CN110302385A - 新型2，4-二硝基苯酚制剂和使用其的方法 - Google Patents

新型2，4-二硝基苯酚制剂和使用其的方法 Download PDF

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Publication number
CN110302385A
CN110302385A CN201910726120.2A CN201910726120A CN110302385A CN 110302385 A CN110302385 A CN 110302385A CN 201910726120 A CN201910726120 A CN 201910726120A CN 110302385 A CN110302385 A CN 110302385A
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composition
compound
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erdnp
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G·I·舒尔曼
R·J·佩里
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Yale University
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Yale University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A61K31/06—Phenols the aromatic ring being substituted by nitro groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/501—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Toxicology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201910726120.2A 2013-08-30 2014-08-29 新型2，4-二硝基苯酚制剂和使用其的方法 Pending CN110302385A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361872294P 2013-08-30 2013-08-30
US61/872,294 2013-08-30
US201361919003P 2013-12-20 2013-12-20
US61/919,003 2013-12-20
CN201480059363.0A CN105682653B (zh) 2013-08-30 2014-08-29 2，4-二硝基苯酚制剂和使用其的方法

Related Parent Applications (1)

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CN110302385A true CN110302385A (zh) 2019-10-08

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CN201480059363.0A Active CN105682653B (zh) 2013-08-30 2014-08-29 2，4-二硝基苯酚制剂和使用其的方法

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US (4) US10786466B2 (enExample)
EP (1) EP3038611B1 (enExample)
JP (4) JP6706204B2 (enExample)
CN (2) CN110302385A (enExample)
WO (1) WO2015031756A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113045428A (zh) * 2019-12-26 2021-06-29 中国农业大学 化合物及其在减脂中的用途

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110302385A (zh) * 2013-08-30 2019-10-08 耶鲁大学 新型2，4-二硝基苯酚制剂和使用其的方法
MX392410B (es) 2015-01-22 2025-03-11 Mitochon Pharmaceuticals Inc Expresión inducida de factor neurotrófico derivado cerebral (bdnf) para tratamiento de enfermedades neuromusculares, neurodegenerativas, autoinmunes, de desarrollo y/o metabólicas.
DE102015016801A1 (de) * 2015-12-23 2017-06-29 Christian Windisch Chemotherapeutisches Verfahren zur Behandlung maliger Geschwülste durch "Entkopplung" der oxidativen Phosphorilierung ("Krebsatmung") in aerob glycolysierenden Zellen (Krebszellen)
TWI794161B (zh) * 2016-03-07 2023-03-01 美商米托控製藥公司 神經肌肉性疾病、神經退化性疾病、自體免疫疾病、發育性疾病、創傷性腦損傷、震盪、乾眼症、聽力損失及／或代謝疾病之二硝基酚（ｄｎｐ）和ｄｎｐ前藥治療
PT3565806T (pt) 2017-01-06 2022-05-19 Rivus Pharmaceuticals Inc Novos derivados de fenilo
WO2019217164A1 (en) * 2018-05-09 2019-11-14 Reyoung Corporation Compositions and methods for treating cancer and other diseases
US20200397807A1 (en) 2019-06-18 2020-12-24 MitoPower, LLC Nicotinyl riboside compounds and their uses
CN110237033A (zh) * 2019-07-30 2019-09-17 成都医学院 一种2,4二硝基苯酚注射液及其制备方法和用途
CN110302154B (zh) * 2019-07-30 2021-09-10 成都医学院 一种2,4-二硝基苯酚脂肪乳及其制备方法和用途
WO2026041069A1 (en) * 2024-08-20 2026-02-26 Polykleitos Pharmaceuticals Llc Pharmaceutical compositions comprising thermoresponsive polymer and uses thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN86102861A (zh) * 1986-04-23 1987-11-11 吴佩璇 一种含三硝基苯、田螺的药品合成
US5851546A (en) * 1995-06-14 1998-12-22 Council Of Scientific & Industrial Research Polymer composition for controlled release of active ingredients in response to pH, and a process of preparing the same
WO1999055774A1 (en) * 1998-04-24 1999-11-04 Eastman Chemical Company Coprecipitation of cellulose esters with functional additives and compositions thus obtainable
US20100056643A1 (en) * 1998-07-27 2010-03-04 St. Jude Pharmaceuticals, Inc. Chemically induced intracellular hyperthermia
WO2011053825A2 (en) * 2009-10-30 2011-05-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Compositions and methods for the treatment or prevention of mitochondrial diseases

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA774573A (en) 1967-12-26 Sehring Richard Derivatives of 2-hydroxy-3,5-dinitrobenzyl alcohol
US2183589A (en) 1939-12-19 Derivatives of compounds of the
US1695656A (en) 1927-03-10 1928-12-18 Firm Gehe & Co A G Method of producing narcotica
US3081224A (en) 1959-01-21 1963-03-12 American Cyanamid Co Methods of removing helminths employing halogenated nitrophenols and their derivatives
NL301998A (enExample) 1962-12-27 1900-01-01
DE3313905A1 (de) 1983-04-16 1984-10-25 Henkel KGaA, 4000 Düsseldorf Neue 2.4-diaminophenolether als kuppler fuer oxidationshaarfaerbemittel
DE3515339A1 (de) 1985-04-27 1986-10-30 Cassella Ag, 6000 Frankfurt Verfahren zur herstellung von 2,4-dinitrophenylethern
US5078908A (en) 1989-10-02 1992-01-07 Allergan, Inc. Methods for generating chlorine dioxide and compositions for disinfecting
US5169645A (en) 1989-10-31 1992-12-08 Duquesne University Of The Holy Ghost Directly compressible granules having improved flow properties
EP0753255B1 (en) 1995-07-11 2000-12-20 Nippon Petrochemicals Co., Ltd. Pesticidal compositions comprising diarylalkanes
US6664297B1 (en) 2000-10-18 2003-12-16 Universidade Federal Do Rio De Janeiro Methods for inhibition and dissolution of amyloidoses by administration of compositions comprising 2,4-dinitrophenol
US20050019399A1 (en) * 2001-09-21 2005-01-27 Gina Fischer Controlled release solid dispersions
MXPA05002728A (es) 2002-09-13 2005-07-25 Cydex Inc Capsulas que contienen composiciones de relleno acuoso estabilizadas con ciclodextrina derivada.
EP1575575B1 (en) 2002-11-08 2010-05-19 High Point Pharmaceuticals, LLC Safe chemical uncouplers for the treatment of obesity
US8569356B2 (en) 2005-10-25 2013-10-29 University Of Florida Research Foundation, Inc. Cyclin dependent kinase inhibitors
EP2196453A1 (en) 2008-12-10 2010-06-16 Cellvir Novel substituted aryl derivatives, their process of preparation and their therapeutical uses as anti-HIV agents
JP2013209295A (ja) 2010-10-13 2013-10-10 Takeda Chem Ind Ltd ペプチド誘導体
CN110302385A (zh) 2013-08-30 2019-10-08 耶鲁大学 新型2，4-二硝基苯酚制剂和使用其的方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN86102861A (zh) * 1986-04-23 1987-11-11 吴佩璇 一种含三硝基苯、田螺的药品合成
US5851546A (en) * 1995-06-14 1998-12-22 Council Of Scientific & Industrial Research Polymer composition for controlled release of active ingredients in response to pH, and a process of preparing the same
WO1999055774A1 (en) * 1998-04-24 1999-11-04 Eastman Chemical Company Coprecipitation of cellulose esters with functional additives and compositions thus obtainable
US20100056643A1 (en) * 1998-07-27 2010-03-04 St. Jude Pharmaceuticals, Inc. Chemically induced intracellular hyperthermia
WO2011053825A2 (en) * 2009-10-30 2011-05-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Compositions and methods for the treatment or prevention of mitochondrial diseases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SEAN MARRACHE ET AL.: "Engineering of blended nanoparticle platform for delivery of mitochondria-acting therapeutics", 《PNAS》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113045428A (zh) * 2019-12-26 2021-06-29 中国农业大学 化合物及其在减脂中的用途
CN113045428B (zh) * 2019-12-26 2022-04-22 中国农业大学 化合物及其在减脂中的用途

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JP7359809B2 (ja) 2023-10-11
US11433033B2 (en) 2022-09-06
JP6706204B2 (ja) 2020-06-03
US10786466B2 (en) 2020-09-29
WO2015031756A1 (en) 2015-03-05
US20220339121A1 (en) 2022-10-27
JP2023133603A (ja) 2023-09-22
US20250228793A1 (en) 2025-07-17
US20200352879A1 (en) 2020-11-12
EP3038611A1 (en) 2016-07-06
EP3038611B1 (en) 2024-04-17
CN105682653A (zh) 2016-06-15
JP2021165309A (ja) 2021-10-14
US20160199310A1 (en) 2016-07-14
HK1225607A1 (en) 2017-09-15
CN105682653B (zh) 2022-10-21
JP2016530279A (ja) 2016-09-29
JP6913137B2 (ja) 2021-08-04
EP3038611A4 (en) 2017-03-29
US11883369B2 (en) 2024-01-30
JP2020002166A (ja) 2020-01-09

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