CN101229293A - Medicine compounds for treating senile dementia and preparing method thereof - Google Patents
Medicine compounds for treating senile dementia and preparing method thereof Download PDFInfo
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- CN101229293A CN101229293A CNA2008100561284A CN200810056128A CN101229293A CN 101229293 A CN101229293 A CN 101229293A CN A2008100561284 A CNA2008100561284 A CN A2008100561284A CN 200810056128 A CN200810056128 A CN 200810056128A CN 101229293 A CN101229293 A CN 101229293A
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Abstract
The invention discloses a medicine combination for treating senile dementia, which is prepared with ten traditional Chinese medicines of manyprickle acanto-panax root, epimedium herb, white peony root, angelica, RhizomaChuanxiong, largehead atractylodes rhizome, oriental waterplantain rhizome, thinleaf milkwort root-bark, poria cocos and grassleaf sweelflag rhizome. The medicine combination of the invention has functions of reinforcing the kidney to strengthen the spleen, nourishing blood to soothe the liver and being benefit for brain, and is used for treating senile dementia. The medicine combination for treating senile dementia has the advantages of good healing effect, no toxic and side effect, suitable for long-term use, convenient to obtain raw materials, low cost, simple production art and wide application value.
Description
Technical field
Belong to Chinese medicine preparation technique field, a kind of specifically treat senile dementia Chinese medicine preparation and preparation method thereof.
Background technology
Senile dementia is one group of common chronic progressive external mental deterioration disease of geratic period, occupies important position in old people's spectrum of disease and death notation.Think at present, senile dementia is because one group of syndrome of the senior cerebral disorder that organic lesion chronic or carrying out property brain structure causes, it is the persistent comprehensive hypophrenia that the patient occurs under the state of Consciousness, showing as memory, computing power, judgment, attention, abstract thinking ability, language function goes down, emotion and behavior disorder are lived on one's own life and the ability to work forfeiture.Senile dementia comprises alzheimer disease (AD), vascular dementia (VD) and Combination dementia etc.
The incidence various countries of senile dementia are not quite identical, and most reports are thought: over-65s Alzheimer prevalence is about 5%, and the statistical result of European and American countries is 4.1%～5.1%.The geographic survey result in nineteen ninety China Shanghai is 4.69%, and wherein alzheimer disease accounts for 60%, and vascular dementia accounts for 27%, and the prevalence of alzheimer disease is higher than vascular dementia.And the survey result of Beijing area is 3.96%, and wherein vascular dementia accounts for 67%.Prevalence of dementia is 8.90% among Guangzhou 75 years old and the above old man.75～79 years old old man's prevalence be 4.85%, 80～84 years old be 9.16%, 85 years old and above be 26.14%.No matter be dementia or AD, perhaps in all ages and classes section, women's prevalence all obviously exceeds 1～4 times of male.Also there is sure relation in the prevalence of age with dementia.The geographic investigation in China Shanghai: 55～59 years old be 0.26%, 60～69 years old be 0.70%, 70～79 years old be 10.58%, 80～84 years old be to be 2.94% more than 11.04%, 85 years old.The analysis in China Shanghai, every increase of age 5 years old, dull-witted prevalence increases by 0.74 times.
At present, doctor trained in Western medicine does not still have the special effect medicine therapeutic senile dementia, generally improves cerebral blood flow with following several drugs, promotes resuming function of brain cell.
(1) each 0.8～1.6 gram of piracetam (piracetam) is oral every day 3 times, but the cerebral blood flow increasing amount is improved cerebral anoxia, promotes the thinking memory.Be 6 weeks a course of treatment, and effective to light moderate senile dementia, severe is invalid.
(2) duxil is each 40 milligrams, and is each 1 time sooner or later, oral.This medicine is a cerebral metabolism promoter, and is widely-used abroad, and intelligence is recovered that better action is arranged, and uses more early, and effect is good more.
(3) vinpocetine (card is blue) is each 5 milligrams, and is oral every day 3 times, can improve the brain metabolism, recovers the ability that brain cell utilizes oxygen.
Motherland's medical science thinks that senile dementia belongs to categories such as motherland's medical science " dementia ", " melancholia " or " depressive psychosis ", " mania syndrome ", " asthenia ".In recent years, some prepare the treatment by Chinese herbs senile dementia, receive satisfied therapeutic effect.As " a kind of Chinese medicine preparation for the treatment of senile dementia " that the CN1857666A patent application proposes, it is the preparation by the preparation of Chinese medicines such as the Radix Astragali, Rhizoma Gastrodiae, Poria, Rhizoma Acori Graminei, Radix Ginseng, Fructus Lycii, Fructus Alpiniae Oxyphyllae, (ripe) Radix Rehmanniae, the Rhizoma Anemarrhenae, Radix Cyathulae, Rhizoma Chuanxiong, Rhizoma Dioscoreae, Herba Epimedii, Radix Polygalae and Radix Curcumae.And for example " Chinese medicine preparation of treatment senile dementia and preparation method thereof " of CN101036768A patent application proposition is the preparation by Rhizoma Polygonati, Radix Polygoni Multiflori Preparata, Radix Angelicae Sinensis, Radix Rehmanniae or Radix Rehmanniae, Herba Eupatorii and Fructus Amomi preparation.Different Chinese medicine preparations, the preparation effect that makes also has difference.
Summary of the invention
The objective of the invention is to overcome present weak point, a kind of good effect is provided, draw materials conveniently the pharmaceutical composition of the treatment senile dementia that expense is cheap, side effect is little at the treatment senile dementia.
The present invention also provides this preparation of drug combination method.
Pharmaceutical composition kidney and spleen invigorating of the present invention, it is soothing the liver to nourish blood, and brain-strengthening is had one's ideas straightened out, and can be used for senile dementia.
Compound prescription of the present invention can form by following prepared:
1, Radix Angelicae Sinensis powder is broken into coarser powder, extract 3 times with 6 times of amount alcohol heating reflux of 60～80%, and each 1.5 hours, merge extractive liquid,, filter, reclaim ethanol, being concentrated into relative density is 1.30～1.35 extractum (50～60 ℃ of heat are surveyed), vacuum drying was pulverized 80 mesh sieves, and was standby.
2, Rhizoma Acori Graminei adds water distillation 6 hours, collects volatile oil.
3, medicinal 8～10 times of water gagings decoct three times in eight flavors such as all the other Radix Et Caulis Acanthopanacis Senticosis, be followed successively by 2 hours, and 1.5 hours, 1 hour, filter, it is 1.15～1.20 extractum (50～60 ℃ of heat are surveyed) that filtrate is concentrated into relative density.
4, add Radix Angelicae Sinensis extract, spray into Rhizoma Acori Graminei volatile oil, drying.
Pharmaceutical composition of the present invention is prepared from by the following weight parts proportion raw material:
8～23 parts of 15～45 parts of Radix Angelicae Sinensis of 8～23 portions of Radix Paeoniae Albas of 15～45 parts of Herba Epimedii of Radix Et Caulis Acanthopanacis Senticosi
8～23 parts of 10～30 parts of Cortex et Radix Polygalae (processed) of 10～30 portions of Rhizoma Alismatis of 8～23 parts of Rhizoma Atractylodis Macrocephalaes of Rhizoma Chuanxiong
5～15 parts of 10～30 parts of Rhizoma Acori Graminei of Poria
Pharmaceutical composition of the present invention is prepared from by the following weight parts proportion raw material:
11～19 parts of 23～38 parts of Radix Angelicae Sinensis of 11～19 portions of Radix Paeoniae Albas of 23～38 parts of Herba Epimedii of Radix Et Caulis Acanthopanacis Senticosi
11～19 parts of Fu of 15～25 parts of Cortex et Radix Polygalae (processed) of 15～25 portions of Rhizoma Alismatis of 11～19 parts of Rhizoma Atractylodis Macrocephalaes of Rhizoma Chuanxiong
8～13 parts of 15～25 parts of Rhizoma Acori Graminei of Siberian cocklebur
Pharmaceutical composition of the present invention is prepared from by following optimum weight part proportion raw material:
15 parts of 15 parts of Rhizoma Chuanxiongs of 30 parts of Radix Angelicae Sinensis of 15 portions of Radix Paeoniae Albas of 30 parts of Herba Epimedii of Radix Et Caulis Acanthopanacis Senticosi
10 parts of 20 parts of Rhizoma Acori Graminei of 15 parts of Poria of 20 parts of Cortex et Radix Polygalae (processed) of 20 portions of Rhizoma Alismatis of the Rhizoma Atractylodis Macrocephalae
Pharmaceutical composition of the present invention can add the medicine acceptable carrier when being prepared into medicament: starch, sucrose, lactose, mannitol, glycerol, cyclodextrin, calcium carbonate, surfactant, agar, Pulvis Talci, calcium stearate, magnesium stearate etc.
Pharmaceutical composition of the present invention can be any pharmaceutically useful dosage form, comprising: tablet, capsule, granule, oral liquid, pill, powder, powder, drop.Preferred dosage form is capsule, tablet, granule.
The wherein said Radix Et Caulis Acanthopanacis Senticosi of pharmaceutical composition of the present invention is the dry root and rhizome of stems and leaves of acanthopanax senticosus (Rupr.et Maxim.) Harms.Main product is in the Northeast and ground such as Hebei, Beijing, Shanxi, Henan.
Herba Epimedii is the dry aerial parts of Berberidaceae plant Herba Epimedii Epimedium brevicornum Maxim., arrow leaf Herba Epimedii Epimedium sagittatum (Sieb.et Zucc.) Maxim., pubescence Herba Epimedii Epimedium pubescensMaxim., Epimedium wushanense Epimedium wushanense T.S.Ying or Herba Epimedii Epimediumkoreanum Nakai.Main product in Heilungkiang, ground such as Jilin, Liaoning, Shandong, Shaanxi, Jiangxi.With Herba Epimedii Preparata is good.
The Radix Paeoniae Alba is the dry root of cohosh Radix Paeoniae Paeonia lactiflora Pall..Main product in Zhejiang, ground such as Sichuan, Anhui.With Radix Paeoniae Alba (parched) is good.
Rhizoma Chuanxiong is the dry rhizome of samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort..Main product in Sichuan, ground such as Yunnan, Guizhou.
When the dry root that is classified as umbelliferae angelica Angelica sinensis (Oliv.) Diels.Main product in Gansu, ground such as Yunnan, Sichuan.
The Rhizoma Atractylodis Macrocephalae is the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Main product in Zhejiang, ground such as Hunan, Hubei, Hebei, Shandong.With Rhizoma Atractylodis Macrocephalae (parched with bran) is good.
Rhizoma Alismatis is the dry tuber of Alismataceae plant Rhizoma Alismatis Alisma orientalis (Sam.) Juzep..Main product is in Sichuan, Fujian and other places.With Rhizoma Alismatis is good.
Radix Polygalae is the dry root of milk wort Radix Polygalae Polygala tenuifolia Willd. or ovum leaf Radix Polygalae Polygala sibiricaL..Main product in Shanxi, ground such as Shaanxi, Henan, Jilin.With Cortex et Radix Polygalae (processed) is good.
Poria is the dry sclerotia of Polyporaceae fungus Poria Poria cocos (Schw.) Wolf.Main product in Yunnan, ground such as Anhui, Hubei, Henan, Sichuan.
Rhizoma Acori Graminei is the dry rhizome of acorus gramineus araceae plant Acorus tatarinowii Schott.Main product in Hubei, ground such as Hunan, Liaoning, Sichuan, Anhui.
The present invention is that classics side's " DANGGUI SHAOYAO SAN " adds flavor.On former side's basis, increase four Chinese medicines such as Rhizoma Acori Graminei, Cortex et Radix Polygalae (processed), Radix Et Caulis Acanthopanacis Senticosi, Herba Epimedii, be added on and play ministerial drug and adjuvant among the former side, be intended to increase the ratio of monarch medicine among the former side, formed the new prescription of a treatment senile dementia.
The DANGGUI SHAOYAO SAN invigorating the spleen and relieving depression of liver-QI was the efficacious prescriptions of treatment gynaecopathia originally, and discovery now can be used for multiple internal medicine illness.Eighties of last century end of the eighties, the clear treatment senile dementia of using it for first of Japanese scholar's water island a surname is obtained obvious curative effects.Modern study shows that DANGGUI SHAOYAO SAN has: (1) free radical resisting detrimental effect; (2) improve old people's sleep effect; (3) regulate body's immunity; (4) improve the learning and memory ability.
The arduous temperature of Radix Et Caulis Acanthopanacis Senticosi, the energy replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization can obviously promote ARA, RNA and proteinic synthesizing in the cerebral tissue, and improves the learning and memory ability; Herba Epimedii Xin Ganwen can kidney invigorating and YANG supporting, can promote the growth promoter of brain cell, and nerve growth factor (NGF) receptor is had tangible potentiation, can reach the effect of dementia by the NGF receptor agonism.The arduous temperature of Cortex et Radix Polygalae (processed), the Fructus Alpiniae Oxyphyllae of calming the nerves, effect with the brain atrophy of preventing, increase brain weight, obvious antagonism learning and memory of little mouse dysfunction, and can alleviate the generation of oxygen-derived free radicals, to reduce oxygen-derived free radicals to brain tissue injury, the m receptor density in the rat brain that can significantly raise, increase the acetylcholine transferase activity, obviously improve the ability of learning and memory of intending the Model of Dementia Mus; Rhizoma Acori Graminei suffering temperature, the refreshment of having one's ideas straightened out can improve and learn and memory, to all types of dysmnesia of mice, comprises that memory acquisition, memory consolidation and memory represents obstacle have improvement effect in various degree.But antidepressant has obvious antidepressant effect to the desperate type animal of behavior.
Beneficial effect of the present invention is:
1, selecting Chinese crude drug for use is raw material, and each component meets the pharmaceutical control and administration rules, utilizes the comprehensive function of the Chinese medicine of respectively distinguishing the flavor of to treat senile dementia, gives full play to the little advantage of herbal toxic effect.
2, the present invention need not to decoct no bitterness sense, taking convenience.
3, good effect of the present invention has no side effect, and is fit to life-time service; Draw materials conveniently, expense is cheap, makes simply, is with a wide range of applications.
Clinical observation shows with these invention treatment senile dementia 78 examples, total effective rate 82.05%.Do blood, urine, just routine and hepatic and renal function inspection before and after the treatment, no abnormality seen changes, and does not find in the medication process that this medicine has tangible untoward reaction.Test shows this invention treatment senile dementia, and good effect has no side effect.
Specific embodiment one
15kg is white for Radix Et Caulis Acanthopanacis Senticosi 30kg Herba Epimedii 15kg Radix Paeoniae Alba 30kg Radix Angelicae Sinensis 15kg Rhizoma Chuanxiong
Art 20kg Rhizoma Alismatis 20kg Cortex et Radix Polygalae (processed) 15kg Poria 20kg Rhizoma Acori Graminei 10kg
Radix Angelicae Sinensis powder is broken into coarser powder, extracts 3 times with 6 times of amount alcohol heating reflux of 60～80%, and each 1.5 hours, merge extractive liquid,, filter, reclaim ethanol, being concentrated into relative density is 1.30～1.35 extractum (50～60 ℃ of heat are surveyed), vacuum drying was pulverized 80 mesh sieves, and was standby; Rhizoma Acori Graminei adds water distillation 6 hours, collects volatile oil; Medicinal 8～10 times of water gagings decoct three times in eight flavors such as all the other Radix Et Caulis Acanthopanacis Senticosis, be followed successively by 2 hours, and 1.5 hours, 1 hour, filter, it is 1.15～1.20 extractum (50～60 ℃ of heat are surveyed) that filtrate is concentrated into relative density; Add Radix Angelicae Sinensis extract, spray into Rhizoma Acori Graminei volatile oil, drying.Be ground into fine powder, encapsulated.Every capsules 0.5g.
Specific embodiment two
Radix Et Caulis Acanthopanacis Senticosi 23kg Herba Epimedii 11kg Radix Paeoniae Alba 23kg Radix Angelicae Sinensis 11kg Rhizoma Chuanxiong 11kg
Rhizoma Atractylodis Macrocephalae 15kg Rhizoma Alismatis 15kg Cortex et Radix Polygalae (processed) 11kg Poria 15kg Rhizoma Acori Graminei 8kg
Radix Angelicae Sinensis powder is broken into coarser powder, extracts 3 times with 6 times of amount alcohol heating reflux of 60～80%, and each 1.5 hours, merge extractive liquid,, filter, reclaim ethanol, being concentrated into relative density is 1.30～1.35 extractum (50～60 ℃ of heat are surveyed), vacuum drying was pulverized 80 mesh sieves, and was standby; Rhizoma Acori Graminei adds water distillation 6 hours, collects volatile oil; Medicinal 8～10 times of water gagings decoct three times in eight flavors such as all the other Radix Et Caulis Acanthopanacis Senticosis, be followed successively by 2 hours, and 1.5 hours, 1 hour, filter, it is 1.15～1.20 extractum (50～60 ℃ of heat are surveyed) that filtrate is concentrated into relative density; Add Radix Angelicae Sinensis extract, spray into Rhizoma Acori Graminei volatile oil, drying.Be ground into fine powder, add appropriate amount of starch, alcohol granulation, after the drying, add an amount of magnesium stearate, tabletting, sugar coating gets final product.Every 0.3g.
Specific embodiment three
Radix Et Caulis Acanthopanacis Senticosi 38kg Herba Epimedii 19kg Radix Paeoniae Alba 38kg Radix Angelicae Sinensis 19kg Rhizoma Chuanxiong 19kg
Rhizoma Atractylodis Macrocephalae 25kg Rhizoma Alismatis 25kg Cortex et Radix Polygalae (processed) 19kg Poria 25kg Rhizoma Acori Graminei 13kg
Radix Angelicae Sinensis powder is broken into coarser powder, extracts 3 times with 6 times of amount alcohol heating reflux of 60～80%, and each 1.5 hours, merge extractive liquid,, filter, reclaim ethanol, being concentrated into relative density is 1.30～1.35 extractum (50～60 ℃ of heat are surveyed), vacuum drying was pulverized 80 mesh sieves, and was standby; Rhizoma Acori Graminei adds water distillation 6 hours, collects volatile oil; Medicinal 8～10 times of water gagings decoct three times in eight flavors such as all the other Radix Et Caulis Acanthopanacis Senticosis, be followed successively by 2 hours, and 1.5 hours, 1 hour, filter, it is 1.15～1.20 extractum (50～60 ℃ of heat are surveyed) that filtrate is concentrated into relative density; Add Radix Angelicae Sinensis extract, spray into Rhizoma Acori Graminei volatile oil, drying.Be ground into fine powder, add an amount of sucrose and soluble starch, alcohol granulation, the pack of dry back gets final product.Every bag of 5g.
Claims (6)
1. a pharmaceutical composition for the treatment of senile dementia is characterized in that raw material contains following medicaments in part by weight: 15～45 parts of Radix Et Caulis Acanthopanacis Senticosis, 8～23 parts of Herba Epimedii, 15～45 parts of the Radix Paeoniae Albas, 8～23 parts of Radix Angelicae Sinensis, 8～23 parts of Rhizoma Chuanxiongs, 10～30 parts of the Rhizoma Atractylodis Macrocephalaes, 10～30 parts of Rhizoma Alismatis, 8～23 parts of Cortex et Radix Polygalae (processed), 10～30 parts in Poria, 5～15 parts of Rhizoma Acori Graminei.
2. require described a kind of pharmaceutical composition for the treatment of senile dementia according to right 1, it is characterized in that raw material contains following medicaments in part by weight: 23～38 parts of Radix Et Caulis Acanthopanacis Senticosis, 11～19 parts of Herba Epimedii, 23～38 parts of the Radix Paeoniae Albas, 11～19 parts of Radix Angelicae Sinensis, 11～19 parts of Rhizoma Chuanxiongs, 15～25 parts of the Rhizoma Atractylodis Macrocephalaes, 15～25 parts of Rhizoma Alismatis, 11～19 parts of Cortex et Radix Polygalae (processed), 15～25 parts in Poria, 8～13 parts of Rhizoma Acori Graminei.
3. require described a kind of pharmaceutical composition for the treatment of senile dementia according to right 1,2, it is characterized in that the optimised quantity of each raw material is: 30 parts of Radix Et Caulis Acanthopanacis Senticosis, 15 parts of Herba Epimedii, 30 parts of the Radix Paeoniae Albas, 15 parts of Radix Angelicae Sinensis, 15 parts of Rhizoma Chuanxiongs, 20 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of Rhizoma Alismatis, 15 parts of Cortex et Radix Polygalae (processed), 20 parts in Poria, 10 parts of Rhizoma Acori Graminei.
4. require described pharmaceutical composition according to right 1-3, can be for being fit to medicinal various dosage forms.
5. the pharmaceutical composition that requires according to right 4 is capsule, tablet, granule.
6. according to the described raw material of right 1-3, its processing technology is:
(1) Radix Angelicae Sinensis powder is broken into coarser powder, extract 3 times with 6 times of amount alcohol heating reflux of 60～80%, and each 1.5 hours, merge extractive liquid,, filter, reclaim ethanol, being concentrated into relative density is 1.30～1.35 extractum (50～60 ℃ of heat are surveyed), vacuum drying was pulverized 80 mesh sieves, and was standby.
(2) Rhizoma Acori Graminei adds water distillation 6 hours, collects volatile oil.
(3) medicinal 8～10 times of water gagings decoct three times in eight flavors such as all the other Radix Et Caulis Acanthopanacis Senticosis, be followed successively by 2 hours, and 1.5 hours, 1 hour, filter, it is 1.15～1.20 extractum (50～60 ℃ of heat are surveyed) that filtrate is concentrated into relative density.
(4) add Radix Angelicae Sinensis extract, spray into Rhizoma Acori Graminei volatile oil, drying.
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| CNA2008100561284A CN101229293A (en) | 2008-01-14 | 2008-01-14 | Medicine compounds for treating senile dementia and preparing method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102430031A (en) * | 2011-12-31 | 2012-05-02 | 兰州太宝制药有限公司 | Traditional Chinese medicine composition for strengthening vitality and invigorating kidneys and preparation method thereof |
| CN102940834A (en) * | 2012-10-10 | 2013-02-27 | 肥西县中医院 | Traditional Chinese medicine for treating senile dementia |
| CN103071150A (en) * | 2012-12-11 | 2013-05-01 | 上海浦东高星生物技术研究所 | Chinese patent medicine for treating Alzheimer's disease |
| WO2015192804A1 (en) * | 2014-06-20 | 2015-12-23 | 四川济生堂药业有限公司 | Pharmaceutical composition for preventing and treating senile dementia and preparation method therefor |
| CN105194498A (en) * | 2015-10-15 | 2015-12-30 | 师冉 | Traditional Chinese medicine composition for treating Alzheimer's disease and preparation method of traditional Chinese medicine composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102430031A (en) * | 2011-12-31 | 2012-05-02 | 兰州太宝制药有限公司 | Traditional Chinese medicine composition for strengthening vitality and invigorating kidneys and preparation method thereof |
| CN102940834A (en) * | 2012-10-10 | 2013-02-27 | 肥西县中医院 | Traditional Chinese medicine for treating senile dementia |
| CN103071150A (en) * | 2012-12-11 | 2013-05-01 | 上海浦东高星生物技术研究所 | Chinese patent medicine for treating Alzheimer's disease |
| CN103071150B (en) * | 2012-12-11 | 2014-08-06 | 上海浦东高星生物技术研究所 | Chinese patent medicine for treating Alzheimer's disease |
| AU2015276657B2 (en) * | 2014-06-20 | 2017-12-14 | Sichuan Jishengtang Pharmaceutical Co., Ltd. | Pharmaceutical composition for preventing and treating senile dementia and preparation method thereof |
| CN105311083A (en) * | 2014-06-20 | 2016-02-10 | 四川济生堂药业有限公司 | Pharmaceutical composition for preventing and treating Alzheimer's disease and preparation method of pharmaceutical composition for preventing and treating Alzheimer's disease |
| JP2017515916A (en) * | 2014-06-20 | 2017-06-15 | スーチョワン ジシェンタン ファーマシューティカル カンパニー リミテッドＳｉｃｈｕａｎ Ｊｉｓｈｅｎｇｔａｎｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．，Ｌｔｄ． | Pharmaceutical composition used for the prevention and treatment of senile dementia and method for producing the same |
| WO2015192804A1 (en) * | 2014-06-20 | 2015-12-23 | 四川济生堂药业有限公司 | Pharmaceutical composition for preventing and treating senile dementia and preparation method therefor |
| EP3159004A4 (en) * | 2014-06-20 | 2018-02-21 | Sichuan Jishengtang Pharmaceutical Co., Ltd. | Pharmaceutical composition for preventing and treating senile dementia and preparation method therefor |
| KR20180099911A (en) * | 2014-06-20 | 2018-09-05 | 쓰촨 지쉔탕 파마슈티칼 코., 엘티디. | Pharmaceutical composition for preventing and treating senile dementia and preparation method thereof |
| RU2671566C2 (en) * | 2014-06-20 | 2018-11-02 | Сичуань Цзишэнтан Фармасьютикал Ко., Лтд. | Pharmaceutical composition for preventing and treating senile dementia and preparation method therefor |
| CN105311083B (en) * | 2014-06-20 | 2019-06-11 | 四川济生堂药业有限公司 | A kind of pharmaceutical composition and preparation method thereof preventing and treating senile dementia |
| KR101990758B1 (en) * | 2014-06-20 | 2019-06-18 | 쓰촨 지쉔탕 파마슈티칼 코., 엘티디. | Pharmaceutical composition for preventing and treating senile dementia and preparation method thereof |
| US10646536B2 (en) | 2014-06-20 | 2020-05-12 | Sichuan Jishengtang Pharmaceutical Co., Ltd. | Pharmaceutical composition for preventing and treating senile dementia and preparation method thereof |
| US11278584B2 (en) | 2014-06-20 | 2022-03-22 | Sichuan Jishengtang Pharmaceutical Cc | Pharmaceutical composition for preventing and treating senile dementia and preparation method thereof |
| CN105194498A (en) * | 2015-10-15 | 2015-12-30 | 师冉 | Traditional Chinese medicine composition for treating Alzheimer's disease and preparation method of traditional Chinese medicine composition |
| CN105194498B (en) * | 2015-10-15 | 2018-12-07 | 师冉 | A kind of Chinese medicine composition and preparation method thereof for treating senile dementia |
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