AU2013263101B2 - Feeder-free derivation of human-induced pluripotent stem cells with synthetic messenger RNA - Google Patents

Feeder-free derivation of human-induced pluripotent stem cells with synthetic messenger RNA Download PDF

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AU2013263101B2
AU2013263101B2 AU2013263101A AU2013263101A AU2013263101B2 AU 2013263101 B2 AU2013263101 B2 AU 2013263101B2 AU 2013263101 A AU2013263101 A AU 2013263101A AU 2013263101 A AU2013263101 A AU 2013263101A AU 2013263101 B2 AU2013263101 B2 AU 2013263101B2
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reprogramming
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mrna
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AU2013263101A1 (en
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Yuhui NI
Jiwu Wang
Luigi Warren
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Allele Biotechnology and Pharmaceuticals Inc
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/606—Transcription factors c-Myc
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1307—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from adult fibroblasts
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    • C12N2510/00—Genetically modified cells

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  • General Chemical & Material Sciences (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2013263101A 2012-05-13 2013-05-13 Feeder-free derivation of human-induced pluripotent stem cells with synthetic messenger RNA Active AU2013263101B2 (en)

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AU2019203335A AU2019203335B2 (en) 2012-05-13 2019-05-13 Feeder-free derivation of human-induced pluripotent stem cells with synthetic messenger RNA

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US201261646292P 2012-05-13 2012-05-13
US61/646,292 2012-05-13
PCT/US2013/040814 WO2013173248A2 (en) 2012-05-13 2013-05-13 Feeder-free derivation of human-induced pluripotent stem cells with synthetic messenger rna

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JP (2) JP6448531B2 (enExample)
KR (2) KR102081811B1 (enExample)
CN (2) CN104520424B (enExample)
AU (2) AU2013263101B2 (enExample)
CA (1) CA2872688C (enExample)
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DK3260140T3 (da) 2011-12-05 2021-04-19 Factor Bioscience Inc Fremgangsmåder og produkter til transficering af celler
US8497124B2 (en) 2011-12-05 2013-07-30 Factor Bioscience Inc. Methods and products for reprogramming cells to a less differentiated state
EP3561054B1 (en) * 2012-05-13 2023-07-05 Allele Biotechnology And Pharmaceuticals, Inc. Feeder-free derivation of human-induced pluripotent stem cells with synthetic messenger rna
US10155929B2 (en) 2012-05-13 2018-12-18 Allele Biotechnology & Pharmaceuticals, Inc. Feeder-free derivation of human-induced pluripotent stem cells with synthetic messenger RNA
US10119150B2 (en) 2012-05-13 2018-11-06 Allele Biotechnology & Pharmaceuticals, Inc. Feeder-free Derivation of human-induced pluripotent stem cells with synthetic messenger RNA
BR122019025681B1 (pt) 2012-11-01 2023-04-18 Factor Bioscience Inc Método para inserir uma sequência de ácido nucleico em uma localização segura de um genoma de uma célula
WO2015117021A1 (en) 2014-01-31 2015-08-06 Factor Bioscience Inc. Methods and products for nucleic acid production and delivery
EP3543339A1 (en) 2015-02-13 2019-09-25 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
EP4470544A3 (en) * 2015-11-23 2025-06-18 The Regents of the University of Colorado, a body corporate Methods and compositions for reprogramming cells
CN109803977B (zh) 2016-08-17 2023-03-17 菲克特生物科学股份有限公司 核酸产品及其施用方法
CA3043372A1 (en) 2016-11-16 2018-05-24 Allele Biotechnology & Pharmaceuticals, Inc. Induction of pancreatic beta cells by stem cell differentiation with rna
AU2017363142B2 (en) * 2016-11-16 2024-05-30 Allele Biotechnology & Pharmaceuticals, Inc. Induction of hepatocytes by stem cell differentiation with RNA
KR102122336B1 (ko) * 2018-10-26 2020-06-12 서울시립대학교 산학협력단 세포전환용 rna 나노입자를 이용한 유도만능줄기세포의 제조방법
EP3969571A4 (en) 2019-05-14 2023-05-24 Aleph Farms Ltd. AGGREGATES OF PLURIPOTENT CELLS AND THEIR USE
WO2021003462A1 (en) 2019-07-03 2021-01-07 Factor Bioscience Inc. Cationic lipids and uses thereof
US10501404B1 (en) 2019-07-30 2019-12-10 Factor Bioscience Inc. Cationic lipids and transfection methods
US20230053060A1 (en) * 2020-01-24 2023-02-16 I Peace, Inc. Method for manufacturing induced pluripotent stem cells
JP2022104813A (ja) 2020-12-29 2022-07-11 アイ ピース，インコーポレイテッド リプログラミング因子を導入された細胞の培養方法

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DK2850179T3 (da) 2019-06-17
EP2850179B1 (en) 2019-03-20
KR102081811B1 (ko) 2020-02-26
CA2872688A1 (en) 2013-11-21
AU2013263101A1 (en) 2014-11-27
KR102215413B1 (ko) 2021-02-16
JP2017184766A (ja) 2017-10-12
ES2729563T3 (es) 2019-11-04
CA2872688C (en) 2023-09-19
KR20200021553A (ko) 2020-02-28
CN110241087A (zh) 2019-09-17
CN104520424B (zh) 2019-06-28
EP3561054A1 (en) 2019-10-30
AU2019203335A1 (en) 2019-05-30
EP2850179A4 (en) 2016-02-24
HK1204005A1 (en) 2015-11-06
ES2951822T3 (es) 2023-10-25
WO2013173248A2 (en) 2013-11-21
EP3561054B1 (en) 2023-07-05
CN104520424A (zh) 2015-04-15
JP6448531B2 (ja) 2019-01-09
KR20150035594A (ko) 2015-04-06
EP2850179A2 (en) 2015-03-25
CN110241087B (zh) 2023-02-03
AU2019203335B2 (en) 2021-10-21
JP2015517311A (ja) 2015-06-22
WO2013173248A3 (en) 2014-12-18
JP6530452B2 (ja) 2019-06-12
EP3561054C0 (en) 2023-07-05

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