CN110291095B - 腺苷类似物及其在调节昼夜节律钟中的应用 - Google Patents
腺苷类似物及其在调节昼夜节律钟中的应用 Download PDFInfo
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- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
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- A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
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- C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
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- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2017/071903 | 2017-01-20 | ||
| CN2017071903 | 2017-01-20 | ||
| PCT/CN2018/073526 WO2018133854A1 (en) | 2017-01-20 | 2018-01-20 | Adenosine analog and its use in regulating the circadian clock |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110291095A CN110291095A (zh) | 2019-09-27 |
| CN110291095B true CN110291095B (zh) | 2023-04-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880007982.3A Active CN110291095B (zh) | 2017-01-20 | 2018-01-20 | 腺苷类似物及其在调节昼夜节律钟中的应用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20210338706A1 (https=) |
| EP (1) | EP3571211A4 (https=) |
| JP (1) | JP7310064B2 (https=) |
| CN (1) | CN110291095B (https=) |
| WO (2) | WO2018133835A1 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| SG11202109090SA (en) | 2019-02-22 | 2021-09-29 | Promaxo Inc | Pseudo-birdcage coil with variable tuning and applications thereof |
| CN110183504B (zh) * | 2019-06-13 | 2023-07-07 | 湖南大学 | 一种具有肿瘤靶向性的吉西他滨前体药物及其制备方法和用途 |
| CN113563401A (zh) * | 2021-07-14 | 2021-10-29 | 河南牧业经济学院 | 一种新型虫草素烷酰胺衍生物及其制备方法和应用 |
| KR20240058859A (ko) | 2021-08-12 | 2024-05-03 | 쿨레온 엘엘씨 | 환각성 및 비환각성 세로토닌 수용체 작용제 및 이의 제조 및 사용 방법 |
| CN117660572A (zh) * | 2023-12-12 | 2024-03-08 | 中科药创(青岛)发酵工程有限公司 | 一种多功效高虫草素含量的蛹虫草固体发酵产物及其制备方法 |
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| FR6164M (https=) * | 1966-10-13 | 1968-07-08 | ||
| US4386093A (en) * | 1981-09-16 | 1983-05-31 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | (±)3-Deazaaristeromycin and uses |
| SU1119336A1 (ru) * | 1983-01-27 | 1986-12-30 | Институт биоорганической химии АН БССР | Способ получени 9- @ - @ -ксилофуранозиладенина |
| GB8712745D0 (en) * | 1987-05-30 | 1987-07-01 | Wellcome Found | Antiviral compounds |
| US6638963B1 (en) * | 1990-12-04 | 2003-10-28 | Oregon Health And Science University | Methods for treating circadian rhythm disorders |
| US5366960A (en) * | 1993-08-26 | 1994-11-22 | Warner-Lambert Company | Method of treating cerebral and cardiovascular disorders employing [R]3-(2-deoxy-β-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidaz 0-[4,5-d][1,3]diazepin-8-ol |
| EP0863148A1 (en) * | 1997-03-03 | 1998-09-09 | K.U. Leuven Research & Development | Compounds derived from adenosine, use of such compound as a medicament, method for synthesizing such a compound and intermediates thereof |
| DE50207103D1 (en) * | 2001-03-14 | 2006-07-20 | Gruenenthal Gmbh | Substituierte pyrazolo- und thiazolopyrimidine als analgetika |
| CN101259129A (zh) * | 2002-11-06 | 2008-09-10 | 惠氏公司 | 急性白血病和骨髓异常增生综合征的组合治疗 |
| ATE445396T1 (de) * | 2004-08-19 | 2009-10-15 | Aventis Pharma Inc | 3-arylthioindol-2-carbonsäureamidderivate und ihre analoge als hemmer von caseinkinase i |
| WO2007111954A2 (en) * | 2006-03-23 | 2007-10-04 | Inotek Phamaceuticals Corporation | Purine compounds and methods of use thereof |
| GB0610059D0 (en) * | 2006-05-19 | 2006-06-28 | Medical Res Council | Uses and methods |
| ES2425179T3 (es) * | 2006-10-25 | 2013-10-11 | The Rockefeller University | Métodos para el tratamiento de trastornos relacionados con beta-amiloide y composiciones para los mismos |
| KR101961601B1 (ko) * | 2009-11-16 | 2019-03-25 | 유니버시티 오브 조지아 리서치 파운데이션, 인코포레이티드 | 바이러스 감염 치료를 위한 2'―플루오로―6'―메틸렌 카보사이클릭 뉴클레오사이드 및 방법 |
| PE20160203A1 (es) * | 2013-08-19 | 2016-04-20 | Hoffmann La Roche | Antagonistas de via para tratar trastornos del sueno por cambio de fase |
| WO2016106704A1 (en) * | 2014-12-31 | 2016-07-07 | Nestec S.A. | A process for preparing a cordyceps extract |
| PL3280414T3 (pl) * | 2016-04-15 | 2024-06-24 | Oxford University Innovation Limited | Modulatory receptora adenozyny w leczeniu schorzeń rytmu okołodobowego |
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2018
- 2018-01-19 WO PCT/CN2018/073378 patent/WO2018133835A1/en not_active Ceased
- 2018-01-20 EP EP18742198.7A patent/EP3571211A4/en active Pending
- 2018-01-20 US US16/479,844 patent/US20210338706A1/en active Pending
- 2018-01-20 WO PCT/CN2018/073526 patent/WO2018133854A1/en not_active Ceased
- 2018-01-20 JP JP2019539888A patent/JP7310064B2/ja active Active
- 2018-01-20 CN CN201880007982.3A patent/CN110291095B/zh active Active
Non-Patent Citations (1)
| Title |
|---|
| 《CkIε/δ-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock》;Yasushi Isojima等;《Proceedings of the National Academy of Sciences of the United States of America》;20091015;第106卷(第37期);第15744-15749页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2018133835A1 (en) | 2018-07-26 |
| JP2020509997A (ja) | 2020-04-02 |
| JP7310064B2 (ja) | 2023-07-19 |
| CN110291095A (zh) | 2019-09-27 |
| WO2018133854A1 (en) | 2018-07-26 |
| EP3571211A1 (en) | 2019-11-27 |
| US20210338706A1 (en) | 2021-11-04 |
| EP3571211A4 (en) | 2021-09-01 |
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