CN110248932B - 用于抑制RORγ和其他用途的嘧啶三环烯酮衍生物 - Google Patents

用于抑制RORγ和其他用途的嘧啶三环烯酮衍生物 Download PDF

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CN110248932B
CN110248932B CN201780085431.4A CN201780085431A CN110248932B CN 110248932 B CN110248932 B CN 110248932B CN 201780085431 A CN201780085431 A CN 201780085431A CN 110248932 B CN110248932 B CN 110248932B
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alkyl
cycloalkyl
aryl
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CN110248932A (zh
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江昕
克里斯多福·F·班德
米莲恩·维斯尼克
玛莎·R·洪德玛
柴克瑞·S·雪登
奇塔斯·里
布萊德利·W·开普利
盖瑞·伯顿
布萊恩·康柏格
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Reata Pharmaceuticals Inc
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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CN201780085431.4A 2016-12-16 2017-12-16 用于抑制RORγ和其他用途的嘧啶三环烯酮衍生物 Active CN110248932B (zh)

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US201662435588P 2016-12-16 2016-12-16
US62/435,588 2016-12-16
PCT/US2017/000094 WO2018111315A1 (en) 2016-12-16 2017-12-16 PYRIMIDINE TRICYCLIC ENONE DERIVATIVES FOR INHIBITION OF RORγ AND OTHER USES

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CN110248932B true CN110248932B (zh) 2023-03-10

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IL267274B1 (en) 2023-11-01
US11292781B2 (en) 2022-04-05
JP2020512289A (ja) 2020-04-23
NZ754764A (en) 2023-04-28
IL267274A (en) 2019-08-29
CA3046183A1 (en) 2018-06-21
EA201991387A1 (ru) 2019-12-30
KR20240019389A (ko) 2024-02-14
CA3046183C (en) 2024-02-20
CO2019007409A2 (es) 2019-07-31
US20220135534A1 (en) 2022-05-05
KR20190110089A (ko) 2019-09-27
AU2017377852C1 (en) 2025-11-13
CN110248932A (zh) 2019-09-17
WO2018111315A8 (en) 2019-07-11
WO2018111315A1 (en) 2018-06-21
CA3223645A1 (en) 2018-06-21
EP3555062A1 (en) 2019-10-23
TW201835051A (zh) 2018-10-01
AU2017377852A1 (en) 2019-07-11
US12195443B2 (en) 2025-01-14
JP7177059B2 (ja) 2022-11-22
MX2019007088A (es) 2019-10-15
US20200131148A1 (en) 2020-04-30
PE20191490A1 (es) 2019-10-21
PH12019501371A1 (en) 2019-10-28
ZA201904227B (en) 2024-02-28
AU2017377852B2 (en) 2022-02-17
IL267274B2 (en) 2024-03-01
US20250188053A1 (en) 2025-06-12
UA127376C2 (uk) 2023-08-02
TWI831738B (zh) 2024-02-11
BR112019012271A2 (pt) 2019-12-03
CL2019001658A1 (es) 2019-09-27

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