CN110241087B - 使用合成的信使rna无饲养细胞地衍生人类诱导性多能干细胞 - Google Patents

使用合成的信使rna无饲养细胞地衍生人类诱导性多能干细胞 Download PDF

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CN110241087B
CN110241087B CN201910468645.0A CN201910468645A CN110241087B CN 110241087 B CN110241087 B CN 110241087B CN 201910468645 A CN201910468645 A CN 201910468645A CN 110241087 B CN110241087 B CN 110241087B
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CN110241087A (zh
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王继武
鲁吉·瓦兰
倪毓辉
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Allele Biotechnology and Pharmaceuticals Inc
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CN201910468645.0A 2012-05-13 2013-05-13 使用合成的信使rna无饲养细胞地衍生人类诱导性多能干细胞 Active CN110241087B (zh)

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US201261646292P 2012-05-13 2012-05-13
US61/646,292 2012-05-13
PCT/US2013/040814 WO2013173248A2 (en) 2012-05-13 2013-05-13 Feeder-free derivation of human-induced pluripotent stem cells with synthetic messenger rna
CN201380025010.4A CN104520424B (zh) 2012-05-13 2013-05-13 使用合成的信使rna无饲养细胞地衍生人类诱导性多能干细胞

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BR112014013664A2 (pt) 2011-12-05 2020-11-03 Factor Bioscience Inc. métodos e produtos para transfectar células
US8497124B2 (en) 2011-12-05 2013-07-30 Factor Bioscience Inc. Methods and products for reprogramming cells to a less differentiated state
US10155929B2 (en) 2012-05-13 2018-12-18 Allele Biotechnology & Pharmaceuticals, Inc. Feeder-free derivation of human-induced pluripotent stem cells with synthetic messenger RNA
US10119150B2 (en) 2012-05-13 2018-11-06 Allele Biotechnology & Pharmaceuticals, Inc. Feeder-free Derivation of human-induced pluripotent stem cells with synthetic messenger RNA
JP6448531B2 (ja) * 2012-05-13 2019-01-09 アリール バイオテクノロジー アンド ファーマシューティカルズ， インコーポレイテッド 合成メッセンジャーｒｎａを使用したヒト人工多能性幹細胞のフィーダーフリー誘導
BR122019025681B1 (pt) * 2012-11-01 2023-04-18 Factor Bioscience Inc Método para inserir uma sequência de ácido nucleico em uma localização segura de um genoma de uma célula
US9770489B2 (en) 2014-01-31 2017-09-26 Factor Bioscience Inc. Methods and products for nucleic acid production and delivery
US11241505B2 (en) 2015-02-13 2022-02-08 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
US11459560B2 (en) 2015-11-23 2022-10-04 The Regents Of The University Of Colorado Methods and compositions for reprogramming cells
US10576167B2 (en) 2016-08-17 2020-03-03 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
EP3541927A4 (en) * 2016-11-16 2020-11-25 Allele Biotechnology And Pharmaceuticals, Inc. INDUCTION OF PANCREATIC BETA CELLS BY DIFFERENTIATION OF STEM CELLS WITH RNA
US20180135023A1 (en) * 2016-11-16 2018-05-17 Allele Biotechnology And Pharmaceuticals, Inc. Induction of hepatocytes by stem cell differentiation with rna
KR102122336B1 (ko) * 2018-10-26 2020-06-12 서울시립대학교 산학협력단 세포전환용 rna 나노입자를 이용한 유도만능줄기세포의 제조방법
JP2022535192A (ja) 2019-05-14 2022-08-05 アレフ ファームス リミテッド 多能性細胞凝集体およびそれらの使用
KR20220039719A (ko) 2019-07-03 2022-03-29 팩터 바이오사이언스 인크. 양이온성 지질 및 이의 용도
US10501404B1 (en) 2019-07-30 2019-12-10 Factor Bioscience Inc. Cationic lipids and transfection methods
US20230053060A1 (en) * 2020-01-24 2023-02-16 I Peace, Inc. Method for manufacturing induced pluripotent stem cells
JP2022104813A (ja) 2020-12-29 2022-07-11 アイ ピース，インコーポレイテッド リプログラミング因子を導入された細胞の培養方法

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KR102081811B1 (ko) 2020-02-26
EP2850179A4 (en) 2016-02-24
EP2850179B1 (en) 2019-03-20
WO2013173248A3 (en) 2014-12-18
EP3561054A1 (en) 2019-10-30
JP6448531B2 (ja) 2019-01-09
CN104520424B (zh) 2019-06-28
DK2850179T3 (da) 2019-06-17
ES2951822T3 (es) 2023-10-25
CA2872688A1 (en) 2013-11-21
JP2015517311A (ja) 2015-06-22
CN104520424A (zh) 2015-04-15
KR102215413B1 (ko) 2021-02-16
AU2019203335B2 (en) 2021-10-21
AU2019203335A1 (en) 2019-05-30
EP2850179A2 (en) 2015-03-25
KR20150035594A (ko) 2015-04-06
CN110241087A (zh) 2019-09-17
KR20200021553A (ko) 2020-02-28
ES2729563T3 (es) 2019-11-04
CA2872688C (en) 2023-09-19
EP3561054C0 (en) 2023-07-05
AU2013263101A1 (en) 2014-11-27
EP3561054B1 (en) 2023-07-05
WO2013173248A2 (en) 2013-11-21
JP2017184766A (ja) 2017-10-12
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