CN110237171B

CN110237171B - Medicine composition for femoral head necrosis and preparation method and application thereof

Info

Publication number: CN110237171B
Application number: CN201910551403.8A
Authority: CN
Inventors: 陈楚翁
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-06-24
Filing date: 2019-06-24
Publication date: 2022-02-11
Anticipated expiration: 2039-06-24
Also published as: CN110237171A

Abstract

The invention discloses a pharmaceutical composition for femoral head necrosis, a preparation method and application thereof, wherein the pharmaceutical composition comprises the following raw materials: 20-30 parts of astragalus membranaceus, 3-10 parts of ginseng, 3-5 parts of antler, 10-15 parts of angelica sinensis, 10-15 parts of honeysuckle, 10-20 parts of oldenlandia diffusa, 10-15 parts of golden cypress, 10-15 parts of rhizoma anemarrhenae, 10-15 parts of cortex lycii radicis, 10-20 parts of poria cocos, 10-15 parts of radix achyranthis bidentatae, 5-10 parts of ligusticum wallichii, 10-20 parts of rhizoma corydalis, 10-20 parts of ground beeltle, 5-10 parts of lumbricus, 10-20 parts of turtle shell, 10-15 parts of rhizoma cyperi, 3-7 parts of radix aconiti preparata, 5-10 parts of frankincense and 5-10 parts of myrrh. The invention also provides a preparation method and application of the composition. The composition can be used for preparing oral preparation for treating femoral head necrosis. The traditional Chinese medicine composition has the characteristics of reasonable formula, small dosage, obvious effect, no toxic or side effect and the like, and can effectively cure femoral head necrosis.

Description

Medicine composition for femoral head necrosis and preparation method and application thereof

Technical Field

The invention relates to a pharmaceutical composition in the field of traditional Chinese medicine preparations, a preparation method and application thereof, in particular to a pharmaceutical composition for femoral head necrosis, a preparation method and application thereof.

Background

Femoral head necrosis is a pathological evolution process caused by hip joint traumatic injury, the femoral head necrosis initially occurs in a load bearing area of femoral head, the necrotic bone trabecular structure is damaged under stress, namely, microfracture, and then the damaged bone tissue is repaired, so that the reason of the bone necrosis is not eliminated, the repair is incomplete, the damage-repair process is continued, and the like, and the structural change of the femoral head, the collapse and deformation of the femoral head, the arthritis and the dysfunction are caused. The serious patient finally needs to be remedied by artificial hip replacement to restore the walking ability.

The traditional Chinese medicine considers that: the disease is caused by the erosion of wind-cold-damp-heat and the infiltration of exogenous pathogenic factors, joint fever, swelling and nerve compression pain, difficult walking, difficult flexion and extension, low fever and no recession, difficult cure due to insufficient primordial qi, reduced immunity, deficiency of liver and kidney, invasion of wind-cold-damp evil into bone collaterals, influence on qi and blood circulation, qi and blood stasis stagnation, unsmooth running, cartilage destruction and meridian obstruction and pain. The principle of treatment is clearing, dredging, regulating and tonifying, and when people want to cure, the immunity function needs to be improved, so that the difficult symptom of femoral necrosis is eradicated.

Disclosure of Invention

The invention aims to provide a pharmaceutical composition, a preparation method and application thereof, and the oral preparation special for the compound traditional Chinese medicine for femoral head necrosis can solve the existing problems and has the characteristics of reasonable formula, small dosage, remarkable effect, no toxic or side effect and the like.

In order to achieve the above object, the present invention provides a pharmaceutical composition for femoral head necrosis, wherein the raw materials of the composition comprise: astragalus root, ginseng, antler, angelica, honeysuckle, oldenlandia diffusa, phellodendron, rhizoma anemarrhenae, cortex lycii radicis, poria cocos, achyranthes, ligusticum wallichii, corydalis tuber, ground beetle, earthworm, turtle shell, rhizoma cyperi, radix aconiti preparata, frankincense and myrrh.

The pharmaceutical composition for femoral head necrosis comprises the following components in parts by weight: 20-30 parts of astragalus membranaceus, 3-10 parts of ginseng, 3-5 parts of antler, 10-15 parts of angelica sinensis, 10-15 parts of honeysuckle, 10-20 parts of oldenlandia diffusa, 10-15 parts of golden cypress, 10-15 parts of rhizoma anemarrhenae, 10-15 parts of cortex lycii radicis, 10-20 parts of poria cocos, 10-15 parts of radix achyranthis bidentatae, 5-10 parts of ligusticum wallichii, 10-20 parts of rhizoma corydalis, 10-20 parts of ground beeltle, 5-10 parts of lumbricus, 10-20 parts of turtle shell, 10-15 parts of rhizoma cyperi, 3-7 parts of radix aconiti preparata, 5-10 parts of frankincense and 5-10 parts of myrrh.

The pharmaceutical composition for femoral head necrosis comprises the following components in parts by weight: 25 parts of astragalus membranaceus, 7 parts of ginseng, 4 parts of deer horn, 12 parts of angelica sinensis, 13 parts of honeysuckle, 15 parts of oldenlandia diffusa, 13 parts of golden cypress, 12 parts of rhizoma anemarrhenae, 12 parts of cortex lycii radicis, 15 parts of poria cocos, 13 parts of radix achyranthis bidentatae, 8 parts of ligusticum wallichii, 15 parts of rhizoma corydalis, 15 parts of ground beeltle, 7 parts of lumbricus, 15 parts of turtle shell, 12 parts of rhizoma cyperi, 5 parts of radix aconiti preparata, 8 parts of frankincense and 7 parts of myrrh.

The invention also provides a preparation method of the pharmaceutical composition for femoral head necrosis, wherein the method comprises the following steps: weighing the raw materials in proportion, respectively cleaning, grinding and crushing, then putting all the ground and crushed medicines into a container, mixing, adding water for soaking, heating and decocting, then filtering to remove residues to obtain a liquid medicine, and finally cooling.

The preparation method of the pharmaceutical composition for femoral head necrosis comprises the step of grinding and crushing the materials to obtain the pharmaceutical composition with the granularity of 30-40 meshes.

The preparation method of the pharmaceutical composition for femoral head necrosis comprises the steps of putting all ground and crushed medicines into a porcelain pot, adding distilled water which is 8-12 times of the total amount of the medicines by weight to cover the medicines, and soaking for 20-40 min.

The preparation method of the pharmaceutical composition for femoral head necrosis comprises the steps of boiling the liquid medicine with strong fire, then boiling with slow fire for 30-60 min, stopping heating, pouring out and filtering the liquid medicine, and pouring the filtered medicine residue into a porcelain jar to be decocted with water.

The preparation method of the pharmaceutical composition for femoral head necrosis comprises the following steps of pouring filtered medicine residues into a porcelain pot, adding distilled water which is 6-8 times of the total amount of the medicines by weight, boiling the medicine liquid with strong fire, then decocting with slow fire for 20-40 min, filtering, pouring out the medicine liquid, and mixing with the medicine liquid obtained at the first time.

The invention also provides application of the pharmaceutical composition prepared by the method, wherein the composition is used for preparing an oral preparation for treating femoral head necrosis.

The application of the pharmaceutical composition for femoral head necrosis prepared by the method is that the oral preparation is taken 2-3 times a day after meals, 200-300 ml is taken every time, and 1 month is a treatment course.

The pharmaceutical composition for femoral head necrosis, the preparation method and the application thereof provided by the invention have the following advantages:

the invention provides a special decoction for radically treating femoral head necrosis and bone mildew, which is researched and prepared by combining clinical experience of effectively treating difficult and complicated symptoms of femoral head necrosis and bone mildew according to a reasonable medicine mass ratio for symptoms.

The invention is along with the continuous development of Chinese medicine and pharmacology, on the aspect of treating the bone rheumatism difficult miscellaneous disease of femoral necrosis, through the new use of clinical original medicine of proved recipe, continuously know and verify in the application process that the prescription has the advantages of excellent curative effect, quick effect, small toxic and side effect and the like when being used for femoral head necrosis and bone mildew, and can cure the osteoarticular disease.

The composition provided by the invention has the characteristics of reasonable formula, pure nature, no additive, no toxic or side effect of animal and plant herbs, no harm to bodies and the like, and is obviously superior to medicines with similar functions.

Detailed Description

The following further describes embodiments of the present invention.

The invention provides a pharmaceutical composition for femoral head necrosis, which comprises the following raw materials: astragalus root, ginseng, antler, angelica, honeysuckle, oldenlandia diffusa, phellodendron, rhizoma anemarrhenae, cortex lycii radicis, poria cocos, achyranthes, ligusticum wallichii, corydalis tuber, ground beetle, earthworm, turtle shell, rhizoma cyperi, radix aconiti preparata, frankincense and myrrh.

Preferably, the composition comprises, in parts by weight: 20-30 parts of astragalus membranaceus, 3-10 parts of ginseng, 3-5 parts of antler, 10-15 parts of angelica sinensis, 10-15 parts of honeysuckle, 10-20 parts of oldenlandia diffusa, 10-15 parts of golden cypress, 10-15 parts of rhizoma anemarrhenae, 10-15 parts of cortex lycii radicis, 10-20 parts of poria cocos, 10-15 parts of radix achyranthis bidentatae, 5-10 parts of ligusticum wallichii, 10-20 parts of rhizoma corydalis, 10-20 parts of ground beeltle, 5-10 parts of lumbricus, 10-20 parts of turtle shell, 10-15 parts of rhizoma cyperi, 3-7 parts of radix aconiti preparata, 5-10 parts of frankincense and 5-10 parts of myrrh.

More preferably, the composition comprises, in parts by weight: 25 parts of astragalus membranaceus, 7 parts of ginseng, 4 parts of deer horn, 12 parts of angelica sinensis, 13 parts of honeysuckle, 15 parts of oldenlandia diffusa, 13 parts of golden cypress, 12 parts of rhizoma anemarrhenae, 12 parts of cortex lycii radicis, 15 parts of poria cocos, 13 parts of radix achyranthis bidentatae, 8 parts of ligusticum wallichii, 15 parts of rhizoma corydalis, 15 parts of ground beeltle, 7 parts of lumbricus, 15 parts of turtle shell, 12 parts of rhizoma cyperi, 5 parts of radix aconiti preparata, 8 parts of frankincense and 7 parts of myrrh.

Wherein, Huang Qi is sweet in nature and warm in flavor, and enters lung and spleen meridians. Mainly used for tonifying qi and strengthening exterior, strengthening spleen and strengthening middle-jiao, and is an essential drug for tonifying middle-jiao and qi, and applied to diseases of deficiency of spleen and kidney qi and diseases of sinking of middle-jiao, such as yang rising and sinking of qi, lung qi deficiency, qi-defensive qi consolidating exterior, kidney qi deficiency spontaneous perspiration, toxin expelling and tissue regeneration, qi and blood deficiency, edema caused by qi deficiency and water dampness failure and dysuria.

Ginseng is sweet in nature, slightly bitter and slightly damp, and enters lung, spleen and heart meridians. It can be used for treating deficiency-type deficiency syndrome, manifested by symptoms of deficiency of both qi and qi, deficiency of lung, spleen, heart, and kidney, thirst quenching, deficiency of qi due to febrile diseases, thirst due to body fluid consumption, diabetes, palpitation due to deficiency of heart and blood, insomnia, and amnesia. Tendons and bones regulating the general Chong and ren meridians, kidney deficiency and weak bones, weakness of waist and knees, metrorrhagia and leukorrhagia, toxin expelling, unhealed ulcer after long-term ulceration, deep-rooted carbuncle of yin type, sore and swelling and inward sinking of women.

Antler is sweet in nature, salty, warm, entering kidney and liver meridians. It can be used for treating kidney yang invigorating, essence and blood replenishing, kidney yang deficiency, essence and blood deficiency, and strengthening tendons and bones.

Dang Gui is sweet in nature and flavor, hydrophilic and warm, enters liver, heart and spleen meridians, and tonifies blood and regulates menstruation, so it is the holy drug for tonifying blood. It can be used for treating blood deficiency syndrome, menoxenia due to blood deficiency and blood stasis, amenorrhea, dysmenorrhea, deficiency-type cold type abdominal pain, traumatic injury, carbuncle, pyocutaneous disease, and arthralgia due to wind cold, loosening bowel to relieve constipation, and constipation due to blood deficiency and intestinal dryness.

The flos Lonicerae is dried bud or flower with initial blossom of Lonicera Japonica Thunb, Lonicera hypoglauca Miq, Lonicera confusa or Lonicera dasystyla of Caprifoliaceae. Sweet in nature and taste and cold in nature; it enters lung, heart and stomach meridians. Has the effects of clearing away heat and toxic materials, and dispelling pathogenic wind and heat. It is mainly used for treating carbuncle, furuncle, wind-heat type affection, early stage of epidemic febrile disease, and dysentery with blood due to toxic heat.

Herba Hedyotidis Diffusae is whole plant of herba Hedyotidis Diffusae of genus Erysia of family Rubiaceae. Bitter, sweet and cold in nature; enter stomach, large intestine and small intestine meridians. Has effects of clearing away heat and toxic materials, resolving carbuncle, resolving hard mass, promoting urination, removing dampness, and treating stranguria. Can be used for treating carbuncle, sore throat, snake bite, stranguria, tumor, damp-heat edema, jaundice, intestinal abscess, pulmonary abscess, skin ulcer, and furuncle.

The phellodendron bark is the dry bark of phellodendron bark of Rutaceae, is bitter in taste and cold in nature, enters kidney and bladder channels, has the effects of clearing heat and drying dampness, purging fire and removing steam, detoxifying and curing sore, and is used for treating damp-heat diarrhea and dysentery, jaundice and dark urine, leukorrhagia pruritus vulvae, stranguria with heat, beriberi flaccidity cramped, bone steaming and overexertion, night sweat, spermatorrhea, pyocutaneous disease and pyogenic infections, eczema and eczema; salted cortex phellodendri is used for nourishing yin and reducing internal heat; can be used for treating hyperactivity of fire due to yin deficiency, night sweat and steaming bone.

Rhizoma anemarrhenae is dried rhizome of Anemarrhena asphodeloides Bunge of Liliaceae. Cultivation is carried out in various places in China, and the most important production area is in the north of Hehe. Removing hair, silt or skin, drying in the sun, and slicing. Bitter in property and cold in nature. It enters lung, stomach and kidney meridians. Has the effects of clearing heat, purging fire, nourishing yin and moistening dryness. Can be used for treating fever polydipsia, lung heat dry cough, hectic fever due to yin-deficiency, internal heat diabetes, and constipation due to intestinal dryness.

Cortex Lycii is also called as fructus Lycii bark, and is root bark of fructus Lycii of Lycium of Solanaceae. Bitter and cold can clear and descend directly into the lower energizer, liver and kidney. Has the effects of clearing heat, removing heat from the body, cooling blood, removing heat from the body, clearing lung-heat, and lowering fire, and can be used for treating consumptive disease, hectic fever, night sweat, lung heat, cough, asthma, hematemesis, epistaxis, stranguria with blood, diabetes, hypertension, carbuncle, and malignant boil.

Poria is dried sclerotium of Poria cocos (Schw.) wolf of Polyporaceae. Digging for more than 7-9 months, removing silt after digging, piling up to generate sweat, spreading and drying until the surface is dry, then generating sweat, repeating for a plurality of times until wrinkles appear and most of internal water is lost, and drying in the shade to obtain Poria cocos; or cutting fresh Poria according to different parts, and drying in the shade to obtain Poria block and Poria tablet. Sweet and bland in flavor, neutral in nature, and entering heart, lung, spleen and kidney meridians. Has effects in promoting diuresis, eliminating dampness, invigorating spleen, and calming heart. It can be used for treating edema, oliguria, palpitation due to phlegm and fluid retention, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia.

Achyranthis radix is a perennial herb of the genus Achyranthis of the family Amaranthaceae. Dried root is used as raw material and unprocessed. Bitter, sweet, sour and neutral in nature. It enters liver and kidney meridians. Has the effects of removing blood stasis, dredging channels, nourishing liver and kidney, strengthening bones and muscles, inducing diuresis, treating stranguria and drawing blood downward. Can be used for treating amenorrhea, dysmenorrhea, soreness of waist and knees, myasthenia of bones and muscles, stranguria, edema, headache, vertigo, toothache, skin ulcer, hematemesis, and epistaxis.

Rhizoma Ligustici Chuanxiong is dried rhizome of Umbelliferae plant rhizoma Ligustici Chuanxiong; digging in 5 months, removing silt, drying in the sun, and removing fibrous root. Sliced, unprocessed or stir-baked with wine. Pungent and warm in nature and taste; entering liver, gallbladder and pericardium; has the effects of promoting qi circulation, resolving stagnation, dispelling pathogenic wind, eliminating dampness, promoting blood circulation, and relieving pain; it can be used for treating wind-cold headache, vertigo, hypochondriac pain, abdominal pain, cold arthralgia, spasm of tendons, amenorrhea, dystocia, puerperal stagnation, pain, carbuncle, cellulitis, and pyocutaneous disease. Can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal pain, pricking pain in chest and hypochondrium, traumatic injury, swelling and pain, headache, and rheumatalgia.

Yan Hu is pungent, bitter and warm in flavor and enters liver, spleen and heart meridians. Is mainly used for promoting blood circulation, removing blood stasis, promoting qi circulation and relieving pain. Qi stagnation in the circulation of blood and qi stagnation in the middle-jiao can be indicated for all kinds of pain, mainly for pain due to stasis, and for any kind of pain, it can be used briefly.

The Eupolyphaga Seu Steleophaga is female dry body of Eupolyphaga Seu Steleophaga or Eupolyphaga Seu Steleophaga of Cyperaceae. Capturing the wild in summer; the breeder can catch the feed all the year round. Scalding with boiling water, and sun drying or oven drying. Salty and cold in nature; it enters liver meridian. Has effects of removing blood stasis, promoting reunion of fractured tendons and bones. Can be used for treating traumatic injury, muscle injury, fracture, swelling and pain, amenorrhea due to blood stasis, puerperal abdominal pain due to blood stasis, and abdominal mass.

Pheretima, earthworm, is prepared by removing impurities and drying in the sun. Has effects of clearing heat, arresting convulsion, dredging collaterals, relieving asthma, and promoting urination. After being stir-baked, the Chinese medicinal composition is used for treating high fever, coma, fright epilepsy and convulsion, arthralgia, cough and asthma due to lung heat, oliguria and edema, hypertension and the like.

Carapax Trionycis is the dorsal scale of Trionycis of Trionychidae. Sweet in nature and taste, salty and cold in nature, entering liver and kidney meridians. Has the effects of nourishing yin, suppressing yang hyperactivity, relieving fever, removing dampness, softening hardness and dissipating stagnation. It is commonly indicated for fever due to yin deficiency, bone-steaming, fatigue-heat, yin deficiency with yang hyperactivity, dizziness, blurred vision, stirring of deficient wind, amenorrhea, mass, chronic malaria and malaria with malaria.

Xiang Fu is pungent, slightly bitter and neutral in flavor, and enters liver, spleen and two jiao meridians. Mainly used for soothing liver and relieving depression, is the key herb for soothing liver, relieving depression, promoting qi circulation and relieving pain, and is the key herb for regulating menstruation, relieving pain and treating gynecological diseases, regulating qi and regulating middle energizer and qi stagnation of spleen and stomach.

The radix Aconiti Preparata is processed product of radix Aconiti. Pungent, bitter and warm in flavor. Heart, liver, kidney, spleen meridians. Has effects of dispelling pathogenic wind, removing dampness, warming channels and relieving pain. Can be used for treating arthralgia due to wind-cold-dampness, arthralgia due to cold-dampness, and hernia pain.

The milk has pungent, bitter and mild taste, has effects of promoting blood circulation, activating qi-flowing, dredging channels, relieving pain, detumescence and promoting granulation, and can be used for treating heart and abdomen pain, rheumatalgia, amenorrhea dysmenorrhea, traumatic injury blood stasis and pain, superficial infection and toxic swelling, enterodynia, unhealed sore, etc.

Has no bitter and mild medicinal properties, has the effects of promoting blood circulation, relieving pain, eliminating swelling and promoting granulation, and can be used for treating chest and abdominal pain due to blood stasis, dysmenorrhea, amenorrhea, abdominal mass, traumatic injury, carbuncle, skin ulcer, intestinal abscess, conjunctival congestion, and swelling and pain.

The invention also provides a preparation method of the pharmaceutical composition for femoral head necrosis, which comprises the following steps: weighing the raw materials in proportion, respectively cleaning, grinding and crushing, then putting all the ground and crushed medicines into a container, mixing, adding water for soaking, heating and decocting, then filtering to remove residues to obtain a liquid medicine, and finally cooling.

Preferably, the particle size of the grinding and crushing is in a range of 30-40 meshes.

Putting all the ground and crushed medicines into a porcelain jar, adding distilled water which is 8-12 times of the total weight of the medicines by weight, covering the medicines, and soaking for 20-40 min, preferably for 30 min.

The heating and decocting are that the liquid medicine is boiled by big fire, then the liquid medicine is boiled by slow fire (small fire) for 30-60 min, the fire is stopped, the liquid medicine is poured out and filtered, and the filtered medicine dregs are poured into a porcelain jar to be decocted by adding water.

Pouring the filtered dregs into a porcelain jar, adding distilled water which is 6-8 times of the total amount of the medicines by weight, decocting the medicine liquid with strong fire, decocting with slow fire for 20-40 min, preferably 30min, filtering, pouring the medicine liquid, and mixing with the medicine liquid obtained at the first time.

The invention also provides application of the pharmaceutical composition prepared by the method, and the composition is used for preparing an oral preparation for treating femoral head necrosis.

The oral preparation is taken after meals, 2-3 times a day, 200-300 ml each time, and 1 month is a treatment course. The disease is cured in 1-3 courses of treatment mildly, and is cured in 3-6 courses of treatment severely.

The pharmaceutical composition for femoral head necrosis, the preparation method and the use thereof according to the present invention will be further described with reference to the following examples.

Examples 1 to 4

In each example, the pharmaceutical composition for femoral head necrosis is prepared according to the raw material component ratios shown in the following table 1. All the raw materials respectively accord with the corresponding national standards.

Table 1 formulation of pharmaceutical composition for femoral head necrosis (in parts by weight).

The embodiments of the invention also provide a preparation method of the pharmaceutical composition for femoral head necrosis and application of the prepared composition.

The method comprises the following steps: weighing the raw materials according to a proportion, respectively cleaning, grinding and crushing, wherein the granularity of grinding and crushing is 30-40 meshes. And then putting all the ground and crushed medicines into a container such as a porcelain jar for mixing, adding distilled water which is 8-12 times of the total weight of the medicines by weight to cover the medicines, and soaking for 20-40 min. And (3) heating and decocting, namely decocting the decoction with strong fire to boil the decoction, then decocting with slow fire (small fire) for 30-60 min, stopping heating, pouring out and filtering the decoction, pouring the filtered decoction dregs into a porcelain jar, adding distilled water which is 6-8 times of the total amount of the medicines by weight, decocting the decoction with strong fire to boil the decoction, then decocting with slow fire for 20-40 min, filtering, pouring out the decoction, mixing the filtrate with the first obtained decoction, and finally cooling.

The embodiments of the invention also provide the application of the composition prepared by the method, and the composition is used for preparing an oral preparation for treating femoral head necrosis.

The common adverse reactions of the medicinal composition for treating femoral head necrosis comprise dry mouth, palpitation and mild gastrointestinal discomfort, and can disappear after stopping administration. The taking notice is as follows: 1. the traditional Chinese medicine preparation with the prescription cannot be taken in an excessive amount and should be used with cautions; 2. patients with severe gastric ulcer should not take the medicine; 3. the pregnant woman is forbidden; 4. the doctor or pharmacist is asked to see the doctor immediately when the patient is forbidden to take the medicine excessively or has adverse reaction; 5. it is forbidden for children and patients with liver and kidney insufficiency.

The composition prepared in each embodiment is used for preparing an external application preparation, and clinical tests of differentiation and treatment are carried out on hundreds of patients according to the types of symptoms and signs at random, 150 patients take the composition, light patients take the composition for 1-3 courses of treatment, heavy patients take the composition for 3-6 courses of treatment, 120 patients are cured totally, and 28 patients are effective, wherein 24 patients are cured after continuing to take the composition for 1 month, the effective rate can reach more than 98%, and the cure rate can reach more than 96%.

Typical case 1: the prescription XX is a female, 42 years old, people in Shuichi county in Jiangxi province, the right hip joint has fever pain and difficulty in walking, the patient is examined to be femoral head necrosis in Nanchang hospital, and needs to be operated, and then transferred to Shanghai hospital, and the patient also belongs to femoral necrosis and needs to be operated. After going round to consult, after 10 doses of the traditional Chinese medicine provided by the invention are used, the traditional Chinese medicine improves the effect, reduces fever and pain, does not cause pain or fever after being continuously used for 3 months, has normal activity function, is used for 1 month after being consolidated, is basically normal after being examined by Nanchang hospital, and has no recurrence after being followed up after half a year.

Typical case 2: leaf XX, female, 54 years old, Wuning county, Jiangxi province, swollen, hard and swollen legs and feet, light pressure pain, black and shiny skin, no-going wearing of trousers and feet, difficult pain and inability to walk. The reason is that when vegetables are picked in a vegetable field in the country, the left thigh bone falls off, the vegetables are sent to a hospital for shooting, the fracture is checked, the bone in the bone is completely blackened, the bones are cured by hospital, the steel plate is fixed, the vegetables are discharged after 1 month, the left shank gall is caused after 3 months, the local medical treatment is improper, the patients are transferred to a southern Chang hospital and are invalid after half month treatment, the patients are advised to perform operation (the left limb is cut off), the patients are not sure, and the patients are rolled to the local place, the process of using the traditional Chinese medicine preparation provided by the invention is as follows: 1. fumigating the Chinese medicinal materials for 10 times; 2. the oral administration of the traditional Chinese medicine is combined internally and externally, the pain is obviously relieved after three days, the red swelling and pain are improved after half a month, the traditional Chinese medicine is continuously taken, the disease is basically cured after three months, the walking is normal, and the disease is followed after one year without relapse.

The invention relates to a medicinal composition for treating femoral head necrosis, which is a special decoction for treating femoral head necrosis and osteomyelitis, and is prepared by firstly using four diagnostic methods (inspection, smell, inquiry and cutting) in combination with western medicine test and X-ray film as basis according to the age and constitution of a patient, dividing monarch, minister, left guide and guide according to the medication of the patient, protecting and assisting channels, and reasonably applying the channel tropism application of ascending, descending, sinking and floating.

The applied solution is as follows: in the formula, astragalus and ginseng are mainly used as monarch drugs and are qi-tonifying holy drugs, ligusticum wallichii (ligusticum wallichii is a blood-qi-tonifying drug) is used for assisting vital qi, the medicines are led to directly reach focus, arthralgia is removed, stagnation is removed, honeysuckle and oldenlandia diffusa are added, and the toxin is released by the exposure of the vital energy, and the effects of removing deficiency fire and inducing diuresis are achieved, so that the effects of lifting and balancing are achieved, the prepared monkshood is added for removing dampness and blood stasis in bones, and the ground beetle and the earthworm can dredge channels and collaterals and recover damaged nerves; the angelica, the achyranthes and the corydalis tuber have the effects of promoting blood circulation to remove blood stasis, and treating and regulating qi and blood and poor flexion and extension of joints; lu Rong Bie Jia, with yin and yang tonifying, is accompanied by Xiang to regulate qi. By combining the formula, the traditional Chinese medicine can clear away damp-heat and toxic stasis inside and outside bones and remove deficient fire, tonify kidney and strengthen bones, and recover necrotic osseous nerves. The traditional Chinese medicine has the effects of strengthening vital qi to eliminate pathogenic factors, dredging channels and collaterals, removing putrefaction, promoting tissue regeneration, curing femoral head necrosis and rehabilitation.

The invention provides a pharmaceutical composition for femoral head necrosis and a preparation method and application thereof, aiming at the etiology and pathogenesis of diseases, the compatibility principle of drugs which supplement each other is utilized, the drugs are purposefully and reasonably compatible according to the organization structure of monarch, minister, assistant and guide, the drugs in the formula and the compatibility thereof are screwed with the pathogenesis of the diseases, and the comprehensive effect after the drug compatibility is highly unified with the established treatment method. The composition is a prescription formed by clinical tests of multiple cases, the functions and the indications of each medicine and the research according to the modern Chinese and western medicine pharmacology, has the characteristics of scientific and reasonable formula, simple and easy preparation method and easy popularization, can effectively radically cure femoral head necrosis, and has no adverse reaction and side effect.

While the present invention has been described in detail with reference to the preferred embodiments, it should be understood that the above description should not be taken as limiting the invention. Various modifications and alterations to this invention will become apparent to those skilled in the art upon reading the foregoing description. Accordingly, the scope of the invention should be determined from the following claims.

Claims

1. A pharmaceutical composition for femoral head necrosis is characterized in that the raw materials of the composition are as follows:

astragalus, ginseng, antler, angelica, honeysuckle, oldenlandia diffusa, phellodendron, rhizoma anemarrhenae, cortex lycii radicis, poria cocos, achyranthes, ligusticum wallichii, corydalis tuber, ground beetle, lumbricus, turtle shell, rhizoma cyperi, radix aconiti preparata, frankincense and myrrh;

the composition comprises the following components in parts by weight: 20-30 parts of astragalus membranaceus, 3-10 parts of ginseng, 3-5 parts of antler, 10-15 parts of angelica sinensis, 10-15 parts of honeysuckle, 10-20 parts of oldenlandia diffusa, 10-15 parts of golden cypress, 10-15 parts of rhizoma anemarrhenae, 10-15 parts of cortex lycii radicis, 10-20 parts of poria cocos, 10-15 parts of radix achyranthis bidentatae, 5-10 parts of ligusticum wallichii, 10-20 parts of rhizoma corydalis, 10-20 parts of ground beeltle, 5-10 parts of lumbricus, 10-20 parts of turtle shell, 10-15 parts of rhizoma cyperi, 3-7 parts of radix aconiti preparata, 5-10 parts of frankincense and 5-10 parts of myrrh.

2. The pharmaceutical composition for femoral head necrosis according to claim 1, wherein the composition comprises, in parts by weight:

25 parts of astragalus membranaceus, 7 parts of ginseng, 4 parts of deer horn, 12 parts of angelica sinensis, 13 parts of honeysuckle, 15 parts of oldenlandia diffusa, 13 parts of golden cypress, 12 parts of rhizoma anemarrhenae, 12 parts of cortex lycii radicis, 15 parts of poria cocos, 13 parts of radix achyranthis bidentatae, 8 parts of ligusticum wallichii, 15 parts of rhizoma corydalis, 15 parts of ground beeltle, 7 parts of lumbricus, 15 parts of turtle shell, 12 parts of rhizoma cyperi, 5 parts of radix aconiti preparata, 8 parts of frankincense and 7 parts of myrrh.

3. A process for the preparation of a pharmaceutical composition according to claim 1 or 2 for femoral head necrosis, said process comprising: weighing the raw materials in proportion, respectively cleaning, grinding and crushing, then putting all the ground and crushed medicines into a container, mixing, adding water for soaking, heating and decocting, then filtering to remove residues to obtain a liquid medicine, and finally cooling.

4. The method of claim 3, wherein the size of the ground particles is in the range of 30-40 mesh.

5. The preparation method of the pharmaceutical composition for femoral head necrosis according to claim 3, wherein in the method, all the ground and crushed medicines are placed into a porcelain pot, distilled water which is 8-12 times of the total amount of the medicines by weight is added to cover the medicines, and the medicines are soaked for 20-40 min.

6. The preparation method of the pharmaceutical composition for the treatment of femoral head necrosis as claimed in claim 3, wherein the heating and decocting is to decoct the liquid medicine with strong fire, then decoct with slow fire for 30-60 min, stop the fire, pour out and filter the liquid medicine, pour the filtered dregs of a decoction into a porcelain jar and decoct with water.

7. The preparation method of the pharmaceutical composition for femoral head necrosis as claimed in claim 6, wherein the method comprises pouring the filtered residues into a porcelain jar, adding distilled water 6-8 times of the total amount of the drugs by weight, decocting with strong fire to boil the liquid medicine, decocting with slow fire for 20-40 min, filtering, pouring out the liquid medicine, and mixing with the first obtained liquid medicine.

8. Use of a pharmaceutical composition prepared according to the method of claim 3, for the preparation of an oral formulation for the treatment of femoral head necrosis.

9. The use of the pharmaceutical composition for femoral head necrosis prepared by the method according to claim 8, wherein the oral preparation is taken 2-3 times a day after meals, 200-300 ml is taken each time, and 1 month is a treatment course.