CN110237188A - A kind of prevention and treatment hyperglycemia, the dendrobium candidum compound granule of hyperlipidemia - Google Patents
A kind of prevention and treatment hyperglycemia, the dendrobium candidum compound granule of hyperlipidemia Download PDFInfo
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Abstract
A kind of prevention and treatment hyperglycemia, the dendrobium candidum compound granule of hyperlipidemia, it is related to health care product development technique field.A kind of prevention and treatment hyperglycemia, the dendrobium candidum compound granule of hyperlipidemia, are made of following raw material: dendrobium candidum, Radix Astragali, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Schisandra chinensis, pharmaceutic adjuvant；The pharmaceutic adjuvant includes mannitol, microcrystalline cellulose, dextrin, calcium monohydrogen phosphate, aspartame.After by adopting the above technical scheme, the invention has the following beneficial effects: use value is high, it can be used for assisting in the treatment of the chronic diseases such as hyperglycemia, hyperlipidemia, fatty liver, with the health-care efficacies such as skin-protecting face nursing, anti-aging, antifatigue, immunological regulation, it is particularly suitable for the prevention of modern society's change of disease spectrum and the daily conditioning of health care, wide market.
Description
Technical field
The present invention relates to health care product development technique fields, and in particular to a kind of dendrobium candidum for preventing and treating hyperglycemia, hyperlipidemia
Compound granule.
Background technique
Modern pharmacology research shows that Dendrobium officinale polysaccharide has enhancing immune and antitumaous effect, and has hypoglycemic, drop
Blood pressure, reducing blood lipid and other effects, but dendrobium candidum as treat or prevent disease development and application still in initial stage.Dendrobium nobile
Mixture is the water pharmacy liquid as prepared by the decoction of the compatibilities such as dendrobium nobile, Radix Astragali, Radix Salviae Miltiorrhizae, radix rehmanniae recen, clinically treats diabetes B
Good result is obtained.
Often use value is not high for compound granule currently on the market, it is more difficult to for assisting in the treatment of hyperglycemia, hyperlipemia
The chronic diseases such as disease, fatty liver do not have the health-care efficacies such as skin-protecting face nursing, anti-aging, antifatigue, immunological regulation, are not suitable with
The prevention of modern society's change of disease spectrum and the daily conditioning of health care, performance is lower in colleague field and generalization is poor.
Summary of the invention
In view of the defects and deficiencies of the prior art, the present invention intends to provide a kind of prevention and treatment hyperglycemia, hyperlipidemia
Dendrobium candidum compound granule, use value is high, can be used for assisting in the treatment of the chronic diseases such as hyperglycemia, hyperlipidemia, fatty liver,
With the health-care efficacies such as skin-protecting face nursing, anti-aging, antifatigue, immunological regulation, it is particularly suitable for modern society's change of disease spectrum
Prevention and the daily conditioning of health care, wide market.
To achieve the above object, the present invention is using following technical scheme:
A kind of prevention and treatment hyperglycemia, the dendrobium candidum compound granule of hyperlipidemia, it is made of the raw material of following weight:
Dendrobium candidum 900-1100g, Radix Astragali 900-1100g, Radix Salviae Miltiorrhizae 700-900g, Rhizoma Chuanxiong 200-400g, Schisandra chinensis 300-500g,
Pharmaceutic adjuvant 800-1600g；
The pharmaceutic adjuvant includes mannitol, microcrystalline cellulose, dextrin, calcium monohydrogen phosphate, aspartame.
Its preparation method comprising the steps of:
Step 1: dendrobium candidum is dried, and the stem of dendrobium candidum is picked out, the stem of dendrobium candidum is crushed
Grinding, obtains dendrobium candidum powder, spare；
Step 2: Radix Astragali, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Schisandra chinensis are carried out pulverization process respectively, each compatibility medicinal powder is obtained, it is spare；
Step 3: mixing and being put into 70% ethanol dendrobium candidum powder, compatibility medicinal powder, refluxing extraction is then carried out, is obtained
To the first extracting solution, it be concentrated and dried spare；
Step 4: the dregs of a decoction after first is extracted extract into the water, the second extracting solution is obtained, it is concentrated and dried
It is spare；
It is mixed Step 5: merging the first, second extract with pharmaceutic adjuvant, is processed into granule after mixing evenly.
The oral dose of the granule can be given using the biology of the external Bionic digestion absorption process evaluation granule of alimentary canal
Property, by the content of naringenin and facing for index ingredient (naringenin) in unilamellar liposome artificial cell film combination dendrobium candidum stem
Bed dosage compares, and formulates recommended oral dose.
The working principle of the invention: dendrobium candidum is dried, and picks out the stem of dendrobium candidum, to iron sheet stone
The stem of dry measure used in former times is smashed and ground, and dendrobium candidum powder is obtained, spare；Radix Astragali, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Schisandra chinensis are crushed respectively
Processing, obtains compatibility medicinal powder, spare；Dendrobium candidum powder, compatibility medicinal powder are mixed and are put into 70% ethanol,
It then extracts, obtains the first extracting solution, be concentrated and dried spare；The dregs of a decoction after first is extracted are put into water and extract, and obtain
To the second extracting solution, it is concentrated and dried spare；Merge the first, second extract to mix with pharmaceutic adjuvant, stirs evenly post-processing system
At granule.
After adopting the above technical scheme, the invention has the following beneficial effects: use value is high, can be used for assisting in the treatment of hyperglycemia,
The chronic diseases such as hyperlipidemia, fatty liver have the health-care efficacies such as skin-protecting face nursing, anti-aging, antifatigue, immunological regulation, special
Not Shi He the prevention of modern society's change of disease spectrum and the daily conditioning of health care, wide market.
Specific embodiment
Embodiment 1
Present embodiment the technical solution adopted is that:
A kind of prevention and treatment hyperglycemia, the dendrobium candidum compound granule of hyperlipidemia, it is made of the raw material of following weight: dendrobium candidum
900g, Radix Astragali 900g, Radix Salviae Miltiorrhizae 700g, Rhizoma Chuanxiong 200g, Schisandra chinensis 300g, pharmaceutic adjuvant 800g；
The pharmaceutic adjuvant includes mannitol, microcrystalline cellulose, dextrin, calcium monohydrogen phosphate, aspartame.
Its preparation method comprising the steps of:
Step 1: dendrobium candidum is dried, and the stem of dendrobium candidum is picked out, the stem of dendrobium candidum is crushed
Grinding, obtains dendrobium candidum powder, spare；
Step 2: Radix Astragali, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Schisandra chinensis are carried out pulverization process respectively, each compatibility medicinal powder is obtained, it is spare；
Step 3: mixing and being put into 70% ethanol dendrobium candidum powder, compatibility medicinal powder, refluxing extraction is then carried out, is obtained
To the first extracting solution, it be concentrated and dried spare；
Step 4: the dregs of a decoction after first is extracted extract into the water, the second extracting solution is obtained, it is concentrated and dried
It is spare；
It is mixed Step 5: merging the first, second extract with pharmaceutic adjuvant, is processed into granule after mixing evenly.
Dendrobium candidum is China's tradition rare traditional Chinese medicine, there is reinforcing stomach reg fluid, nourishing Yin and clearing heat, promote longevity and other effects, it enjoys
There is the good reputation of " gold in medicine ", the research in terms of prevention and therapeutic efficiency has more report.Modern pharmacology research table
Bright, Dendrobium officinale polysaccharide has enhancing immune and antitumaous effect, and there is hypoglycemic, lowering blood pressure and blood fat and other effects.But stone
Dry measure used in former times polysaccharide characteristic is not strong, therefore, the strong index components of a kind of dendrobium candidum stem position characteristic, controllability is found, to raising
Quality control level marks very necessary as the effect of evaluation dendrobium candidum medicinal material and product.It studies from dendrobium candidum stem
Position is separated to 1 flavanone constituents --- and naringenin, the document report ingredient have apparent anti-inflammatory, antibacterial, analgesia, resist
The effects of oxidation, antitumor and immunological regulation.And other positions (leaf, Hua Hegen) of dendrobium candidum are free of naringenin, thus shaddock ped
Element can be used as the indication ingredient of dendrobium candidum stem.
Radix Astragali is the dry root of astragalus mongholicus or astragalus membranaceus of leguminous plant, and there is tonifying Qi and lifting yang, strengthening exterior and reducing sweat, Li Shui to disappear
Swollen, shengjin nourishing and other effects.Radix Astragali chemical component containing there are many, wherein polysaccharide, saponin(e, flavones are main actives, can be increased
The immunity of strong body, has and inhibits tumour, hypoglycemic, anti-bacteria and anti-virus, anti-aging and other effects.Pharmacological research proves, Radix Astragali
Main active one of of the polysaccharide as Radix Astragali has antitumor, anti-aging, antiviral, strengthen immunity, promotes immune device
The generation of official's function and antibody improves the effects of cardiovascular function, bidirectional modulation blood glucose.
Radix Salviae Miltiorrhizae is the drying root and rhizome of Lamiaceae Salvia plant Radix Salviae Miltiorrhizae, is one of most common drug for invigorating blood circulation and eliminating stasis,
Careless portion's top grade is listed in Shennong's Herbal, Gu has the saying of " Radix Salviae Miltiorrhizae simply, function is with four objects ": green blood of enriching blood, merits and demerits are returned
Ground;Blood is adjusted to hold back blood, power bears Chinese herbaceous peony;One of the main Chinese medicine of removing blood stasis and bringing forth new life, property times Rhizoma Chuanxiong and modern medicine study.In modern times
Medicine chemical research shows that the main pharmacodynamics ingredient of Radix Salviae Miltiorrhizae can be divided into 2 classes: one kind is fat-soluble diterpene-kind compound, such as Radix Salviae Miltiorrhizae
Ketone I, tanshinone IIA, Cryptotanshinone etc.；Another kind of is water-soluble phenolic compounds, such as tanshin polyphenolic acid B, alkannic acid, rosemary
Acid etc..Wherein liposoluble ingredient has a variety of pharmacological activity, such as cardiovascular and cerebrovascular activity, anti-tumor activity, antioxidant activity.
Rhizoma Chuanxiong cultivated plant, main product is in Sichuan, on Yunnan, Guizhou, Guangxi and other places, is grown on mild climatic environment.It is ancient
Rhizoma Chuanxiong has white-skinned face function in side's record, and effective component mainly has volatile oil, organic acid, alkaloid and triterpene compound
Deng.Rhizoma Chuanxiong extract has anti-inflammatory, anti-oxidation stress, neuroprotection, Ca2+ overloading, protection blood vessel endothelium, anti-cerebral ischemia Reperfu- sion
The effects of damage.Rhizoma Chuanxiong total phenolic acids are as an effective component group, solidifying with antiplatelet based on ferulic acid and chlorogenic acid
A variety of pharmacological activity such as collection, antithrombotic, anti-oxidant, removing free radical, prevention and treatment of coronary heart disease.
Schisandra chinensis is the Chinese medicine for being listed in top grade in Shennong's Herbal.Modern pharmacology research is the result shows that Schisandra chinensis
Contained lignanoid has protection cardiac muscle, lowering blood pressure and blood fat, liver protection and other effects, and triterpene has anti-inflammatory, antiviral, anti-swollen
Tumor and other effects.Early in the Song Dynasty, the prescription about Schisandra chinensis hepatoprotective effect has just been spread in generation.Modern pharmacological studies have shown that the five tastes
Son may have a variety of therapeutic effects, such as liver protection, anti-inflammatory and antioxidation.Studies at home and abroad show that mentioning from Schisandra chinensis
Take object and various monomer components to hepatopathy caused by a variety of causes such as alcoholic liver injury, non-alcoholic hepatic injury, liver fibrosis
There is therapeutic effect.
Embodiment 2
The present embodiment is with embodiment 1 the difference lies in that it is made of the raw material of following weight: dendrobium candidum 1000g, Radix Astragali
1000g, Radix Salviae Miltiorrhizae 800g, Rhizoma Chuanxiong 300g, Schisandra chinensis 400g, pharmaceutic adjuvant 1200g；
The pharmaceutic adjuvant includes mannitol, microcrystalline cellulose, dextrin, calcium monohydrogen phosphate, aspartame.
Other raw material compositions, preparation method are same as Example 1.
Embodiment 3
The present embodiment is with embodiment 1 the difference lies in that it is made of the raw material of following weight: dendrobium candidum 1100g, Radix Astragali
1100g, Radix Salviae Miltiorrhizae 900g, Rhizoma Chuanxiong 400g, Schisandra chinensis 500g, pharmaceutic adjuvant 1600g；
The pharmaceutic adjuvant includes mannitol, microcrystalline cellulose, dextrin, calcium monohydrogen phosphate, aspartame.
Other raw material compositions, preparation method are same as Example 1.
After adopting the above technical scheme, the invention has the following beneficial effects: use value is high, can be used for assisting in the treatment of hyperglycemia,
The chronic diseases such as hyperlipidemia, fatty liver have the health-care efficacies such as skin-protecting face nursing, anti-aging, antifatigue, immunological regulation, special
Not Shi He the prevention of modern society's change of disease spectrum and the daily conditioning of health care, wide market.
The above is only used to illustrate the technical scheme of the present invention and not to limit it, and those of ordinary skill in the art are to of the invention
The other modifications or equivalent replacement that technical solution is made as long as it does not depart from the spirit and scope of the technical scheme of the present invention should all
It is included within the scope of the claims of the present invention.
Claims (6)
1. a kind of prevention and treatment hyperglycemia, the dendrobium candidum compound granule of hyperlipidemia, which is characterized in that it by following weight raw material
Composition:
Dendrobium candidum 900-1100g, Radix Astragali 900-1100g, Radix Salviae Miltiorrhizae 700-900g, Rhizoma Chuanxiong 200-400g, Schisandra chinensis 300-500g,
Pharmaceutic adjuvant 800-1600g；
The pharmaceutic adjuvant includes mannitol, microcrystalline cellulose, dextrin, calcium monohydrogen phosphate, aspartame.
2. a kind of prevention and treatment hyperglycemia, the dendrobium candidum compound granule of hyperlipidemia according to claim 1, feature exist
In it is made of the raw material of following weight: dendrobium candidum 900g, Radix Astragali 900g, Radix Salviae Miltiorrhizae 700g, Rhizoma Chuanxiong 200g, Schisandra chinensis 300g,
Pharmaceutic adjuvant 800g；
The pharmaceutic adjuvant includes mannitol, microcrystalline cellulose, dextrin, calcium monohydrogen phosphate, aspartame.
3. a kind of prevention and treatment hyperglycemia, the dendrobium candidum compound granule of hyperlipidemia according to claim 1, feature exist
In: it is made of the raw material of following weight: dendrobium candidum 1000g, Radix Astragali 1000g, Radix Salviae Miltiorrhizae 800g, Rhizoma Chuanxiong 300g, Schisandra chinensis
400g, pharmaceutic adjuvant 1200g；
The pharmaceutic adjuvant includes mannitol, microcrystalline cellulose, dextrin, calcium monohydrogen phosphate, aspartame.
4. a kind of prevention and treatment hyperglycemia, the dendrobium candidum compound granule of hyperlipidemia according to claim 1, feature exist
In it is made of the raw material of following weight: dendrobium candidum 1100g, Radix Astragali 1100g, Radix Salviae Miltiorrhizae 900g, Rhizoma Chuanxiong 400g, Schisandra chinensis
500g, pharmaceutic adjuvant 1600g；
The pharmaceutic adjuvant includes mannitol, microcrystalline cellulose, dextrin, calcium monohydrogen phosphate, aspartame.
5. a kind of prevention and treatment hyperglycemia, the dendrobium candidum compound granule of hyperlipidemia according to claim 1, feature exist
In its preparation method comprising the steps of:
Step 1: dendrobium candidum is dried, and the stem of dendrobium candidum is picked out, the stem of dendrobium candidum is crushed
Grinding, obtains dendrobium candidum powder, spare；
Step 2: Radix Astragali, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Schisandra chinensis are carried out pulverization process respectively, each compatibility medicinal powder is obtained, it is spare；
Step 3: mixing and being put into 70% ethanol dendrobium candidum powder, compatibility medicinal powder, refluxing extraction is then carried out, is obtained
To the first extracting solution, it be concentrated and dried spare；
Step 4: the dregs of a decoction after first is extracted extract into the water, the second extracting solution is obtained, it is concentrated and dried
It is spare；
It is mixed Step 5: merging the first, second extract with pharmaceutic adjuvant, is processed into granule after mixing evenly.
6. a kind of prevention and treatment hyperglycemia, the dendrobium candidum compound granule of hyperlipidemia according to claim 5, feature exist
In: the oral dose of the granule, will using the Manual Suture of the external Bionic digestion absorption process evaluation granule of alimentary canal
The content of naringenin and the clinical of index ingredient (naringenin) are used in unilamellar liposome artificial cell film combination dendrobium candidum stem
Pharmaceutical quantities compare, and formulate recommended oral dose.
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| CN114099616A (en) * | 2021-10-08 | 2022-03-01 | 北京中医药大学 | Traditional Chinese medicine composition for resisting long-term endurance fatigue |
| CN114099616B (en) * | 2021-10-08 | 2022-12-09 | 北京中医药大学 | Traditional Chinese medicine composition for resisting long-endurance fatigue |
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Application publication date: 20190917 |