CN110267658B - 用sGC刺激剂治疗CNS疾病 - Google Patents

用sGC刺激剂治疗CNS疾病 Download PDF

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Publication number
CN110267658B
CN110267658B CN201780080543.0A CN201780080543A CN110267658B CN 110267658 B CN110267658 B CN 110267658B CN 201780080543 A CN201780080543 A CN 201780080543A CN 110267658 B CN110267658 B CN 110267658B
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pain
compound
pharmaceutically acceptable
compounds
syndrome
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Chinese (zh)
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CN110267658A (zh
Inventor
J.琼格
T.W-H.李
R.R.艾扬格
N.R.珀尔
P.格马诺
M.D.里巴德尼拉
K.唐
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Di Shan Duo Pharmaceutical Co
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Di Shan Duo Pharmaceutical Co
Cyclerion Therapeutics Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201780080543.0A 2016-11-08 2017-11-07 用sGC刺激剂治疗CNS疾病 Active CN110267658B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662419059P 2016-11-08 2016-11-08
US62/419,059 2016-11-08
PCT/US2017/060299 WO2018089328A1 (en) 2016-11-08 2017-11-07 Treatment of cns diseases with sgc stimulators

Publications (2)

Publication Number Publication Date
CN110267658A CN110267658A (zh) 2019-09-20
CN110267658B true CN110267658B (zh) 2024-02-02

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US (4) US11690828B2 (enExample)
EP (1) EP3538096B1 (enExample)
JP (2) JP7150740B2 (enExample)
KR (1) KR102475124B1 (enExample)
CN (1) CN110267658B (enExample)
AU (2) AU2017359018C1 (enExample)
BR (1) BR112019009449A2 (enExample)
CA (1) CA3042548A1 (enExample)
CL (1) CL2019001256A1 (enExample)
EA (1) EA201991147A1 (enExample)
ES (1) ES2972711T3 (enExample)
IL (1) IL266275B2 (enExample)
MA (1) MA46752A (enExample)
MX (2) MX2019005342A (enExample)
PH (1) PH12019501016A1 (enExample)
SG (1) SG10202104865UA (enExample)
TW (1) TWI812601B (enExample)
WO (1) WO2018089328A1 (enExample)

Families Citing this family (11)

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AU2017356887B2 (en) * 2016-11-08 2022-06-30 Cyclerion Therapeutics, Inc. sGC stimulators
WO2019055859A1 (en) * 2017-09-14 2019-03-21 Ironwood Pharmaceuticals, Inc. TREATMENT OF METABOLIC SYNDROME BY SGC STIMULATOR
US12220414B2 (en) 2018-07-11 2025-02-11 Tisento Therapeutics Inc. Use of sGC stimulators for the treatment of mitochondrial disorders
WO2020150698A1 (en) * 2019-01-18 2020-07-23 The Johns Hopkins University Prevention of anesthetic-induced neurocognitive dysfunction
CN114929207A (zh) * 2019-12-05 2022-08-19 载度思生命科学有限公司 利奥西呱的调节释放型药物组合物
WO2021158059A1 (ko) 2020-02-07 2021-08-12 건국대학교 글로컬산학협력단 릴메니딘 화합물을 유효성분으로 포함하는 취약 x 증후군 또는 관련 발달 장애 치료용 조성물
CN112924573B (zh) * 2021-01-21 2022-01-04 山东英盛生物技术有限公司 一种阿比多尔、利巴韦林、氯喹的hplc-ms/ms检测方法
WO2022225902A1 (en) * 2021-04-20 2022-10-27 Cyclerion Therapeutics, Inc. Treatment of cns diseases with sgc stimulators
CN117915917A (zh) * 2021-04-20 2024-04-19 帝善多制药公司 使用sGC刺激剂的CNS疾病治疗
EP4456897A4 (en) * 2021-12-31 2025-12-10 Tenax Therapeutics Inc ORAL FORMULATIONS OF LEVOSIMENDAN FOR THE TREATMENT OF PULMONARY HYPERTENSION WITH HEART FAILURE AND PRESERVED EJECTION FRACTION
CN120752026A (zh) * 2023-02-03 2025-10-03 R·P·谢勒技术有限公司 渗透药用胶囊

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IL266275A (en) 2019-06-30
AU2017359018A1 (en) 2019-05-30
IL266275B1 (en) 2023-08-01
IL266275B2 (en) 2023-12-01
MA46752A (fr) 2019-09-18
NZ753434A (en) 2025-10-31
AU2023270267A1 (en) 2023-12-07
JP2022160605A (ja) 2022-10-19
MX2022010852A (es) 2022-09-27
ES2972711T3 (es) 2024-06-14
US20190343813A1 (en) 2019-11-14
EA201991147A1 (ru) 2019-11-29
BR112019009449A2 (pt) 2019-07-30
SG10202104865UA (en) 2021-06-29
US11690828B2 (en) 2023-07-04
US20250108040A1 (en) 2025-04-03
WO2018089328A1 (en) 2018-05-17
US20260000653A1 (en) 2026-01-01
JP7150740B2 (ja) 2022-10-11
TW201822765A (zh) 2018-07-01
MX2019005342A (es) 2019-10-02
CN110267658A (zh) 2019-09-20
WO2018089328A8 (en) 2019-03-28
AU2017359018C1 (en) 2023-12-21
TWI812601B (zh) 2023-08-21
CL2019001256A1 (es) 2019-10-04
US20230381153A1 (en) 2023-11-30
KR20190094167A (ko) 2019-08-12
EP3538096B1 (en) 2024-02-28
CA3042548A1 (en) 2018-05-17
KR102475124B1 (ko) 2022-12-08
EP3538096A1 (en) 2019-09-18
JP2019534327A (ja) 2019-11-28
EP3538096C0 (en) 2024-02-28
AU2017359018B2 (en) 2023-08-31
PH12019501016A1 (en) 2019-09-09

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