CN110234403A - 作为sting激动剂的环状二核苷酸 - Google Patents

作为sting激动剂的环状二核苷酸 Download PDF

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Publication number
CN110234403A
CN110234403A CN201880009026.9A CN201880009026A CN110234403A CN 110234403 A CN110234403 A CN 110234403A CN 201880009026 A CN201880009026 A CN 201880009026A CN 110234403 A CN110234403 A CN 110234403A
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compound
mmol
added
mixture
give
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CN201880009026.9A
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English (en)
Chinese (zh)
Inventor
S.伊曼纽尔
M.里克特
P.J.康诺利
J.P.爱德华兹
王广义
S.K.塔提孔达
L.贝高曼
钟明宏
G.比尼昂
W.舍彭斯
M.维勒沃耶
J.W.J.F.图林
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Janssen Biotech Inc
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Centocor Ortho Biotech Inc
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Publication of CN110234403A publication Critical patent/CN110234403A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
CN201880009026.9A 2017-01-27 2018-01-26 作为sting激动剂的环状二核苷酸 Pending CN110234403A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762451351P 2017-01-27 2017-01-27
US201762451301P 2017-01-27 2017-01-27
US62/451301 2017-01-27
US62/451351 2017-01-27
US201762454135P 2017-02-03 2017-02-03
US62/454135 2017-02-03
PCT/IB2018/050498 WO2018138685A2 (en) 2017-01-27 2018-01-26 Cyclic dinucleotides as sting agonists

Publications (1)

Publication Number Publication Date
CN110234403A true CN110234403A (zh) 2019-09-13

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CN201880009026.9A Pending CN110234403A (zh) 2017-01-27 2018-01-26 作为sting激动剂的环状二核苷酸

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US (2) US11492367B2 (OSRAM)
EP (1) EP3573718B1 (OSRAM)
JP (2) JP7275031B2 (OSRAM)
CN (1) CN110234403A (OSRAM)
AU (1) AU2018212788A1 (OSRAM)
ES (1) ES2924186T3 (OSRAM)
WO (1) WO2018138685A2 (OSRAM)

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TWI874791B (zh) 2020-02-18 2025-03-01 美商基利科學股份有限公司 抗病毒化合物
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112321589A (zh) * 2020-02-18 2021-02-05 山东科巢生物制药有限公司 一种抗病毒药物瑞德西韦及其中间体的合成方法
CN112321589B (zh) * 2020-02-18 2022-05-03 山东科巢生物制药有限公司 一种抗病毒药物瑞德西韦及其中间体的合成方法

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JP2020505405A (ja) 2020-02-20
JP2022180398A (ja) 2022-12-06
ES2924186T3 (es) 2022-10-05
US20190375782A1 (en) 2019-12-12
JP7275031B2 (ja) 2023-05-17
WO2018138685A3 (en) 2018-10-04
US11492367B2 (en) 2022-11-08
WO2018138685A2 (en) 2018-08-02
US20230146410A1 (en) 2023-05-11
AU2018212788A1 (en) 2019-07-25
EP3573718A2 (en) 2019-12-04
EP3573718B1 (en) 2022-06-01

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