CN110314033A - A kind of Medical cold application - Google Patents
A kind of Medical cold application Download PDFInfo
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- CN110314033A CN110314033A CN201910665053.8A CN201910665053A CN110314033A CN 110314033 A CN110314033 A CN 110314033A CN 201910665053 A CN201910665053 A CN 201910665053A CN 110314033 A CN110314033 A CN 110314033A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0203—Cataplasms, poultices or compresses, characterised by their contents; Bags therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0261—Compresses or poultices for effecting heating or cooling medicated
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- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Thermal Sciences (AREA)
- Dermatology (AREA)
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- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of Medical cold application, the Medical cold application is prepared using freeze-drying after functional component is attached on non-woven fabrics or silk fabric；The functional component includes cooling composition and moisture-keeping composition；The cooling composition includes borneol, menthol and camphor.Moisture-free in Medical cold of the present invention application, without adding preservative, it is possible to reduce because of skin damage or allergic phenomena caused by preservative；Using relatively flexibly, wetting time is quick, can be used after cooperating clear water or the wetting of other nutritive waters.The cold compress patch of frozen dried can reduce the loss of heat-sensitive substance, and some oxidizable substances are protected in cold compress patch, improve the stability of cold compress patch.Physics suitable for closed soft tissue brings down a fever, cold compress physical therapy.Heat is taken away by the vaporization of cold compress patch contained humidity and natural cooling ingredient, can achieve partial cooling, achievees the effect that cold compress pain relieving, percutaneous absorbtion, sustained-release administration.
Description
Technical field
The present invention relates to a kind of medical equipments, and in particular to a kind of Medical cold application.
Background technique
Cold compress patch in the market is improved according to traditional cold compress mode (such as: cold water, ice water, alcohol), with high score
The TDDS newtype drug release system prepared based on sub- gel is core, is generally made of back sheet, gel layer, adherent layer.
Heat is taken away by the vaporization of contained humidity in high-molecular gel and natural cooling ingredient, can achieve partial cooling, it is therein
Drug ingedient is combined with hydrogel, by aquation, drug ingedient can be made to readily penetrate through fat deposit, be penetrated into subcutaneous group
It knits, go directly lesions position, acts on affected part, achievees the effect that cold compress pain relieving, percutaneous absorbtion, sustained-release administration.In the market these
There is the defects of patch is inconvenient to carry, and cool feeling release is too fast, leads to the senses of discomfort such as generation piloerection, shiver with cold in cold compress.
Summary of the invention
A kind of Medical cold application is provided it is an object of the invention to overcome the shortcomings of the prior art place.
To achieve the above object, the technical scheme adopted by the invention is as follows: a kind of Medical cold applies the Medical cold application and adopts
It is prepared with functional component is attached on non-woven fabrics or silk fabric rear freeze-drying；
The functional component includes cooling composition and moisture-keeping composition；
The cooling composition includes borneol, menthol and camphor.
Medical cold application (Medical cold application) of the present invention belongs to medical machinery first kind product, and it is soft to be suitable for closed
The physics of tissue brings down a fever, cold compress physical therapy.Heat, Ke Yida are taken away by the vaporization of cold compress patch contained humidity and natural cooling ingredient
To partial cooling, functional component therein is combined with water, by aquation, functional component can be made to readily penetrate through fat
Layer, penetrates into subcutaneous tissue, and go directly lesions position, acts on affected part, reaches the effect of cold compress pain relieving, percutaneous absorbtion, sustained-release administration
Fruit.Cold compress patch can be such that local capillary shrinks, and mitigate contrafluxion, and the sensibility of nerve endings can be made to reduce and mitigate pain
Bitterly, cooling is brought down a fever, and can reduce regional flow, prevents inflammation and diffusion of suppurating.Intracorporal heat transfer can be dissipated, increase heat dissipation,
Reduce body temperature.Cold compress is suitable for the tissue damage of early stage local software, hyperpyretic patient and heatstroke person, toothache etc. and needs cold compress crowd.
Moisture-free in Medical cold of the present invention application, without adding preservative, it is possible to reduce because of skin damage caused by preservative
Or allergic phenomena；Using relatively flexibly, wetting time is quick, can be used after cooperating clear water or the wetting of other nutritive waters.In addition,
The present invention uses frozen dried, reduces the loss of heat-sensitive substance, and some oxidizable substances are protected in cold compress patch,
Improve the stability of cold compress patch.
Resin and volatile oil processed goods of the borneol mainly from Dipterocarpaceae plant extract the crystallization obtained, can be used for matching
Rosemary processed and lavender type essence, effect harmless to the human body.Menthol is freshener, essence camphor has multiple efficacies,
It can be used as stacte fragrance and medical drugs.Medically it is mainly used as preservative, local anesthetic, carminative and cardiotonic etc..
This three kinds of ingredient synergy, can increase cool feeling, and Lavender Extract has cooling effect.In addition, Medical cold application of the present invention
In also added the ingredient with moisture-keeping efficacy, skin cooling while can also be skin replenishing water and preserving moisture.
Preferably, the cooling composition contains the following parts by weight: 0.5~3 part of borneol, 0.5~3 part of menthol
With 0.5~3 part of camphor.When arranging in pairs or groups using said ratio, there is mild cooling and inirritative effect.
It is highly preferred that the cooling composition contains the following parts by weight: 2 parts of borneol, 2 parts of menthol and camphor 2
Part.
Preferably, the moisture-keeping composition contains the following parts by weight: 10 13~28 parts of polyglycereol, glycine betaine 13
~28 parts, 15~25 parts of mannitol, hydrolysis 3~8 parts of pyrenomycetes (SCLEROTIUM ROLFSSII) glue, curdlan
0.5~3 part of class, 0.5~3 part of jellyfish extract, 0.5~3 part of hydrolytic collagen, 0.5~1.5 part of Sodium Hyaluronate, ceramide
1.4~3.9 parts of composition；The ceramide composition contains the following parts by weight: 0.2~0.8 part of Cer EOS,
0.2~0.8 part of Cer NS, 0.5~1.5 part of Cer NP, 4 0.2~0.8 part of ceramide and Cer AP II
0.2~0.8 part.
Curdlan has good rheological characteristic, almost has all advantages of xanthan gum, thermal stability is better than Huang
Virgin rubber.Jellyfish extract can make Skin Cell more complete tough, moisturizing, water lock, crease-resistant, and there are also whitenings and effect of releiving.Water
Solution collagen is efficient moisture-retention composition, skin-active, inducing tissue regeneration, and the main bonding substance in human connective tissue, molecular weight is big,
Moisture-retaining capacity more preferably compared with polyalcohols, mainly to support cell, especially suitable for after skin exfoliating, skin be in most thin rank
Physical therapy made by section is protected.Sodium Hyaluronate is also known as sodium hyaluronate sodium, belongs to skin conditioner, is a kind of acid mucopolysaccharide, naturally
It is present in cornea skin, can absorb itself 1000 times of moisture of weight, reaches by retaining moisture of skin, preventing moisture through table
Skin is lost, and the barrier reparation when skin is damaged, and skin is enabled not feel drying after, increases gloss, it can
With improve skin-nourishing metabolism, make skin it is soft, it is smooth, go wrinkle, increase elasticity, prevent aging, be good again while moisturizing
Skin penetration enhancer.It is used cooperatively with other nutritional ingredients, the more preferable effect for promoting nutrient absorption can be played.
Cer EOS is made skin conditioning agent and moisturizer in cosmetics and is used, it can intensive repair of skin natural skin
Adipose membrane strengthens the defensive enginery of skin surface barrier, there is good closure, reduces moisture evaporation and is lost, is suitble to all fleshes
Skin type.
Cer NS makees the effect of skin conditioning agent, antioxidant and moisturizer in cosmetics, it can improve sebum
Inhibit active smegma while film, make skin water and oil balance, enhances the same ceramide of self-protection function of skin
1, relatively it is suitble to skin greasing and has the young skin of demand.The ingredient has good action to skin moisturizing maintenance, is in cuticula
Important skin-active ingredient, can enhance skin barrier, reconstituted cell.The especially needed more ceramides of stimulated skin, have
Studies have shown that wiping the product containing ceramide ingredient can be reduced red and swollen and percutaneous water loss, enhancing skin barrier is played
Effect.
Cer NP is a kind of lipid matter, artificial synthesized ingredient, the structure of matter phase of it and composition keratoderma
Closely, skin can be penetrated into quickly, helped the update of skin natural containment, can be promoted the balance and cutin of nature aquation
Water in layer combines, and forms a kind of reticular structure, locks moisture.There is good action to skin moisturizing maintenance, is weight in cuticula
The skin-active ingredient wanted, can enhance skin barrier, and reconstituted cell forms effective barrier to prevent water loss and reduce external rings
The influence in border.The especially needed more ceramides of stimulated skin, some researches show that wipe the production containing ceramide ingredient
Product can be reduced red and swollen and percutaneous water loss, plays the role of enhancing skin barrier and impaired skin is helped to alleviate drying regime.
Ceramide 4 can increase horny layer of epidermis thickness, improve skin moisture holding capacity, reduce wrinkle, enhance skin elasticity,
Delay skin aging.
It can inhibit active smegma to Cer AP II while improving sebum film, be shelled by scaling of skin
The natural stripping process normalization for making skin is fallen, allows skin water and oil balance, enhances the same ceramide of self-protection function of skin
1, relatively it is suitble to skin greasing and has the young skin of demand.The ingredient has good action to skin moisturizing maintenance, is in cuticula
Important skin-active ingredient can enhance skin barrier, reconstituted cell, and can form effective barrier to prevent water loss and reduce outer
The influence of portion's environment.The especially needed more ceramides of stimulated skin, some researches show that wipe and contain ceramide ingredient
Product can be reduced red and swollen and percutaneous water loss, play the work that enhancing skin barrier helps impaired skin to alleviate drying regime
With.
Institute's moisture-keeping composition of the present invention can cooperate effectively replenishing water and preserving moisture under said ratio, promote natural hydration
Balance.
It is highly preferred that the moisture-keeping composition contains the following parts by weight: 10 18 parts of polyglycereol, 18 parts of glycine betaine,
20 parts of mannitol, 5 parts of pyrenomycetes (SCLEROTIUM ROLFSSII) glue of hydrolysis, 2 parts of curdlan class, jellyfish are extracted
2 parts of object, 2 parts of hydrolytic collagen, 1 part of Sodium Hyaluronate, 2 parts of ceramide composition；The ceramide composition includes following
The component of parts by weight: 0.5 part of Cer EOS, 0.5 part of Cer NS, 1 part of Cer NP, 4 0.5 parts of ceramide and
0.5 part of Cer AP II.Especially under said ratio, replenishing water and preserving moisture better effect.
Preferably, the functional component also contains the following parts by weight: 0.5~3 part of carboxymethylchitosan,
0.5~3 part of Gotu Kola P.E, 3~8 parts of rough gentian root extract and 2~6 parts of beta glucan.
Carboxymethylchitosan is natural polysaccharide source, and user's skin allergy symptom is effectively relieved.Centella
Main component asiaticosid in (CENTELLA ASIATICA) extract has facilitation to fibroblasts from hypertrophic scars vigor,
So scar of dispelling.Rough gentian (GENTIANA SCABRA) root extract has good activation effect to luciferase, says
It is bright to have effect to atopic dermatitis and allergy, it can inhibit stimulation, play anti-inflammatory effect.Beta glucan is poly- for natural plant
The effects of sugar, certain antiallergic are anti-inflammatory.The ingredient is water solubility, can there is preferable compatibility with most of raw materials, and no allergic reaction is gone back
Skin moisture-keeping ability can be improved.Mentioned component its effective component in the preparation process of the cold compress patch of freeze-drying can be protected largely
When staying in the cold compress patch of the freeze-drying, and cooperating through inventor's discovery using mentioned component and proportion, skin can be preferably repaired
Skin barrier.
It is highly preferred that the functional component also contains the following parts by weight: 2 parts of carboxymethylchitosan, product
Careless 2 parts of the extract of snow, 5 parts of rough gentian root extract and 4 parts of beta glucan.Each ingredient use said ratio when repairing effect more preferably.
Preferably, the functional component also contains the following parts by weight: boswellia serrata (BOSWELLIA SERRATA)
0.5~3 part of extract, 0.5~3 part of kuh-seng (SOPHORA FLAVESCENS) extract, Radix Glycyrrhizae (GLYCYRRHIZA
URALENSIS) 0.5~3 part of root extract, 2~4 parts of cnidium monnieri (CNIDIUM MONNIERI) berry extract, sweet wormwood
0.5~1.5 part of extract of (ARTEMISIA ANNUA).
Boswellia serrata (BOSWELLIA SERRATA) extract has good activation to peroxidase activated receptor,
It plays an important role in skin injury agglutination, illustrates there is good anti-inflammatory.Kuh-seng (SOPHORA FLAVESCENS)
Extract is mainly derived from the root of kuh-seng, and effective component is mainly matrine, for treating eczema and dermatitis, there is antibacterial
The effect of anti-inflammatory.0.5~3 part of root extract of Radix Glycyrrhizae (GLYCYRRHIZA URALENSIS) to the proliferation function of myocyte, to blood
The facilitation of endothelial cell proliferation, the promotion that -4 type of collagen is generated, to NO inhibition generated etc., to some bacteriums
It significantly inhibits, can be used as anti-inflammatory agent.Cnidium monnieri is traditional Chinese medicine, is applied to the illness such as treatment skin eczema already,
It is related to the inhibition of tinea bacterium, mould etc.；From cnidium monnieri extract be the tests such as moisture absorption can illustrate it have good hygroscopicity and
Moisture retention.Sweet wormwood water extract has broad spectrum antibacterial, can be used as the antibacterial agent of cosmetics, and external application can mitigate or eliminate body odour,
Relevant dermatopathy can be prevented and treated；Sweet wormwood water has stronger bacteriostasis to staphylococcus epidermis, micrococcus catarrhalis etc., to gold
Staphylococcus aureus, Pseudomonas aeruginosa etc. have certain inhibiting effect.
The above-mentioned components matching with anti-inflammatory efficacy can increase anti-inflammatory reparation effect of the cold compress patch to a certain extent,
It sterilize cold compress patch of the present invention can also while with cold compress effect anti-inflammatory, it is anti-without addition in the cold compress patch ingredient
Rotten agent is able to achieve the antibacterial and shelf effect of the cold compress patch.
It is highly preferred that the functional component also contains the following parts by weight: boswellia serrata (BOSWELLIA
SERRATA) 2 parts of extract, 2 parts of kuh-seng (SOPHORA FLAVESCENS) extract, Radix Glycyrrhizae (GLYCYRRHIZA
URALENSIS) 2 parts of root extract, 3 parts of cnidium monnieri (CNIDIUM MONNIERI) berry extract, sweet wormwood (ARTEMISIA ANNUA)
1 part of extract.
Preferably, Medical cold application preparation method the following steps are included:
(1), by polyglycereol 10, glycine betaine, mannitol, borneol, menthol, camphor, hydrolysis Scleroglucan, Bacillus alcaligenes
Polysaccharide, carboxymethylchitosan, Sodium Hyaluronate and ceramide composition are added in emulsion pot, and stirring is warming up to
85-90 DEG C, evenly dispersed to without obvious particle, inspection, discharging to be stored in the container sterilized after qualified keeps the temperature；
(2), the material after emulsification stirring is carried out recycling repeatedly in Drying tunnel, then heated material is coated in nonwoven
On cloth or silk fabric, elementary semi-finished products are made；
(3), by jellyfish extract, hydrolytic collagen, Gotu Kola P.E, boswellia serrata extract, kuh-seng root extract, sweet
Grass roots extract, rough gentian root extract, beta glucan, cnidium monnieri berry extract, Artemisinin are mixed evenly, inspection, close
Discharging is stored in the container sterilized after lattice, is injected in non-woven fabrics or the silk fabric surface of elementary semi-finished products, recycles repeatedly spray
It is incident upon uniformly；
(4), the semi-finished product that spraying is completed are lyophilized at -196 DEG C~-40 DEG C, dehumidifier, encapsulation is to get Medical cold application.
The freeze temperature is -196 DEG C to -40 DEG C, is preferably lyophilized under vacuum conditions, can be conventional using this field
Program freeze-drying is lyophilized.Using cold compress patch made of above-mentioned preparation method, the activity of effective component is not degraded with temperature at any time, living
Property ingredient is unlikely to deteriorate, efficacy lasting, cold compress patch it is light-weight easy to carry and transport.And the cold compress patch being lyophilized, can take
Aircraft is not necessarily to preservative, therefore milder, more friendly to skin, and functional component storage stability in film cloth improves, and uses effect
Fruit is good, more environmentally friendly, and reduces transport and cost.Cold compress patch after drying is loose porous, in spongy, add dissolve after water it is rapid
And it is complete, almost recover immediately original character.
The beneficial effects of the present invention are: the present invention provides a kind of Medical cold application, Medical cold application of the present invention
Middle moisture-free, without adding preservative, it is possible to reduce because of skin damage or allergic phenomena caused by preservative；Using cleverer
Living, wetting time is quick, can be used after cooperating clear water or the wetting of other nutritive waters.In addition, the present invention uses frozen dried, subtract
The loss of heat-sensitive substance is lacked, some oxidizable substances are protected in cold compress patch, improve the stability of cold compress patch.
Physics suitable for closed soft tissue brings down a fever, cold compress physical therapy.Pass through the vaporization of cold compress patch contained humidity and natural cooling ingredient
Heat is taken away, can achieve partial cooling, functional component therein is combined with hydrogel, by aquation, can make function
Effect ingredient readily penetrates through fat deposit, penetrates into subcutaneous tissue, and go directly lesions position, acts on affected part, reaches cold compress pain relieving, percutaneous
It absorbs, the effect of sustained-release administration.
Specific embodiment
To better illustrate the object, technical solutions and advantages of the present invention, below in conjunction with specific embodiment to the present invention
It is described further.
Examples 1 to 6
Medical cold described in Examples 1 to 6 application formula be shown in Table 1, preparation method the following steps are included:
(1), by polyglycereol 10, glycine betaine, mannitol, borneol, menthol, camphor, hydrolysis Scleroglucan, Bacillus alcaligenes
Polysaccharide, carboxymethylchitosan, Sodium Hyaluronate and ceramide composition are added in emulsion pot, and stirring is warming up to
85-90 DEG C, evenly dispersed to without obvious particle, inspection, discharging to be stored in the container sterilized after qualified keeps the temperature；
(2), the material after emulsification stirring is carried out recycling repeatedly in Drying tunnel, is then coated in non-woven fabrics or silk fabric
On, elementary semi-finished products are made；
(3), by jellyfish extract, hydrolytic collagen, Gotu Kola P.E, boswellia serrata extract, kuh-seng root extract, sweet
Grass roots extract, rough gentian root extract, beta glucan, cnidium monnieri berry extract, Artemisinin are mixed evenly, inspection, close
Discharging is stored in the container sterilized after lattice, is injected in non-woven fabrics or the silk fabric surface of elementary semi-finished products, recycles repeatedly spray
It is incident upon uniformly；
(4), the semi-finished product that spraying is completed are lyophilized, dehumidifier at -196 DEG C~-40 DEG C, are encapsulated to get the Medical cold
Application.
The formula of the application of Medical cold described in 1 Examples 1 to 6 of table
Embodiment 7
One, dispel pain, cooling, mildness effect
Experimental method: 45 female volunteers of selection (skin sensitivity, local software tissue damage, 25-35 years old, average year
28 years old age), it is divided into 9 groups, every group of 5 people use the embodiment of the present invention 1~6 and commercial products 1~3 (common cold compress patch, non-jelly
It is drying standby)；Cold compress pain relieving and cooling effect are observed in continuous use 10 days.The application method of cold compress patch described in Examples 1 to 6 are as follows:
1. taking out film cloth, aluminium foil film is torn at the always open place along pallet；2. measuring about 25ml pure water to pour into pallet, one point is infiltrated
Clock；3. by the smooth expansion of film cloth, required position 15~remove after twenty minutes is spread on；4. remaining essence can gently massage help essence
Liquid fully absorbs.The application method of the competing product 1~3 in market is directly to use.
The pain that will dispel effect is divided into I class (pain of dispelling is general), II class (pain of dispelling effect is fine), Group III (pain of dispelling effect is preferable), IV
Four grades of class (pain of dispelling effect is very good) count the evaluation number of each grade of cooling effect.Cooling effect is divided into I class (drop
Temp effect is general), II class (cooling effect is fine), Group III (cooling effect is preferable), IV class (cooling effect is very good) four etc.
Grade, counts the evaluation number of each grade.Test result is shown in Table 2.
Mildness
Examples 1 to 6 and market competing product are placed on gauze.Selection volunteer 45,25-35 years old female volunteers,
Volunteer is randomly divided into 9 groups, every group of 5 people carry out patch test using the competing product 1~3 of Examples 1 to 6 and market respectively.
Patch test (patch test) is that the solution of debita spissitudo is prepared according to the property of tested material as reagent, will be real
It applies the freeze-drying film of example 1~6 addition 25nL water and is prepared into solution as test solution, be affixed on skin in a suitable approach, centainly
Observe whether body generates hypersensitivity to it after time, patch test is the master for being clinically used for IV type hypersensitivity of detection at present
Want method.
Table 2 dispel pain, cooling, mildness effect
As it can be seen from table 1 cold compress patch described in Examples 1 to 6 has preferably dispel pain and ice compress effect, it is superior to market
The product 1~3 of purchase, and it is mild non-stimulated, wherein the effect of embodiment 1 is best.
Two, after-sun recovery effect
After-sun recovery test
Experimental method: the aspiration trier for choosing 180 20-30 one full year of life difference sunburn degree carries out application test, at random
It is divided into 9 groups, the continuous use present invention 7 days carries out sensory evaluation to effect is repaired.Statistical result is as shown in table 3 below:
Criterion is as follows:
Effect is obvious: skin is checked after, rubescent symptom of itching completely disappears, no inflammation；
Effect is general: substantially reduced with rear symptom；
It is invalid: with rear symptom without mitigation.
3 after-sun recovery effect of table
Can be seen that cold compress patch described in Examples 1 to 6 from the test result of table 3 has certain effect to after-sun recovery, and
Better than the general cold compress patch bought in the market, wherein the cold compress patch repairing effect of embodiment 1 is best.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention
The limitation of range is protected, although the invention is described in detail with reference to the preferred embodiments, those skilled in the art should
Understand, it can be with modification or equivalent replacement of the technical solution of the present invention are made, without departing from the essence of technical solution of the present invention
And range.
Claims (10)
1. a kind of Medical cold application, which is characterized in that the Medical cold application is attached to non-woven fabrics or silkworm using by functional component
Freeze-drying is prepared after on silk cloth；
The functional component includes cooling composition and moisture-keeping composition；
The cooling composition includes borneol, menthol and camphor.
2. Medical cold application as described in claim 1, which is characterized in that the cooling composition includes the group of following parts by weight
Point: 0.5~3 part of borneol, 0.5~3 part of menthol and 0.5~3 part of camphor.
3. Medical cold application as described in claim 1, which is characterized in that the cooling composition includes the group of following parts by weight
Point: 2 parts of borneol, 2 parts of menthol and 2 parts of camphor.
4. Medical cold application as described in claim 1, which is characterized in that the moisture-keeping composition includes the group of following parts by weight
Point: 10 13~28 parts of polyglycereol, 15~25 parts of mannitol, 3~8 parts of Scleroglucan of hydrolysis, produces alkali at 13~28 parts of glycine betaine
0.5~3 part of bacillus polysaccharide, 0.5~3 part of jellyfish extract, 0.5~3 part of hydrolytic collagen, 0.5~1.5 part of Sodium Hyaluronate,
1.4~3.9 parts of ceramide composition；The ceramide composition contains the following parts by weight: Cer EOS 0.2
~0.8 part, 0.2~0.8 part of Cer NS, 0.5~1.5 part of Cer NP, 4 0.2~0.8 part of ceramide and nerve
0.2~0.8 part of 6 II of amide.
5. Medical cold application as described in claim 1, which is characterized in that the moisture-keeping composition includes the group of following parts by weight
Point: 10 18 parts of polyglycereol, 18 parts of glycine betaine, 20 parts of mannitol, hydrolysis 5 parts of Scleroglucan, 2 parts of curdlan class, water
2 parts of female extract, 2 parts of hydrolytic collagen, 1 part of Sodium Hyaluronate, 2 parts of ceramide composition；The ceramide composition packet
Component containing following parts by weight: 0.5 part of Cer EOS, 0.5 part of Cer NS, 1 part of Cer NP, ceramide 4
0.5 part and 0.5 part of Cer AP II.
6. Medical cold application as claimed in claim 4, which is characterized in that the functional component also includes the group of following parts by weight
Point: 0.5~3 part of carboxymethylchitosan, 0.5~3 part of Gotu Kola P.E, 3~8 parts of rough gentian root extract and β-Portugal are poly-
2~6 parts of sugar.
7. Medical cold application as claimed in claim 6, which is characterized in that the functional component also includes the group of following parts by weight
Point: 2 parts of carboxymethylchitosan, 2 parts of Gotu Kola P.E, 5 parts of rough gentian root extract and 4 parts of beta glucan.
8. Medical cold applies as claimed in claim 1 or 6, which is characterized in that the functional component also includes following parts by weight
Component: 0.5~3 part of boswellia serrata extract, 0.5~3 part of shrubby sophora extract, 0.5~3 part of licorice root extract, cnidium monnieri fruit mention
Take 2~4 parts of object, 0.5~1.5 part of Artemisinin.
9. Medical cold application as claimed in claim 8, which is characterized in that the functional component also includes the group of following parts by weight
Point: 2 parts of boswellia serrata extract, 2 parts of shrubby sophora extract, 2 parts of licorice root extract, 3 parts of cnidium monnieri berry extract, Artemisinin
1 part.
10. Medical cold applies as described in any one of claim 1~9, which is characterized in that the preparation side of the Medical cold application
Method the following steps are included:
(1), by polyglycereol 10, glycine betaine, mannitol, borneol, menthol, camphor, hydrolysis Scleroglucan, curdlan
Class, carboxymethylchitosan, Sodium Hyaluronate and ceramide composition are added in emulsion pot, and stirring is warming up to 85-90
DEG C, evenly dispersed to without obvious particle, inspection, discharging to be stored in the container sterilized after qualified keeps the temperature；
(2), the material after emulsification stirring is carried out recycling in Drying tunnel repeatedly, heated material, be then coated in non-woven fabrics or
In silk fabric, elementary semi-finished products are made；
(3), by jellyfish extract, hydrolytic collagen, Gotu Kola P.E, boswellia serrata extract, kuh-seng root extract, licorice
Extract, rough gentian root extract, beta glucan, cnidium monnieri berry extract, Artemisinin are mixed evenly, inspection, after qualified
Discharging is stored in the container sterilized, is injected in non-woven fabrics or the silk fabric surface of elementary semi-finished products, circulation multi-injection is extremely
Uniformly；
(4), the semi-finished product that spraying is completed are lyophilized at -196 DEG C~-40 DEG C, dehumidifier, encapsulation is to get Medical cold application.
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|---|---|---|---|
| CN201910665053.8A CN110314033A (en) | 2019-07-22 | 2019-07-22 | A kind of Medical cold application |
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|---|---|---|---|
| CN201910665053.8A CN110314033A (en) | 2019-07-22 | 2019-07-22 | A kind of Medical cold application |
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Family
ID=68124247
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| CN110859700A (en) * | 2019-11-29 | 2020-03-06 | 贵州太和制药有限公司 | Medical cooling patch and preparation method thereof |
| CN111281646A (en) * | 2020-03-28 | 2020-06-16 | 广州市赛迪药业科技有限公司 | Production process of medical cold compress patch |
| CN111671572A (en) * | 2020-06-19 | 2020-09-18 | 北京本真工坊生物科技有限公司 | Preparation method of freeze-dried medical dressing and freeze-dried medical cold compress patch |
| CN113648372A (en) * | 2021-09-10 | 2021-11-16 | 张掖市中医医院 | A topical ointment for treating dermatoses, and its preparation method |
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