetrapeptide-3 is a bionic peptide which is formed by dehydrating and condensing four amino acids existing in a human body, can accelerate the synthesis of extracellular matrix proteins (such as laminin, collagen III and VII), increase the volume and the length of hair follicles and strengthen hair roots; repairing epidermal dermal junction tissue, and enhancing the attachment function of pileus to fix hair in hair follicle.

Compared with the prior art, the action mechanisms of various components in the composition aim at alopecia, the components are combined together to have the synergistic effect, and the shampoo containing the composition has good anti-hair loss and hair-fixing effects and is safe to use.

Detailed Description

The following examples are given to further illustrate the embodiments of the present invention, but are not intended to limit the invention.

Example 1:

the anti-hair loss and hair-fixing composition comprises the following components in percentage by mass: sphinganine: panthenol: nicotinamide: acetyl tetrapeptide-3: adenosine is 0.001: 0.001: 0.001: 10.0: 10.0; the preparation method comprises the following steps:

(1) dissolving sphinganine in ethanol, mixing, heating, stirring to dissolve uniformly to obtain a mixture A, and cooling to 40 deg.C for use;

in the mixture A, the mass ratio of the sphinganine to the ethanol is 1: 5.

the heating temperature is 60-80 ℃, and the stirring speed is 80-200 rpm/min; further, the stirring speed is 150 rpm/min; the stirring time is 5min to 20min, and further, the stirring time is 10 min.

Preferably, the mass ratio of the mixture A, the panthenol, the nicotinamide, the acetyl tetrapeptide-3 and the adenosine to the deionized water is 1: 2.

Preferably, the temperature is set to be 25-45 ℃ during stirring, further, the stirring temperature is 40 ℃, and the stirring speed is 50-180 rpm/min; further, the stirring speed is 100 rpm/min; the stirring time is 5min to 10min, and further, the stirring time is 5 min.

Example 2:

the anti-hair loss and hair-fixing composition comprises the following components in percentage by mass: sphinganine: panthenol: nicotinamide: acetyl tetrapeptide-3: adenosine is 3: 4: 4: 4: 5; the preparation method comprises the following steps:

(1) dissolving sphinganine in pentanediol, mixing, heating, stirring to dissolve uniformly to obtain a mixture A, and cooling to 40 deg.C for use;

in the mixture A, the mass ratio of the sphinganine to the pentanediol is 1: 10.

The mass ratio of the mixture A, the panthenol, the nicotinamide, the acetyl tetrapeptide-3 and the adenosine to the deionized water is 1: 3.

The temperature is set to be 25-45 ℃ during stirring, further, the stirring temperature is 40 ℃, and the stirring speed is 50-180 rpm/min; further, the stirring speed is 100 rpm/min; the stirring time is 5min to 10min, and further, the stirring time is 5 min.

Example 3:

the anti-hair loss and hair-fixing composition comprises the following components in percentage by mass: sphinganine: panthenol: nicotinamide: acetyl tetrapeptide-3: adenosine is 10.0: 10.0: 10.0: 0.001: 0.001; the preparation method comprises the following steps:

(1) dissolving sphinganine in 1, 3-propanediol, mixing and heating, stirring until the sphinganine is dissolved uniformly to obtain a mixture A, and cooling to 40 ℃ for later use;

in the mixture A, the mass ratio of the sphinganine to the 1, 3-propanediol is 1: 20.

The mass ratio of the mixture A, the panthenol, the nicotinamide, the acetyl tetrapeptide-3 and the adenosine to the deionized water is 1: 5.

Example 4:

a shampoo containing an anti-hair loss and hair-fixing composition comprises the following components in parts by mass:

0.01 part of acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer; 80 parts of purified water; 0.05 part of allantoin; 20 parts of sodium laureth sulfate; 0.5 part of palm kernel oil amide DEA; 5 parts of sodium lauryl sulfate; 0.05 part of zinc chloride; 0.8 part of cocamide methyl MEA; 0.1 part of piroctone olamine; 0.5 part of triethanolamine; 100.01 parts of polyquaternium; 0.5 part of guar gum hydroxypropyl trimethyl ammonium chloride; 0.1 part of zinc pyrithione; 0.8 part of sodium polynaphthalenesulfonate; 0.5 part of sodium lauroyl sarcosinate; 5 parts of sodium lauroyl glutamate; 0.1 part of lauryl diethylene diamino glycine; 2 parts of cocoyl hydroxyethyl imidazoline; 0.1 part of PPG-3 new base ether; 1 part of C12-13 alcohol lactate; 0.1 part of polydimethylsiloxane; 230.2 parts of laureth; 0.1 part of sodium laureth sulfate; 2 parts of dimethiconol; 0.1 part of dodecyl benzene sulfonic acid TEA salt; 3 parts of lauramidopropyl hydroxysulfobetaine; 70.5 parts of polyquaternium; 0.5 part of sodium chloride; 0.4 part of phenoxyethanol; 0.5 part of ethylhexyl glycerin; 0.01 part of citric acid; 10 parts of hair loss preventing and hair fixing composition.

Example 5:

0.2 part of acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer; 70 parts of purified water; 0.5 part of allantoin; 10 parts of sodium laureth sulfate; 1 part of palm kernel oil amide DEA; 2 parts of sodium lauryl sulfate; 0.5 part of zinc chloride; 0.4 part of cocamide methyl MEA; 0.3 part of piroctone olamine; 0.1 part of triethanolamine; 100.5 parts of polyquaternium; 0.2 part of guar gum hydroxypropyl trimethyl ammonium chloride; 0.3 part of zinc pyrithione; 0.5 part of sodium polynaphthalenesulfonate; 2 parts of sodium lauroyl sarcosinate; 3 parts of sodium lauroyl glutamate; 0.5 part of lauryl diethylene diamino glycine; 1 part of cocoyl hydroxyethyl imidazoline; 0.6 part of PPG-3 new base ether; 0.6 part of C12-13 alcohol lactate; 1 part of polydimethylsiloxane; 230.1 parts of laureth; 0.5 part of sodium laureth sulfate; 1 part of dimethiconol; 0.5 part of dodecyl benzene sulfonic acid TEA salt; 1 part of lauramidopropyl hydroxysulfobetaine; 72 parts of polyquaternium; 0.2 part of sodium chloride; 0.8 part of phenoxyethanol; 0.2 part of ethylhexyl glycerin; 0.2 part of citric acid; 5 parts of hair loss preventing and hair fixing composition.

Example 6

0.5 part of acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer; 60 parts of purified water; 1 part of allantoin; 5 parts of sodium laureth sulfate; palm kernel oil amide DEA 3 parts; 1 part of sodium lauryl sulfate; 1 part of zinc chloride; 0.1 part of cocamide methyl MEA; 0.5 part of piroctone olamine; 0.01 part of triethanolamine; 101 parts of polyquaternium; 0.05 part of guar gum hydroxypropyl trimethyl ammonium chloride; 0.5 part of zinc pyrithione; 0.1 part of sodium polynaphthalenesulfonate; 5 parts of sodium lauroyl sarcosinate; 0.1 part of sodium lauroyl glutamate; 1 part of lauryl diethylene diamino glycine; 0.5 part of cocoyl hydroxyethyl imidazoline; 1 part of PPG-3 new base ether; 0.1 part of C12-13 alcohol lactate; 1.5 parts of polydimethylsiloxane; laureth-230.05 parts; 1 part of sodium laureth sulfate; 0.1 part of dimethiconol; 1 part of dodecyl benzene sulfonic acid TEA salt; 0.1 part of lauramidopropyl hydroxysulfobetaine; 73 parts of polyquaternium; 0.0001 part of sodium chloride; 1 part of phenoxyethanol; 0.05 part of ethylhexyl glycerol; 0.5 part of citric acid; 0.01 part of hair loss preventing and hair fixing composition.

The preparation method of the above embodiments 4 to 6, comprising the steps of:

In order to embody the effects of the invention in the aspects of preventing hair loss and fixing hair, the following contrast experiments are set:

subject: 60 qualified subjects were selected according to inclusion and exclusion criteria and were randomly and evenly divided into test and control groups.

And (3) inclusion standard: healthy males or females aged 18-60 years; the length of the hair is 5-40 cm; the hair loss is more than 10, and the hair loss count is more than 10 after 2 weeks of elution according to a 60-time hair combing method (the same trained technician adopts a comb with the same specification, and evenly combs 60 times from the left front to the left back and from the right front to the right back, and 30 times respectively left and right); no special hair-dressing treatments such as hair dyeing, hair waving, shaping and the like are performed in nearly 1 month;

exclusion criteria: pregnant or lactating women, or those who have a pregnancy plan recently; severe androgenic alopecia, alopecia areata, inflammatory cicatricial alopecia or other patients with scalp/hair disorders; patients with psychiatric or psychological disorders; or those with long-term sleep, mood control disorders; the cosmetic with the alopecia preventing effect or other products with the hair growing effect are used within nearly 3 months; those who have taken or topically applied any medication that affects hair growth within approximately 6 months; those who have received hair transplant treatment; curly hair, highly sensitive; other clinical trial participants took part in the last 2 months; clinical assessments considered unsuitable for participants.

Subject restriction: during screening and testing of the subject, the hair can not be washed within 48 +/-4 hours before each visit, the hair washing time before each visit is basically consistent, and the hair can not be combed on the visit day; during the test period, the hair cannot be treated within 2 weeks before each visit evaluation; during the test period, no hair care and hairdressing treatment measures can be carried out, and any treatment for preventing alopecia and promoting hair growth can not be accepted; the original living habits need to be kept during the test period, and the large emotional fluctuation is avoided.

The test substance: (1) test products: the shampoo added with the anti-hair loss composition of the invention. (2) Control product: the shampoo product with the efficacy of preventing alopecia is declared on the market. (3) And (3) products in an elution period: the corresponding test product matrix formula product does not contain the anti-hair loss functional component.

The using method comprises the following steps: the test product and the control product are issued by the staff according to the random table, and the product use instruction is carried out on the test subject according to the use instruction, so that the test subject can be ensured to use the test object correctly in the test period. The subjects were used for 12 weeks, during which the subjects were asked to record the time of use and any discomfort and adverse symptoms during use.

Test equipment: the comb is moderate in comb tooth density (the space between the teeth is 1.0mm), 2.5cm in comb tooth length and 13cm in comb length (no comb handle), the combs of the same specification and material are used in the whole test process, and the disinfection is performed according to the relevant requirements in medical institution disinfection technical Specification (WS-T367 and 2012) after each use.

Environmental conditions: test results the temperature observed is 21 +/-1 ℃ and the relative humidity is 50 +/-10% RH, the visual evaluation is carried out under the constant illumination condition (the illumination of a fluorescent tube or an LED with the color temperature of 5500-6500K), and the subject can be evaluated and tested after the subject is adapted for 30 minutes under the environment condition.

The test process comprises the following steps:

(1) recruiting volunteer subjects to the group as required, inquiring the subjects according to enrollment and exclusion criteria and the like before the group, and inquiring the subjects about disease history, health conditions and other problems, and meanwhile counting the number of the alopecia by adopting a 60-time combing method and recording;

(2) qualified subjects underwent a 2-week washout period (product used during the washout period, see above); after the elution period is finished, combing the hair for 60 times again, and entering the formal test only if the hair loss count is still more than 10;

(3) dividing the subject selected in the formal test into a test product group and a control product group according to a layering random method;

(4) evaluating the pre-product hair basic value of the selected subjects, including hair loss counting and hair density evaluation, and recording; the same evaluations and tests were performed again at 4 weeks, 8 weeks, 12 weeks after the product use;

(5) counting the hair loss: combing the hair of the testee by a trained worker by adopting a 60-time combing method during each visit of the testee, counting the fallen hair and recording;

(6) the evaluation of hair density was carried out on the part of the subject to be fixed before and after the application of the product. The specific method comprises the following steps:

fixing a 2 cm-2 cm hair cutting area (lateral temporalis of the head) on the head of a subject, positioning, ensuring that the hair cutting area is consistent when the subject visits the eye every time, cutting the hair until the residual length does not exceed 1mm, counting the number and density of local hairs by using a manual counting method, and recording. Subjects were followed up and data were recorded as follows:

analysis of the data using the SPSS software revealed that the hair loss count of the subjects before and after 12 weeks of use of the test products was in accordance with a normal distribution (P > 0.05).

According to the matched sample T test before and after the product is used for 12 weeks, the counting of the alopecia before and after the use has statistical significance (P is less than 0.05), namely the counting of the alopecia before and after the use of the product is obviously improved, and the product has obvious effect in the aspect of alopecia prevention.

The normal test is carried out on the hair loss counting difference value (the hair loss counting after the product is used for 12 weeks-the hair loss counting before the product is used) of the product and the comparison product after the product and the comparison product are used for 12 weeks, the obtained difference values of the two groups of data are in accordance with the normal distribution (P is more than 0.05), and the independent sample T test is carried out on the two groups of data, so that the two groups of data have statistical significance (P is less than 0.05), namely the hair loss counting difference value before and after the product is used is obviously different from the hair loss counting difference value before and after the product is used in the comparison product, and the hair loss prevention effect of the product is obviously better than that of the comparison product.

In conclusion, compared with the prior art, the action mechanisms of various components in the composition are respectively emphasized for alopecia, the components are combined together to have the synergistic hair-strengthening effect, and the shampoo containing the composition has good hair-loss-preventing and hair-strengthening effects and is safe to use.

The embodiments of the present invention have been described in detail with reference to the examples, but the present invention is not limited to the described embodiments. It will be appreciated by those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims.

Claims

1. The anti-hair loss and hair-fixing composition is characterized by comprising the following components in percentage by mass: sphinganine: panthenol: nicotinamide: acetyl tetrapeptide-3: adenosine is 0.001-10.0: 0.001-10.0: 0.001-10.0: 0.001-10.0: 0.001 to 10.0; the preparation method comprises the following steps:

2. The anti-hair loss hair fixative composition of claim 1, wherein in step (1), the polyol is a mixture of one or more of pentanediol, 1,3 propanediol, 1,3 butanediol.

3. The anti-hair loss hair fixative composition of claim 2, wherein the polyol is pentanediol.

4. The anti-hair loss and hair-fixing composition according to claim 1, wherein in the mixture A, the mass ratio of the sphinganine to the ethanol or the polyol is 1:5 to 20.

5. The hair loss prevention and hair solidification composition according to claim 1, wherein in the step (1), the heating temperature is 60-80 ℃, and the stirring speed is 80-200 rpm/min; the stirring time is 5min to 20 min.

6. The hair loss prevention and hair solidification composition as claimed in claim 1, wherein in the step (2), the mass ratio of the mixture A, the panthenol, the nicotinamide, the acetyl tetrapeptide-3, the adenosine and the deionized water is 1: 2-5.

7. The hair loss preventing and hair fixing composition according to claim 1, wherein in the step (2), the temperature during stirring is set to be 25-45 ℃, the stirring speed is 50-180 rpm/min, and the stirring time is 5-10 min.

8. Use of the hair loss prevention and hair solidification composition according to claim 1 for preparing hair care products with hair loss prevention and hair solidification functions, wherein the hair care products comprise shampoo, hair conditioner and scalp care solution.

9. A shampoo containing the anti-hair loss and hair-fixing composition of claim 1, which is characterized by comprising the following components in parts by mass:

10. A method of preparing the shampoo of claim 9 comprising the steps of: