CN110248932B - 用于抑制RORγ和其他用途的嘧啶三环烯酮衍生物 - Google Patents

用于抑制RORγ和其他用途的嘧啶三环烯酮衍生物 Download PDF

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CN110248932B
CN110248932B CN201780085431.4A CN201780085431A CN110248932B CN 110248932 B CN110248932 B CN 110248932B CN 201780085431 A CN201780085431 A CN 201780085431A CN 110248932 B CN110248932 B CN 110248932B
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alkyl
cycloalkyl
aryl
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CN110248932A (zh
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江昕
克里斯多福·F·班德
米莲恩·维斯尼克
玛莎·R·洪德玛
柴克瑞·S·雪登
奇塔斯·里
布萊德利·W·开普利
盖瑞·伯顿
布萊恩·康柏格
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Reata Pharmaceuticals Inc
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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  • Pain & Pain Management (AREA)
  • Immunology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201780085431.4A 2016-12-16 2017-12-16 用于抑制RORγ和其他用途的嘧啶三环烯酮衍生物 Active CN110248932B (zh)

Applications Claiming Priority (3)

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US201662435588P 2016-12-16 2016-12-16
US62/435,588 2016-12-16
PCT/US2017/000094 WO2018111315A1 (en) 2016-12-16 2017-12-16 PYRIMIDINE TRICYCLIC ENONE DERIVATIVES FOR INHIBITION OF RORγ AND OTHER USES

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CN110248932B true CN110248932B (zh) 2023-03-10

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US (3) US11292781B2 (https=)
EP (1) EP3555062A1 (https=)
JP (1) JP7177059B2 (https=)
KR (2) KR20240019389A (https=)
CN (1) CN110248932B (https=)
AU (1) AU2017377852C1 (https=)
CA (2) CA3046183C (https=)
CL (1) CL2019001658A1 (https=)
CO (1) CO2019007409A2 (https=)
EA (1) EA201991387A1 (https=)
IL (1) IL267274B2 (https=)
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NZ (1) NZ754764A (https=)
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PH (1) PH12019501371A1 (https=)
TW (1) TWI831738B (https=)
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WO (1) WO2018111315A1 (https=)
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PE20221838A1 (es) 2020-04-24 2022-11-29 Astrazeneca Ab Formulaciones farmaceuticas
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KR20240019389A (ko) 2024-02-14
TW201835051A (zh) 2018-10-01
PH12019501371A1 (en) 2019-10-28
US20200131148A1 (en) 2020-04-30
NZ754764A (en) 2023-04-28
BR112019012271A2 (pt) 2019-12-03
ZA201904227B (en) 2024-02-28
US20220135534A1 (en) 2022-05-05
US20250188053A1 (en) 2025-06-12
US12195443B2 (en) 2025-01-14
US11292781B2 (en) 2022-04-05
AU2017377852A1 (en) 2019-07-11
KR20190110089A (ko) 2019-09-27
EA201991387A1 (ru) 2019-12-30
PE20191490A1 (es) 2019-10-21
IL267274B2 (en) 2024-03-01
IL267274A (en) 2019-08-29
CA3046183A1 (en) 2018-06-21
CA3223645A1 (en) 2018-06-21
UA127376C2 (uk) 2023-08-02
JP7177059B2 (ja) 2022-11-22
TWI831738B (zh) 2024-02-11
CL2019001658A1 (es) 2019-09-27
CO2019007409A2 (es) 2019-07-31
WO2018111315A1 (en) 2018-06-21
AU2017377852B2 (en) 2022-02-17
MX2019007088A (es) 2019-10-15
IL267274B1 (en) 2023-11-01
CN110248932A (zh) 2019-09-17
WO2018111315A8 (en) 2019-07-11
CA3046183C (en) 2024-02-20
JP2020512289A (ja) 2020-04-23

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