CN110248656A - 一种蓝萼甲素衍生物及其药学上可接受的盐或药物组合物及在制备治疗银屑病药物中的用途 - Google Patents

一种蓝萼甲素衍生物及其药学上可接受的盐或药物组合物及在制备治疗银屑病药物中的用途 Download PDF

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CN110248656A
CN110248656A CN201880009428.9A CN201880009428A CN110248656A CN 110248656 A CN110248656 A CN 110248656A CN 201880009428 A CN201880009428 A CN 201880009428A CN 110248656 A CN110248656 A CN 110248656A
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phenyl
glaucocalyxin
derivative
pharmaceutically acceptable
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CN110248656B (zh
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冯海梅
周仁森
俞云会
江传亮
邓世平
刘乾
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Suzhou Pharmavan Cancer Research Center Co ltd
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Suzhou Pharmavan Cancer Research Center Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

一种蓝萼甲素衍生物及其药学上可接受的盐或药物组合物及其在制备治疗银屑病的药物中的用途。

Description

PCT国内申请，说明书已公开。

Claims (15)

  1. PCT国内申请，权利要求书已公开。
CN201880009428.9A 2017-02-23 2018-02-02 一种蓝萼甲素衍生物及其药学上可接受的盐或药物组合物及在制备治疗银屑病药物中的用途 Active CN110248656B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2017/074538 2017-02-23
CN2017074538 2017-02-23
PCT/CN2018/075061 WO2018153235A1 (zh) 2017-02-23 2018-02-02 一种蓝萼甲素衍生物及其药学上可接受的盐或药物组合物及在制备治疗银屑病药物中的用途

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CN110248656A true CN110248656A (zh) 2019-09-17
CN110248656B CN110248656B (zh) 2022-05-24

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Country Status (5)

Country Link
US (1) US11406622B2 (zh)
EP (1) EP3586843B1 (zh)
JP (1) JP6860677B2 (zh)
CN (1) CN110248656B (zh)
WO (1) WO2018153235A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113018250A (zh) * 2021-02-25 2021-06-25 杭州泽宇生物技术有限公司 一种天然药物的外用制剂、制备方法及其应用

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116966179A (zh) * 2022-04-22 2023-10-31 苏州沪云新药研发股份有限公司 二萜化合物衍生物或其盐在制备防治特应性皮炎的药物中的应用
CN115317477B (zh) * 2022-04-26 2023-09-19 新乡医学院 研究蓝萼庚素对非酒精性脂肪肝的治疗作用和机制的方法

Citations (5)

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CN104356090A (zh) * 2014-10-30 2015-02-18 新乡医学院 一种蓝萼甲素的噻唑衍生物及其制备方法和应用
CN104761460A (zh) * 2015-03-26 2015-07-08 苏州沪云肿瘤研究中心股份有限公司 蓝萼甲素衍生物及其制备方法和应用
CN104817464A (zh) * 2015-03-26 2015-08-05 苏州沪云肿瘤研究中心股份有限公司 二甲氨基蓝萼甲素盐酸盐晶型
CN104887652A (zh) * 2015-05-13 2015-09-09 苏州沪云肿瘤研究中心股份有限公司 蓝萼甲素衍生物及其药学上可接受的盐的剂型
WO2016150208A1 (zh) * 2015-03-26 2016-09-29 苏州沪云肿瘤研究中心股份有限公司 包含蓝萼甲素衍生物或其盐的药物组合物和剂型

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SI1477166T1 (sl) 2003-04-28 2006-12-31 Biofrontera Bioscience Gmbh Uporaba riluzola, kombiniranega s primernimi pomoznimi in dodatnimi snovmi, za zdravljenje bolezni,za katere je znacilna hiperproliferacija keratinocitov, se zlasti nevrodermitisa in psoriaze
CN1254238C (zh) 2003-04-29 2006-05-03 宿州绿源中医药科技有限公司 王枣子乙素在制备细胞免疫抑制药物中的应用

Patent Citations (5)

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CN104356090A (zh) * 2014-10-30 2015-02-18 新乡医学院 一种蓝萼甲素的噻唑衍生物及其制备方法和应用
CN104761460A (zh) * 2015-03-26 2015-07-08 苏州沪云肿瘤研究中心股份有限公司 蓝萼甲素衍生物及其制备方法和应用
CN104817464A (zh) * 2015-03-26 2015-08-05 苏州沪云肿瘤研究中心股份有限公司 二甲氨基蓝萼甲素盐酸盐晶型
WO2016150208A1 (zh) * 2015-03-26 2016-09-29 苏州沪云肿瘤研究中心股份有限公司 包含蓝萼甲素衍生物或其盐的药物组合物和剂型
CN104887652A (zh) * 2015-05-13 2015-09-09 苏州沪云肿瘤研究中心股份有限公司 蓝萼甲素衍生物及其药学上可接受的盐的剂型

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GANG BIAN等: "DGT, a novel heterocyclic diterpenoid, effectively suppresses psoriasis via inhibition of STAT3 phosphorylation", 《GANG BIAN等》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113018250A (zh) * 2021-02-25 2021-06-25 杭州泽宇生物技术有限公司 一种天然药物的外用制剂、制备方法及其应用
WO2022178983A1 (zh) * 2021-02-25 2022-09-01 杭州泽宇生物技术有限公司 一种天然药物的外用制剂、制备方法及其应用

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Publication number Publication date
WO2018153235A1 (zh) 2018-08-30
EP3586843A1 (en) 2020-01-01
EP3586843A4 (en) 2020-08-26
JP6860677B2 (ja) 2021-04-21
EP3586843B1 (en) 2022-11-16
US20200061029A1 (en) 2020-02-27
JP2020503366A (ja) 2020-01-30
US11406622B2 (en) 2022-08-09
CN110248656B (zh) 2022-05-24

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