CN110234652B - 苯并咪唑衍生物及其制备方法和用途 - Google Patents
苯并咪唑衍生物及其制备方法和用途 Download PDFInfo
- Publication number
- CN110234652B CN110234652B CN201780078241.XA CN201780078241A CN110234652B CN 110234652 B CN110234652 B CN 110234652B CN 201780078241 A CN201780078241 A CN 201780078241A CN 110234652 B CN110234652 B CN 110234652B
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- fluoro
- methyl
- compound
- pyridin
- pyrimidin
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2016/111457 | 2016-12-22 | ||
| CN2016111457 | 2016-12-22 | ||
| CNPCT/CN2017/080661 | 2017-04-14 | ||
| CN2017080661 | 2017-04-14 | ||
| PCT/CN2017/117950 WO2018113771A1 (en) | 2016-12-22 | 2017-12-22 | Benzimidazole derivatives, preparation methods and uses theirof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110234652A CN110234652A (zh) | 2019-09-13 |
| CN110234652B true CN110234652B (zh) | 2020-11-10 |
Family
ID=62624617
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780078241.XA Active CN110234652B (zh) | 2016-12-22 | 2017-12-22 | 苯并咪唑衍生物及其制备方法和用途 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11053238B2 (enExample) |
| EP (1) | EP3559000B1 (enExample) |
| JP (1) | JP7105781B2 (enExample) |
| KR (1) | KR102543603B1 (enExample) |
| CN (1) | CN110234652B (enExample) |
| AU (1) | AU2017379041B2 (enExample) |
| CA (1) | CA3047876C (enExample) |
| DK (1) | DK3559000T3 (enExample) |
| ES (1) | ES2917377T3 (enExample) |
| TW (1) | TWI732083B (enExample) |
| WO (1) | WO2018113771A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106608879A (zh) * | 2015-10-27 | 2017-05-03 | 甘李药业股份有限公司 | 一种蛋白激酶抑制剂及其制备方法和医药用途 |
| US11351170B2 (en) | 2017-08-15 | 2022-06-07 | Beijing Xuanyi Pharmasciences Co., Ltd. | Substituted pyrimidines as CDK4/6 inhibitors |
| KR20200131246A (ko) | 2018-02-15 | 2020-11-23 | 누베이션 바이오 인크. | 키나제 억제제로서의 헤테로시클릭 화합물 |
| EP3812386A4 (en) * | 2018-06-21 | 2022-03-30 | Betta Pharmaceuticals Co., Ltd | CRYSTALLINE FORM OF A CDK4/6 ACTIVITY INHIBITOR COMPOUND AND USE THEREOF |
| BR112021022105A2 (pt) * | 2019-05-05 | 2021-12-28 | Qilu Regor Therapeutics Inc | Inibidores de cdk |
| CN111138455B (zh) * | 2020-01-16 | 2022-03-04 | 郑州大学 | 一种手性四氢呋喃并恶嗪稠合苯并咪唑衍生物及其制备方法和用途 |
| WO2021218939A1 (zh) * | 2020-04-28 | 2021-11-04 | 贝达药业股份有限公司 | 稠环化合物及其在医药上的应用 |
| KR102269420B1 (ko) | 2020-09-18 | 2021-06-24 | 전용석 | 긴급대피용 마스크장치 |
| WO2022113003A1 (en) | 2020-11-27 | 2022-06-02 | Rhizen Pharmaceuticals Ag | Cdk inhibitors |
| WO2022149057A1 (en) | 2021-01-05 | 2022-07-14 | Rhizen Pharmaceuticals Ag | Cdk inhibitors |
| CN120682247A (zh) * | 2021-02-03 | 2025-09-23 | 江苏恒瑞医药股份有限公司 | 稠三环类细胞周期蛋白-依赖性激酶抑制剂及其制备方法和医药用途 |
| CN112979567B (zh) * | 2021-03-05 | 2023-07-18 | 中国医科大学 | Cdk12小分子抑制剂的化合物及其应用 |
| TWI912499B (zh) * | 2021-03-24 | 2026-01-21 | 大陸商貝達藥業股份有限公司 | 藥物組合、包含其的試劑盒及其用途 |
| WO2023131179A1 (zh) * | 2022-01-05 | 2023-07-13 | 贝达药业股份有限公司 | 苯并咪唑衍生物或其盐在治疗白血病中的用途 |
| WO2024027631A1 (zh) * | 2022-08-01 | 2024-02-08 | 江苏恒瑞医药股份有限公司 | 一种稠三环类衍生物的晶型及制备方法 |
| CN120936609A (zh) * | 2023-07-19 | 2025-11-11 | 浙江同源康医药股份有限公司 | 用作cdk2/4蛋白激酶抑制剂的化合物及其应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102264725A (zh) * | 2008-12-22 | 2011-11-30 | 伊莱利利公司 | 蛋白激酶抑制剂 |
| CN105153119A (zh) * | 2015-09-11 | 2015-12-16 | 广州科擎新药开发有限公司 | 吡啶嘧啶胺类化合物或吡啶吡啶胺类化合物及其应用 |
| WO2016173505A1 (en) * | 2015-04-28 | 2016-11-03 | Shanghai Fochon Pharmaceutical Co., Ltd. | Certain protein kinase inhibitor |
| WO2017071516A1 (zh) * | 2015-10-27 | 2017-05-04 | 甘李药业股份有限公司 | 一种蛋白激酶抑制剂及其制备方法和医药用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2804225C (en) * | 2010-07-02 | 2018-05-01 | Aska Pharmaceutical Co., Ltd. | Heterocyclic compound and p27kip1 degradation inhibitor |
| UA111756C2 (uk) | 2011-11-03 | 2016-06-10 | Ф. Хоффманн-Ля Рош Аг | Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона |
| WO2016014904A1 (en) | 2014-07-24 | 2016-01-28 | Beta Pharma, Inc. | 2-h-indazole derivatives as cyclin-dependent kinase (cdk) inhibitors and therapeutic uses thereof |
| UY36630A (es) * | 2015-04-17 | 2016-11-30 | Abbvie Inc | Moduladores tricíclicos de la señalización por tnf |
-
2017
- 2017-12-22 TW TW106145306A patent/TWI732083B/zh active
- 2017-12-22 ES ES17882916T patent/ES2917377T3/es active Active
- 2017-12-22 KR KR1020197020604A patent/KR102543603B1/ko active Active
- 2017-12-22 US US16/471,415 patent/US11053238B2/en active Active
- 2017-12-22 JP JP2019534709A patent/JP7105781B2/ja active Active
- 2017-12-22 WO PCT/CN2017/117950 patent/WO2018113771A1/en not_active Ceased
- 2017-12-22 CN CN201780078241.XA patent/CN110234652B/zh active Active
- 2017-12-22 CA CA3047876A patent/CA3047876C/en active Active
- 2017-12-22 AU AU2017379041A patent/AU2017379041B2/en active Active
- 2017-12-22 EP EP17882916.4A patent/EP3559000B1/en active Active
- 2017-12-22 DK DK17882916.4T patent/DK3559000T3/da active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102264725A (zh) * | 2008-12-22 | 2011-11-30 | 伊莱利利公司 | 蛋白激酶抑制剂 |
| WO2016173505A1 (en) * | 2015-04-28 | 2016-11-03 | Shanghai Fochon Pharmaceutical Co., Ltd. | Certain protein kinase inhibitor |
| CN105153119A (zh) * | 2015-09-11 | 2015-12-16 | 广州科擎新药开发有限公司 | 吡啶嘧啶胺类化合物或吡啶吡啶胺类化合物及其应用 |
| WO2017071516A1 (zh) * | 2015-10-27 | 2017-05-04 | 甘李药业股份有限公司 | 一种蛋白激酶抑制剂及其制备方法和医药用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| TW201829406A (zh) | 2018-08-16 |
| CN110234652A (zh) | 2019-09-13 |
| US11053238B2 (en) | 2021-07-06 |
| KR102543603B1 (ko) | 2023-06-14 |
| KR20190114971A (ko) | 2019-10-10 |
| EP3559000A4 (en) | 2020-05-27 |
| JP2020504747A (ja) | 2020-02-13 |
| EP3559000A1 (en) | 2019-10-30 |
| WO2018113771A1 (en) | 2018-06-28 |
| CA3047876C (en) | 2023-08-29 |
| ES2917377T3 (es) | 2022-07-08 |
| DK3559000T3 (da) | 2022-06-07 |
| EP3559000B1 (en) | 2022-03-23 |
| RU2019121937A (ru) | 2021-01-22 |
| CA3047876A1 (en) | 2018-06-28 |
| AU2017379041A1 (en) | 2019-07-25 |
| TWI732083B (zh) | 2021-07-01 |
| US20210130345A1 (en) | 2021-05-06 |
| JP7105781B2 (ja) | 2022-07-25 |
| RU2019121937A3 (enExample) | 2021-02-09 |
| AU2017379041B2 (en) | 2021-08-26 |
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